Jérôme Bejaud
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View article: Azacitidine Omega-3 Self-Assemblies: Synthesis, Characterization, and Potent Applications for Myelodysplastic Syndromes
Azacitidine Omega-3 Self-Assemblies: Synthesis, Characterization, and Potent Applications for Myelodysplastic Syndromes Open
5-Azacitidine, a cytidine analogue used as a hypomethylating agent, is one of the main drugs for the treatment of myelodysplastic syndromes (MDSs) and acute myeloid leukemia (AML) in the elderly. However, after administration, it exhibits …
View article: New In Vitro Coculture Model for Evaluating Intestinal Absorption of Different Lipid Nanocapsules
New In Vitro Coculture Model for Evaluating Intestinal Absorption of Different Lipid Nanocapsules Open
Standard models used for evaluating the absorption of nanoparticles like Caco-2 ignore the presence of vascular endothelium, which is a part of the intestinal multi-layered barrier structure. Therefore, a coculture between the Caco-2 epith…
View article: Infectious Diseases 2015 : Evaluation of interaction mechanisms between Acinetobacter baumannii bacteria and lipidic nanocapsules by flow cytometry - Angelique Montagu - University of Angers
Infectious Diseases 2015 : Evaluation of interaction mechanisms between Acinetobacter baumannii bacteria and lipidic nanocapsules by flow cytometry - Angelique Montagu - University of Angers Open
Acinetobacter baumannii is an important nosocomial pathogen, resistant to many commonly-used antibiotics. Considering the limited number of antibiotics in development, interesting strategies could lay on the use of natural resources especi…
View article: <p>Di-<em>O</em>-lauroyl-decitabine-lipid nanocapsules: toward extending decitabine activity</p>
Di-<em>O</em>-lauroyl-decitabine-lipid nanocapsules: toward extending decitabine activity Open
Decitabine (C12)2 as a prodrug showed high encapsulation efficiency, a good stability in plasma with no impact on its activity on leukemia cells and improved pharmacokinetics.
View article: Model Affitin and PEG modifications onto siRNA lipid nanocapsules: cell uptake and <i>in vivo</i> biodistribution improvements
Model Affitin and PEG modifications onto siRNA lipid nanocapsules: cell uptake and <i>in vivo</i> biodistribution improvements Open
Surface modifications of siRNA LNCs were assessed with innovative TE-PEG polymers and an Affitin model, in comparison to classic DSPE-PEG LNCs, in order to evaluate the potential tumor targeting of siRNA after intravenous administration.
View article: Drug delivery to tumours using a novel 5-FU derivative encapsulated into lipid nanocapsules
Drug delivery to tumours using a novel 5-FU derivative encapsulated into lipid nanocapsules Open
In this work, a novel lipophilic 5-fluorouracil (5-FU) derivative was synthesised and encapsulated into lipid nanocapsules (LNC). 5-FU was modified with lauric acid to give a lipophilic mono-lauroyl-derivative (5-FU-C12, MW of about 342 g/…