John Gaffney
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View article: Supplementary Figure S2 from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer
Supplementary Figure S2 from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer Open
Supplementary Figure S2. Illustration of the data that is used to derive the ΔR1, HFMRI and HVMRI parameters.
View article: Figure 3 from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer
Figure 3 from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer Open
Waterfall plots showing change in HVMRI, NVMRI, and WTV at W2. Four patterns seen were (A) lesions with significant hypoxia modification and reduction in WTV. Diamonds indicate tumors in which the hypoxic fraction remained unchanged; B, tu…
View article: Supplementary Figure S4 from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer
Supplementary Figure S4 from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer Open
Supplementary Figure S4. Motion correction effect on ΔR1 time-series.
View article: Supplementary Figure S1 from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer
Supplementary Figure S1 from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer Open
Supplementary Figure S1. Summary of MR imaging protocol and gas challenge timings.
View article: Supplementary Table S3 from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer
Supplementary Table S3 from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer Open
Supplementary Table S3. Results from repeatability assessment including results from Shapiro-Wilks test for normality and whether data were subsequently log-transformed to obtain wCV and RC data.
View article: Supplementary Figure S6 from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer
Supplementary Figure S6 from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer Open
Supplementary Figure S6. Histograms of baseline OE-MRI biomarker results.
View article: Supplementary Table S1 from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer
Supplementary Table S1 from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer Open
Supplementary Table S1. MR sequence parameters for T1 mapping, OE-MRI and DCE-MRI sequences.
View article: Table 2 from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer
Table 2 from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer Open
Pretreatment repeatability data for 21 lesions from 12 patients acquired at two pretreatment BL timepoints (BL0 and BL1).
View article: Table 3 from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer
Table 3 from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer Open
Evaluation of concordance of hypoxia modification in patients with two or more lesions, by assessing serial values of HVMRI at pretreatment and W2 and W4.
View article: Figure 1 from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer
Figure 1 from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer Open
Treatment-induced changes in OE-MRI–derived biomarkers. A, Example hypoxia maps for a large metastatic lymph node (patient 7) obtained at two BL timepoints (BL0 and BL1) and W2 and W4 of radiation treatment. Corresponding ΔR1 maps are prov…
View article: Figure 2 from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer
Figure 2 from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer Open
HVMRI changes at W2. A, Waterfall plot showing the percentage change in HVMRI from BL to W2 in all lesions, categorized as primary tumors or nodal metastases. B, Analysis of the 17 lesions imaged at both W2 and W4 compares the reduction fr…
View article: Supplementary Figure S8 from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer
Supplementary Figure S8 from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer Open
Supplementary Figure S8. Treatment-induced changes in OE-MRI biomarkers relative to baseline (BL).
View article: Supplementary Figure S5 from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer
Supplementary Figure S5 from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer Open
Supplementary Figure S5. OE-MRI biomarker repeatability.
View article: Table 1 from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer
Table 1 from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer Open
Clinical information and MRI scan details for image datasets from the 24 patients used in subsequent analysis.
View article: Supplementary Table S4 from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer
Supplementary Table S4 from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer Open
Supplementary Table S4. Summary of cohort lesion parameter median values at baseline and W2 and W4.
View article: Supplementary Figure S7 from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer
Supplementary Figure S7 from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer Open
Supplementary Figure S7. Treatment-induced changes in OE-MRI biomarker ΔR1.
View article: Supplementary Table S2 from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer
Supplementary Table S2 from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer Open
Supplementary Table S2. Whole tumor volume (WTV) measurements for each lesion (T = Primary Tumor, N = Metastatic Lymph Node) and patient at the baseline (BL).
View article: Supplementary Figure S3 from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer
Supplementary Figure S3 from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer Open
Supplementary Figure S3. Patient recruitment and imaging sample size.
View article: Supplementary Table S2 from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer
Supplementary Table S2 from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer Open
Supplementary Table S2. Whole tumor volume (WTV) measurements for each lesion (T = Primary Tumor, N = Metastatic Lymph Node) and patient at the baseline (BL).
View article: Supplementary Table S3 from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer
Supplementary Table S3 from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer Open
Supplementary Table S3. Results from repeatability assessment including results from Shapiro-Wilks test for normality and whether data were subsequently log-transformed to obtain wCV and RC data.
View article: Supplementary Figure S5 from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer
Supplementary Figure S5 from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer Open
Supplementary Figure S5. OE-MRI biomarker repeatability.
View article: Data from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer
Data from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer Open
Purpose:Hypoxia mediates treatment resistance in solid tumors. We evaluated if oxygen-enhanced MRI–derived hypoxic volume (HVMRI) is repeatable and can detect radiotherapy-induced hypoxia modification in human papillomavirus–associated oro…
View article: Supplementary Figure S6 from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer
Supplementary Figure S6 from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer Open
Supplementary Figure S6. Histograms of baseline OE-MRI biomarker results.
View article: Supplementary Table S1 from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer
Supplementary Table S1 from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer Open
Supplementary Table S1. MR sequence parameters for T1 mapping, OE-MRI and DCE-MRI sequences.
View article: Supplementary Figure S2 from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer
Supplementary Figure S2 from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer Open
Supplementary Figure S2. Illustration of the data that is used to derive the ΔR1, HFMRI and HVMRI parameters.
View article: Supplementary Figure S1 from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer
Supplementary Figure S1 from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer Open
Supplementary Figure S1. Summary of MR imaging protocol and gas challenge timings.
View article: Supplementary Figure S3 from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer
Supplementary Figure S3 from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer Open
Supplementary Figure S3. Patient recruitment and imaging sample size.
View article: Supplementary Figure S8 from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer
Supplementary Figure S8 from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer Open
Supplementary Figure S8. Treatment-induced changes in OE-MRI biomarkers relative to baseline (BL).
View article: Supplementary Figure S7 from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer
Supplementary Figure S7 from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer Open
Supplementary Figure S7. Treatment-induced changes in OE-MRI biomarker ΔR1.
View article: Supplementary Figure S4 from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer
Supplementary Figure S4 from Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer Open
Supplementary Figure S4. Motion correction effect on ΔR1 time-series.