Jeremy Rees
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Adult Medulloblastoma Presenting With Audiovestibular Symptoms and an Alternating Unterberger Test Open
A man in his 30s presented with a four-week history of vertigo, unilateral tinnitus, and nausea on a background of a three-year history of asymmetric audiovestibular symptoms attributed to peripheral vestibular pathology. The neurological …
View article: CLINICAL AND SURVIVAL OUTCOMES IN ADULT H3 G34 GLIOMA PATIENTS: A RETROSPECTIVE ANALYSIS ACROSS 13 UK CARE CENTRES
CLINICAL AND SURVIVAL OUTCOMES IN ADULT H3 G34 GLIOMA PATIENTS: A RETROSPECTIVE ANALYSIS ACROSS 13 UK CARE CENTRES Open
AIMS H3 G34R-mutated gliomas, also known as diffuse hemispheric gliomas, are rare, highly aggressive tumours predominantly affecting children and young adults. In paediatric and adolescent populations, the median time to progression is app…
PROGNOSIS OF IDH-MUTANT ADULT LOW-GRADE GLIOMA IN THE MODERN ERA Open
AIMS Since 2016, the standard oncological treatment of high-risk adult diffuse IDH-mutant low-grade gliomas (LGG) after initial surgery has changed from the sole use of radiotherapy (RT-alone) to the combined use of radio- therapy and chem…
COMBINED DW-MRI AND DW-MRS SENSITIVITY TO GLIOMA TUMOUR MICROENVIRONMENT: A PRELIMINARY STUDY Open
AIMS The glioma tumor microenvironment (TME) plays a major role in tumourigenesis of gliomas, encompassing a complex network of cells and biomolecules that contribute to radio-resistance and poor outcomes. Diffusion-weighted (DW) MRI probe…
View article: CTNI-14. RADIOTHERAPY VERSUS TMZ FOR HIGH-RISK LOW-GRADE GLIOMA. FINAL RESULTS AFTER MEDIAN FOLLOW-UP OF 13 YEARS OF PHASE III EORTC/NCIC-CTG/TROG/MRC-CTU (EORTC 22033-26033) STUDY
CTNI-14. RADIOTHERAPY VERSUS TMZ FOR HIGH-RISK LOW-GRADE GLIOMA. FINAL RESULTS AFTER MEDIAN FOLLOW-UP OF 13 YEARS OF PHASE III EORTC/NCIC-CTG/TROG/MRC-CTU (EORTC 22033-26033) STUDY Open
BACKGROUND We previously reported on progression-free survival of our randomized phase 3 trial [Lancet Oncol. 2016;17:1521-1532]. Here we report results of long-term follow-up (FU) including overall survival (OS) and molecular subgroup ana…
MATHEMATICAL MODELLING OF SURVIVAL IN LOW GRADE GLIOMAS AT MALIGNANT TRANSFORMATION Open
AIMS Low grade gliomas (LGG) represent 14.6% of gliomas and may remain stable years after initial diagnosis. MRI features suggesting malignant transformation (MT) include enlargement of non-enhancing areas and increasing enhancement but ha…
ADULT HISTONE G34 MUTANT GLIOMAS - A SINGLE CENTRE EXPERIENCE OVER 10 YEARS Open
AIMS Histone G-34-mutant (H3 G34) gliomas are rare, aggressive infiltrating tumours of the cerebral hemispheres and are classified as WHO grade 4 paediatric type diffuse high-grade glioma. They most commonly affect children and adolescents…
Clinical, Imaging and Neurogenetic Features of Patients with Gliomatosis Cerebri Referred to a Tertiary Neuro-Oncology Centre Open
Introduction: Gliomatosis cerebri describes a rare growth pattern of diffusely infiltrating glioma. The treatment options are limited and clinical outcomes remain poor. To characterise this population of patients, we examined referrals to …
The Two-Week-Wait Referral Pathway: Not Fit for Purpose Open
AIMS The two-week-wait (2WW) referral pathway was set up by the Department of Health to improve early diagnosis and overall survival of cancer. Brain tumours, however, present with non-specific neurological symptoms. As such, this study se…
Seizure Semiology Over Time in Adult Diffuse Glioma Open
AIMS Patients with gliomas often present with generalised seizures, but subsequently develop focal seizures on treatment. The occurrence of a single generalised seizure at onset precludes the return of a driving licence, even if a patient …
Radiation and the nervous system Open
Radiation therapy is widely used for benign and malignant brain tumours as it is effective and well tolerated. However, damage to the surrounding healthy nervous system tissue leads to a variety of complications both in the short term and …
Management of Immune Effector Cell-Associated Neurotoxicity Syndrome (ICANS) Open
A common and challenging side effect associated with CAR-T cell therapy is immune cell-associated neurotoxicity syndrome (ICANS), which occurs in 20–60% of patients, of whom 12–30% have severe (≥ grade 3) symptoms.
View article: Pembrolizumab for the treatment of progressive multifocal leukoencephalopathy following anti‐CD19 CAR‐T therapy: a case report
Pembrolizumab for the treatment of progressive multifocal leukoencephalopathy following anti‐CD19 CAR‐T therapy: a case report Open
Progressive multifocal leukoencephalopathy (PML) is an opportunistic brain infection with few treatment options and poor survival when reversal of the underlying immune dysfunction is not achievable. JC polyomavirus reactivation resulting …
Peripheral nerve neurolymphomatosis: Clinical features, treatment, and outcomes Open
Introduction: This series characterises nine patients with neurohistopathologically proven peripheral nerve neurolymphomatosis. Methods: A search of the hospital neuropathology database from 2002 to 2019 identified biopsy proven cases. Cli…
Seizure outcomes and survival in adult low-grade glioma over 11 years: living longer and better Open
Background:
\nThere has been a trend toward earlier and more aggressive resection for low-grade gliomas (LGGs). This study set out to compare seizure control and survival of adults with LGG seen in the same neuro-oncology clinic over 11 ye…
View article: Noninvasive diffusion magnetic resonance imaging of brain tumour cell size for the early detection of therapeutic response
Noninvasive diffusion magnetic resonance imaging of brain tumour cell size for the early detection of therapeutic response Open
Cancer cells differ in size from those of their host tissue and are known to change in size during the processes of cell death. A noninvasive method for monitoring cell size would be highly advantageous as a potential biomarker of malignan…
Seizure outcomes and survival in adult low-grade glioma over 11 years: living longer and better Open
Background There has been a trend toward earlier and more aggressive resection for low-grade gliomas (LGGs). This study set out to compare seizure control and survival of adults with LGG seen in the same neuro-oncology clinic over 11 years…
Survival and Seizure Control have improved for Adult Low-Grade Gliomas over the last eleven years Open
Background There has been a trend towards earlier and more aggressive resection for adult Low-Grade Gliomas (LGG) in the last decade. This study set out to compare seizure control and survival of unselected adults with LGG seen in the same…
Single centre, retrospective review of gamma-knife stereotactic radiosurgery and other therapies on prevalence of seizures in patients with brain metastases Open
Background An increasing number of patients with brain metastases (BM) are having stereotactic radiosurgery (SRS), but it is not known whether this causes epilepsy. Methods We carried out a retrospective review of patients surviving one-ye…
Quantification of tumour microstructure in low and high-grade brain tumours using VERDICT MRI: an initial feasibility study Open
INTRODUCTION: VERDICT (Vascular, Extracellular, and Restricted Diffusion for Cytometry in Tumours) MRI is a diffusion imaging technique which gives information about tumour microstructure beyond ADC measures and structural imaging. VERDICT…
Diffusion-weighted MRI may support the identification of non-enhancing IDH wildtype astrocytoma Open
AIM: To determine if apparent diffusion coefficient (ADC) measurements permit the distinction of non-enhancing IDH mutant (IDHmut) from IDH wildtype (IDHwt) astrocytoma. BACKGROUND: Lack of Gadolinium contrast enhancement represents a typi…
View article: Quantitation of brain tumour microstructure response to Temozolomide therapy using non-invasive VERDICT MRI
Quantitation of brain tumour microstructure response to Temozolomide therapy using non-invasive VERDICT MRI Open
There has been slow progress in the development of new therapeutic strategies for treating brain tumours, partly because assessment of treatment response is difficult and largely reliant on simple bi-dimensional measurements of MRI contras…