Jesper Hjortnaes
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View article: Ratio of regurgitant fraction to aortic valve area for risk stratification of patients with mixed aortic valvular disease
Ratio of regurgitant fraction to aortic valve area for risk stratification of patients with mixed aortic valvular disease Open
Background In patients with mixed aortic valve disease (MAVD), defined as the combination of aortic stenosis (AS) and aortic regurgitation (AR), the assessment of the severity of each valve lesion is challenging, as most of the echocardiog…
View article: Cut from the same cloth? investigating the personality of interventional and surgical cardiovascular specialists
Cut from the same cloth? investigating the personality of interventional and surgical cardiovascular specialists Open
View article: ENDOCOR: a nationwide consortium of endocarditis teams—initiating a registry for infective endocarditis within the Netherlands Heart Registration
ENDOCOR: a nationwide consortium of endocarditis teams—initiating a registry for infective endocarditis within the Netherlands Heart Registration Open
View article: Sex difference in aortic root replacement with a stentless bioprosthesis
Sex difference in aortic root replacement with a stentless bioprosthesis Open
OBJECTIVES To investigate and quantify differences in survival and reinterventions between sexes after aortic root replacement with a stentless bioprosthesis, stratified for preoperative valve lesion. METHODS Elective adults undergoing aor…
View article: Massive expansion and cryopreservation of functional human induced pluripotent stem cell-derived cardiomyocytes
Massive expansion and cryopreservation of functional human induced pluripotent stem cell-derived cardiomyocytes Open
View article: Survival outcomes after surgery for type-a aortic dissection: a contemporary Dutch nationwide registry study
Survival outcomes after surgery for type-a aortic dissection: a contemporary Dutch nationwide registry study Open
OBJECTIVES To describe the nationwide survival outcomes after surgery for type-A dissection (TAAD). METHODS All patients who underwent surgery for TAAD in the Netherlands between 2018 and 2021 were identified in the Netherlands Heart Regis…
View article: Intraoperative assessment of myocardial perfusion using near-infrared fluorescence and indocyanine green: A literature review
Intraoperative assessment of myocardial perfusion using near-infrared fluorescence and indocyanine green: A literature review Open
This literature review highlights that NIRF imaging has been broadly researched qualitatively, showing promise for guiding CABG surgery through visualization of graft flow. However, the critical step of incorporating quantification to accu…
View article: Glycogen synthase kinase-3 inhibition and insulin enhance proliferation and inhibit maturation of human iPSC-derived cardiomyocytes via TCF and FOXO signaling
Glycogen synthase kinase-3 inhibition and insulin enhance proliferation and inhibit maturation of human iPSC-derived cardiomyocytes via TCF and FOXO signaling Open
Embryonic signaling pathways exert stage-specific effects during cardiac development, yet the precise signals for proliferation or maturation remain elusive. To uncover the cues for proliferation, we performed a combinatory cell-cycle scre…
View article: Total aortic arch replacement versus proximal aortic repair for acute type a aortic dissection: A single-center 30-year experience
Total aortic arch replacement versus proximal aortic repair for acute type a aortic dissection: A single-center 30-year experience Open
In-hospital mortality after acute type A aortic dissection decreased over time despite the implementation of an aggressive approach to the dissected aortic arch. Long-term survival appears favorable after total arch replacement, but remain…
View article: Cryopreservation of Human Adult Ventricular Tissue for the Preparation of Viable Myocardial Slices
Cryopreservation of Human Adult Ventricular Tissue for the Preparation of Viable Myocardial Slices Open
Living myocardial slices (LMS) are ultrathin sections of adult myocardium that can be maintained in culture. These slices provide a unique platform for studying interactions between cardiomyocytes (CMs), other cardiac cell types, and the e…
View article: miR-24-3p secreted as extracellular vesicle cargo by cardiomyocytes inhibits fibrosis in human cardiac microtissues
miR-24-3p secreted as extracellular vesicle cargo by cardiomyocytes inhibits fibrosis in human cardiac microtissues Open
Aims Cardiac fibrosis in response to injury leads to myocardial stiffness and heart failure. At the cellular level, fibrosis is triggered by the conversion of cardiac fibroblasts (CF) into extracellular matrix-producing myofibroblasts. miR…
View article: Involving the next generation of cardiovascular surgeons
Involving the next generation of cardiovascular surgeons Open
View article: Cryopreservation of human adult ventricular tissue for the preparation of viable myocardial slices
Cryopreservation of human adult ventricular tissue for the preparation of viable myocardial slices Open
Funding Acknowledgements Type of funding sources: Public grant(s) – EU funding. Main funding source(s): REGeRNA Myocardial slices are ultra-thin slices of living adult myocardium which can be cultured. As a multicellular 3-D culture model,…
View article: Novel ex-vivo calcification model for human aortic valves reveals patient-specific effect of compound
Novel ex-vivo calcification model for human aortic valves reveals patient-specific effect of compound Open
Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Dekker grant Background Aortic stenosis (AS) is a narrowing of the aortic valve opening due to calcification and valve thicke…
View article: Intracellular proteomics and extracellular vesiculomics as a metric of disease recapitulation in 3D-bioprinted aortic valve arrays
Intracellular proteomics and extracellular vesiculomics as a metric of disease recapitulation in 3D-bioprinted aortic valve arrays Open
In calcific aortic valve disease (CAVD), mechanosensitive valvular cells respond to fibrosis- and calcification-induced tissue stiffening, further driving pathophysiology. No pharmacotherapeutics are available to treat CAVD because of the …
View article: Introducing a novel ex-vivo calcification model for human aortic valves
Introducing a novel ex-vivo calcification model for human aortic valves Open
Background Aortic stenosis (AS) is a narrowing of the aortic valve opening due to calcification and thickening of the leaflets. There are currently no effective pharmacological treatments for AS, and surgery or percutaneous interventions a…
View article: Light transmittance in human atrial tissue and transthoracic illumination in rats support translatability of optogenetic cardioversion of AF
Light transmittance in human atrial tissue and transthoracic illumination in rats support translatability of optogenetic cardioversion of AF Open
Background Optogenetics could offer a solution to the current lack of an ambulatory method for rapid automated cardioversion of AF, but key translational aspects remain to be studied. Objective To investigate whether optogenetic cardiovers…
View article: Aortic valve visualization and pressurization device: a novel device for intraoperative evaluation of aortic valve repair procedures
Aortic valve visualization and pressurization device: a novel device for intraoperative evaluation of aortic valve repair procedures Open
OBJECTIVES Aortic valve repair procedures are technically challenging, and current intraoperative evaluation methods often fail to predict the final echocardiographic result. We have developed a novel intraoperative aortic valve visualizat…
View article: Single-cell analysis of human fetal epicardium reveals its cellular composition and identifies CRIP1 as a modulator of EMT
Single-cell analysis of human fetal epicardium reveals its cellular composition and identifies CRIP1 as a modulator of EMT Open
The epicardium plays an essential role in cardiogenesis by providing cardiac cell types and paracrine cues to the developing myocardium. The human adult epicardium is quiescent, but recapitulation of developmental features may contribute t…
View article: Cyclic strain has antifibrotic effects on the human cardiac fibroblast transcriptome in a human cardiac fibrosis-on-a-chip platform
Cyclic strain has antifibrotic effects on the human cardiac fibroblast transcriptome in a human cardiac fibrosis-on-a-chip platform Open
In cardiac fibrosis, in response to stress or injury, cardiac fibroblasts deposit excessive amounts of collagens which contribute to the development of heart failure. The biochemical stimuli in this process have been extensively studied, b…
View article: Intracellular Proteomics and Extracellular Vesiculomics as a Metric of Disease Recapitulation in 3D Bioprinted Aortic Valve Arrays
Intracellular Proteomics and Extracellular Vesiculomics as a Metric of Disease Recapitulation in 3D Bioprinted Aortic Valve Arrays Open
In calcific aortic valve disease (CAVD), mechanosensitive valvular cells respond to fibrosis- and calcification-induced tissue stiffening, further driving pathophysiology. No pharmacotherapeutics are available to treat CAVD, due to the lac…
View article: Light transmittance in human atrial tissue and transthoracic illumination in rats support translatability of optogenetic cardioversion of atrial fibrillation
Light transmittance in human atrial tissue and transthoracic illumination in rats support translatability of optogenetic cardioversion of atrial fibrillation Open
Background Optogenetics could offer a solution to the current lack of an ambulatory method for the rapid automated cardioversion of atrial fibrillation (AF), but key translational aspects remain to be studied. Objective To investigate whet…
View article: Extensive aortic root endocarditis with extension into the intervalvular fibrous body: an updated report of a mitral valve sparing approach
Extensive aortic root endocarditis with extension into the intervalvular fibrous body: an updated report of a mitral valve sparing approach Open
OBJECTIVES Aortic root abscess can spread to include adjacent cardiac structures, including the central or intervalvular fibrous body and mitral valve. After radical debridement, complex surgical correction is needed. We describe the resul…
View article: Using multi-omic network analysis to identify cancer-relevant signaling pathways and novel biomarkers
Using multi-omic network analysis to identify cancer-relevant signaling pathways and novel biomarkers Open
While several driver mutations for multiple cancer types have been identified by large-scale genomic analyses, their functional involvement in known signaling pathways and therapeutic implications remain relatively unknown.Recently, effort…
View article: The Aortic Root in Acute Type A Dissection: Repair or Replace?
The Aortic Root in Acute Type A Dissection: Repair or Replace? Open
View article: Computed tomography follow-up after elective proximal aortic surgery: Less is more?
Computed tomography follow-up after elective proximal aortic surgery: Less is more? Open
View article: Pirfenidone Has Anti-fibrotic Effects in a Tissue-Engineered Model of Human Cardiac Fibrosis
Pirfenidone Has Anti-fibrotic Effects in a Tissue-Engineered Model of Human Cardiac Fibrosis Open
A fundamental process in the development and progression of heart failure is fibrotic remodeling, characterized by excessive deposition of extracellular matrix proteins in response to injury. Currently, therapies that effectively target an…
View article: Sarcomere Disassembly and Transfection Efficiency in Proliferating Human iPSC-Derived Cardiomyocytes
Sarcomere Disassembly and Transfection Efficiency in Proliferating Human iPSC-Derived Cardiomyocytes Open
Contractility of the adult heart relates to the architectural degree of sarcomeres in individual cardiomyocytes (CMs) and appears to be inversely correlated with the ability to regenerate. In this study we utilized multiple imaging techniq…
View article: Radiation Induces Valvular Interstitial Cell Calcific Response in an in vitro Model of Calcific Aortic Valve Disease
Radiation Induces Valvular Interstitial Cell Calcific Response in an in vitro Model of Calcific Aortic Valve Disease Open
Background: Mediastinal ionizing radiotherapy is associated with an increased risk of valvular disease, which demonstrates pathological hallmarks similar to calcific aortic valve disease (CAVD). Despite advances in radiotherapy techniques,…
View article: Superimposed Tissue Formation in Human Aortic Valve Disease: Differences between Regurgitant and Stenotic Valves
Superimposed Tissue Formation in Human Aortic Valve Disease: Differences between Regurgitant and Stenotic Valves Open
The formation of superimposed tissue (SIT), a layer on top of the original valve leaflet, has been described in patients with mitral regurgitation as a major contributor to valve thickening and possibly as a result of increased mechanical …