Jerrold L. Vitek
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View article: Parkinsonism disrupts the balance between excitatory and inhibitory activity within the primary motor cortex during movement
Parkinsonism disrupts the balance between excitatory and inhibitory activity within the primary motor cortex during movement Open
Parkinson’s disease (PD) has been associated with alterations in neuronal activity in the basal ganglia-thalamocortical (BGTC) network. Previous studies have suggested that cortical disinhibition is a feature of PD, but there has been litt…
View article: Five-Year Outcomes from Deep Brain Stimulation of the Subthalamic Nucleus for Parkinson Disease
Five-Year Outcomes from Deep Brain Stimulation of the Subthalamic Nucleus for Parkinson Disease Open
Importance The Implantable Neurostimulator for the Treatment of Parkinson’s Disease (INTREPID) trial was a randomized, double-blind, sham-controlled study of subthalamic nucleus (STN) deep brain stimulation (DBS) for the treatment of Parki…
View article: Alterations in beta oscillatory activity occur with the emergence of parkinsonian motor signs across the basal ganglia-thalamocortical network
Alterations in beta oscillatory activity occur with the emergence of parkinsonian motor signs across the basal ganglia-thalamocortical network Open
View article: Site-specific neuronal and motor effects of short-term intermittent burst deep brain stimulation in non-human primates
Site-specific neuronal and motor effects of short-term intermittent burst deep brain stimulation in non-human primates Open
View article: Sleep firing rate homeostasis is disrupted in mild parkinsonism
Sleep firing rate homeostasis is disrupted in mild parkinsonism Open
Sleep-associated downscaling of neuronal firing, i.e., firing rate homeostasis (FRH ), is essential for restorative sleep. Sleep dysfunction is common in Parkinson’s disease (PD), but FRH has not been investigated. Here, using a within-sub…
View article: Parkinsonism Disrupts Neuronal Modulation in the Presupplementary Motor Area during Movement Preparation
Parkinsonism Disrupts Neuronal Modulation in the Presupplementary Motor Area during Movement Preparation Open
Multiple studies suggest that Parkinson's disease (PD) is associated with changes in neuronal activity throughout the basal ganglia-thalamocortical motor circuit. There are limited electrophysiological data, however, describing how parkins…
View article: Impairment of neuronal activity in the dorsolateral prefrontal cortex occurs early in parkinsonism
Impairment of neuronal activity in the dorsolateral prefrontal cortex occurs early in parkinsonism Open
Background Parkinson’s disease (PD) is often characterized by altered rates and patterns of neuronal activity in the sensorimotor regions of the basal ganglia thalamocortical network. Little is known, however, regarding how neuronal activi…
View article: Externalization Techniques in Neurosurgical Procedures for Real-Time Neuromodulation Monitoring and Optimization
Externalization Techniques in Neurosurgical Procedures for Real-Time Neuromodulation Monitoring and Optimization Open
View article: Externalization Techniques in Neurosurgical Procedures for Real-Time Neuromodulation Monitoring and Optimization
Externalization Techniques in Neurosurgical Procedures for Real-Time Neuromodulation Monitoring and Optimization Open
View article: Differentiating Postural and Kinetic Tremor Responses to Deep Brain Stimulation in Essential Tremor
Differentiating Postural and Kinetic Tremor Responses to Deep Brain Stimulation in Essential Tremor Open
Background While deep brain stimulation (DBS) targeting the ventral intermediate nucleus (VIM) of thalamus or posterior subthalamic area (PSA) can suppress forms of action tremor in people with Essential Tremor, previous studies have sugge…
View article: Parkinsonism disrupts neuronal modulation in the pre-supplementary motor area during movement preparation
Parkinsonism disrupts neuronal modulation in the pre-supplementary motor area during movement preparation Open
Multiple studies suggest that Parkinson’s disease (PD) is associated with changes in neuronal activity throughout the basal ganglia-thalamocortical motor circuit. There are limited electrophysiological data, however, describing how parkins…
View article: Impairment of Neuronal Activity in the Dorsolateral Prefrontal Cortex Occurs Early in Parkinsonism
Impairment of Neuronal Activity in the Dorsolateral Prefrontal Cortex Occurs Early in Parkinsonism Open
Background Parkinson’s disease (PD) is often characterized by altered rates and patterns of neuronal activity in the sensorimotor regions of the basal ganglia thalamocortical network. Little is known, however, regarding how neuronal activi…
View article: Reduced subthalamic and subthalamic-cortical coherences associated with the therapeutic carryover effect of coordinated reset deep brain stimulation
Reduced subthalamic and subthalamic-cortical coherences associated with the therapeutic carryover effect of coordinated reset deep brain stimulation Open
View article: A Patient-Centered Perspective on Changes in Personal Characteristics After Deep Brain Stimulation
A Patient-Centered Perspective on Changes in Personal Characteristics After Deep Brain Stimulation Open
Importance Deep brain stimulation (DBS) results in improvements in motor function and quality of life in patients with Parkinson disease (PD), which might impact a patient’s perception of valued personal characteristics. Prior studies inve…
View article: Neural pathways associated with reduced rigidity during pallidal deep brain stimulation for Parkinson’s disease
Neural pathways associated with reduced rigidity during pallidal deep brain stimulation for Parkinson’s disease Open
Subject-specific computational models of pallidal deep brain stimulation, in conjunction with quantitative measures of forearm rigidity, were used to examine the neural pathways mediating stimulation-induced changes in rigidity in people w…
View article: Deep brain stimulation pulse sequences to optimally modulate frequency-specific neural activity
Deep brain stimulation pulse sequences to optimally modulate frequency-specific neural activity Open
Objective . Precise neuromodulation systems are needed to identify the role of neural oscillatory dynamics in brain function and to advance the development of brain stimulation therapies tailored to each patient’s signature of brain dysfun…
View article: Slow-wave sleep dysfunction in mild parkinsonism is associated with excessive beta and reduced delta oscillations in motor cortex
Slow-wave sleep dysfunction in mild parkinsonism is associated with excessive beta and reduced delta oscillations in motor cortex Open
Increasing evidence suggests slow-wave sleep (SWS) dysfunction in Parkinson’s disease (PD) is associated with faster disease progression, cognitive impairment, and excessive daytime sleepiness. Beta oscillations (8–35 Hz) in the basal gang…
View article: DiMANI: diffusion MRI for anatomical nuclei imaging—Application for the direct visualization of thalamic subnuclei
DiMANI: diffusion MRI for anatomical nuclei imaging—Application for the direct visualization of thalamic subnuclei Open
The thalamus is a centrally located and heterogeneous brain structure that plays a critical role in various sensory, motor, and cognitive processes. However, visualizing the individual subnuclei of the thalamus using conventional MRI techn…
View article: Active contact proximity to the cerebellothalamic tract predicts initial therapeutic current requirement with DBS for ET: an application of 7T MRI
Active contact proximity to the cerebellothalamic tract predicts initial therapeutic current requirement with DBS for ET: an application of 7T MRI Open
Objective To characterize how the proximity of deep brain stimulation (DBS) active contact locations relative to the cerebellothalamic tract (CTT) affect clinical outcomes in patients with essential tremor (ET). Background DBS is an effect…
View article: Excessive cortical beta oscillations are associated with slow-wave sleep dysfunction in mild parkinsonism
Excessive cortical beta oscillations are associated with slow-wave sleep dysfunction in mild parkinsonism Open
Increasing evidence associates slow-wave sleep (SWS) dysfunction with neurodegeneration. Using a within-subject design in the nonhuman primate model of Parkinson’s disease (PD), we found that reduced SWS quantity in mild parkinsonism was a…
View article: Paradoxical Modulation of <scp>STN β‐Band</scp> Activity with Medication Compared to Deep Brain Stimulation
Paradoxical Modulation of <span>STN β‐Band</span> Activity with Medication Compared to Deep Brain Stimulation Open
Background Excessive subthalamic nucleus (STN) β‐band (13–35 Hz) synchronized oscillations has garnered interest as a biomarker for characterizing disease state and developing adaptive stimulation systems for Parkinson's disease (PD). Obje…
View article: Low-frequency deep brain stimulation reveals resonant beta-band evoked oscillations in the pallidum of Parkinson’s Disease patients
Low-frequency deep brain stimulation reveals resonant beta-band evoked oscillations in the pallidum of Parkinson’s Disease patients Open
Introduction Evidence suggests that spontaneous beta band (11–35 Hz) oscillations in the basal ganglia thalamocortical (BGTC) circuit are linked to Parkinson’s disease (PD) pathophysiology. Previous studies on neural responses in the motor…
View article: Effect of subthalamic coordinated reset deep brain stimulation on Parkinsonian gait
Effect of subthalamic coordinated reset deep brain stimulation on Parkinsonian gait Open
Introduction Coordinated Reset Deep Brain Stimulation (CR DBS) is a novel DBS approach for treating Parkinson's disease (PD) that uses lower levels of burst stimulation through multiple contacts of the DBS lead. Though CR DBS has been demo…
View article: 3D printed guide tube system for acute Neuropixels probe recordings in non-human primates
3D printed guide tube system for acute Neuropixels probe recordings in non-human primates Open
Objective. Neuropixels (NP) probes are a significant advance in electrophysiological recording technology that enable monitoring of hundreds of neurons in the brain simultaneously at different depths. Application of this technology has bee…
View article: Classification of electrically-evoked potentials in the parkinsonian subthalamic nucleus region
Classification of electrically-evoked potentials in the parkinsonian subthalamic nucleus region Open
Electrically evoked compound action potentials (ECAPs) generated in the subthalamic nucleus (STN) contain features that may be useful for titrating deep brain stimulation (DBS) therapy for Parkinson’s disease. Delivering a strong therapeut…
View article: Lateral cerebellothalamic tract activation underlies DBS therapy for Essential Tremor
Lateral cerebellothalamic tract activation underlies DBS therapy for Essential Tremor Open
This study provides a detailed understanding of the fiber pathways responsible for therapy and side effects of DBS for Essential Tremor, and suggests a model-based programming approach will enable more selective activation of lateral fiber…
View article: A Patient-Centered Perspective on Personality Change Following Deep Brain Stimulation
A Patient-Centered Perspective on Personality Change Following Deep Brain Stimulation Open
View article: European Academy of Neurology/Movement Disorder <scp>Society European</scp> Section's guidelines on pallidotomy for Parkinson's disease: let's remain accurate
European Academy of Neurology/Movement Disorder <span>Society European</span> Section's guidelines on pallidotomy for Parkinson's disease: let's remain accurate Open
View article: Spatiotemporal scaling changes in gait in a progressive model of Parkinson's disease
Spatiotemporal scaling changes in gait in a progressive model of Parkinson's disease Open
Objective Gait dysfunction is one of the most difficult motor signs to treat in patients with Parkinson's disease (PD). Understanding its pathophysiology and developing more effective therapies for parkinsonian gait dysfunction will requir…
View article: Parkinsonian daytime sleep-wake classification using deep brain stimulation lead recordings
Parkinsonian daytime sleep-wake classification using deep brain stimulation lead recordings Open
Excessive daytime sleepiness is a recognized non-motor symptom that adversely impacts the quality of life of people with Parkinson's disease (PD), yet effective treatment options remain limited. Deep brain stimulation (DBS) of the subthala…