Jesse C. DeSimone
YOU?
Author Swipe
View article: Moderating effects of plasma glial fibrillary acidic protein along the Alzheimer's disease continuum
Moderating effects of plasma glial fibrillary acidic protein along the Alzheimer's disease continuum Open
INTRODUCTION Glial fibrillary acidic protein (GFAP) may contribute to Alzheimer's pathology at early disease stages. GFAP moderation of Alzheimer's disease (AD)‐related neurodegeneration and cognition is unclear. METHODS We examined plasma…
View article: Automated Imaging Differentiation for Parkinsonism
Automated Imaging Differentiation for Parkinsonism Open
Importance Magnetic resonance imaging (MRI) paired with appropriate disease-specific machine learning holds promise for the clinical differentiation of Parkinson disease (PD), multiple system atrophy (MSA) parkinsonian variant, and progres…
View article: Informing etiological heterogeneity of mild cognitive impairment and risk for progression to dementia with plasma p-tau217
Informing etiological heterogeneity of mild cognitive impairment and risk for progression to dementia with plasma p-tau217 Open
MCI is etiologically heterogeneous. The presence of Alzheimer's pathology defined by elevated plasma p-tau217 in individuals with MCI significantly worsens prognosis. Neuropsychiatric symptoms may contribute to cognitive complaints and ris…
View article: Utility of Plasma Biomarkers in Screening for Brain Amyloid in the 1Florida Alzheimer Disease Research Center (ADRC)
Utility of Plasma Biomarkers in Screening for Brain Amyloid in the 1Florida Alzheimer Disease Research Center (ADRC) Open
Background With the emergence of anti‐amyloid drugs, there is an increased need to determine the presence of brain amyloid in people using non‐invasive, cost‐effective biomarkers. The goal of this study was to determine the added and stand…
View article: Neuroimaging and biofluid biomarkers across race and ethnicity in older adults across the spectrum of cognition
Neuroimaging and biofluid biomarkers across race and ethnicity in older adults across the spectrum of cognition Open
View article: Plasma p‐tau217 concordance with amyloid PET among ethnically diverse older adults
Plasma p‐tau217 concordance with amyloid PET among ethnically diverse older adults Open
INTRODUCTION Commercially available plasma p‐tau217 biomarker tests are not well studied in ethnically diverse samples. METHODS We evaluated associations between ALZPath plasma p‐tau217 and amyloid‐beta positron emission tomography (Aβ‐PET…
View article: Diffusion MRI relates to plasma Aβ42/40 in PET negative participants without dementia
Diffusion MRI relates to plasma Aβ42/40 in PET negative participants without dementia Open
INTRODUCTION Magnetic resonance imaging (MRI) biomarkers are needed for indexing early biological stages of Alzheimer's disease (AD), such as plasma amyloid‐β (Aβ42/40) positivity in Aβ positron emission tomography (PET) negative individua…
View article: MEG measured delta waves increase in adolescents after concussion
MEG measured delta waves increase in adolescents after concussion Open
Introduction The purpose of this study is to determine if delta waves, measured by magnetoencephalography (MEG), increase in adolescents due to a sports concussion. Methods Twenty‐four adolescents (age 14–17) completed pre‐ and postseason …
View article: Cell-specific effects of Dyt1 knock-out on sensory processing, network-level connectivity, and motor deficits
Cell-specific effects of Dyt1 knock-out on sensory processing, network-level connectivity, and motor deficits Open
View article: Mapping default mode connectivity alterations following a single season of subconcussive impact exposure in youth football
Mapping default mode connectivity alterations following a single season of subconcussive impact exposure in youth football Open
Repetitive head impact (RHI) exposure in collision sports may contribute to adverse neurological outcomes in former players. In contrast to a concussion, or mild traumatic brain injury, “subconcussive” RHIs represent a more frequent and as…
View article: α-Synuclein Induces Progressive Changes in Brain Microstructure and Sensory-Evoked Brain Function That Precedes Locomotor Decline
α-Synuclein Induces Progressive Changes in Brain Microstructure and Sensory-Evoked Brain Function That Precedes Locomotor Decline Open
In vivo functional and structural brain imaging of synucleinopathies in humans have provided a rich new understanding of the affected networks across the cortex and subcortex. Despite this progress, the temporal relationship between…
View article: Reply: Thalamotomy for tremor normalizes aberrant pre-therapeutic visual cortex functional connectivity
Reply: Thalamotomy for tremor normalizes aberrant pre-therapeutic visual cortex functional connectivity Open
View article: Network-level connectivity is a critical feature distinguishing dystonic tremor and essential tremor
Network-level connectivity is a critical feature distinguishing dystonic tremor and essential tremor Open
Dystonia is a movement disorder characterized by involuntary muscle co-contractions that give rise to disabling movements and postures. A recent expert consensus labelled the incidence of tremor as a core feature of dystonia that can affec…
View article: Forebrain knock-out of torsinA reduces striatal free-water and impairs whole-brain functional connectivity in a symptomatic mouse model of DYT1 dystonia
Forebrain knock-out of torsinA reduces striatal free-water and impairs whole-brain functional connectivity in a symptomatic mouse model of DYT1 dystonia Open
View article: In vivo imaging reveals impaired connectivity across cortical and subcortical networks in a mouse model of DYT1 dystonia
In vivo imaging reveals impaired connectivity across cortical and subcortical networks in a mouse model of DYT1 dystonia Open
View article: Sensory and motor cortex function contributes to symptom severity in spinocerebellar ataxia type 6
Sensory and motor cortex function contributes to symptom severity in spinocerebellar ataxia type 6 Open
View article: Free-water imaging in Parkinson’s disease and atypical parkinsonism
Free-water imaging in Parkinson’s disease and atypical parkinsonism Open
Conventional single tensor diffusion analysis models have provided mixed findings in the substantia nigra of Parkinson's disease, but recent work using a bi-tensor analysis model has shown more promising results. Using a bi-tensor model, f…
View article: The Antisaccade Task: Visual Distractors Elicit a Location-Independent Planning ‘Cost’
The Antisaccade Task: Visual Distractors Elicit a Location-Independent Planning ‘Cost’ Open
The presentation of a remote - but not proximal - distractor concurrent with target onset increases prosaccade reaction times (RT) (i.e., the remote distractor effect: RDE). The competitive integration model asserts that the RDE represents…