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Heparan sulfate Sulfatases are essential for patterning of human stem cell-derived midbrain dopaminergic neurons Open

Chiara Tremolanti, Carmen Abaurre, Yu-Chun Chien, Carmen Saltó, C.H. Mitchell , et al. · 2025

Midbrain dopaminergic neurons (mDA) are selectively lost in Parkinson’s disease (PD), driving sustained efforts to generate bona fide mDA neurons from human-induced pluripotent stem cells (iPSCs) for replacement therapy. While morphogen gr…

Correction: Heparanase inhibition as a systemic approach to protect the endothelial glycocalyx and prevent microvascular complications in diabetes Open

Monica Gamez, Hesham E. Elhegni, Sarah Fawaz, Kwan Ho Ho, Neill Campbell , et al. · 2024

Heparanase inhibition as a systemic approach to protect the endothelial glycocalyx and prevent microvascular complications in diabetes Open

Monica Gamez, Hesham E. Elhegni, Sarah Fawaz, Kwan Ho Ho, Neill Campbell , et al. · 2024

Background Diabetes mellitus is a chronic disease which is detrimental to cardiovascular health, often leading to secondary microvascular complications, with huge global health implications. Therapeutic interventions that can be applied to…

Developing a patient-informed conceptual model of advanced and metastatic melanoma Open

S. McFadden, S. Pattanaik, Joanne S. Buzaglo, Jeremy E. Turnbull, S. Van Tomme · 2024

Background: Patients with advanced or metastatic melanoma experience symptoms that negatively affect their Health-Related Quality-of-Life. To our knowledge, there is no existing conceptual model (CM) consisting of relevant signs, symptoms,…

Heparin Precursors with Reduced Anticoagulant Properties Retain Antiviral and Protective Effects That Potentiate the Efficacy of Sofosbuvir against Zika Virus Infection in Human Neural Progenitor Cells Open

Isabel Pagani, Linda Ottoboni, Paola Panina‐Bordignon, Gianvito Martino, Guido Poli , et al. · 2023

Zika virus (ZIKV) infection during pregnancy can result in severe birth defects, such as microcephaly, as well as a range of other related health complications. Heparin, a clinical-grade anticoagulant, is shown to protect neural progenitor…

Supplementary Table 1 from MYCN-Dependent Expression of Sulfatase-2 Regulates Neuroblastoma Cell Survival Open

Valeria Solari, Lucia Borriello, Gianluca Turcatel, Hiroyuki Shimada, Richard Sposto , et al. · 2023

Sequences of primers used for RT-PCR.

Supplemental Figure 2 from MYCN-Dependent Expression of Sulfatase-2 Regulates Neuroblastoma Cell Survival Open

Valeria Solari, Lucia Borriello, Gianluca Turcatel, Hiroyuki Shimada, Richard Sposto , et al. · 2023

Negative control for figure 2.

Data from MYCN-Dependent Expression of Sulfatase-2 Regulates Neuroblastoma Cell Survival Open

Valeria Solari, Lucia Borriello, Gianluca Turcatel, Hiroyuki Shimada, Richard Sposto , et al. · 2023

Heparan sulfate proteoglycans (HSPG) play a critical role in the interaction of tumor cells and their microenvironment. HSPG activity is dictated by sulfation patterns controlled by sulfotransferases, which add sulfate groups, and sulfatas…

Supplementary Table 1 from MYCN-Dependent Expression of Sulfatase-2 Regulates Neuroblastoma Cell Survival Open

Valeria Solari, Lucia Borriello, Gianluca Turcatel, Hiroyuki Shimada, Richard Sposto , et al. · 2023

Sequences of primers used for RT-PCR.

Data from MYCN-Dependent Expression of Sulfatase-2 Regulates Neuroblastoma Cell Survival Open

Valeria Solari, Lucia Borriello, Gianluca Turcatel, Hiroyuki Shimada, Richard Sposto , et al. · 2023

Heparan sulfate proteoglycans (HSPG) play a critical role in the interaction of tumor cells and their microenvironment. HSPG activity is dictated by sulfation patterns controlled by sulfotransferases, which add sulfate groups, and sulfatas…

Supplemental Figure 2 from MYCN-Dependent Expression of Sulfatase-2 Regulates Neuroblastoma Cell Survival Open

Valeria Solari, Lucia Borriello, Gianluca Turcatel, Hiroyuki Shimada, Richard Sposto , et al. · 2023

Negative control for figure 2.

Supplemental Figure 1 from MYCN-Dependent Expression of Sulfatase-2 Regulates Neuroblastoma Cell Survival Open

Valeria Solari, Lucia Borriello, Gianluca Turcatel, Hiroyuki Shimada, Richard Sposto , et al. · 2023

Analysis of enzyme expression in other non -neuroblastoma cell lines.

Supplemental Figure 1 from MYCN-Dependent Expression of Sulfatase-2 Regulates Neuroblastoma Cell Survival Open

Valeria Solari, Lucia Borriello, Gianluca Turcatel, Hiroyuki Shimada, Richard Sposto , et al. · 2023

Analysis of enzyme expression in other non -neuroblastoma cell lines.

Low sulfated heparan sulfate mimetic differentially affects repair in immune‐mediated and toxin‐induced experimental models of demyelination Open

Susan L. Lindsay, George A. McCanney, Jiangshan Zhan, Miriam Scheld, Rebecca Sherrard Smith , et al. · 2023

There is an urgent need for therapies that target the multicellular pathology of central nervous system (CNS) disease. Modified, nonanticoagulant heparins mimic the heparan sulfate glycan family and are known regulators of multiple cellula…

Validation of Recombinant Heparan Sulphate Reagents for CNS Repair Open

Susan L. Lindsay, Rebecca Sherrard Smith, Edwin A. Yates, Colin Cartwright, Bryan E. Thacker , et al. · 2023

Therapies that target the multicellular pathology of central nervous system (CNS) disease/injury are urgently required. Modified non-anticoagulant heparins mimic the heparan sulphate (HS) glycan family and have been proposed as therapeutic…

Analysis of Heparin Samples by Attenuated Total Reflectance Fourier-Transform Infrared Spectroscopy in the Solid State Open

Anthony Devlin, Courtney J. Mycroft‐West, Jeremy E. Turnbull, Marcelo A. Lima, Marco Guerrini , et al. · 2023

Heparin is a polydisperse, heterogeneous polysaccharide of the glycosaminoglycan (GAG) class that has found widespread clinical use as a potent anticoagulant and is classified as an essential medicine by the World Health Organization. The …

Supplementary Material for: Thyroid Dysfunction After Atezolizumab and Bevacizumab is Associated with Favorable Outcomes in Hepatocellular Carcinoma Open

James M. Clegg, Scott E. Guimond, Jeremy E. Turnbull, Zhen J. Wang, Nirali M. Patel , et al. · 2023

Introduction: Atezolizumab and bevacizumab (Ate/Bev) combination has become the new first-line systemic therapy for unresectable hepatocellular carcinoma (HCC). Although several studies reported thyroid dysfunction after treatment with imm…

Chemokine CXCL4 interactions with extracellular matrix proteoglycans mediate widespread immune cell recruitment independent of chemokine receptors Open

Anna L. Gray, Richard Karlsson, Abigail R. E. Roberts, Amanda J. L. Ridley, Nabina Pun , et al. · 2023

High sensitivity (zeptomole) detection of BODIPY-labelled heparan sulfate (HS) disaccharides by ion-paired RP-HPLC and LIF detection enables analysis of HS from mosquito midguts Open

Marissa L. Maciej-Hulme, Anaëlle C. N. Leprince, Andre Lavin, Scott E. Guimond, Jeremy E. Turnbull , et al. · 2023

Ultra-sensitive disaccharide compositional analysis of heparin and heparan sulfate facilitated by ion-paired, reversed phase HPLC coupled with laser-induced fluorescence detection.

Editorial: C. elegans as an emerging model of pharmacological innovation Open

Zebo Huang, Ma Long, Ajay Mishra, Jeremy E. Turnbull, Haijun Tu · 2022

EDITORIAL article Front. Pharmacol., 27 September 2022Sec. Experimental Pharmacology and Drug Discovery Volume 13 - 2022 | https://doi.org/10.3389/fphar.2022.1029752

Evidence for Multiple Binding Modes in the Initial Contact Between SARS‐CoV‐2 Spike S1 Protein and Cell Surface Glycans** Open

Michela Parafioriti, Minghong Ni, Maurice Petitou, Courtney J. Mycroft‐West, Timothy R. Rudd , et al. · 2022

Infection of host cells by SARS‐CoV‐2 begins with recognition by the virus S (spike) protein of cell surface heparan sulfate (HS), tethering the virus to the extracellular matrix environment, and causing the subunit S1‐RBD to undergo a con…

Evidence for multiple binding modes in the initial contact between SARS-CoV-2 spike S1 protein and cell surface glycans Open

Michela Parafioriti, Minghong Ni, Maurice Petitou, Courtney J. Mycroft‐West, Timothy R. Rudd , et al. · 2022

Infection of host cells by SARS-CoV-2 begins with recognition by the virus S (spike) protein of cell surface heparan sulfate (HS), tethering the virus to the extracellular matrix environment, and causing the subunit S1-RBD to undergo a con…

Chemokine CXCL4 interactions with extracellular matrix proteoglycans mediate wide-spread non-receptor mediated immune cell recruitment Open

Anna L. Gray, Richard Karlsson, Abigail R. E. Roberts, Amanda J. L. Ridley, Nabina Pun , et al. · 2022

Leukocyte recruitment from the vasculature into tissues is a crucial component of the immune system, but is also key to inflammatory disease. Chemokines are central to this process but have yet to be therapeutically targeted during inflamm…

Initial contact between SARS-CoV-2 spike S1 protein and cell surface glycans involves multiple binding modes Open

Michela Parafioriti, Minghong Ni, Maurice Petitou, Courtney J. Mycroft‐West, Timothy R. Rudd , et al. · 2022

Infection of host cells by SARS-CoV-2 begins with recognition by the virus S (spike) protein of cell surface heparan sulfate (HS), tethering the virus to the extracellular matrix environment, and causing the subunit S1-RBD to undergo a con…

Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 by Disrupting the Spike–ACE2 Interaction Open

Scott E. Guimond, Courtney J. Mycroft‐West, Neha S. Gandhi, Julia A. Tree, Thuy T. Le , et al. · 2022

Heparan sulfate (HS) is a cell surface polysaccharide recently identified as a coreceptor with the ACE2 protein for the S1 spike protein on SARS-CoV-2 virus, providing a tractable new therapeutic target. Clinically used heparins demonstrat…

Dissecting structure-function of 3-O-sulfated heparin and engineered heparan sulfates Open

Richard Karlsson, Pradeep Chopra, Apoorva Joshi, Zhang Yang, Sergey Y. Vakhrushev , et al. · 2021

This study provides proof of concept for cell-based heparin without heparin-induced thrombocytopenia side effects.

The Hyperlipidaemic Drug Fenofibrate Significantly Reduces Infection by SARS-CoV-2 in Cell Culture Models Open

Scott Davies, Courtney J. Mycroft‐West, Isabel Pagani, Harriet J. Hill, Yen‐Hsi Chen , et al. · 2021

The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic has caused a significant number of fatalities and worldwide disruption. To identify drugs to repurpose to treat SARS-CoV-2 infections, we established a screen to mea…

Decision letter: Heparin-binding motif mutations of human diamine oxidase allow the development of a first-in-class histamine-degrading biopharmaceutical Open

Jeremy E. Turnbull, Ding Xu · 2021

Article Figures and data Abstract Introduction Materials and methods Results Discussion Data availability References Decision letter Author response Article and author information Metrics Abstract Background: Excessive plasma histamine con…

Tian-Huang Formula, a Traditional Chinese Medicinal Prescription, Improves Hepatosteatosis and Glucose Intolerance Targeting AKT-SREBP Nexus in Diet-Induced Obese Rats Open

Kunping Li, Yang Yu, Min Yuan, Chu‐Mei Zhang, Xianglu Rong , et al. · 2021

The progressive increase of metabolic diseases underscores the necessity for developing effective therapies. Although we found Tian-Huang formula (THF) could alleviate metabolic disorders, the underlying mechanism remains to be fully under…

The hyperlipidaemic drug fenofibrate significantly reduces infection by SARS-CoV-2 in cell culture models Open

Scott Davies, Courtney J. Mycroft‐West, Isabel Pagani, Harriet J. Hill, Yen‐Hsi Chen , et al. · 2021

The SARS-CoV-2 pandemic has caused a significant number of fatalities and worldwide disruption. To identify drugs to repurpose to treat SARS-CoV-2 infections, we established a screen to measure dimerization of ACE2, the primary receptor fo…

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