Jeremy D. Marks
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View article: The Effect of Postnatal Steroids on Lung Ultrasound Scores and Extubation Readiness in Very Low Birth Weight infants
The Effect of Postnatal Steroids on Lung Ultrasound Scores and Extubation Readiness in Very Low Birth Weight infants Open
Objective: We assessed the utility of lung ultrasound scores (LUSs) to predict extubation readiness in VLBW infants, and determined the effect of postnatal steroids on LUSs in babies who were chronically ventilated for > 30 days. Study Des…
View article: A Randomized Clinical Trial of Inhaled Nitric Oxide Treatment in Premature Infants Reveals the Effect of Maternal Racial Identity on Efficacy
A Randomized Clinical Trial of Inhaled Nitric Oxide Treatment in Premature Infants Reveals the Effect of Maternal Racial Identity on Efficacy Open
Respiratory distress syndrome increases the risk of death and bronchopulmonary dysplasia (BPD) in premature infants. Inhaled nitric oxide (iNO) may reduce these risks. Recent meta-analyses have suggested that iNO is effective only at doses…
View article: Emerging Activity Patterns and Synaptogenesis in Dissociated Hippocampal Cultures
Emerging Activity Patterns and Synaptogenesis in Dissociated Hippocampal Cultures Open
Cultures of dissociated hippocampal neurons display a stereotypical development of network activity patterns within the first three weeks of maturation. During this process, network connections develop and the associated spiking patterns r…
View article: Principles and Guidelines for Sharing Biomedical Data for Secondary Use: The University of Chicago Perspective
Principles and Guidelines for Sharing Biomedical Data for Secondary Use: The University of Chicago Perspective Open
Academic medical centers are generating an increasing amount of biomedical data and there is an increasing demand for biomedical data for research purposes by research projects, research consortia, companies, and other third parties. At th…
View article: International Delphi Expert Consensus on Safe Return to Surgical and Endoscopic Practice: From the Coronavirus Global Surgical Collaborative.
International Delphi Expert Consensus on Safe Return to Surgical and Endoscopic Practice: From the Coronavirus Global Surgical Collaborative. Open
The Delphi process resulted in 99 recommendations. These consensus statements provide expert guidance, based on scientific methodology, for the safe resumption of surgical activities during the COVID-19 pandemic.
View article: Correlates of Normal and Abnormal General Movements in Infancy and Long-Term Neurodevelopment of Preterm Infants: Insights from Functional Connectivity Studies at Term Equivalence
Correlates of Normal and Abnormal General Movements in Infancy and Long-Term Neurodevelopment of Preterm Infants: Insights from Functional Connectivity Studies at Term Equivalence Open
Preterm infants born before 32 weeks gestation have increased risks for neurodevelopmental impairment at two years of age. How brain function differs between preterm infants with normal or impaired development is unknown. However, abnormal…
View article: Tailoring Biomimetic Phosphorylcholine-Containing Block Copolymers as Membrane-Targeting Cellular Rescue Agents
Tailoring Biomimetic Phosphorylcholine-Containing Block Copolymers as Membrane-Targeting Cellular Rescue Agents Open
Some synthetic polymers can block cell death when applied following an injury that would otherwise kill the cell. This cellular rescue occurs through interactions of the polymers with cell membranes. However, general principles for designi…
View article: Poloxamer 188 decreases membrane toxicity of mutant SOD1 and ameliorates pathology observed in SOD1 mouse model for ALS
Poloxamer 188 decreases membrane toxicity of mutant SOD1 and ameliorates pathology observed in SOD1 mouse model for ALS Open
View article: Mitochondrial mechanisms of neuronal rescue by F-68, a hydrophilic Pluronic block co-polymer, following acute substrate deprivation
Mitochondrial mechanisms of neuronal rescue by F-68, a hydrophilic Pluronic block co-polymer, following acute substrate deprivation Open
View article: Sumoylation of Na V 1.2 Channels Mediates the Early Response to Acute Hypoxia in Central Neurons
Sumoylation of Na V 1.2 Channels Mediates the Early Response to Acute Hypoxia in Central Neurons Open
View article: SUMOylation of NaV1.2 channels mediates the early response to acute hypoxia in central neurons
SUMOylation of NaV1.2 channels mediates the early response to acute hypoxia in central neurons Open
The mechanism for the earliest response of central neurons to hypoxia—an increase in voltage-gated sodium current ( I Na )—has been unknown. Here, we show that hypoxia activates the Small Ubiquitin-like Modifier (SUMO) pathway in rat cereb…
View article: Author response: SUMOylation of NaV1.2 channels mediates the early response to acute hypoxia in central neurons
Author response: SUMOylation of NaV1.2 channels mediates the early response to acute hypoxia in central neurons Open
Full text Figures and data Side by side Abstract eLife digest Introduction Results Discussion Materials and methods References Decision letter Author response Article and author information Metrics Abstract The mechanism for the earliest r…
View article: White Matter Injury and General Movements in High-Risk Preterm Infants
White Matter Injury and General Movements in High-Risk Preterm Infants Open
Aberrant general movements at 10-15 weeks' postterm are associated with adverse neurodevelopmental outcomes and specific white matter microstructure abnormalities for cognitive, language, and motor delays.
View article: Secreted protein acidic and rich in cysteine (SPARC) induces lipotoxicity in neuroblastoma by regulating transport of albumin complexed with fatty acids
Secreted protein acidic and rich in cysteine (SPARC) induces lipotoxicity in neuroblastoma by regulating transport of albumin complexed with fatty acids Open
SPARC is a matrix protein that mediates interactions between cells and the microenvironment. In cancer, SPARC may either promote or inhibit tumor growth depending upon the tumor type. In neuroblastoma, SPARC is expressed in the stromal Sch…
View article: Network burst activity in hippocampal neuronal cultures: the role of synaptic and intrinsic currents
Network burst activity in hippocampal neuronal cultures: the role of synaptic and intrinsic currents Open
The goal of this work was to define the contributions of intrinsic and synaptic mechanisms toward spontaneous network-wide bursting activity, observed in dissociated rat hippocampal cell cultures. This network behavior is typically charact…