Jerry Leung
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View article: Single-particle multi-parametric microscopy reveals structural, size, and payload heterogeneity in mRNA-loaded lipid nanoparticles
Single-particle multi-parametric microscopy reveals structural, size, and payload heterogeneity in mRNA-loaded lipid nanoparticles Open
Deciphering the heterogeneity of mRNA-containing lipid nanoparticles (LNPs) is essential for understanding the relationship between their microscopic properties and therapeutic function. Here, by combining alternating laser excitation (ALE…
View article: Liposomal lipid nanoparticles for extrahepatic delivery of mRNA
Liposomal lipid nanoparticles for extrahepatic delivery of mRNA Open
View article: RNA therapeutics to control fibrinolysis: review on applications in biology and medicine
RNA therapeutics to control fibrinolysis: review on applications in biology and medicine Open
View article: Exploring Mechanisms of Lipid Nanoparticle‐Mucus Interactions in Healthy and Cystic Fibrosis Conditions
Exploring Mechanisms of Lipid Nanoparticle‐Mucus Interactions in Healthy and Cystic Fibrosis Conditions Open
Mucus forms the first defense line of human lungs, and as such hampers the efficient delivery of therapeutics to the underlying epithelium. This holds particularly true for genetic cargo such as CRISPR‐based gene editing tools which cannot…
View article: Lipid nanoparticles and siRNA targeting plasminogen provide lasting inhibition of fibrinolysis in mouse and dog models of hemophilia A
Lipid nanoparticles and siRNA targeting plasminogen provide lasting inhibition of fibrinolysis in mouse and dog models of hemophilia A Open
Antifibrinolytic drugs are used extensively for on-demand treatment of severe acute bleeding. Controlling fibrinolysis may also be an effective strategy to prevent or lessen chronic recurring bleeding in bleeding disorders such as hemophil…
View article: Exploring Mechanisms of Lipid Nanoparticle-Mucus Interactions in Healthy and Cystic Fibrosis Conditions
Exploring Mechanisms of Lipid Nanoparticle-Mucus Interactions in Healthy and Cystic Fibrosis Conditions Open
Mucus forms the first defense line of human lungs, and as such hampers the efficient delivery of therapeutics to the underlying epithelium. This holds particularly true for genetic cargo such as CRISPR-based gene editing tools which cannot…
View article: Genetically engineered transfusable platelets using mRNA lipid nanoparticles
Genetically engineered transfusable platelets using mRNA lipid nanoparticles Open
Platelet transfusions are essential for managing bleeding and hemostatic dysfunction and could be expanded as a cell therapy due to the multifunctional role of platelets in various diseases. Creating these cell therapies will require modif…
View article: Lipid Nanoparticle-Mediated Hit-and-Run Approaches Yield Efficient and Safe <i>In Situ</i> Gene Editing in Human Skin
Lipid Nanoparticle-Mediated Hit-and-Run Approaches Yield Efficient and Safe <i>In Situ</i> Gene Editing in Human Skin Open
Despite exciting advances in gene editing, the efficient delivery of genetic tools to extrahepatic tissues remains challenging. This holds particularly true for the skin, which poses a highly restrictive delivery barrier. In this study, we…
View article: Elimination of fibrin polymer formation or crosslinking, but not fibrinogen deficiency, is protective against diet‐induced obesity and associated pathologies
Elimination of fibrin polymer formation or crosslinking, but not fibrinogen deficiency, is protective against diet‐induced obesity and associated pathologies Open
View article: Aortic intimal resident macrophages are essential for maintenance of the non-thrombogenic intravascular state
Aortic intimal resident macrophages are essential for maintenance of the non-thrombogenic intravascular state Open
View article: Suppression of fibrin(ogen)-driven pathologies in disease models through controlled knockdown by lipid nanoparticle delivery of siRNA
Suppression of fibrin(ogen)-driven pathologies in disease models through controlled knockdown by lipid nanoparticle delivery of siRNA Open
Fibrinogen plays a pathologic role in multiple diseases. It contributes to thrombosis and modifies inflammatory and immune responses, supported by studies in mice expressing fibrinogen variants with altered function or with a germline fibr…
View article: Hypofibrinogenemia with preserved hemostasis and protection from thrombosis in mice with an <i>Fga</i> truncation mutation
Hypofibrinogenemia with preserved hemostasis and protection from thrombosis in mice with an <i>Fga</i> truncation mutation Open
Genetic variants within the fibrinogen Aα chain encoding the αC-region commonly result in hypodysfibrinogenemia in patients. However, the (patho)physiological consequences and underlying mechanisms of such mutations remain undefined. Here,…
View article: Kernel Flux: a whole-head 432-magnetometer optically-pumped magnetoencephalography (OP-MEG) system for brain activity imaging during natural human experiences
Kernel Flux: a whole-head 432-magnetometer optically-pumped magnetoencephalography (OP-MEG) system for brain activity imaging during natural human experiences Open
MEG based on optically-pumped magnetometry (OP-MEG) operates with miniaturized, wearable insulation, in contrast to massive cryogenic dewars for SQUID-MEG, and allows placement of the sensors close to the scalp. This allows more natural he…
View article: Sustained depletion of FXIII-A by inducing acquired FXIII-B deficiency
Sustained depletion of FXIII-A by inducing acquired FXIII-B deficiency Open
The activated form of coagulation factor XIII (FXIII-A2B2), FXIII-A*, is a hemostatic enzyme essential for inhibiting fibrinolysis by irreversibly crosslinking fibrin and antifibrinolytic proteins. Despite its importance, there are no modu…
View article: Lipid nanoparticle technology for therapeutic gene regulation in the liver
Lipid nanoparticle technology for therapeutic gene regulation in the liver Open
Hereditary genetic disorders, cancer, and infectious diseases of the liver affect millions of people around the globe and are a major public health burden. Most contemporary treatments offer limited relief as they generally aim to alleviat…
View article: Fusion-dependent formation of lipid nanoparticles containing macromolecular payloads
Fusion-dependent formation of lipid nanoparticles containing macromolecular payloads Open
Neutralization of the pH (and ionizable lipid) drives the fusion of precursor vesicles into the electron-dense core structures attributed to lipid nanoparticles.