Jesse D. Plotkin
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View article: Microglia-containing neural organoids as brain microphysiological systems for long-term culture
Microglia-containing neural organoids as brain microphysiological systems for long-term culture Open
Microglia, essential for brain development, homeostasis, and neuroinflammation, originate from the yolk sac during embryogenesis and migrate into the developing brain. Because of this developmental origin, many brain organoid models natura…
View article: The Baltimore declaration toward the exploration of organoid intelligence
The Baltimore declaration toward the exploration of organoid intelligence Open
Thomas Hartung1,2*Lena Smirnova1Itzy E. Morales Pantoja1Akwasi Akwaboah3Dowlette-Mary Alam El Din1Cynthia A. Berlinicke4J. Lomax Boyd5Brian S. Caffo6Ben Cappiello7Tzahi Cohen-Karni8,9J. Lowry Curley7Ralph Etienne-Cummings3Raha Dastgheyb10D…
View article: First Organoid Intelligence (OI) workshop to form an OI community
First Organoid Intelligence (OI) workshop to form an OI community Open
The brain is arguably the most powerful computation system known. It is extremely efficient in processing large amounts of information and can discern signals from noise, adapt, and filter faulty information all while running on only 20 wa…
View article: Organoid intelligence (OI): the new frontier in biocomputing and intelligence-in-a-dish
Organoid intelligence (OI): the new frontier in biocomputing and intelligence-in-a-dish Open
Recent advances in human stem cell-derived brain organoids promise to replicate critical molecular and cellular aspects of learning and memory and possibly aspects of cognition in vitro . Coining the term “organoid intelligence” (OI) to en…
View article: Design and Testing of Dual-Targeted Gd<sub>3</sub>N@C80-Containing Glioblastoma Theranostics
Design and Testing of Dual-Targeted Gd<sub>3</sub>N@C80-Containing Glioblastoma Theranostics Open
The majority of the malignant brain tumors are gliomas with glioblastoma being the most common and aggressive type. Due to its extreme infiltrative nature and higher occurrence frequency, finding new glioblastoma therapeutics and diagnosti…
View article: Human Mast Cells From Adipose Tissue Target and Induce Apoptosis of Breast Cancer Cells
Human Mast Cells From Adipose Tissue Target and Induce Apoptosis of Breast Cancer Cells Open
Mast cells (MC) are important immune sentinels found in most tissue and widely recognized for their role as mediators of Type I hypersensitivity. However, they also secrete anti-cancer mediators such as tumor necrosis factor alpha (TNF-α) …