Jerry Y. Y. Heng
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View article: Transfer Learning Assessment of Data-driven Crystallisation Processes via Constrained Neural Ordinary Differential Equations
Transfer Learning Assessment of Data-driven Crystallisation Processes via Constrained Neural Ordinary Differential Equations Open
Modelling complex crystallisation processes remains challenging due to limited experimental datasets, high measurement noise, and the need for generalisability across varying operating conditions. Neural Ordinary Differential Equations (NO…
View article: Post-breakage Crystal Regeneration: Multiple Breakage Sites, Growth Kinetics, and Effects on Mass Production
Post-breakage Crystal Regeneration: Multiple Breakage Sites, Growth Kinetics, and Effects on Mass Production Open
View article: Environmental Impacts of Trichlorosilane: Process Optimization, Life Cycle Assessment, and the Importance of Processing History
Environmental Impacts of Trichlorosilane: Process Optimization, Life Cycle Assessment, and the Importance of Processing History Open
Trichlorosilane (TCS) is a platform chemical used in the manufacture of silicon metals, silicones, and functional silanes. Despite this, very little information is available on the environmental impact (EI) associated with its manufacture.…
View article: Model-based approach to template-induced macromolecule crystallisation
Model-based approach to template-induced macromolecule crystallisation Open
Biomacromolecules have intricate crystallisation behaviour due to their size and many interactions in solution and can often only crystallise in narrow ranges of experimental conditions. High solute concentrations are needed for crystal nu…
View article: Integrating sustainability into chemical engineering Education: Experiences from imperial college London
Integrating sustainability into chemical engineering Education: Experiences from imperial college London Open
With the sustainability transition actively underway in society, there is a strong impetus for higher education institutions to provide suitable learning opportunities for their students. Chemical engineers are especially well-positioned t…
View article: Surface Wrinkling of Plasma‐Exposed PDMS is Caused by Water Vapor Sorption: An Optical Environmental Sensor
Surface Wrinkling of Plasma‐Exposed PDMS is Caused by Water Vapor Sorption: An Optical Environmental Sensor Open
Wrinkling of polydimethylsiloxane (PDMS) has unlocked a plethora of technological applications, from tunable surface wetting to photonic response. Surface undulations with prescribed wavelength and amplitude are excited by in‐plane mechani…
View article: Integrated <i>In Vitro</i>/<i>In Silico</i> Uncertainty Quantification Method for Protein Crystallization Models
Integrated <i>In Vitro</i>/<i>In Silico</i> Uncertainty Quantification Method for Protein Crystallization Models Open
The complexity of protein crystallization and in silico modeling challenges process intensification and the wider adoption of crystallization in biomanufacturing. For computational models to support and replace extensive experiments…
View article: A Review of Dry Powder Coating: Techniques, Theory, and Applications
A Review of Dry Powder Coating: Techniques, Theory, and Applications Open
View article: The effect of solvents on crystal regeneration
The effect of solvents on crystal regeneration Open
Regeneration of paracetamol crystals following cleavage along the (010) plane was studied in ethanol, tetrahydrofuran, and acetone. All solvents facilitated crystal regeneration with rates influenced by crystal–solvent interactions and sol…
View article: Innovative Photothermal Membrane Distillation: Mitigating Temperature Polarisation with Rice Husk Biochar
Innovative Photothermal Membrane Distillation: Mitigating Temperature Polarisation with Rice Husk Biochar Open
View article: Photocatalytic Treatment of Final Discharge Palm Oil Mill Effluent (Pome) Using Dual-Layer Hollow Fiber Ceramic Membranes with Tio2-Embedded Mullite: Performance Evaluation and Mechanistic Insights
Photocatalytic Treatment of Final Discharge Palm Oil Mill Effluent (Pome) Using Dual-Layer Hollow Fiber Ceramic Membranes with Tio2-Embedded Mullite: Performance Evaluation and Mechanistic Insights Open
View article: Laboratory-Scale Simulation of Palm Oil Mill Final Effluent: Water Quality Analysis and Synthetic Wastewater Formulation
Laboratory-Scale Simulation of Palm Oil Mill Final Effluent: Water Quality Analysis and Synthetic Wastewater Formulation Open
View article: Facile orientation control of MOF-303 hollow fiber membranes by a dual-source seeding method
Facile orientation control of MOF-303 hollow fiber membranes by a dual-source seeding method Open
Metal‒organic frameworks (MOFs) are nanoporous crystalline materials with enormous potential for further development into a new class of high-performance membranes. However, the preparation of defect-free and water-stable MOF membranes wit…
View article: Predicting the Solubility of Amino Acids and Peptides with the SAFT-γ Mie Approach: Neutral and Charged Models
Predicting the Solubility of Amino Acids and Peptides with the SAFT-γ Mie Approach: Neutral and Charged Models Open
Modeling approaches that can be used to predict accurately the solubility of amino acids and peptides are of interest for the design of new pharmaceutical processes and in the development of new peptide-based therapeutics. We investigate t…
View article: Superhydrophobic cotton for addressing fatbergs through oily wastewater treatment
Superhydrophobic cotton for addressing fatbergs through oily wastewater treatment Open
Fats, oils and grease (FOGs) deposits in sewers have recently become a significant problem, causing financial strain on water companies, damaging sewer lines, and exposing the environment to dirty water through sanitary sewer overflows. De…
View article: High-alumina and low-lithium glass-ceramics modulated by heat treatment and its structural evolution mechanism
High-alumina and low-lithium glass-ceramics modulated by heat treatment and its structural evolution mechanism Open
View article: Process-Induced Crystal Surface Anisotropy and the Impact on the Powder Properties of Odanacatib
Process-Induced Crystal Surface Anisotropy and the Impact on the Powder Properties of Odanacatib Open
Crystalline active pharmaceutical ingredients with comparable size and surface area can demonstrate surface anisotropy induced during crystallization or downstream unit operations such as milling. To the extent that varying surface propert…
View article: Uncovering Cocrystal Formation and Competition Mechanism of Polyhydroxy Natural Products: Cases of Quercetin, Hesperidin, Resveratrol, and Curcumin
Uncovering Cocrystal Formation and Competition Mechanism of Polyhydroxy Natural Products: Cases of Quercetin, Hesperidin, Resveratrol, and Curcumin Open
Understanding drug cocrystal formation and its competitive mechanism is important for improving the physicochemical properties of drugs. In this article, the cocrystal formation of polyhydroxy natural products and their competitive mechani…
View article: Uncovering crystal growth and regeneration mechanism to control crystal morphology: The case study of aceclofenac
Uncovering crystal growth and regeneration mechanism to control crystal morphology: The case study of aceclofenac Open
View article: Sequence-dependent dipeptide solubility in ethanol-water and DMSO-water solutions
Sequence-dependent dipeptide solubility in ethanol-water and DMSO-water solutions Open
Reliable solubility data is crucial for controlling and optimising crystallisation conditions, to provide a cost-effective purification method with the potential for scaling up. This study investigated the effect of amino acid sequence on …
View article: A scoping review of professional skills development in engineering education from 1980–2020
A scoping review of professional skills development in engineering education from 1980–2020 Open
Engineering students are expected to develop their professional skills throughout the course of their degrees. Yet, there is no clear consensus among educators of which skills are being developed or how this is done effectively. This scopi…
View article: Simple one-pot fabrication of durable superhydrophobic cotton wool using octadecyltrimethoxysilane modified silica-sol for oil-water separation
Simple one-pot fabrication of durable superhydrophobic cotton wool using octadecyltrimethoxysilane modified silica-sol for oil-water separation Open
A fluorine-free superhydrophobic cotton is successfully fabricated using a simple and cost-effective one-pot synthesis method, employing octadecyltrimethoxysilane (ODTMS) as a modifying silane in a silica-sol. Unlike conventional technique…
View article: A regime map for dry powder coating: the influence of material properties and process parameters
A regime map for dry powder coating: the influence of material properties and process parameters Open
A numerical study is carried out to investigate the combined influence of material properties and process parameters on coating quality in a high shear mixer (specifically an FT4 Powder Rheometer) to construct a regime map. The Discrete El…
View article: The role of mixing and surface hydrophobicity on the operation of a continuous tubular slug flow crystalliser for lysozyme
The role of mixing and surface hydrophobicity on the operation of a continuous tubular slug flow crystalliser for lysozyme Open
View article: CCDC 2039235: Experimental Crystal Structure Determination
CCDC 2039235: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2039234: Experimental Crystal Structure Determination
CCDC 2039234: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2039237: Experimental Crystal Structure Determination
CCDC 2039237: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Development of Nanopackaging for Storage and Transport of Loaded Lipid Nanoparticles
Development of Nanopackaging for Storage and Transport of Loaded Lipid Nanoparticles Open
Easily deploying new vaccines globally to combat disease outbreaks has been highlighted as a major necessity by the World Health Organization. RNA-based vaccines using lipid nanoparticles (LNPs) as a drug delivery system were employed to g…
View article: Experimental Elucidation of Templated Crystallization and Secondary Processing of Peptides
Experimental Elucidation of Templated Crystallization and Secondary Processing of Peptides Open
The crystallization of peptides offers a sustainable and inexpensive alternative to the purification process. In this study, diglycine was crystallised in porous silica, showing the porous templates’ positive yet discriminating effect. The…
View article: A numerical analysis of the influence of material properties on dry powder coating performance
A numerical analysis of the influence of material properties on dry powder coating performance Open
Dry powder coating is a preferable surface modification technique over the traditional aqueous coating technique due to reduced energy waste and less environmental impact. Despite the benefits of dry powder coating, excessive amount of coa…