Yu Zhou
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Parameter-Determined Effects: Advances in Transcranial Focused Ultrasound for Modulating Neural Excitation and Inhibition Open
Transcranial focused ultrasound stimulation (tFUS), an emerging non-invasive neuromodulation technique, has garnered growing attention owing to its high spatial resolution and precise targeting capability for deep brain structures. A body …
View article: Adjuvanted Recombinant Hemagglutinin Vaccine Provides Durable and Broad-Spectrum Immunogenicity in Mice
Adjuvanted Recombinant Hemagglutinin Vaccine Provides Durable and Broad-Spectrum Immunogenicity in Mice Open
Background: Seasonal influenza vaccines must be reformulated annually due to the high genetic variability and antigenic drift of circulating influenza viruses. The annual update, guided by World Health Organization (WHO) recommendations, r…
View article: Modular Design of Hydrogel Adhesives for Enhanced Tissue Healing
Modular Design of Hydrogel Adhesives for Enhanced Tissue Healing Open
Hydrogel adhesives exhibit significant potential in various biomedical fields such as wound hemostasis and healing. However, there is a lack of general strategies for preparing hydrogel adhesives that can be adapted to a variety of complex…
Prolyl-tRNA synthetase inhibition disrupts oncogenic translation in T-cell acute lymphoblastic leukemia Open
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive blood cancer marked by the abnormal growth of immature thymocytes. 5-year survival rate in T-ALL is about 85% in children and less than 50% in adults. Relapsed/refractory T-ALL r…
Beyond Correctness: Harmonizing Process and Outcome Rewards through RL Training Open
Reinforcement learning with verifiable rewards (RLVR) has emerged to be a predominant paradigm for mathematical reasoning tasks, offering stable improvements in reasoning ability. However, Outcome Reward Models (ORMs) in RLVR are too coars…
A cross-sectional study of factors influencing sexual health among spouses of patients with cervical cancer Open
Background After treatment, cervical cancer patients commonly experience sexual health problems that lead to marital conflict. However, the sexual health cognition, distress and needs of patients’ spouses remain unclear. This study examine…
Biocatalytic 3D binary crystals formed through the self-assembly of enzyme-embedded ferritin Open
Enzyme-embedded protein cage crystals are formed via electrostatic co-crystallization, enabling reusable biocatalytic assemblies with spatial control.
View article: Protein Cage Directed Assembly of Binary Nanoparticle Superlattices
Protein Cage Directed Assembly of Binary Nanoparticle Superlattices Open
Inorganic nanoparticles can be assembled into superlattices with unique optical and magnetic properties arising from collective behavior. Protein cages can be utilized to guide this assembly by encapsulating nanoparticles and promoting the…
View article: Ultrasonic Control of Protein Splicing by Split Inteins
Ultrasonic Control of Protein Splicing by Split Inteins Open
Utilizing ultrasound as an external stimulus to remotely modulate the activity of proteins is an important aspect of sonopharmacology and establishes the basis for the emerging field of sonogenetics. Here, we describe an ultrasound-respons…
A nanoparticle vaccine displaying varicella-zoster virus gE antigen induces a superior cellular immune response than a licensed vaccine in mice and non-human primates Open
Herpes zoster (HZ), also known as shingles, remains a significant global health issue and most commonly seen in elderly individuals with an early exposure history to varicella-zoster virus (VZV). Currently, the licensed vaccine Shingrix, w…
View article: Promotion effect suggested by hexadecanoic acid on the oxidative tolerance of S. cerevisiae during its co-culture with E. coli
Promotion effect suggested by hexadecanoic acid on the oxidative tolerance of S. cerevisiae during its co-culture with E. coli Open
Co-fermentation performed by Saccharomyces cerevisiae and Escherichia coli or other microbes has been widely used in industrial fermentation. Meanwhile, the co-cultured microbes might regulate each other’s metabolisms or cell behaviors inc…
Optimization of Fermentation Process of Wheat Germ Protein by Aspergillus niger and Analysis of Antioxidant Activity of Peptide Open
Utilizing wheat embryos as the raw material and employing Aspergillus niger as the fermentation strain, wheat embryo polypeptides were produced through microbial liquid fermentation. The protein concentration post-fermentation served as th…
Preclinical Development of a Stabilized RH5 Virus-Like Particle Vaccine that Induces Improved Anti-Malarial Antibodies Open
The development of a highly effective vaccine against the pathogenic blood-stage infection of human malaria will require a delivery platform that can induce an antibody response of both maximal quantity and functional quality. One strategy…
View article: Research and Practice of STEM-based Vocational Ability Cultivation System for Higher Vocational Students
Research and Practice of STEM-based Vocational Ability Cultivation System for Higher Vocational Students Open
Students' mastery of STEM at the stage of higher vocational study will help them to engage in engineering and technology-related careers after graduation, because science and math are the foundation of engineering and technology. Through t…
DNASE1L3-mediated PANoptosis enhances the efficacy of combination therapy for advanced hepatocellular carcinoma Open
Rationale: The introduction of combination therapy utilizing tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors for advanced hepatocellular carcinoma (HCC) has significantly altered the management of affected patients. Howe…
GPAT3 is a potential therapeutic target to overcome sorafenib resistance in hepatocellular carcinoma Open
Background: Sorafenib is the standard treatment for advanced hepatocellular carcinoma (HCC), but acquired resistance during the treatment greatly limits its clinical efficiency. Lipid metabolic disorder plays an important role in hepatocar…
In vivo polynucleotide mechanochemistry to steer cellular function Open
Original data underpinning Figures, Schemes, Videos, and Tables of the manuscript and supplementary information.
Optimized methyl donor and reduced precursor degradation pathway for seleno-methylselenocysteine production in Bacillus subtilis Open
Background Seleno-methylselenocysteine (SeMCys) is an effective component of selenium supplementation with anti-carcinogenic potential that can ameliorate neuropathology and cognitive deficits. In a previous study, a SeMCys producing strai…