Jeslin J. L. Tan
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View article: TREM-1 activation is a potential key regulator in driving severe pathogenesis of enterovirus A71 infection
TREM-1 activation is a potential key regulator in driving severe pathogenesis of enterovirus A71 infection Open
Hand, foot and mouth disease (HFMD), caused by enterovirus A71 (EV-A71), presents mild to severe disease, and sometimes fatal neurological and respiratory manifestations. However, reasons for the severe pathogenesis remain undefined. To in…
View article: Novel differential linear B‐cell epitopes to identify Zika and dengue virus infections in patients
Novel differential linear B‐cell epitopes to identify Zika and dengue virus infections in patients Open
[This corrects the article DOI: 10.1002/cti2.1066.].
View article: TREM-1 activation is a key regulator in driving severe pathogenesis of enterovirus 71 infection
TREM-1 activation is a key regulator in driving severe pathogenesis of enterovirus 71 infection Open
Hand, foot and mouth disease (HFMD), caused by enterovirus 71 (EV71), presents mild to severe disease, and sometimes fatal neurological and respiratory manifestations. However, reasons for the severe pathogenesis remain undefined. To inves…
View article: Novel differential linear B-cell epitopes to identify Zika and dengue virus infections in patients
Novel differential linear B-cell epitopes to identify Zika and dengue virus infections in patients Open
Background Recent Zika virus (ZIKV) outbreaks challenged existing laboratory diagnostic standards, especially for serology-based methods. Due to the genetic and structural similarity of ZIKV with other flaviviruses, this results in cross-r…
View article: Mutating chikungunya virus non‐structural protein produces potent live‐attenuated vaccine candidate
Mutating chikungunya virus non‐structural protein produces potent live‐attenuated vaccine candidate Open
Currently, there are no commercially available live-attenuated vaccines against chikungunya virus (CHIKV). Here, CHIKVs with mutations in non-structural proteins (nsPs) were investigated for their suitability as attenuated CHIKV vaccines. …
View article: <i>Viperin</i> controls chikungunya virus–specific pathogenic T cell IFNγ Th1 stimulation in mice
<i>Viperin</i> controls chikungunya virus–specific pathogenic T cell IFNγ Th1 stimulation in mice Open
Chikungunya virus (CHIKV) has been a worldwide threat since its reemergence in La Reunion Island in 2004. Expression of the interferon-stimulated protein Viperin correlates with viral load burden in patients, and studies in mice have demon…
View article: Immunological observations and transcriptomic analysis of trimester-specific full-term placentas from three Zika virus-infected women.
Immunological observations and transcriptomic analysis of trimester-specific full-term placentas from three Zika virus-infected women. Open
OBJECTIVES: Effects of Zika virus (ZIKV) infection on placental development during pregnancy are unclear. METHODS: Full-term placentas from three women, each infected with ZIKV during specific pregnancy trimesters, were harvested for anato…
View article: Novel differential linear B‐cell epitopes to identify Zika and dengue virus infections in patients
Novel differential linear B‐cell epitopes to identify Zika and dengue virus infections in patients Open
Objectives Recent Zika virus ( ZIKV ) outbreaks challenged existing laboratory diagnostic standards, especially for serology‐based methods. Because of the genetic and structural similarity of ZIKV with other flaviviruses, this results in c…
View article: Immunological observations and transcriptomic analysis of trimester‐specific full‐term placentas from three Zika virus‐infected women
Immunological observations and transcriptomic analysis of trimester‐specific full‐term placentas from three Zika virus‐infected women Open
Objectives Effects of Zika virus (ZIKV) infection on placental development during pregnancy are unclear. Methods Full‐term placentas from three women, each infected with ZIKV during specific pregnancy trimesters, were harvested for anatomi…
View article: Plasmodium co-infection protects against chikungunya virus-induced pathologies
Plasmodium co-infection protects against chikungunya virus-induced pathologies Open
Co-infection with Plasmodium and chikungunya virus (CHIKV) has been reported in humans, but the impact of co-infection on pathogenesis remains unclear. Here, we show that prior exposure to Plasmodium suppresses CHIKV-associated pathologies…
View article: Longitudinal Study of Cellular and Systemic Cytokine Signatures to Define the Dynamics of a Balanced Immune Environment During Disease Manifestation in Zika Virus–Infected Patients
Longitudinal Study of Cellular and Systemic Cytokine Signatures to Define the Dynamics of a Balanced Immune Environment During Disease Manifestation in Zika Virus–Infected Patients Open
This is the first comprehensive study that highlights specific cellular changes and immune signatures during ZIKV disease progression, and it provides valuable insights into ZIKV immunopathogenesis.
View article: Zika Virus Infection Preferentially Counterbalances Human Peripheral Monocyte and/or NK Cell Activity
Zika Virus Infection Preferentially Counterbalances Human Peripheral Monocyte and/or NK Cell Activity Open
ZIKV reemerged in recent years, causing outbreaks in many parts of the world. Alarmingly, ZIKV infection has been associated with neurological complications such as Guillain-Barré syndrome (GBS) in adults and congenital fetal growth-associ…
View article: Zika virus infection preferentially counterbalances human peripheral monocyte and/or NK-cell activity
Zika virus infection preferentially counterbalances human peripheral monocyte and/or NK-cell activity Open
Zika virus (ZIKV) has re-emerged in the population and caused unprecedented global outbreaks. Here, the transcriptomic consequences of ZIKV infection were studied systematically firstly in human peripheral blood CD14 + monocytes and monocy…
View article: Specific Biomarkers Associated With Neurological Complications and Congenital Central Nervous System Abnormalities From Zika Virus–Infected Patients in Brazil
Specific Biomarkers Associated With Neurological Complications and Congenital Central Nervous System Abnormalities From Zika Virus–Infected Patients in Brazil Open
This study identified several key markers for the control of ZIKV pathogenesis. This will allow a better understanding of the molecular mechanisms of ZIKV infection in patients.
View article: Zika Virus Infects Human Fetal Brain Microglia and Induces Inflammation
Zika Virus Infects Human Fetal Brain Microglia and Induces Inflammation Open
Our results highlight an important role for microglia and neuroinflammation during congenital ZIKV pathogenesis.
View article: Severity of Plasma Leakage Is Associated With High Levels of Interferon γ–Inducible Protein 10, Hepatocyte Growth Factor, Matrix Metalloproteinase 2 (MMP-2), and MMP-9 During Dengue Virus Infection
Severity of Plasma Leakage Is Associated With High Levels of Interferon γ–Inducible Protein 10, Hepatocyte Growth Factor, Matrix Metalloproteinase 2 (MMP-2), and MMP-9 During Dengue Virus Infection Open
This study identified several key markers for exacerbated dengue pathogenesis, notably plasma leakage. This will allow a better understanding of the molecular mechanisms of DHF and DSS in patients with dengue.