Jeremy K. Nicholson
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View article: Inhibition of IRAK4 by microbial trimethylamine blunts metabolic inflammation and ameliorates glycemic control
Inhibition of IRAK4 by microbial trimethylamine blunts metabolic inflammation and ameliorates glycemic control Open
The global type 2 diabetes epidemic is a major health crisis. Although the microbiome has roles in the onset of insulin resistance (IR), low-grade inflammation and diabetes, the microbial compounds controlling these processes remain to be …
View article: Interlaboratory clinical chemistry parameter variation in seven-day acute hydrazine toxicity studies in the Sprague-Dawley rat
Interlaboratory clinical chemistry parameter variation in seven-day acute hydrazine toxicity studies in the Sprague-Dawley rat Open
Clinical chemistry retains its position as a cornerstone of toxicological assessment, yet inter-laboratory variability in baseline values remains a challenge for the integration and interpretation of multisite datasets. This study leverage…
View article: Evaluation of imputation strategies for multi-centre studies: Application to a large clinical pathology dataset
Evaluation of imputation strategies for multi-centre studies: Application to a large clinical pathology dataset Open
As part of a strategy for accommodating missing data in large heterogeneous datasets, two Random Forest-based (RF) imputation methods, missForest and MICE were evaluated along with several strategies to help navigate the inherently incompl…
View article: Age- and sex-specific lipoprotein profiles in general and cardiometabolic population cohorts
Age- and sex-specific lipoprotein profiles in general and cardiometabolic population cohorts Open
The specific funding of this article is provided in the acknowledgements section.
View article: Correction to “Benchtop Proton NMR Spectroscopy for High-Throughput Lipoprotein Quantification in Human Serum and Plasma”
Correction to “Benchtop Proton NMR Spectroscopy for High-Throughput Lipoprotein Quantification in Human Serum and Plasma” Open
View article: Epigenome-Wide Association Study of Mediterranean Diet on Blood DNA Methylation Patterns during Pregnancy: A Pilot Study
Epigenome-Wide Association Study of Mediterranean Diet on Blood DNA Methylation Patterns during Pregnancy: A Pilot Study Open
Background/Objectives: Consumption of a Mediterranean Diet (MD) has been associated with reduced incidence of non-communicable diseases and reduced overall mortality, with epigenomic effects representing plausible mediators. The aim of thi…
View article: NMR Spectroscopy-Based Lipoprotein and Glycoprotein Biomarkers Differentiate Acute and Chronic Inflammation in Diverse Healthy and Disease Population Cohorts
NMR Spectroscopy-Based Lipoprotein and Glycoprotein Biomarkers Differentiate Acute and Chronic Inflammation in Diverse Healthy and Disease Population Cohorts Open
Understanding the distribution and variation in NMR-based inflammatory markers is crucial to the evaluation of their clinical utility in disease prognosis and diagnosis. We applied high-resolution 1H NMR spectroscopy of blood pl…
View article: Correction: Long COVID clinical evaluation, research and impact on society: a global expert consensus
Correction: Long COVID clinical evaluation, research and impact on society: a global expert consensus Open
View article: Effects of short‐term exercise on plasma metabolic and lipidomic profiles of individuals with type 2 diabetes
Effects of short‐term exercise on plasma metabolic and lipidomic profiles of individuals with type 2 diabetes Open
Type 2 diabetes mellitus (T2DM) is a common metabolic disorder characterized by chronic hyperglycaemia, with physical inactivity and excessive adiposity as predisposing factors. This clinical trial aimed to investigate the effects of an ex…
View article: Children with Post COVID-19 Multisystem Inflammatory Syndrome Display Unique Pathophysiological Metabolic Phenotypes
Children with Post COVID-19 Multisystem Inflammatory Syndrome Display Unique Pathophysiological Metabolic Phenotypes Open
SARS-CoV-2 infections in children lead to symptoms from mild respiratory illness to severe postacute sequelae of COVID-19, including multisystem inflammatory syndrome in Children (MIS-C). We conducted a metabolic profiling of 147 children'…
View article: NMR spectroscopy-derived index for the nutritional assessment of extra virgin olive oils based on fatty acids profiling
NMR spectroscopy-derived index for the nutritional assessment of extra virgin olive oils based on fatty acids profiling Open
View article: Dried Blood Spot Lipidomics in Diabetes
Dried Blood Spot Lipidomics in Diabetes Open
Comprehensive lipidomic profiling in diabetes has identified disease-associated lipid signatures that may support more personalised monitoring beyond routine glycaemic control. Dried blood spot (DBS) microsampling offers a minimally invasi…
View article: Analytical quality control in targeted lipidomics: Evaluating the performance of commercial plasma as a surrogate for pooled study samples
Analytical quality control in targeted lipidomics: Evaluating the performance of commercial plasma as a surrogate for pooled study samples Open
This study provides a comprehensive comparison of QC strategies and emphasizes the importance of careful QC workflow selection. While PQCs offer advantages, sQCs serve as a suitable alternative for quality assessment and pre-processing. Th…
View article: A clinical chemical atlas of xenobiotic toxicity for the Sprague–Dawley rat
A clinical chemical atlas of xenobiotic toxicity for the Sprague–Dawley rat Open
The Consortium for Metabonomic Toxicology (COMET) studies was designed to model metabolic responses to organ- and mechanism-specific toxins to predict acute drug toxicity in rats. A range of clinical chemical parameters were measured in 7-…
View article: Long COVID clinical evaluation, research and impact on society: a global expert consensus
Long COVID clinical evaluation, research and impact on society: a global expert consensus Open
View article: Benchtop Proton NMR Spectroscopy for High-Throughput Lipoprotein Quantification in Human Serum and Plasma
Benchtop Proton NMR Spectroscopy for High-Throughput Lipoprotein Quantification in Human Serum and Plasma Open
We report the successful development and translation of high-field nuclear magnetic resonance (NMR) based comprehensive lipoprotein analysis to routine benchtop systems. This demonstrates the potential to reimagine population level cardiov…
View article: Longitudinal study on immunologic, lipoproteomic, and inflammatory responses indicates the safety of sequential COVID-19 vaccination
Longitudinal study on immunologic, lipoproteomic, and inflammatory responses indicates the safety of sequential COVID-19 vaccination Open
COVID-19 vaccines are crucial in reducing SARS-CoV-2 transmission and severe health outcomes. Despite widespread administration, their long-term systemic effects on human metabolism remain inadequately understood. This longitudinal study a…
View article: Evaluation of tissue-specific extraction protocols for comprehensive lipid profiling
Evaluation of tissue-specific extraction protocols for comprehensive lipid profiling Open
This study presents a new approach to studying lipid profiles derived from diverse tissues that substantially improve comprehensive lipid species' detection sensitivity and reliability. Our systematic evaluation provides evidence that tail…
View article: Dried blood spot microsampling: A semi-quantitative 4D-lipidomics approach using ultrahigh-performance liquid chromatography - high-resolution mass spectrometry (UHPLC - HRMS)
Dried blood spot microsampling: A semi-quantitative 4D-lipidomics approach using ultrahigh-performance liquid chromatography - high-resolution mass spectrometry (UHPLC - HRMS) Open
Dried blood spot (DBS) sample collections can offer a minimally invasive, cost-effective alternative to traditional venepuncture for remote sampling and high-frequency metabolic profiling. We present an optimized protocol for DBS-based ext…
View article: NMR spectroscopy derived plasma biomarkers of inflammation in human populations: Influences of age, sex and adiposity
NMR spectroscopy derived plasma biomarkers of inflammation in human populations: Influences of age, sex and adiposity Open
Understanding the distribution and variation in inflammatory markers is crucial for advancing our knowledge of inflammatory processes and evaluating their clinical utility in diagnosing and monitoring acute and chronic disease. 1 H NMR spe…
View article: Evaluation of imputation strategies for multi-centre studies: Application to a large clinical pathology dataset
Evaluation of imputation strategies for multi-centre studies: Application to a large clinical pathology dataset Open
As part of a strategy for accommodating missing data in large heterogeneous datasets, two Random Forest-based (RF) imputation methods, missForest and MICE were evaluated along with several strategies to help them handle the inherent struct…
View article: Clinical prediction of wound re-epithelisation outcomes in non-severe burn injury using the plasma lipidome
Clinical prediction of wound re-epithelisation outcomes in non-severe burn injury using the plasma lipidome Open
Whilst wound repair in severe burns has received substantial research attention, non-severe burns (0.7), whilst high-density lipoprotein subfractions, phosphatidylinositols, phosphatidylcholines, and phosphatidylserines were associated wit…
View article: Transacylation and hydrolysis of the acyl glucuronides of ibuprofen and its α-methyl-substituted analogues investigated by 1H NMR spectroscopy and computational chemistry: Implications for drug design
Transacylation and hydrolysis of the acyl glucuronides of ibuprofen and its α-methyl-substituted analogues investigated by 1H NMR spectroscopy and computational chemistry: Implications for drug design Open
Drugs and drug metabolites containing a carboxylic-acid moiety can undergo in vivo conjugation to form 1-β-O-acyl-glucuronides (1-β-O-AGs). In addition to hydrolysis, these conjugates can undergo spontaneous acyl migration, and anomerisati…
View article: Optical control and coherent coupling of spin diffusive modes in thermal gases
Optical control and coherent coupling of spin diffusive modes in thermal gases Open
Quantum science and technology devices exploiting collective spins in thermal gases are extremely appealing due to their simplicity and robustness. This comes at the cost of dealing with the random thermal motion of the atoms which is usua…
View article: Microbial Indoles: Key Regulators of Organ Growth and Metabolic Function
Microbial Indoles: Key Regulators of Organ Growth and Metabolic Function Open
Gut microbes supporting body growth are known but the mechanisms are less well documented. Using the microbial tryptophan metabolite indole, known to regulate prokaryotic cell division and metabolic stress conditions, we mono-colonized ger…
View article: Unravelling inulin molecules in food sources using a matrix-assisted laser desorption/ionization magnetic resonance mass spectrometry (MALDI-MRMS) pipeline
Unravelling inulin molecules in food sources using a matrix-assisted laser desorption/ionization magnetic resonance mass spectrometry (MALDI-MRMS) pipeline Open
Inulin, a polysaccharide characterized by a β-2,1 fructosyl-fructose structure terminating in a glucosyl moiety, is naturally present in plant roots and tubers. Current methods provide average degrees of polymerization (DP) but lack inform…
View article: Stratification of Sepsis Patients on Admission into the Intensive Care Unit According to Differential Plasma Metabolic Phenotypes
Stratification of Sepsis Patients on Admission into the Intensive Care Unit According to Differential Plasma Metabolic Phenotypes Open
Delayed diagnosis of patients with sepsis or septic shock is associated with increased mortality and morbidity. UPLC-MS and NMR spectroscopy were used to measure panels of lipoproteins, lipids, biogenic amines, amino acids, and tryptophan …
View article: Cross-Validation of Metabolic Phenotypes in SARS-CoV-2 Infected Subpopulations Using Targeted Liquid Chromatography–Mass Spectrometry (LC-MS)
Cross-Validation of Metabolic Phenotypes in SARS-CoV-2 Infected Subpopulations Using Targeted Liquid Chromatography–Mass Spectrometry (LC-MS) Open
To ensure biological validity in metabolic phenotyping, findings must be replicated in independent sample sets. Targeted workflows have long been heralded as ideal platforms for such validation due to their robust quantitative capability. …
View article: Extracellular vesicles as a promising source of lipid biomarkers for breast cancer detection in blood plasma
Extracellular vesicles as a promising source of lipid biomarkers for breast cancer detection in blood plasma Open
Extracellular vesicles (EVs), including exosomes and microvesicles, mediate intercellular communication in cancer, from development to metastasis. EV‐based liquid biopsy is a promising strategy for cancer diagnosis as EVs can be found in c…
View article: Optical control and coherent coupling of spin diffusive modes in thermal gases
Optical control and coherent coupling of spin diffusive modes in thermal gases Open
Collective spins in thermal gases are at the core of a multitude of science and technology applications. In most of them, the random thermal motion of the particles is considered detrimental as it is responsible for decoherence and noise. …