Jeremy J. Heit
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View article: Neuroimaging Predictors of Futile Recanalization in Anterior Circulation Stroke: A Systematic Review and Meta-Analysis
Neuroimaging Predictors of Futile Recanalization in Anterior Circulation Stroke: A Systematic Review and Meta-Analysis Open
AIS: Acute Ischemic Stroke; CCR: Cerebral Collateral Recycle; EVT: Endovascular Thrombectomy; FR: Futile Recanalization; HIR: Hypoperfusion Intensity Ratio; LVO: Large Vessel Occlusion; MT: Mechanical Thrombectomy; rCBV: Relative Cerebral …
View article: Cerebral Blood Volume Index Is Associated with Futile Recanalization After Endovascular Thrombectomy in Anterior Circulation Large Vessel Occlusion Stroke
Cerebral Blood Volume Index Is Associated with Futile Recanalization After Endovascular Thrombectomy in Anterior Circulation Large Vessel Occlusion Stroke Open
EVT＝ Endovascular Thrombectomy; LVO＝ Large Vessel Occlusion; AIS＝ Acute Ischemic Stroke; HIR＝Hypoperfusion Intensity Ratio; ROC＝ Receiver Operating Characteristic; AUC＝ Area Under the Curve; HT＝ Hemorrhagic Transformation; Tmax＝ Time-to-Ma…
View article: Both Infarcted and Noninfarcted Brain Regions Contribute to Deep Learning–Based MRI Prediction of Acute Stroke Outcome
Both Infarcted and Noninfarcted Brain Regions Contribute to Deep Learning–Based MRI Prediction of Acute Stroke Outcome Open
While the best performance came from by using the full brain imaging volume, we demonstrate that the infarct location, its signal characteristics, and importantly, the noninfarcted regions all contribute to the predictions. The noninfarcte…
View article: Prolonged Venous Transit Is Associated with Unfavorable Functional Outcomes in Large Core Stroke
Prolonged Venous Transit Is Associated with Unfavorable Functional Outcomes in Large Core Stroke Open
PVT is independently associated with unfavorable outcomes in patients with large core AIS-LVO. These findings suggest PVT may serve as a prognostic marker, warranting further investigation and validation in larger prospective studies to gu…
View article: Redefining Ischemic Core, Penumbra, and Target Mismatch on Perfusion Imaging in Acute Anterior Distal Medium Vessel Occlusion
Redefining Ischemic Core, Penumbra, and Target Mismatch on Perfusion Imaging in Acute Anterior Distal Medium Vessel Occlusion Open
BACKGROUND Recent trials of endovascular thrombectomy (EVT) for acute distal medium vessel occlusions (DMVOs) were negative but also used inconsistent imaging‐based inclusion criteria, whereas many successful large vessel occlusion (LVO) E…
View article: Unfavorable Perfusion Collateral Impairment Score Is Associated with Higher Odds of Poor Outcomes in Large Vessel Occlusion Stroke
Unfavorable Perfusion Collateral Impairment Score Is Associated with Higher Odds of Poor Outcomes in Large Vessel Occlusion Stroke Open
BACKGROUND Effective collateral circulation significantly influences clinical outcomes in patients with acute ischemic stroke due to large vessel occlusion. We developed and evaluated a composite Perfusion Collateral Impairment Score (PCIS…
View article: Prolonged venous transit - where venous outflow meets financial outflow: a cost analysis
Prolonged venous transit - where venous outflow meets financial outflow: a cost analysis Open
View article: Prolonged Venous Transit Is Associated With Unfavorable Outcomes in Anterior Circulation Distal Medium Vessel Stroke
Prolonged Venous Transit Is Associated With Unfavorable Outcomes in Anterior Circulation Distal Medium Vessel Stroke Open
Background and Purpose Distal medium‐vessel occlusion (DMVO) strokes represent a significant proportion of acute ischemic stroke cases, yet optimal management remains unclear. Prolonged venous transit (PVT), a marker of poor venous outflow…
View article: Demographic and Premorbid Clinical Factors Predict Modified Rankin Score in Large and Medium Vessel Occlusion Ischemic Strokes
Demographic and Premorbid Clinical Factors Predict Modified Rankin Score in Large and Medium Vessel Occlusion Ischemic Strokes Open
Background/Objectives: We report on the association of clinical, demographic, and peri- and intraoperative factors with patient outcomes in large- and, separately, medium-vessel acute ischemic stroke (AIS) occlusions treated with mechanica…
View article: Interobserver and Intraobserver Variability in the Assessment of Prolonged Venous Transit in Anterior Circulation Large-Vessel Occlusion Ischemic Stroke
Interobserver and Intraobserver Variability in the Assessment of Prolonged Venous Transit in Anterior Circulation Large-Vessel Occlusion Ischemic Stroke Open
Qualitative PVT assessment demonstrated substantial interobserver and almost perfect intraobserver reliability. These findings support the use of PVT as a consistent marker of impaired venous outflow in AIS-LVO. Future studies should explo…
View article: Hypoperfusion intensity ratio is associated with follow-up infarct volume in medium vessel occlusions: A multicenter multinational study
Hypoperfusion intensity ratio is associated with follow-up infarct volume in medium vessel occlusions: A multicenter multinational study Open
Medium vessel occlusion (MeVO) contributes significantly to acute ischemic stroke (AIS). The hypoperfusion intensity ratio (HIR), reflecting collateral circulation via the ratio of Tmax >10s to Tmax >6s volumes, predicts infarct progressio…
View article: Endovascular management of tandem occlusions: current evidence and future directions
Endovascular management of tandem occlusions: current evidence and future directions Open
Tandem occlusions (TOs)—concurrent extracranial large artery steno-occlusion and intracranial artery occlusion—represent a challenging clinical predicament. Stroke due to TOs is associated with high mortality and morbidity. Because of incr…
View article: Baseline predictors of poor clinical outcome despite recanalization of distal middle cerebral artery occlusions
Baseline predictors of poor clinical outcome despite recanalization of distal middle cerebral artery occlusions Open
Objective Mechanical thrombectomy (MT) is well-established for the treatment of acute ischemic stroke (AIS) from large vessel occlusion (LVO), with growing data supporting the expansion to distal and medium vessel occlusions (DMVO). Despit…
View article: Integrating perfusion imaging derived venous outflow and tissue-level collateral parameters in a comprehensive clinical model enhances prognostication in large vessel occlusion stroke
Integrating perfusion imaging derived venous outflow and tissue-level collateral parameters in a comprehensive clinical model enhances prognostication in large vessel occlusion stroke Open
View article: Hemorrhagic transformation during inter-hospital transfer for thrombectomy: Incidence, associated factors, and relationship with outcome
Hemorrhagic transformation during inter-hospital transfer for thrombectomy: Incidence, associated factors, and relationship with outcome Open
Background: Patients with acute ischemic stroke with a large vessel occlusion (AIS-LVO) admitted to primary stroke centers (PSC) often require inter-hospital transfer to a comprehensive stroke center (CSC) for endovascular therapy (EVT). W…
View article: Intravenous Thrombolysis Use before Inter‐Facility Transfer for Thrombectomy: Association with Efficacy and Safety Outcomes
Intravenous Thrombolysis Use before Inter‐Facility Transfer for Thrombectomy: Association with Efficacy and Safety Outcomes Open
Objective Patients with acute ischemic stroke and large vessel occlusion (LVO) often require transfer from primary stroke centers (PSCs) to thrombectomy‐capable centers. This study assessed the efficacy and safety of intravenous thrombolys…
View article: Arterial Spin-Labeling MRI Identifies Abnormal Perfusion Metric at the Gray Matter/CSF Interface in Cerebral Small Vessel Disease
Arterial Spin-Labeling MRI Identifies Abnormal Perfusion Metric at the Gray Matter/CSF Interface in Cerebral Small Vessel Disease Open
nGCI, a novel perfusion metric that may capture features of perfusion at the GM-CSF boundary, was strongly correlated with WMH and PVS severity. Further, longitudinal studies are required to determine the potential role of nGCI as a predic…
View article: Perimesencephalic Subarachnoid Hemorrhage Bleeding Patterns Are Not Always Benign: Prognostic Impact of an Aneurysmal Pathology
Perimesencephalic Subarachnoid Hemorrhage Bleeding Patterns Are Not Always Benign: Prognostic Impact of an Aneurysmal Pathology Open
Background/Objectives: Perimesencephalic subarachnoid hemorrhage (pmSAH) is generally considered to be a benign variant of spontaneous SAH. However, in rare cases, an underlying aneurysm may be present, altering both clinical management an…
View article: The relative cerebral blood volume (rCBV) <42% is independently associated with prolonged hospitalization in anterior circulation large vessel occlusion
The relative cerebral blood volume (rCBV) <42% is independently associated with prolonged hospitalization in anterior circulation large vessel occlusion Open
Background The pretreatment rCBV <42% lesion volume on CT Perfusion (CTP) has recently been shown to predict 90-day functional outcomes in stroke patients. However, its association with length of stay (LOS) has not yet been explored. This …
View article: Impact of Helicopter Transfer on Recanalization and Outcomes in Anterior Large Vessel Occlusion Strokes
Impact of Helicopter Transfer on Recanalization and Outcomes in Anterior Large Vessel Occlusion Strokes Open
BACKGROUND: For patients with acute ischemic stroke due to a large vessel occlusion admitted in primary stroke centers, helicopter transfer to comprehensive stroke centers is often used to expedite access to mechanical thrombectomy. Some s…
View article: Neuroinflammation and acute ischemic stroke: impact on translational research and clinical care
Neuroinflammation and acute ischemic stroke: impact on translational research and clinical care Open
Background Stroke, encompassing both ischemic and hemorrhagic subtypes, is a leading cause of mortality and disability globally and current treatments remain limited. Neuroinflammation plays a crucial role in the pathophysiology of stroke,…
View article: Acute ischemic stroke patient factors associated with poor outcomes in patients with favorable collaterals and successful thrombectomy
Acute ischemic stroke patient factors associated with poor outcomes in patients with favorable collaterals and successful thrombectomy Open
View article: Prolonged Venous Transit as a Superior Predictor of Functional Outcomes in Successfully Reperfused Large Vessel Occlusions: Comparative Analysis With Cerebral Blood Volume Index and Hypoperfusion Intensity Ratio
Prolonged Venous Transit as a Superior Predictor of Functional Outcomes in Successfully Reperfused Large Vessel Occlusions: Comparative Analysis With Cerebral Blood Volume Index and Hypoperfusion Intensity Ratio Open
Background Collateral status plays a crucial role in outcomes after acute ischemic stroke due to large vessel occlusion. Tissue‐level collaterals and venous outflow are key components following mechanical thrombectomy. This study evaluates…
View article: Redefining ischemic core, penumbra, and target mismatch on CT perfusion in acute anterior distal medium vessel occlusion
Redefining ischemic core, penumbra, and target mismatch on CT perfusion in acute anterior distal medium vessel occlusion Open
Background Recent trials of endovascular thrombectomy (EVT) for acute distal medium vessel occlusions (DMVOs) were negative but also used inconsistent imaging-based inclusion criteria, whereas many successful large vessel occlusion (LVO) E…
View article: Volume contracted state, mortality and functional outcomes in patients with acute ischaemic stroke due to large vessel occlusion
Volume contracted state, mortality and functional outcomes in patients with acute ischaemic stroke due to large vessel occlusion Open
Background Acute ischaemic stroke (AIS) is a leading cause of mortality and disability globally, with volume contracted state (VCS), as indicated by an elevated blood urea nitrogen to creatinine (BUN/Cr) ratio, potentially influencing outc…
View article: Efficacy and safety of mechanical thrombectomy in distal medium middle cerebral artery occlusion ischemic stroke patients on low-dose aspirin
Efficacy and safety of mechanical thrombectomy in distal medium middle cerebral artery occlusion ischemic stroke patients on low-dose aspirin Open
Background: Acute ischemic stroke (AIS) from distal medium vessel occlusion (DMVO) presents unique treatment challenges. Mechanical thrombectomy (MT) is emerging as a viable option for these patients, yet the role of pre-stroke aspirin tre…
View article: Clinical outcomes of patients with unsuccessful mechanical thrombectomy versus best medical management of medium vessel occlusion stroke in the middle cerebral artery territory
Clinical outcomes of patients with unsuccessful mechanical thrombectomy versus best medical management of medium vessel occlusion stroke in the middle cerebral artery territory Open
Background Current randomized controlled trials are investigating the efficacy and safety of mechanical thrombectomy (MT) in patients with medium vessel occlusion (MeVO) stroke. Whether best medical management (MM) is more efficient than u…
View article: The relative cerebral blood volume (rCBV) < 42% is independently associated with hemorrhagic transformation in anterior circulation large vessel occlusion
The relative cerebral blood volume (rCBV) < 42% is independently associated with hemorrhagic transformation in anterior circulation large vessel occlusion Open
Background Pretreatment CT perfusion (CTP) marker relative cerebral blood volume (rCBV) < 42% lesion volume has recently shown to predict poor collateral status and poor 90-day functional outcome. However, there is a paucity of studies ass…
View article: Role and Prognostic Implications of Venous Outflow Assessment in Acute Ischemic Stroke
Role and Prognostic Implications of Venous Outflow Assessment in Acute Ischemic Stroke Open
Introduction The venous outflow profile (VOP) is a crucial yet often overlooked aspect affecting stroke outcomes. It plays a major role in the physiopathology of acute cerebral ischemia, as it accounts for both the upstream arterial collat…
View article: Impaired Sphenoparietal Venous Drainage Is Associated With Increased Risk of Vasospasm in Aneurysmal Subarachnoid Hemorrhage
Impaired Sphenoparietal Venous Drainage Is Associated With Increased Risk of Vasospasm in Aneurysmal Subarachnoid Hemorrhage Open
Background Adequate venous drainage of brain parenchyma is essential to maintain cerebral perfusion and clearance of cerebrospinal fluid. The cortical vein opacification score (COVES) is a radiographic metric calculated from a computed tom…