J. Scott VanEpps
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View article: Multiscale Hybrid Surface Topographies Orchestrate Immune Regulation, Antibacterial Defense, and Tissue Regeneration
Multiscale Hybrid Surface Topographies Orchestrate Immune Regulation, Antibacterial Defense, and Tissue Regeneration Open
Implant‐associated complications—including infection, adverse immune responses, and poor tissue integration—pose significant risks to patients, often leading to implant failure, revision surgeries, or chronic disease. Current chemical‐base…
View article: GenomicGapID: leveraging spatial distribution of conserved genomic sites for broad-spectrum microbial identification
GenomicGapID: leveraging spatial distribution of conserved genomic sites for broad-spectrum microbial identification Open
Bacterial detection and identification methods can be broadly classified as either untargeted with expansive taxonomic coverage or targeted with narrow taxonomic focus. Untargeted approaches, such as culture and sequencing, are often time-…
View article: Development of a Rapid, Culture-Free, Universal Microbial Identification System Using Internal Transcribed Spacer Targeting Primers
Development of a Rapid, Culture-Free, Universal Microbial Identification System Using Internal Transcribed Spacer Targeting Primers Open
The indiscriminate administration of broad-spectrum antibiotics is a primary contributor to the increasing prevalence of antibiotic resistance. Unfortunately, culture, the gold standard for bacterial identification is a time intensive proc…
View article: Identification of cultural conversations in therapy using natural language processing models.
Identification of cultural conversations in therapy using natural language processing models. Open
Researchers have historically focused on understanding therapist multicultural competency and orientation through client self-report measures and behavioral coding. While client perceptions of therapist cultural competency and multicultura…
View article: GenomicGapID: Leveraging Spatial Distribution of Conserved Genomic Sites for Broad-Spectrum Microbial Identification
GenomicGapID: Leveraging Spatial Distribution of Conserved Genomic Sites for Broad-Spectrum Microbial Identification Open
Bacterial detection and identification methods can be broadly classified as either untargeted with expansive taxonomic coverage or targeted with narrow taxonomic focus. Untargeted approaches, such as culture and sequencing, are often time-…
View article: Coupled Self-Replication and Self-Assembly of Inorganic Nanoparticles into Biosimilar Networks
Coupled Self-Replication and Self-Assembly of Inorganic Nanoparticles into Biosimilar Networks Open
Processes of self-replication, engineered using (bio)organic molecules and amphiphilic microdroplets, reveal fundamental requirements for the origin of life (1–4). However, their practical significance is limited by the absence of higher-l…
View article: Rapid diagnosis of bloodstream infections using a culture-free phenotypic platform
Rapid diagnosis of bloodstream infections using a culture-free phenotypic platform Open
Background Bloodstream infections (BSIs) are a life-threatening acute medical condition and current diagnostics for BSIs suffer from long turnaround time (TAT). Here we show the validation of a rapid detection-analysis platform (RDAP) for …
View article: Sepsis Trajectory Prediction Using Privileged Information and Continuous Physiological Signals
Sepsis Trajectory Prediction Using Privileged Information and Continuous Physiological Signals Open
The aim of this research is to apply the learning using privileged information paradigm to sepsis prognosis. We used signal processing of electrocardiogram and electronic health record data to construct support vector machines with and wit…
View article: Stretchable, Nano‐Crumpled MXene Multilayers Impart Long‐Term Antibacterial Surface Properties (Adv. Mater. Interfaces 16/2023)
Stretchable, Nano‐Crumpled MXene Multilayers Impart Long‐Term Antibacterial Surface Properties (Adv. Mater. Interfaces 16/2023) Open
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View article: Stretchable, Nano‐Crumpled MXene Multilayers Impart Long‐Term Antibacterial Surface Properties
Stretchable, Nano‐Crumpled MXene Multilayers Impart Long‐Term Antibacterial Surface Properties Open
Infections are a significant risk to patients who receive medical implants, and can often lead to implant failure, tissue necrosis, and even amputation. So far, although various surface modification approaches are proposed for prevention a…
View article: Self‐Organization of Iron Sulfide Nanoparticles into Complex Multicompartment Supraparticles
Self‐Organization of Iron Sulfide Nanoparticles into Complex Multicompartment Supraparticles Open
Self‐assembled compartments from nanoscale components are found in all life forms. Their characteristic dimensions are in 50–1000 nm scale, typically assembled from a variety of bioorganic “building blocks”. Among the various functions tha…
View article: Stretchable, nano-crumpled MXene multilayers impart long-term antibacterial surface properties
Stretchable, nano-crumpled MXene multilayers impart long-term antibacterial surface properties Open
Infections are a significant risk to patients who receive medical implants, and can often lead to implant failure, tissue necrosis, and even amputation. So far, although various surface modification approaches have been proposed for preven…
View article: Featured Cover
Featured Cover Open
The cover image is based on the Research Article Chiral chromatography and surface chirality of carbon nanoparticles by Misché A. Hubbard et al., https://doi.org/10.1002/chir.23507.
View article: Chiral chromatography and surface chirality of carbon nanoparticles
Chiral chromatography and surface chirality of carbon nanoparticles Open
Chiral carbon nanoparticles (CNPs) represent a rapidly evolving area of research for optical and biomedical technologies. Similar to small molecules, applications of CNPs as well as fundamental relationships between their optical activity …
View article: Molecular Architecture of PSMα1 Functional Amyloids
Molecular Architecture of PSMα1 Functional Amyloids Open
Biofilms are structurally and functionally complex networks of bacteria and nanoscale macromolecules that play an important role in a myriad of settings from personal health and agriculture to power productions and fuel storage. Amyloid na…
View article: A Multiphysics Modeling of Electromagnetic Signaling Phenomena at kHz-GHz Frequencies in Bacterial Biofilms
A Multiphysics Modeling of Electromagnetic Signaling Phenomena at kHz-GHz Frequencies in Bacterial Biofilms Open
This paper presents a model that describes a possible mechanism for electromagnetic (EM) signal transmission and reception by bacterial cells within their biofilm communities. Bacterial cells in biofilms are embedded into a complex extrace…
View article: Molecular Architecture and Helicity of Bacterial Amyloid Nanofibers: Implications for the Design of Nanoscale Antibiotics
Molecular Architecture and Helicity of Bacterial Amyloid Nanofibers: Implications for the Design of Nanoscale Antibiotics Open
Amyloid nanofibers are abundant in microorganisms and are integral components of many biofilms, serving various purposes, from virulent to structural. Nonetheless, the precise characterization of bacterial amyloid nanofibers has been elusi…
View article: Dosage‐Dependent Antimicrobial Activity of DNA‐Histone Microwebs Against <i>Staphylococcus Aureus</i>
Dosage‐Dependent Antimicrobial Activity of DNA‐Histone Microwebs Against <i>Staphylococcus Aureus</i> Open
Neutrophil extracellular traps (NETs) are antimicrobial cobweb‐structured materials produced by immune cells for clearance of pathogens in the body, but are paradoxically associated with biofilm formation and exacerbated lung infections. T…
View article: Staphylococcus epidermidis Has Growth Phase Dependent Affinity for Fibrinogen and Resulting Fibrin Clot Elasticity
Staphylococcus epidermidis Has Growth Phase Dependent Affinity for Fibrinogen and Resulting Fibrin Clot Elasticity Open
Bacterial infection and thrombosis are highly correlated, especially in patients with indwelling medical devices. Coagulase-negative staphylococci, typified by Staphylococcus epidermidis , are a common cause of medical device infections ow…
View article: A novel swine model of the acute respiratory distress syndrome using clinically relevant injury exposures
A novel swine model of the acute respiratory distress syndrome using clinically relevant injury exposures Open
To date, existing animal models of the acute respiratory distress syndrome (ARDS) have failed to translate preclinical discoveries into effective pharmacotherapy or diagnostic biomarkers. To address this translational gap, we developed a h…
View article: Improved diagnostic prediction of the pathogenicity of bloodstream isolates of Staphylococcus epidermidis
Improved diagnostic prediction of the pathogenicity of bloodstream isolates of Staphylococcus epidermidis Open
With an estimated 440,000 active cases occurring each year, medical device associated infections pose a significant burden on the US healthcare system, costing about $9.8 billion in 2013. Staphylococcus epidermidis is the most common cause…
View article: A comprehensive assessment of multi-system responses to a renal inoculation of uropathogenic E. coli in swine
A comprehensive assessment of multi-system responses to a renal inoculation of uropathogenic E. coli in swine Open
Background The systemic responses to infection and its progression to sepsis remains poorly understood. Progress in the field has been stifled by the shortcomings of experimental models which include poor replication of the human condition…
View article: Improved diagnostic prediction of the pathogenicity of bloodstream isolates of<i>Staphylococcus epidermidis</i>
Improved diagnostic prediction of the pathogenicity of bloodstream isolates of<i>Staphylococcus epidermidis</i> Open
With an estimated 440,000 active cases occurring each year, medical device associated infections pose a significant burden on the US healthcare system, costing about $9.8 billion in 2013. Staphylococcus epidermidis is the most common cause…
View article: Struct2Graph: A graph attention network for structure based predictions of protein-protein interactions
Struct2Graph: A graph attention network for structure based predictions of protein-protein interactions Open
Background Development of new methods for analysis of protein-protein interactions (PPIs) at molecular and nanometer scales gives insights into intracellular signaling pathways and will improve understanding of protein functions, as well a…
View article: Differential Effects of Heated Perfusate on Morphology, Viability, and Dissemination of Staphylococcus epidermidis Biofilms
Differential Effects of Heated Perfusate on Morphology, Viability, and Dissemination of Staphylococcus epidermidis Biofilms Open
Bacterial biofilms are a leading cause of medical device infections. Staphylococcus epidermidis is commonly responsible for these types of infections. With increasing occurrences of antibacterial resistance, there has been a new push to ex…