Jérôme Jullien
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View article: Digital Reprogramming Decodes Epigenetic Barriers of Cell Fate Changes
Digital Reprogramming Decodes Epigenetic Barriers of Cell Fate Changes Open
Fates of differentiated cells in our body can be induced to change by nuclear reprogramming. In this way, cells valuable for therapeutic purposes and disease modeling can be produced. However, the efficiency of this process is low, partly …
View article: Sperm derived H2AK119ub1 is required for embryonic development in <i>Xenopus laevis</i>
Sperm derived H2AK119ub1 is required for embryonic development in <i>Xenopus laevis</i> Open
Deposition of H2AK119ub1 by the polycomb repressive complexe-1 plays a key role in the initiation of facultative heterochromatin formation in somatic cells. Here we evaluate the contribution of sperm derived H2AK119ub1 to embryo developmen…
View article: Type-I interferons promote innate immune tolerance in macrophages exposed to Mycobacterium ulcerans vesicles
Type-I interferons promote innate immune tolerance in macrophages exposed to Mycobacterium ulcerans vesicles Open
Buruli ulcer is a chronic infectious disease caused by Mycobacterium ulcerans . The pathogen persistence in host skin is associated with the development of ulcerative and necrotic lesions leading to permanent disabilities in most patients.…
View article: DNA-induced spatial entrapment of general transcription machinery can stabilize gene expression in a nondividing cell
DNA-induced spatial entrapment of general transcription machinery can stabilize gene expression in a nondividing cell Open
Significance How differentiated cells such as muscle or nerve maintain their gene expression for prolonged times is currently elusive. Here, using Xenopus oocyte, we have shown that the stability of gene expression in nondividing cells may…
View article: Secreted inhibitors drive the loss of regeneration competence in <i>Xenopus</i> limbs
Secreted inhibitors drive the loss of regeneration competence in <i>Xenopus</i> limbs Open
Absence of a specialized wound epidermis is hypothesized to block limb regeneration in higher vertebrates. However, the factors preventing its formation in regeneration-incompetent animals are poorly understood. To characterize the endogen…
View article: Fluid mechanics of mosaic ciliated tissues
Fluid mechanics of mosaic ciliated tissues Open
In tissues as diverse as amphibian skin and the human airway, the cilia that propel fluid are grouped in sparsely distributed multiciliated cells (MCCs). We investigate fluid transport in this “mosaic” architecture, with emphasis on the tr…
View article: A real‐world implementation of a nationwide, long‐term monitoring program to assess the impact of agrochemicals and agricultural practices on biodiversity
A real‐world implementation of a nationwide, long‐term monitoring program to assess the impact of agrochemicals and agricultural practices on biodiversity Open
Biodiversity has undergone a major decline throughout recent decades, particularly in farmland. Agricultural practices are recognized to be an important pressure on farmland biodiversity, and pesticides are suspected to be one of the main …
View article: Secreted inhibitors drive the loss of regeneration competence in<i>Xenopus</i>limbs
Secreted inhibitors drive the loss of regeneration competence in<i>Xenopus</i>limbs Open
Absence of a specialised wound epidermis is hypothesised to block limb regeneration in higher vertebrates. To elucidate the cellular and molecular determinants of this tissue, we performed single-cell transcriptomics in regeneration-compet…
View article: The myeloid lineage is required for the emergence of a regeneration-permissive environment following <i>Xenopus</i> tail amputation
The myeloid lineage is required for the emergence of a regeneration-permissive environment following <i>Xenopus</i> tail amputation Open
Regeneration-competent vertebrates are considered to suppress inflammation faster than non-regenerating ones. Hence, understanding the cellular mechanisms affected by immune cells and inflammation can help develop strategies to promote tis…
View article: Identification of a regeneration-organizing cell in the <i>Xenopus</i> tail
Identification of a regeneration-organizing cell in the <i>Xenopus</i> tail Open
A tale of tadpole tail regeneration Some vertebrates, including some amphibians, show a remarkable, if sometimes restricted, ability to regenerate lost appendages. Aztekin et al. compared naturally occurring regeneration-competent and -inc…
View article: Chromatin Accessibility Impacts Transcriptional Reprogramming in Oocytes
Chromatin Accessibility Impacts Transcriptional Reprogramming in Oocytes Open
Oocytes have a remarkable ability to reactivate silenced genes in somatic cells. However, it is not clear how the chromatin architecture of somatic cells affects this transcriptional reprogramming. Here, we investigated the relationship be…
View article: Reprogramming towards totipotency is greatly facilitated by synergistic effects of small molecules
Reprogramming towards totipotency is greatly facilitated by synergistic effects of small molecules Open
Animal cloning has been achieved in many species by transplanting differentiated cell nuclei to unfertilized oocytes. However, the low efficiencies of cloning have remained an unresolved issue. Here we find that the combination of two smal…
View article: H3K4 Methylation-Dependent Memory of Somatic Cell Identity Inhibits Reprogramming and Development of Nuclear Transfer Embryos
H3K4 Methylation-Dependent Memory of Somatic Cell Identity Inhibits Reprogramming and Development of Nuclear Transfer Embryos Open
Vertebrate eggs can induce the nuclear reprogramming of somatic cells to enable production of cloned animals. Nuclear reprogramming is relatively inefficient, and the development of the resultant embryos is frequently compromised, in part …
View article: Nerve Growth Factor Signaling from Membrane Microdomains to the Nucleus: Differential Regulation by Caveolins
Nerve Growth Factor Signaling from Membrane Microdomains to the Nucleus: Differential Regulation by Caveolins Open
Membrane microdomains or “lipid rafts” have emerged as essential functional modules of the cell, critical for the regulation of growth factor receptor-mediated responses. Herein we describe the dichotomy between caveolin-1 and caveolin-2, …
View article: Sperm is epigenetically programmed to regulate gene transcription in embryos
Sperm is epigenetically programmed to regulate gene transcription in embryos Open
For a long time, it has been assumed that the only role of sperm at fertilization is to introduce the male genome into the egg. Recently, ideas have emerged that the epigenetic state of the sperm nucleus could influence transcription in th…
View article: Appendix B. Demonstration: the sum of the squared scores of the pixels on the factorial axes of the MADIFA is equal to the Mahalanobis distances.
Appendix B. Demonstration: the sum of the squared scores of the pixels on the factorial axes of the MADIFA is equal to the Mahalanobis distances. Open
Demonstration: the sum of the squared scores of the pixels on the factorial axes of the MADIFA is equal to the Mahalanobis distances.
View article: Appendix C. Results of the principal component analyses performed to identify the correlations on the study area, and in the chamois niche.
Appendix C. Results of the principal component analyses performed to identify the correlations on the study area, and in the chamois niche. Open
Results of the principal component analyses performed to identify the correlations on the study area, and in the chamois niche.
View article: The Expression of TALEN before Fertilization Provides a Rapid Knock-Out Phenotype in Xenopus laevis Founder Embryos
The Expression of TALEN before Fertilization Provides a Rapid Knock-Out Phenotype in Xenopus laevis Founder Embryos Open
Recent advances in genome editing using programmable nucleases have revolutionized gene targeting in various organisms. Successful gene knock-out has been shown in Xenopus, a widely used model organism, although a system enabling less mosa…