Jesse Crayle
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View article: ALSUntangled #75: Portable neuromodulation stimulator therapy
ALSUntangled #75: Portable neuromodulation stimulator therapy Open
Spurred by patient interest, ALSUntangled herein examines the potential of the Portable Neuromodulation Stimulator (PoNS™) in treating amyotrophic lateral sclerosis (ALS). The PoNS™ device, FDA-approved for the treatment of gait deficits i…
View article: ALSUntangled #78: Zinc
ALSUntangled #78: Zinc Open
ALSUntangled reviews alternative and off-label treatments for people living with amyotrophic lateral sclerosis (PALS). In this review, we assess the utilization of dietary zinc supplements for modulating ALS pathology and progression. Stud…
View article: ALSUntangled #76: Wahls protocol
ALSUntangled #76: Wahls protocol Open
The Wahls diet is a modified Paleolithic diet that emphasizes dark green leafy vegetables, colorful fruits, high-quality animal proteins, and omega-3 polyunsaturated fatty acids, while limiting grains, legumes, dairy products, sugar, and p…
View article: Genetic Associations With an Amyotrophic Lateral Sclerosis Reversal Phenotype
Genetic Associations With an Amyotrophic Lateral Sclerosis Reversal Phenotype Open
This study was registered with ClinicalTrials.gov (NCT03464903) on March 14, 2018. The first participant was enrolled on June 22, 2018.
View article: ALSUntangled #74: Withania Somnifera (Ashwagandha)
ALSUntangled #74: Withania Somnifera (Ashwagandha) Open
ALSUntangled reviews alternative and off-label treatments on behalf of people with ALS (PALS) who ask about them. Here, we review withania somnifera (WS) commonly known as ashwagandha or winter cherry. WS has plausible mechanisms for slowi…
View article: ALSUntangled #70: caffeine
ALSUntangled #70: caffeine Open
ALSUntangled reviews alternative and off-label treatments for people living with amyotrophic lateral sclerosis (PALS). Here, we review caffeine which has plausible mechanisms for slowing ALS progression. However, pre-clinical studies are c…
View article: ALSUntangled #68: ozone therapy
ALSUntangled #68: ozone therapy Open
ALSUntangled reviews alternative and off-label treatments for people living with amyotrophic lateral sclerosis (PALS). Here we review ozone therapy. Ozone therapy has possible mechanisms for slowing ALS progression based on its antioxidant…
View article: Study of “ALS reversals”: LifeTime environmental exposures (StARLiTE)
Study of “ALS reversals”: LifeTime environmental exposures (StARLiTE) Open
We previously reported on a series of patients diagnosed with ALS whom had an extraordinary course defined by substantial and sustained improvement in weakness and function. For this study, twenty-five of these "ALS Reversals" completed ex…
View article: ALSUntangled #64: butyrates
ALSUntangled #64: butyrates Open
ALSUntangled reviews alternative and off-label treatments for people living with amyotrophic lateral sclerosis (PALS). Here we review butyrate and its different chemical forms (butyrates). Butyrates have plausible mechanisms for slowing AL…
View article: ALSUntangled #62: vitamin C
ALSUntangled #62: vitamin C Open
Vitamin C is one of the most common supplements taken by people with ALS. As an antioxidant, it has a plausible mechanism for slowing disease progression and there are some flawed pre-clinical studies and case reports suggesting benefit. H…
View article: ALSUntangled 59: Tamoxifen
ALSUntangled 59: Tamoxifen Open
Here we use the ALSUntangled methodology to review Tamoxifen as an ALS treatment. We show that it has plausible mechanisms, a positive preclinical study, a case report and 2 small trials suggesting benefits. We show that it appears reasona…
View article: Cytosine deamination and the precipitous decline of spontaneous mutation during Earth's history
Cytosine deamination and the precipitous decline of spontaneous mutation during Earth's history Open
Cytosine deamination appears to be largely responsible for spontaneous mutations in the modern world. Because of its sensitivity to temperature (Q10 = 4), that reaction would have furnished a mechanism for rapid evolution on a warm earth. …
View article: “ALS reversals”: demographics, disease characteristics, treatments, and co-morbidities
“ALS reversals”: demographics, disease characteristics, treatments, and co-morbidities Open
Objective: To identify differences in demographics, disease characteristics, treatments, and co-morbidities between patients with “amyotrophic lateral sclerosis (ALS) reversals” and those with typically progressive ALS. Methods: Cases of p…
View article: Cytosine deamination and the precipitous decline of spontaneous mutation during Earth's history
Cytosine deamination and the precipitous decline of spontaneous mutation during Earth's history Open
Significance Cytosine deamination appears to be largely responsible for spontaneous mutations in the modern world. Because of its sensitivity to temperature (Q 10 = 4), that reaction would have furnished a mechanism for rapid evolution on …
View article: Potentiation of amygdala AMPA receptor activity selectively promotes escalated alcohol self‐administration in a CaMKII‐dependent manner
Potentiation of amygdala AMPA receptor activity selectively promotes escalated alcohol self‐administration in a CaMKII‐dependent manner Open
Growing evidence indicates that drugs of abuse gain control over the individual by usurping glutamate‐linked mechanisms of neuroplasticity in reward‐related brain regions. Accordingly, we have shown that glutamate α‐amino‐3‐hydroxy‐5‐methy…