Jeroen D. Langereis
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View article: Glycoproteomics analysis of complement factor H and its complement-regulatory function during Streptococcus pneumoniae-associated hemolytic uremic syndrome
Glycoproteomics analysis of complement factor H and its complement-regulatory function during Streptococcus pneumoniae-associated hemolytic uremic syndrome Open
Hemolytic uremic syndrome caused by an invasive Streptococcus pneumoniae infection (SP-HUS) is a rare and severe disease that primarily affects children under two years of age. The pathophysiology of SP-HUS remains poorly understood, and t…
View article: Effects of simulated Martian environmental stressors on specific human pathogen–immune system interactions
Effects of simulated Martian environmental stressors on specific human pathogen–immune system interactions Open
The identification of health risks associated with long-term crewed missions to Mars is critical for mission planning and crew safety. Human-associated pathogens can be part of the microbiome and are likely to be transported during these m…
View article: Epigenetic control of the ferric uptake regulator (Fur) and fumarate nitrate reductase (FNR) master regulatory proteins contributes to <i>Haemophilus influenzae</i> survival during lung infection
Epigenetic control of the ferric uptake regulator (Fur) and fumarate nitrate reductase (FNR) master regulatory proteins contributes to <i>Haemophilus influenzae</i> survival during lung infection Open
DNA regulatory elements that dictate how the bacterial pathobiont Haemophilus influenzae infects and adapts to the airways of immunocompromised patients suffering from chronic obstructive pulmonary disease (COPD) are poorly understood. Thi…
View article: Differential effects of C5 inhibition, C3 inhibition, and alternative pathway inhibition on bacterial killing in vitro
Differential effects of C5 inhibition, C3 inhibition, and alternative pathway inhibition on bacterial killing in vitro Open
Contains fulltext : 317901.pdf (Publisher’s version ) (Open Access)
View article: Salivary polyreactive antibodies and<i>Haemophilus influenzae</i>are associated with respiratory infection severity in young children with recurrent respiratory infections
Salivary polyreactive antibodies and<i>Haemophilus influenzae</i>are associated with respiratory infection severity in young children with recurrent respiratory infections Open
Background Recurrent respiratory tract infections (rRTIs) are a common reason for immunodiagnostic testing in children, which relies on serum antibody level measurements. However, because RTIs predominantly affect the respiratory mucosa, s…
View article: Mycoplasma pneumoniae carriage in children with recurrent respiratory tract infections is associated with a less diverse and altered microbiota
Mycoplasma pneumoniae carriage in children with recurrent respiratory tract infections is associated with a less diverse and altered microbiota Open
Wilhelmina Children's Hospital Research Fund, 'Christine Bader Stichting Irene KinderZiekenhuis', Sophia Scientific Research Foundation, ESPID Fellowship funded by Seqirus, Hypatia Fellowship funded by Radboudumc and The Netherlands Organi…
View article: The immunological effects of intradermal particle-based vaccine delivery using a novel microinjection needle studied in a human skin explant model
The immunological effects of intradermal particle-based vaccine delivery using a novel microinjection needle studied in a human skin explant model Open
For intradermal (ID) immunisation, novel needle-based delivery systems have been proposed as a better alternative to the Mantoux method. However, the penetration depth of needles in the human skin and its effect on immune cells residing in…
View article: The contribution of the alternative pathway in complement activation on cell surfaces depends on the strength of classical pathway initiation
The contribution of the alternative pathway in complement activation on cell surfaces depends on the strength of classical pathway initiation Open
Objectives The complement system is an important component of innate immunity. The alternative pathway (AP) amplification loop is considered an essential feed forward mechanism for complement activation. However, the role of the AP in clas…
View article: Intradermal administration of the pneumococcal conjugate vaccine in mice results in lower antibody responses as compared to intramuscular administration
Intradermal administration of the pneumococcal conjugate vaccine in mice results in lower antibody responses as compared to intramuscular administration Open
Intradermal vaccination was inferior to intramuscular immunization in inducing serotype-specific antibodies.
View article: Differential Pneumococcal Growth Features in Severe Invasive Disease Manifestations
Differential Pneumococcal Growth Features in Severe Invasive Disease Manifestations Open
Streptococcus pneumoniae is a leading infectious cause of deaths worldwide. To understand the course and outcome of pneumococcal infection, most research has focused on the host and its response to contain bacterial growth.
View article: Comparative pangenome analysis of capsulated Haemophilus influenzae serotype f highlights their high genomic stability
Comparative pangenome analysis of capsulated Haemophilus influenzae serotype f highlights their high genomic stability Open
View article: Endocarditis Caused by Nontypeable <i>Streptococcus pneumoniae</i>
Endocarditis Caused by Nontypeable <i>Streptococcus pneumoniae</i> Open
The Streptococcus pneumoniae capsule is regarded as indispensable in bacteremia. We report an infant with a ventricular septal defect and infective endocarditis caused by nontypeable S. pneumoniae. In-depth investigation confirmed a defici…
View article: Nasopharyngeal colonisation dynamics of bacterial pathogens in patients with fever in rural Burkina Faso: an observational study
Nasopharyngeal colonisation dynamics of bacterial pathogens in patients with fever in rural Burkina Faso: an observational study Open
View article: Additional file 3 of Nasopharyngeal colonisation dynamics of bacterial pathogens in patients with fever in rural Burkina Faso: an observational study
Additional file 3 of Nasopharyngeal colonisation dynamics of bacterial pathogens in patients with fever in rural Burkina Faso: an observational study Open
Additional file 3: SPSS output file.
View article: Additional file 2 of Nasopharyngeal colonisation dynamics of bacterial pathogens in patients with fever in rural Burkina Faso: an observational study
Additional file 2 of Nasopharyngeal colonisation dynamics of bacterial pathogens in patients with fever in rural Burkina Faso: an observational study Open
Additional file 2: Overview of qPCR results.
View article: Additional file 1 of Nasopharyngeal colonisation dynamics of bacterial pathogens in patients with fever in rural Burkina Faso: an observational study
Additional file 1 of Nasopharyngeal colonisation dynamics of bacterial pathogens in patients with fever in rural Burkina Faso: an observational study Open
Additional file 1: Additional tables.
View article: Intranasal vaccination with protein bodies elicit strong protection against Streptococcus pneumoniae colonization
Intranasal vaccination with protein bodies elicit strong protection against Streptococcus pneumoniae colonization Open
Protein bodies (PBs) are particles consisting of insoluble, aggregated proteins with potential as a vaccine formulation. PBs can contain high concentrations of antigen, are stable and relatively resistant to proteases, release antigen slow…
View article: Dynamic tracing of sugar metabolism reveals the mechanisms of action of synthetic sugar analogs
Dynamic tracing of sugar metabolism reveals the mechanisms of action of synthetic sugar analogs Open
Synthetic sugar analogs are widely applied in metabolic oligosaccharide engineering (MOE) and as novel drugs to interfere with glycoconjugate biosynthesis. However, mechanistic insights on their exact cellular metabolism over time are most…
View article: Examining the distribution and impact of single nucleotide polymorphisms in the capsular locus of serotype 19A.
Examining the distribution and impact of single nucleotide polymorphisms in the capsular locus of serotype 19A. Open
Streptococcus pneumoniae serotype 19A prevalence has increased after implementation of PCV7 and PCV10 vaccines. In this study, we have provided, with high accuracy, the genetic diversity of the 19A serotype in a cohort of Dutch invasive pn…
View article: Examining the Distribution and Impact of Single-Nucleotide Polymorphisms in the Capsular Locus of Streptococcus pneumoniae Serotype 19A
Examining the Distribution and Impact of Single-Nucleotide Polymorphisms in the Capsular Locus of Streptococcus pneumoniae Serotype 19A Open
Streptococcus pneumoniae serotype 19A prevalence has increased after the implementation of the PCV7 and PCV10 vaccines. In this study, we have provided, with high accuracy, the genetic diversity of the 19A serotype in a cohort of Dutch inv…
View article: Phase Variation in HMW1A Controls a Phenotypic Switch in Haemophilus influenzae Associated with Pathoadaptation during Persistent Infection
Phase Variation in HMW1A Controls a Phenotypic Switch in Haemophilus influenzae Associated with Pathoadaptation during Persistent Infection Open
Human-adapted bacterial pathogens have evolved specific mechanisms to colonize their host niche. Phase variation is a contingency strategy to allow adaptation to changing conditions, as phase-variable bacterial loci rapidly and reversibly …
View article: Structure–Activity Relationship of Fluorinated Sialic Acid Inhibitors for Bacterial Sialylation
Structure–Activity Relationship of Fluorinated Sialic Acid Inhibitors for Bacterial Sialylation Open
Bacterial pathogens such as Nontypeable Haemophilus influenzae (NTHi) can evade the immune system by taking up and presenting host-derived sialic acids. Herein, we report a detailed structure-activity relationship of sialic acid-bas…
View article: Immunomodulatory aged neutrophils are augmented in blood and skin of psoriasis patients
Immunomodulatory aged neutrophils are augmented in blood and skin of psoriasis patients Open
View article: Infection Manager System (IMS) as a new hemocytometry-based bacteremia detection tool: A diagnostic accuracy study in a malaria-endemic area of Burkina Faso
Infection Manager System (IMS) as a new hemocytometry-based bacteremia detection tool: A diagnostic accuracy study in a malaria-endemic area of Burkina Faso Open
Background New hemocytometric parameters can be used to differentiate causes of acute febrile illness (AFI). We evaluated a software algorithm–Infection Manager System (IMS)—which uses hemocytometric data generated by Sysmex hematology ana…
View article: Complement factor D haplodeficiency is associated with a reduced complement activation speed and diminished bacterial killing
Complement factor D haplodeficiency is associated with a reduced complement activation speed and diminished bacterial killing Open
Objectives Complete deficiency of alternative pathway (AP) complement factors, explained by homozygous mutations, is a well‐known risk factor for invasive bacterial infections; however, this is less obvious for heterozygous mutations. We d…
View article: Dynamic analysis of sugar metabolism reveals the mechanisms of action of synthetic sugar analogs
Dynamic analysis of sugar metabolism reveals the mechanisms of action of synthetic sugar analogs Open
Synthetic sugar analogs are widely applied in metabolic oligosaccharide engineering (MOE) and as novel drugs to interfere with glycoconjugate biosynthesis. However, mechanistic insights on their exact metabolism in the cell and over time a…
View article: Eculizumab impairs Neisseria meningitidis serogroup B killing in whole blood despite 4CMenB vaccination of PNH patients
Eculizumab impairs Neisseria meningitidis serogroup B killing in whole blood despite 4CMenB vaccination of PNH patients Open
Complement C5 inhibitor eculizumab has a great impact on the treatment of patients with paroxysmal nocturnal hemoglobinuria (PNH). However, this treatment success has a major drawback: a substantially increased susceptibility for life-thre…
View article: Antibody Binding and Complement-Mediated Killing of Invasive Haemophilus influenzae Isolates from Spain, Portugal, and the Netherlands
Antibody Binding and Complement-Mediated Killing of Invasive Haemophilus influenzae Isolates from Spain, Portugal, and the Netherlands Open
Haemophilus influenzae is a Gram-negative bacterium that can be classified into typeable (types a through f) and nontypeable (NTHi) groups. This opportunistic pathogen asymptomatically colonizes the mucosal epithelium of the upper respirat…
View article: Viral-bacterial (co-)occurrence in the upper airways and the risk of childhood pneumonia in resource-limited settings
Viral-bacterial (co-)occurrence in the upper airways and the risk of childhood pneumonia in resource-limited settings Open
View article: Aetiology of acute febrile illness in children in a high malaria transmission area in West Africa
Aetiology of acute febrile illness in children in a high malaria transmission area in West Africa Open
Viral respiratory infections are a common cause of childhood AFI in high malaria transmission areas, next to malaria and IBI. These findings highlight the importance of interventions to improve targeted treatment with antimicrobials. Most …