Jérôme Gracy
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View article: <i>Zymoseptoria tritici</i> Effectors Structurally Related to Killer Proteins <scp>UmV</scp> ‐ <scp>KP4</scp> and <scp>UmV</scp> ‐ <scp>KP6</scp> Inhibit Fungal Growth, and Define Extended Protein Families in Fungi
<i>Zymoseptoria tritici</i> Effectors Structurally Related to Killer Proteins <span>UmV</span> ‐ <span>KP4</span> and <span>UmV</span> ‐ <span>KP6</span> Inhibit Fungal Growth, and Define Extended Protein Families in Fungi Open
Fungal effectors play crucial roles in plant infection. Despite low sequence identity, they were recently discovered to belong to families with similar three‐dimensional structures. In this study, we elucidated the structures of Zt‐NIP1 an…
View article: Understanding evolutionary and functional relationships of RNA polymerases in plant and fungal viruses through structural modeling and divergence date estimations
Understanding evolutionary and functional relationships of RNA polymerases in plant and fungal viruses through structural modeling and divergence date estimations Open
RNA-dependent RNA polymerases (RdRps) are crucial for replication of RNA viruses and serve as key marker genes for defining deep taxonomic ranks and for understanding viral evolutionary history. Despite shared functions and conserved amino…
View article: <i>Zymoseptoria tritici</i>effectors structurally related to killer proteins UmV-KP4 and UmV-KP6 are toxic to fungi, and define extended protein families in fungi
<i>Zymoseptoria tritici</i>effectors structurally related to killer proteins UmV-KP4 and UmV-KP6 are toxic to fungi, and define extended protein families in fungi Open
Fungal effectors play crucial roles in plant infection. Despite low sequence identity, effectors were recently classified into structural families. In this study, we have elucidated the structures of Zt-NIP1 and Mycgr3-91409 effectors of t…
View article: @TOME 3.0: Interfacing Protein Structure Modeling and Ligand Docking
@TOME 3.0: Interfacing Protein Structure Modeling and Ligand Docking Open
Knowledge of protein-ligand complexes is essential for efficient drug design. Virtual docking can bring important information on putative complexes but it is still far from being simultaneously fast and accurate. Receptors are flexible and…
View article: The structural landscape and diversity of Pyricularia oryzae MAX effectors revisited
The structural landscape and diversity of Pyricularia oryzae MAX effectors revisited Open
Magnaporthe AVRs and ToxB-like (MAX) effectors constitute a family of secreted virulence proteins in the fungus Pyricularia oryzae (syn . Magnaporthe oryzae) , which causes blast disease on numerous cereals and grasses. In spite of high se…
View article: The structural landscape and diversity of<i>Pyricularia oryzae</i>MAX effectors revisited
The structural landscape and diversity of<i>Pyricularia oryzae</i>MAX effectors revisited Open
Magnaporthe AVRs and ToxB-like (MAX) effectors constitute a family of secreted virulence proteins in the fungus Pyricularia oryzae (syn. Magnaporthe oryzae) , which causes blast disease on numerous cereals and grasses. In spite of high seq…
View article: Adaptive evolution in virulence effectors of the rice blast fungus Pyricularia oryzae
Adaptive evolution in virulence effectors of the rice blast fungus Pyricularia oryzae Open
Plant pathogens secrete proteins called effectors that target host cellular processes to promote disease. Recently, structural genomics has identified several families of fungal effectors that share a similar three-dimensional structure de…
View article: SecretoMyc, a web-based database on mycobacteria secreted proteins and structure-based homology identification using bio-informatics tools
SecretoMyc, a web-based database on mycobacteria secreted proteins and structure-based homology identification using bio-informatics tools Open
To better understand the interaction between the host and the Mycobacterium tuberculosis pathogen, it is critical to identify its potential secreted proteins. While various experimental methods have been successful in identifying proteins …
View article: A Mycobacterium tuberculosis Effector Targets Mitochondrion, Controls Energy Metabolism, and Limits Cytochrome <i>c</i> Exit
A Mycobacterium tuberculosis Effector Targets Mitochondrion, Controls Energy Metabolism, and Limits Cytochrome <i>c</i> Exit Open
In this article, using a combination of techniques (bioinformatics, structural biology, and cell biology), we identified and characterized a new class of effectors present only in intracellular mycobacteria. These proteins specifically tar…
View article: Adaptive evolution in virulence effectors of the rice blast fungus<i>Pyricularia oryzae</i>
Adaptive evolution in virulence effectors of the rice blast fungus<i>Pyricularia oryzae</i> Open
Plant pathogens secrete proteins called effectors that target host cellular processes to promote disease. Recently, structural genomics has identified several families of fungal effectors that share a similar three-dimensional structure de…
View article: A new family of structurally conserved fungal effectors displays epistatic interactions with plant resistance proteins
A new family of structurally conserved fungal effectors displays epistatic interactions with plant resistance proteins Open
Recognition of a pathogen avirulence (AVR) effector protein by a cognate plant resistance (R) protein triggers a set of immune responses that render the plant resistant. Pathogens can escape this so-called Effector-Triggered Immunity (ETI)…
View article: Characterization of epistatic interactions within a family of structurally conserved fungal effectors and of their broad-spectrum recognition by a plant resistance protein
Characterization of epistatic interactions within a family of structurally conserved fungal effectors and of their broad-spectrum recognition by a plant resistance protein Open
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View article: Programmable receptors enable bacterial biosensors to detect pathological biomarkers in clinical samples
Programmable receptors enable bacterial biosensors to detect pathological biomarkers in clinical samples Open
Bacterial biosensors, or bactosensors, are promising agents for medical and environmental diagnostics. However, the lack of scalable frameworks to systematically program ligand detection limits their applications. Here we show how novel, c…
View article: A synthetic receptor platform enables rapid and portable monitoring of liver dysfunction via engineered bacteria.
A synthetic receptor platform enables rapid and portable monitoring of liver dysfunction via engineered bacteria. Open
Bacterial biosensors, or bactosensors, are promising field-deployable agents for medical and environmental diagnostics. However, the lack of scalable frameworks to systematically program ligand detection limits their applications. Here we …
View article: A synthetic receptor platform enables rapid and portable monitoring of liver dysfunction via engineered bacteria
A synthetic receptor platform enables rapid and portable monitoring of liver dysfunction via engineered bacteria Open
Bacterial biosensors, or bactosensors, are promising field-deployable agents for medical and environmental diagnostics. However, the lack of scalable frameworks to systematically program ligand detection limits their applications. Here we …
View article: A<i>Mycobacterium tuberculosis</i>effector targets mitochondrion, controls energy metabolism and limits cytochrome c exit
A<i>Mycobacterium tuberculosis</i>effector targets mitochondrion, controls energy metabolism and limits cytochrome c exit Open
Host metabolism reprogramming is a key feature of Mycobacterium tuberculosis (Mtb) infection that enables the survival of this pathogen within phagocytic cells and modulates the immune response facilitating the spread of the tuberculosis d…
View article: A new family of structurally conserved fungal effectors displays epistatic interactions with plant resistance proteins
A new family of structurally conserved fungal effectors displays epistatic interactions with plant resistance proteins Open
Recognition of a pathogen avirulence (AVR) effector protein by a cognate plant resistance (R) protein triggers a set of immune responses that render the plant resistant. Pathogens can escape this so-called Effector-Triggered Immunity (ETI)…
View article: Peer Review #1 of "Comprehensive classification of the plant non-specific lipid transfer protein superfamily towards its sequence–structure–function analysis (v0.1)"
Peer Review #1 of "Comprehensive classification of the plant non-specific lipid transfer protein superfamily towards its sequence–structure–function analysis (v0.1)" Open
Background.Non-specific Lipid Transfer Proteins (nsLTPs) are widely distributed in the plant kingdom and constitute a superfamily of related proteins.Several hundreds of different nsLTP sequences -and counting -have been characterized so f…
View article: Peer Review #3 of "Comprehensive classification of the plant non-specific lipid transfer protein superfamily towards its sequence–structure–function analysis (v0.1)"
Peer Review #3 of "Comprehensive classification of the plant non-specific lipid transfer protein superfamily towards its sequence–structure–function analysis (v0.1)" Open
Background.Non-specific Lipid Transfer Proteins (nsLTPs) are widely distributed in the plant kingdom and constitute a superfamily of related proteins.Several hundreds of different nsLTP sequences -and counting -have been characterized so f…
View article: Comprehensive classification of the plant non-specific lipid transfer protein superfamily towards its sequence–structure–function analysis
Comprehensive classification of the plant non-specific lipid transfer protein superfamily towards its sequence–structure–function analysis Open
Background Non-specific Lipid Transfer Proteins (nsLTPs) are widely distributed in the plant kingdom and constitute a superfamily of related proteins. Several hundreds of different nsLTP sequences—and counting—have been characterized so fa…
View article: Comprehensive classification of the plant non-specific lipid transfer protein superfamily towards its Sequence -Structure -Function analysis
Comprehensive classification of the plant non-specific lipid transfer protein superfamily towards its Sequence -Structure -Function analysis Open
Background. Non-specific Lipid Transfer Proteins (nsLTPs) are widely distributed in the plant kingdom and constitute a superfamily of related proteins. More than 800 different sequences have been characterized so far, but their biological …
View article: Comprehensive classification of the plant non-specific lipid transfer protein superfamily towards its Sequence – Structure – Function analysis.
Comprehensive classification of the plant non-specific lipid transfer protein superfamily towards its Sequence – Structure – Function analysis. Open
Background. Non-specific Lipid Transfer Proteins (nsLTPs) are widely distributed in the plant kingdom and constitute a superfamily of related proteins. More than 800 different sequences have been characterized so far, but their biological …
View article: Comprehensive classification of the plant non-specific lipid transfer protein superfamily towards its Sequence – Structure – Function analysis.
Comprehensive classification of the plant non-specific lipid transfer protein superfamily towards its Sequence – Structure – Function analysis. Open
Background. Non-specific Lipid Transfer Proteins (nsLTPs) are widely distributed in the plant kingdom and constitute a superfamily of related proteins. More than 800 different sequences have been characterized so far, but their biological …
View article: KNOTTIN: the database of inhibitor cystine knot scaffold after 10 years, toward a systematic structure modeling
KNOTTIN: the database of inhibitor cystine knot scaffold after 10 years, toward a systematic structure modeling Open
Knottins, or inhibitor cystine knots (ICKs), are ultra-stable miniproteins with multiple applications in drug design and medical imaging. These widespread and functionally diverse proteins are characterized by the presence of three interwo…
View article: Recognition of the <i>Magnaporthe oryzae</i> Effector AVR-Pia by the Decoy Domain of the Rice NLR Immune Receptor RGA5
Recognition of the <i>Magnaporthe oryzae</i> Effector AVR-Pia by the Decoy Domain of the Rice NLR Immune Receptor RGA5 Open
Nucleotide binding domain and leucine-rich repeat proteins (NLRs) are important receptors in plant immunity that allow recognition of pathogen effectors. The rice (Oryza sativa) NLR RGA5 recognizes the Magnaporthe oryzae effector AVR-Pia t…
View article: Structure Analysis Uncovers a Highly Diverse but Structurally Conserved Effector Family in Phytopathogenic Fungi
Structure Analysis Uncovers a Highly Diverse but Structurally Conserved Effector Family in Phytopathogenic Fungi Open
Phytopathogenic ascomycete fungi possess huge effector repertoires that are dominated by hundreds of sequence-unrelated small secreted proteins. The molecular function of these effectors and the evolutionary mechanisms that generate this t…
View article: Molecular evolution of MAX effectors in the rice blast fungus Pyricularia oryzae
Molecular evolution of MAX effectors in the rice blast fungus Pyricularia oryzae Open
Fungal plant pathogens secrete proteins, termed “effectors”, that enable them to interact with their hosts and to influence the outcome of the interaction. Attempts to probe into the evolutionary, molecular and functional drivers of effect…