Jerry Saunders
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View article: Discovery of novel hybrid pyrrolidin-2-one derivatives exhibiting potent antiseizure and antinociceptive effects in preclinical models
Discovery of novel hybrid pyrrolidin-2-one derivatives exhibiting potent antiseizure and antinociceptive effects in preclinical models Open
In the present study, a series of novel derivatives based on the pyrrolidin-2-one scaffold were designed using a framework combination approach, synthesized, and comprehensively evaluated through in vitro and in vivo assays conducted on Sw…
View article: Atrial Mass in Pregnancy: A Rare Case of Intracardiac Ectopic Liver
Atrial Mass in Pregnancy: A Rare Case of Intracardiac Ectopic Liver Open
We report a case of a 41-year-old female who was found to have a 2.7-cm right atrial mass during the third trimester of her pregnancy. She underwent successful surgical resection 4 months after an uneventful delivery. Pathologic examinatio…
View article: Discovery and Profiling of New Multimodal Phenylglycinamide Derivatives as Potent Antiseizure and Antinociceptive Drug Candidates
Discovery and Profiling of New Multimodal Phenylglycinamide Derivatives as Potent Antiseizure and Antinociceptive Drug Candidates Open
We developed a focused series of original phenyl-glycinamide derivatives which showed potent activity across in vivo mouse seizure models, namely, maximal electroshock (MES) and 6 Hz (using both 32 and 44 mA current intensities) seizure mo…
View article: Long-acting PGE2 and Lisinopril Mitigate H-ARS
Long-acting PGE2 and Lisinopril Mitigate H-ARS Open
Thrombocytopenia is a major complication in hematopoietic-acute radiation syndrome (H-ARS) that increases the risk of mortality from uncontrolled hemorrhage. There is a great demand for new therapies to improve survival and mitigate bleedi…
View article: Lung megakaryocytes are immune modulatory cells
Lung megakaryocytes are immune modulatory cells Open
Although platelets are the cellular mediators of thrombosis, they are also immune cells. Platelets interact both directly and indirectly with immune cells, impacting their activation and differentiation, as well as all phases of the immune…
View article: Aged marrow macrophages expand platelet-biased hematopoietic stem cells via interleukin-1B
Aged marrow macrophages expand platelet-biased hematopoietic stem cells via interleukin-1B Open
The bone marrow microenvironment (BMME) contributes to the regulation of hematopoietic stem cell (HSC) function, though its role in age-associated lineage skewing is poorly understood. Here we show that dysfunction of aged marrow macrophag…