Jerzy Krupiński
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View article: Aquaporin-4 polymorphisms modify the penetrance of Parkinson’s disease in <i>leucine-rich repeat kinase 2</i> carriers
Aquaporin-4 polymorphisms modify the penetrance of Parkinson’s disease in <i>leucine-rich repeat kinase 2</i> carriers Open
Background Pathogenic mutations in the leucine-rich repeat kinase-2 ( LRRK2 ) gene are the most common cause of familial Parkinson’s disease (PD). LRRK2 shows incomplete penetrance, yet the biological factors influencing disease expression…
View article: A Pilot Study: The Effect of CPAP Intervention on Sleep Architecture and Cognition in Alzheimer’s Disease Patients with Obstructive Sleep Apnea
A Pilot Study: The Effect of CPAP Intervention on Sleep Architecture and Cognition in Alzheimer’s Disease Patients with Obstructive Sleep Apnea Open
Background: Obstructive sleep apnea (OSA) is highly prevalent in the early stages of Alzheimer’s disease (AD), and its hallmark, sleep fragmentation, may accelerate cognitive decline. Continuous positive airway pressure (CPAP) improves OSA…
View article: Abnormal sleep blood pressure patterns are associated with the diffusion tensor imaging along the perivascular space index in cognitively impaired individuals
Abnormal sleep blood pressure patterns are associated with the diffusion tensor imaging along the perivascular space index in cognitively impaired individuals Open
Introduction Blood pressure (BP) physiologically dips during sleep, and a lack of dipping is associated with adverse health outcomes and cognitive decline. Vascular pulsatility is the primary driver of glymphatic cerebrospinal fluid (CSF) …
View article: Sleep and Risk of Multiple Sclerosis: Bridging the Gap Between Inflammation and Neurodegeneration via Glymphatic Failure
Sleep and Risk of Multiple Sclerosis: Bridging the Gap Between Inflammation and Neurodegeneration via Glymphatic Failure Open
Epidemiological studies identified insufficient and poor-quality sleep as independent risk factors for multiple sclerosis (MS). The glymphatic system, active during slow-wave sleep, clears brain waste through perivascular astrocytic aquapo…
View article: The Effect of CPAP Intervention on Sleep Architecture and Cognition in Alzheimer’s Disease Patients with Obstructive Sleep Apnea
The Effect of CPAP Intervention on Sleep Architecture and Cognition in Alzheimer’s Disease Patients with Obstructive Sleep Apnea Open
Background Obstructive sleep apnea (OSA) is highly prevalent in the early stages of Alzheimer’s disease (AD), and its hallmark, sleep fragmentation, may accelerate cognitive decline. Continuous positive airway pressure (CPAP) improves OSA-…
View article: The Effect of CPAP Intervention on Sleep Architecture and Cognition in Alzheimer’s Disease Patients with Obstructive Sleep Apnea
The Effect of CPAP Intervention on Sleep Architecture and Cognition in Alzheimer’s Disease Patients with Obstructive Sleep Apnea Open
Background Obstructive sleep apnea (OSA) is highly prevalent in the early stages of Alzheimer’s disease (AD), and its hallmark, sleep fragmentation, may accelerate cognitive decline. Continuous positive airway pressure (CPAP) improves OSA-…
View article: The Inflammatory Nexus: Unraveling Shared Pathways and Promising Treatments in Alzheimer’s Disease and Schizophrenia
The Inflammatory Nexus: Unraveling Shared Pathways and Promising Treatments in Alzheimer’s Disease and Schizophrenia Open
Alzheimer’s disease (AD) and schizophrenia are traditionally considered distinct clinical entities, yet growing evidence highlights substantial overlap in their molecular and neuroinflammatory pathogenesis. This review explores current ins…
View article: Corrigendum to “What drives task performance in fluency tasks in people who had COVID-19?” [Language and Health 2 (2024) 100031]
Corrigendum to “What drives task performance in fluency tasks in people who had COVID-19?” [Language and Health 2 (2024) 100031] Open
The authors regret the oversight and would like to correct the institution and author's deanonymization. Specifically, in Section 2 (Current study), we would like add “Hospital Universitari MútuaTerrassa” after “…and were assessed at the…”…
View article: Abnormal sleep blood pressure patterns are associated with diffusion tensor imaging along perivascular spaces index in cognitively impaired individuals
Abnormal sleep blood pressure patterns are associated with diffusion tensor imaging along perivascular spaces index in cognitively impaired individuals Open
Blood pressure (BP) physiologically dips during sleep, and lack of dipping associates with adverse health outcomes and cognitive decline. Vascular pulsatility is the main driver of glymphatic cerebrospinal fluid transport, which removes me…
View article: Glymphatic system clearance and Alzheimer’s disease risk: a CSF proteome-wide study
Glymphatic system clearance and Alzheimer’s disease risk: a CSF proteome-wide study Open
Background The emerging evidence of the role of the glymphatic system (GS) in Alzheimer’s disease (AD) provides new opportunities for intervention from the earliest stages of the disease. The aim of the study is to evaluate the efficacy of…
View article: What drives task performance in fluency tasks in people who had COVID-19?
What drives task performance in fluency tasks in people who had COVID-19? Open
BackgroundSome people who had COVID-19 have been shown to perform below a normative sample on fluency tasks. Unveiling the factors driving performance in this population can explain their underlying impairments. In this article we assess (…
View article: The Immune System’s Role in Glymphatic System Clearance and Alzheimer’s Disease Risk: A Csf Proteome-wide Study
The Immune System’s Role in Glymphatic System Clearance and Alzheimer’s Disease Risk: A Csf Proteome-wide Study Open
Background: The emerging evidence of the role of the glymphatic system (GS) in Alzheimer’s disease (AD) provides new opportunities for intervention from the earliest stages of the disease. The aim of the study is to evaluate the efficacy o…
View article: Glymphatic system health in early Alzheimer’s disease and its relationship to sleep, cognition and CSF biomarkers
Glymphatic system health in early Alzheimer’s disease and its relationship to sleep, cognition and CSF biomarkers Open
BACKGROUND The glymphatic system is thought to facilitate waste clearance from the brain during sleep. Impairment in this system may underpin the elevated deposition of pathological proteins in neurodegenerative conditions like Alzheimer’s…
View article: Sex-Stratified Genome-Wide Association Study in the Spanish Population Identifies a Novel Locus for Lacunar Stroke
Sex-Stratified Genome-Wide Association Study in the Spanish Population Identifies a Novel Locus for Lacunar Stroke Open
BACKGROUND: Ischemic stroke (IS) represents a significant health burden globally, necessitating a better understanding of its genetic underpinnings to improve prevention and treatment strategies. Despite advances in IS genetics, studies fo…
View article: Long Neurocognitive and Neuropsychiatric Sequelae in Participants with Post-COVID-19 Infection: A Longitudinal Study
Long Neurocognitive and Neuropsychiatric Sequelae in Participants with Post-COVID-19 Infection: A Longitudinal Study Open
Objective: To evaluate and characterize the cognitive changes in COVID-19 participants at 6-month follow-up, and to explore a possible association with clinical symptoms, emotional disturbance and disease severity. Methods: This single-cen…
View article: Neurocognitive and Neuropsychiatric Sequelae in Long COVID-19 Infection
Neurocognitive and Neuropsychiatric Sequelae in Long COVID-19 Infection Open
Objective: To characterize the cognitive profile of long COVID-19 subjects and its possible association with clinical symptoms, emotional disturbance, biomarkers, and disease severity. Methods: We performed a single-center cross-sectional …
View article: Diffusion tensor imaging analysis along the perivascular space in the UK biobank
Diffusion tensor imaging analysis along the perivascular space in the UK biobank Open
We propose that the metric, calculated for the first time in a large-scale, population-based cohort, is a stable measure, but one for which stronger links to glymphatic system function are needed before it can be used to understand the rel…
View article: Impairments in sleep and brain molecular clearance in people with cognitive deterioration and biological evidence of AD: a report of four cases
Impairments in sleep and brain molecular clearance in people with cognitive deterioration and biological evidence of AD: a report of four cases Open
Background Recent evidence suggests that the failure of the glymphatic system – the brain’s waste clearance system, which is active during sleep – plays a key role in the pathophysiology of Alzheimer’s Disease (AD). Glymphatic function can…
View article: Randomized Phase II Study of the Safety and Efficacy of Semorinemab in Participants With Mild-to-Moderate Alzheimer Disease: Lauriet
Randomized Phase II Study of the Safety and Efficacy of Semorinemab in Participants With Mild-to-Moderate Alzheimer Disease: Lauriet Open
The Lauriet study is registered on ClinicalTrials.gov, NCT03828747, and EudraCT 2018-003398-87.
View article: Altered sleep and neurovascular dysfunction in alpha-synucleinopathies: the perfect storm for glymphatic failure
Altered sleep and neurovascular dysfunction in alpha-synucleinopathies: the perfect storm for glymphatic failure Open
Clinical and cognitive progression in alpha-synucleinopathies is highly heterogeneous. While some patients remain stable over long periods of time, other suffer early dementia or fast motor deterioration. Sleep disturbances and nocturnal b…
View article: Effect of Bypassing the Closest Stroke Center in Patients with Intracerebral Hemorrhage
Effect of Bypassing the Closest Stroke Center in Patients with Intracerebral Hemorrhage Open
Importance Prehospital transfer protocols are based on rapid access to reperfusion therapies for patients with ischemic stroke. The effect of different protocols among patients receiving a final diagnosis of intracerebral hemorrhage (ICH) …
View article: Citicoline May Prevent Cognitive Decline in Patients with Cerebrovascular Disease
Citicoline May Prevent Cognitive Decline in Patients with Cerebrovascular Disease Open
SCC subjects showed an improvement in language and attention domains, while those with MCI performed better after 12 months in total scores of MoCA and RBANS domains, some converting back to SCC. This supports the idea that citicoline may …
View article: Impairments in sleep and brain molecular clearance in people with cognitive deterioration and biological evidence of AD: A report of four cases
Impairments in sleep and brain molecular clearance in people with cognitive deterioration and biological evidence of AD: A report of four cases Open
Background: Recent evidence suggests that the failure of the glymphatic system – the brain’s waste clearance system, which is active during sleep – plays a key role in the pathophysiology of Alzheimer’s Disease (AD). Glymphatic function ca…
View article: Sex and gender differences in acute stroke care: metrics, access to treatment and outcome. A territorial analysis of the Stroke Code System of Catalonia
Sex and gender differences in acute stroke care: metrics, access to treatment and outcome. A territorial analysis of the Stroke Code System of Catalonia Open
Introduction: Previous studies have reported differences in the management and outcome of women stroke patients in comparison with men. We aim to analyze sex and gender differences in the medical assistance, access to treatment and outcome…
View article: Association of Time of Day With Outcomes Among Patients Triaged for a Suspected Severe Stroke in Nonurban Catalonia
Association of Time of Day With Outcomes Among Patients Triaged for a Suspected Severe Stroke in Nonurban Catalonia Open
Background: We aim to assess whether time of day modified the treatment effect in the RACECAT trial (Direct Transfer to an Endovascular Center Compared to Transfer to the Closest Stroke Center in Acute Stroke Patients With Suspected Large …
View article: Impact of COVID‐19 infection on cognition and its association with neurological symptoms
Impact of COVID‐19 infection on cognition and its association with neurological symptoms Open
Objective : To characterize the cognitive profile following COVID‐19 infection and its possible association to clinical symptoms, emotional disturbance, biomarkers, and disease severity. Methods : This was a single‐center cross‐sectional c…
View article: Workflow Times and Outcomes in Patients Triaged for a Suspected Severe Stroke
Workflow Times and Outcomes in Patients Triaged for a Suspected Severe Stroke Open
Introduction Current recommendations for regional stroke destination suggest that patients with severe acute stroke in non‐urban areas should be triaged based on the estimated transport time to a referral thrombectomy‐capable center. Metho…