Explanipedia

Head Vessel Reintervention Post-Type A Dissection Repair With a Hybrid Stent Prosthesis Open

Ryaan EL‐Andari, Jeremy Rempel, Michael C. Moon · 2025

Branch vessel involvement and endovascular intervention should be considered in cases of adverse aortic remodeling following ATAAD repair, potentially reducing the need for open reintervention.

Literature review and DELPHI consensus on follow-up and retreatment of intracranial aneurysms with intrasaccular devices Open

Alexander Stebner, Petra Cimflová, Salome Bosshart, Marie-Sophie Schüngel, Satoru Fujiwara , et al. · 2025

Background Intracranial aneurysms are increasingly detected incidentally due to broader use of neuroimaging. Intrasaccular devices are frequently used to prevent rupture, yet standardized follow-up and retreatment strategies remain undefin…

Province of Alberta Jurisdictional Standardized Operating Protocol (SOP) for Screening Brain Vascular Malformations Open

Ryan A. Spychka, Michael D. Hill, Jeremy Rempel, Sandeep Naik, Richard Owen , et al. · 2025

Objective: Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant genetic disorder leading to vascular malformations in different organ systems. Approximately 10% of patients with HHT have brain vascular malformations (BVMs).…

Bench-to-bedside: Use of particle image velocimetry to assess iterative development of cerebral bifurcation flow diverter and its proof of principle Open

Sina G. Yazdi, D. Mercier, Kai Kallenberg, Michael Chow, Jeremy Rempel , et al. · 2025

Brain aneurysms are at risk of rupture causing death or disability. Many treatments exist for wide neck bifurcation aneurysms, the most common type of aneurysm, but none have become definitive standard of care because a variety of deficien…

Improvements in endovascular stroke treatment workflow over 5 years: ESCAPE to ESCAPE-NA1 Open

Johanna M. Ospel, Mayank Goyal, Ryan McTaggart, Alexandre Y. Poppe, Andrew M. Demchuk , et al. · 2025

Background and Purpose Rapid treatment is a major determinant of outcome in acute ischemic stroke patients with large vessel occlusion. We used patient-level data from the ESCAPE and ESCAPE-NA1 trials to evaluate whether and to what extent…

Factors Influencing Nerinetide Effect on Clinical Outcome in Patients Without Alteplase Treatment in the ESCAPE-NA1 Trial Open

Mayank Goyal, Bijoy K. Menon, Johanna M. Ospel, Mohammed Almekhlafi, Charlotte Zerna , et al. · 2025

Background and Purpose In the ESCAPE-NA1 (Efficacy and Safety of Nerinetide for the Treatment of Acute Ischaemic Stroke) trial, treatment with nerinetide was associated with improved outcomes in patients who did not receive intravenous alt…

Flow Diversion for the Treatment of Distal Circulation Aneurysms: A Randomized Comparison Open

William Boisseau, Tim E. Darsaut, Robert Fahed, Brian Drake, Howard Lesiuk , et al. · 2024

Distal circulation aneurysms treated with FDs in FIAT showed an encouraging trend, but this analysis was underpowered. Further randomized trials are needed.

Effects of reperfusion grade and reperfusion strategy on the clinical outcome: Insights from ESCAPE-NA1 trial Open

Petra Cimflová, Johanna M. Ospel, Nishita Singh, Martha Marko, Nima Kashani , et al. · 2024

Background We evaluated the association of reperfusion quality and different patterns of achieved reperfusion with clinical and radiological outcomes in the ESCAPE NA1 trial. Methods Data are from the ESCAPE-NA1 trial. Good clinical outcom…

Utility of automated CT perfusion software in acute ischemic stroke with large and medium vessel occlusion Open

Rezan Ashayeri Ahmadabad, Kim Tran, Yiran Zhang, Mahesh Kate, Sachin Mishra , et al. · 2024

Background Early diagnosis of large vessel occlusion (LVO) in acute stroke often requires CT angiography (CTA). Automated CT perfusion (CTP) software, which identifies blood flow abnormalities, enhances LVO diagnosis and patient selection …

Time From Hospital Arrival Until Endovascular Thrombectomy and Patient-Reported Outcomes in Acute Ischemic Stroke Open

Raed A. Joundi, Eric E. Smith, Aravind Ganesh, Raul G. Nogueira, Ryan McTaggart , et al. · 2024

Importance The time-benefit association of endovascular thrombectomy (EVT) in ischemic stroke with patient-reported outcomes is unknown. Objective To assess the time-dependent association of EVT with self-reported quality of life in patien…

CJN volume 51 issue 2 Cover and Front matter Open

Tejas Sankar, S. Tucker, Mimma Anello, Aleksandra Pikula, Esther Bui , et al. · 2024

Endovascular Parent Vessel Occlusion Versus Flow Diversion in the Treatment of Large and Giant Aneurysms: A Randomized Comparison Open

William Boisseau, Tim E. Darsaut, Robert Fahed, Pierre Olivier Comby, Brian Drake , et al. · 2024

The comparison between PVO and FD was inconclusive. More randomized trials are needed to better determine the role of FD in large aneurysms eligible for PVO.

Nerinetide Reduces Early Infarct Growth Among Stroke Patients Undergoing EVT Without Intravenous Alteplase Open

Nathaniel Rex, Johanna M. Ospel, Rosalie McDonough, Nima Kashani, Leon A. Rinkel , et al. · 2024

Background Nerinetide treatment was associated with better clinical outcomes among patients with stroke undergoing endovascular treatment who were not treated with concurrent alteplase in the randomized ESCAPE‐NA1 (Efficacy and Safety of N…

Prevalence of “Ghost Infarct Core” after Endovascular Thrombectomy Open

Johanna M. Ospel, Nathaniel Rex, Leon A. Rinkel, Nima Kashani, Brian Buck , et al. · 2024

CTP ghost core occurred in ∼1 of 10 patients, indicating that CTP frequently overestimates the infarct core size at baseline, particularly in young patients with complete recanalization and short ischemia duration.

Mediation of Age and Thrombectomy Outcome by Neuroimaging Markers of Frailty in Patients With Stroke Open

Faysal Benali, Nishita Singh, Joachim Fladt, Tanaporn Jaroenngarmsamer, Fouzi Bala , et al. · 2024

Importance Age is a leading predictor of poor outcomes after brain injuries like stroke. The extent to which age is associated with preexisting burdens of brain changes, visible on neuroimaging but rarely considered in acute decision-makin…

Symptomatic Non-stenotic Carotid Disease in Embolic Stroke of Undetermined Source Open

Martha Marko, Nishita Singh, Johanna M. Ospel, Kazutaka Uchida, Mohammed Almekhlafi , et al. · 2023

Safety and Efficacy of Dual Thrombolytic Therapy With Mutant Prourokinase and Small Bolus Alteplase for Ischemic Stroke Open

Nadinda A.M. van der Ende, Bob Roozenbeek, Lucas Smagge, Sven P. R. Luijten, Leo A.M. Aerden , et al. · 2023

Importance Dual thrombolytic treatment with small bolus alteplase and mutant prourokinase has the potential to be a safer and more efficacious treatment for ischemic stroke than alteplase alone because mutant prourokinase is designed to ac…

A Pragmatic Randomized Trial Comparing Surgical Clipping and Endovascular Treatment of Unruptured Intracranial Aneurysms Open

Tim E. Darsaut, J. Max Findlay, Michel W. Bojanowski, C. Chalaala, Daniela Iancu , et al. · 2023

Surgical clipping is more effective than endovascular treatment of unruptured intracranial aneurysms in terms of the frequency of the primary outcome of treatment failure. Results were mainly driven by angiographic results at 1 year.

Direct to Angiosuite in Acute Stroke with Mobile Stroke Unit Open

Radhika Nair, Jeremy Rempel, Khurshid Khan, Thomas Jeerakathil, Rene van Dijk , et al. · 2023

Background: Early reperfusion has the best likelihood for a favorable outcome in acute ischemic stroke (AIS) with large vessel occlusion (LVO). Our experience with mobile stroke unit (MSU) for direct to angiosuite (DTAS) transfer in AIS pa…

Stent-Assisted Coiling in the Treatment of Unruptured Intracranial Aneurysms: A Randomized Clinical Trial Open

William Boisseau, Tim E. Darsaut, Robert Fahed, Brian Drake, Howard Lesiuk , et al. · 2023

The STAT trial did not show stent-assisted coiling to be superior to coiling alone for wide-neck, large, or recurrent unruptured aneurysms.

CJN volume 50 issue 2 Cover and Front matter Open

Aliya Szpindel, Tasnia Rahman, Sarah Bouhadoun, Stuart Lubarsky, Fraser Moore , et al. · 2023

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Endovascular treatment of brain arteriovenous malformations: clinical outcomes of patients included in the registry of a pragmatic randomized trial Open

Jean Raymond, Jean-Christophe Gentric, Elsa Magro, Lorena Nico, Emma Bacchus , et al. · 2022

OBJECTIVE The role of endovascular treatment in the management of patients with brain arteriovenous malformations (AVMs) remains uncertain. AVM embolization can be offered as stand-alone curative therapy or prior to surgery or stereotactic…

Dual thrombolytic therapy with mutant pro-urokinase and small bolus alteplase for ischemic stroke (DUMAS): study protocol for a multicenter randomized controlled phase II trial Open

Nadinda A.M. van der Ende, Bob Roozenbeek, Lucas Smagge, Sven P. R. Luijten, Leo A.M. Aerden , et al. · 2022

Flow Diversion in the Treatment of Intracranial Aneurysms: A Pragmatic Randomized Care Trial Open

Jean Raymond, Daniela Iancu, William Boisseau, Jose Danilo Bengzon Diestro, Ruby Klink , et al. · 2022

For patients with mostly unruptured, large, anterior circulation (carotid) aneurysms, flow diversion was more effective than the alternative standard management option in terms of angiographic outcome.

Canadian Association of Radiologists Guidance on Contrast Associated Acute Kidney Injury Open

D. Blair Macdonald, Casey Hurrell, Andreu F. Costa, Matthew D. F. McInnes, Martin O‘Malley , et al. · 2022

Iodinated contrast media (ICM) is one of the most frequently administered pharmaceuticals. In Canada, over 5.4 million computed tomography (CT) examinations were performed in 2019, of which 50% were contrast enhanced. Acute kidney injury (…

How to Define Fast and Slow Progressors in Any-Type Occlusion Acute Ischemic Stroke Open

Ali Zohair Nomani, Jeremy Rempel, Khurshid Khan, Ashfaq Shuaib, Glen C. Jickling · 2022

The variable rate of infarct progression in acute ischemic stroke as assessed by various thresholds excludes a substantial proportion of patients due to time or core constraints. We evaluated 106 patients with any-type occlusion to compare…

Canadian Association of Radiologists Guidance on Contrast-Associated Acute Kidney Injury Open

D. Blair Macdonald, Casey Hurrell, Andreu F. Costa, Matthew D. F. McInnes, Martin O‘Malley , et al. · 2022

Purpose: Iodinated contrast media is one of the most frequently administered pharmaceuticals. In Canada, over 5.4 million computed tomography (CT) examinations were performed in 2019, of which 50% were contrast enhanced. Acute kidney injur…

Flow Diversion in the Treatment of Intracranial Aneurysms: A Pragmatic Randomized Care Trial Open

Jean Raymond, Daniela Iancu, William Boisseau, Jose Danilo Bengzon Diestro, Ruby Klink , et al. · 2022

The Utility of Superselective Rotational Angiography for Frameless Stereotactic Navigation During Craniotomy for Micro-Arteriovenous Malformation Open

Cian O’Kelly, Jeremy Rempel, Rob Ashforth, Tim E. Darsaut, Michael Chow · 2021

Superselective 3-dimensional angiographic images merged to baseline MRI sequences facilitates planning and navigation during surgery for micro-AVMs.

Assessment of Discrepancies Between Follow-up Infarct Volume and 90-Day Outcomes Among Patients With Ischemic Stroke Who Received Endovascular Therapy Open

Aravind Ganesh, Johanna M. Ospel, Bijoy K. Menon, Andrew M. Demchuk, Ryan McTaggart , et al. · 2021

In this study, discrepancies between functional outcome and post-EVT infarct volume were associated with differences in pretreatment factors, such as age and comorbidities, and posttreatment complications related to index stroke evolution,…

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