Jerome Jatzlau
YOU?
Author Swipe
View article: TGFb-induced SMAD1/5 activation drives transient epithelial-to-mesenchymal transition in trophoblasts
TGFb-induced SMAD1/5 activation drives transient epithelial-to-mesenchymal transition in trophoblasts Open
Successful human placental development requires fetal trophoblasts to undergo epithelial-to-mesenchymal and mesenchymal-to-endothelial transitions, enabling invasion and remodeling of maternal spiral arteries for proper placental perfusion…
View article: Entwicklung von chemischen Initiatoren der Dimerisierung von HaloTag und SNAP‐Tag zur Untersuchung von Signaltransduktion induziert durch Rezeptor‐Oligomerisierung
Entwicklung von chemischen Initiatoren der Dimerisierung von HaloTag und SNAP‐Tag zur Untersuchung von Signaltransduktion induziert durch Rezeptor‐Oligomerisierung Open
Zusammenfassung Protein‐Protein‐Interaktionen gezielt kontrollieren zu können ist essenziell für die Analyse von Signalwegen, insbesondere solcher, die durch das Binden von Liganden eine Oligomerisierung von Rezeptoren herbeiführen und som…
View article: Developing HaloTag and SNAP‐Tag Chemical Inducers of Dimerization to Probe Receptor Oligomerization and Downstream Signaling
Developing HaloTag and SNAP‐Tag Chemical Inducers of Dimerization to Probe Receptor Oligomerization and Downstream Signaling Open
Controlling protein–protein interactions is critical for dissecting signaling pathways, especially those initiated by ligand‐receptor interactions, which alter receptor oligomerization and drive downstream signaling cascades. Traditional m…
View article: Rare but specific: 5-bp composite motifs define SMAD binding in BMP signaling
Rare but specific: 5-bp composite motifs define SMAD binding in BMP signaling Open
Background Receptor-activated SMADs trimerize with SMAD4 to regulate context-dependent target gene expression. However, the presence of a single SMAD1/5/8 binding motif in cis-regulatory elements alone does not trigger transcription in nat…
View article: Leucine-rich α-2 glycoprotein 1 (LRG1) during inflammatory complications after allogeneic stem cell transplantation and CAR-T cell therapy
Leucine-rich α-2 glycoprotein 1 (LRG1) during inflammatory complications after allogeneic stem cell transplantation and CAR-T cell therapy Open
Background Previous data indicated that the leucine-rich α-2 glycoprotein 1 (LRG1) pathway contributes to vascular dysfunction during cancer growth. Therapeutic targeting of LRG1 normalized tumor vessel dysfunction and enhanced the efficac…
View article: Atheroprone Flow Activates SMAD-FOXO1 to drive Endothelial-to-Mesenchymal Transition and Atherosclerosis
Atheroprone Flow Activates SMAD-FOXO1 to drive Endothelial-to-Mesenchymal Transition and Atherosclerosis Open
Background Cardiovascular diseases are the leading cause of death worldwide with atherosclerosis as the main underlying pathology. A hallmark of atherosclerotic lesion formation is endothelial-to-mesenchymal transition (EndoMT) triggered b…
View article: Dynamic remodeling of septin structures fine-tunes myogenic differentiation
Dynamic remodeling of septin structures fine-tunes myogenic differentiation Open
Controlled myogenic differentiation is integral to the development, maintenance and repair of skeletal muscle, necessitating precise regulation of myogenic progenitors and resident stem cells. The transformation of proliferative muscle pro…
View article: BMP Stimulation Differentially Affects Phosphorylation and Protein Stability of β-Catenin in Breast Cancer Cell Lines
BMP Stimulation Differentially Affects Phosphorylation and Protein Stability of β-Catenin in Breast Cancer Cell Lines Open
Increased expression and nuclear translocation of β-CATENIN is frequently observed in breast cancer, and it correlates with poor prognosis. Current treatment strategies targeting β-CATENIN are not as efficient as desired. Therefore, detail…
View article: Protocol for chromatin accessibility profiling of human endothelial cells cultured under fluid shear stress using ATAC-seq
Protocol for chromatin accessibility profiling of human endothelial cells cultured under fluid shear stress using ATAC-seq Open
Chromatin accessibility influences gene regulation and can be quantified using assay for transposase-accessible chromatin with high-throughput sequencing (ATAC-seq). Recapitulating in vivo fluid shear stress (FSS) mechano-regimes in vitro …
View article: The Activation of the Fibrodysplasia Ossificans Progressiva-Inducing ALK2-R206H Mutant Depends on the Distinct Homo-Oligomerization Patterns of ACVR2B and ACVR2A
The Activation of the Fibrodysplasia Ossificans Progressiva-Inducing ALK2-R206H Mutant Depends on the Distinct Homo-Oligomerization Patterns of ACVR2B and ACVR2A Open
Mutations in activin-like kinase 2 (ALK2), e.g., ALK2-R206H, induce aberrant signaling to SMAD1/5/8, leading to Fibrodysplasia Ossificans Progressiva (FOP). In spite of extensive studies, the underlying mechanism is still unclear. Here, we…
View article: Author Correction: Enhancer hijacking at the ARHGAP36 locus is associated with connective tissue to bone transformation
Author Correction: Enhancer hijacking at the ARHGAP36 locus is associated with connective tissue to bone transformation Open
View article: Characterization of Fibrodysplasia Ossificans Progessiva relevant Acvr1/Acvr2 Activin receptors in medaka (Oryzias latipes)
Characterization of Fibrodysplasia Ossificans Progessiva relevant Acvr1/Acvr2 Activin receptors in medaka (Oryzias latipes) Open
Activin and Bone Morphogenetic Protein (BMP) signaling plays crucial roles in vertebrate organ formation, including osteo- and angiogenesis, and tissue homeostasis, such as neuronal maintenance. Activin and BMP signaling needs to be precis…
View article: Reorganization of Septin structures regulates early myogenesis
Reorganization of Septin structures regulates early myogenesis Open
Controlled myogenic differentiation is crucial for developmental formation, homeostatic maintenance and adult repair of skeletal muscle and relies on cell fate determinants in myogenic progenitors or resident stem cells. Proliferating musc…
View article: Fluid shear stress-modulated chromatin accessibility reveals the mechano-dependency of endothelial SMAD1/5-mediated gene transcription
Fluid shear stress-modulated chromatin accessibility reveals the mechano-dependency of endothelial SMAD1/5-mediated gene transcription Open
Bone morphogenetic protein (BMP) signaling and fluid shear stress (FSS) mediate complementary functions in vascular homeostasis and disease development. It remains to be shown whether altered chromatin accessibility downstream of BMP and F…
View article: Enhancer hijacking at the ARHGAP36 locus is associated with connective tissue to bone transformation
Enhancer hijacking at the ARHGAP36 locus is associated with connective tissue to bone transformation Open
View article: FKBP12 is a major regulator of ALK2 activity in multiple myeloma cells
FKBP12 is a major regulator of ALK2 activity in multiple myeloma cells Open
View article: A versatile Halo- and SNAP-tagged BMP/TGFβ receptor library for quantification of cell surface ligand binding
A versatile Halo- and SNAP-tagged BMP/TGFβ receptor library for quantification of cell surface ligand binding Open
View article: Atheroprone fluid shear stress-regulated ALK1-Endoglin-SMAD signaling originates from early endosomes
Atheroprone fluid shear stress-regulated ALK1-Endoglin-SMAD signaling originates from early endosomes Open
View article: A versatile Halo- and SNAP-tagged BMP/TGFβ receptor library for quantification of cell surface ligand binding
A versatile Halo- and SNAP-tagged BMP/TGFβ receptor library for quantification of cell surface ligand binding Open
The TGFβ superfamily of secreted growth factors comprises more than 30 members including TGFβs, BMPs and Activins. While all TGFβ superfamily members signal through heteromeric receptor complexes to regulate a plethora of developmental and…
View article: BMP9 and Fluid Shear Stress Regulate Endothelial Chromatin Accessibility and Expression of SMAD Low Affinity Target Genes
BMP9 and Fluid Shear Stress Regulate Endothelial Chromatin Accessibility and Expression of SMAD Low Affinity Target Genes Open
View article: Additional file 3 of Atheroprone fluid shear stress-regulated ALK1-Endoglin-SMAD signaling originates from early endosomes
Additional file 3 of Atheroprone fluid shear stress-regulated ALK1-Endoglin-SMAD signaling originates from early endosomes Open
Additional file 3. RNAseq csv file: Differential expression values of LSS vs. HSS.
View article: Additional file 2 of Atheroprone fluid shear stress-regulated ALK1-Endoglin-SMAD signaling originates from early endosomes
Additional file 2 of Atheroprone fluid shear stress-regulated ALK1-Endoglin-SMAD signaling originates from early endosomes Open
Additional file 2. RNAseq csv file: RPKM values.
View article: Differential Impact of Fluid Shear Stress and YAP/TAZ on BMP/TGF‐β Induced Osteogenic Target Genes
Differential Impact of Fluid Shear Stress and YAP/TAZ on BMP/TGF‐β Induced Osteogenic Target Genes Open
Bone is a remarkable dynamic structure, which integrates mechanical and biochemical signaling inputs. Interstitial fluid in the intramedullary space transmits signals derived from compression‐induced fluid shear stress (FSS) to stimulate o…
View article: Picomolar FKBP inhibitors enabled by a single water-displacing methyl group in bicyclic [4.3.1] aza-amides
Picomolar FKBP inhibitors enabled by a single water-displacing methyl group in bicyclic [4.3.1] aza-amides Open
Enhancement by displacement. A single methyl group displaces a water molecule from the binding site of FKBPs, resulting in the most potent binders known, outperforming the natural products FK506 and rapamycin in biochemical and cellular as…
View article: BMP signalling in a mechanical context – Implications for bone biology
BMP signalling in a mechanical context – Implications for bone biology Open
Bone Morphogenetic Proteins (BMPs) are extracellular multifunctional signalling cytokines and members of the TGFβ super family. These pleiotropic growth factors crucially promote bone formation, remodeling and healing after injury. Additio…
View article: Biomechanical stress provides a second hit in the establishment of BMP/TGFβ-related vascular disorders
Biomechanical stress provides a second hit in the establishment of BMP/TGFβ-related vascular disorders Open
Cardiovascular disorders are still the leading cause for mortality in the western world and challenge economies with steadily increasing healthcare costs. Understanding the precise molecular pathomechanisms behind and identifying players i…
View article: BMPR2 acts as a gatekeeper to protect endothelial cells from increased TGFβ responses and altered cell mechanics
BMPR2 acts as a gatekeeper to protect endothelial cells from increased TGFβ responses and altered cell mechanics Open
Cardiovascular disorders are still the leading cause for mortality in the western world and challenge economies with steadily increasing healthcare costs. Understanding the precise molecular pathomechanisms behind and identifying players i…
View article: AMOT130 drives BMP-SMAD signaling at the apical membrane in polarized cells
AMOT130 drives BMP-SMAD signaling at the apical membrane in polarized cells Open
We found that the tight-junction protein angiomotin (AMOT130) interacts with the BMP receptor BMPR2 and thereby supports BMP/SMAD signaling exclusively at the apical side of polarized epithelial and endothelial cells. BMP-mediated internal…
View article: IRS4, a novel modulator of BMP/Smad and Akt signalling during early muscle differentiation
IRS4, a novel modulator of BMP/Smad and Akt signalling during early muscle differentiation Open