Explanipedia

Virus-encoded glycosyltransferases hypermodify DNA with diverse glycans Open

Jesse D. Pyle, Sean Lund, Katherine H. O’Toole, Lana Saleh · 2024

Enzymatic modification of DNA nucleobases can coordinate gene expression, nuclease protection, or mutagenesis. We recently discovered a clade of phage-specific cytosine methyltransferase (MT) and 5-methylpyrimidine dioxygenase (5mYOX) enzy…

Virus-encoded glycosyltransferases hypermodify DNA with diverse glycans Open

Jesse D. Pyle, Sean Lund, Katherine H. O’Toole, Lana Saleh · 2023

Enzymatic modification of DNA nucleobases can coordinate gene expression, protection from nucleases, or mutagenesis. We recently discovered a new clade of phage-specific cytosine methyltransferase (MT) and 5-methylpyrimidine dioxygenase (5…

Analysis of 6.4 million SARS-CoV-2 genomes identifies mutations associated with fitness Open

Fritz Obermeyer, Martin Jankowiak, Nikolaos Barkas, S. F. Schaffner, Jesse D. Pyle , et al. · 2022

Repeated emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with increased fitness underscores the value of rapid detection and characterization of new lineages. We have developed PyR 0 , a hierarchical Baye…

Analysis of 6.4 million SARS-CoV-2 genomes identifies mutations associated with fitness Open

Fritz Obermeyer, Martin Jankowiak, Nikolaos Barkas, S. F. Schaffner, Jesse D. Pyle , et al. · 2021

Repeated emergence of SARS-CoV-2 variants with increased fitness necessitates rapid detection and characterization of new lineages. To address this need, we developed PyR 0 , a hierarchical Bayesian multinomial logistic regression model th…

Isolation of Reconstructed Functional Ribonucleoprotein Complexes of Machupo Virus Open

Jesse D. Pyle, Sean P. J. Whelan · 2021

Arenaviruses are rodent-borne pathogens that can cause severe disease in humans. All arenaviruses begin the infection cycle with delivery of the virus replication machinery into the cytoplasm of the host cell.

Synergistic Block of SARS-CoV-2 Infection by Combined Drug Inhibition of the Host Entry Factors PIKfyve Kinase and TMPRSS2 Protease Open

Alex J.B. Kreutzberger, Anwesha Sanyal, Ravi Ojha, Jesse D. Pyle, Olli Vapalahti , et al. · 2021

Infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is causing the coronavirus disease 2019 (COVID-2019) global pandemic. There are ongoing efforts to uncover effective antiviral agents that could mitigate the severit…

Synergistic block of SARS-CoV-2 infection by combined drug inhibition of the host entry factors PIKfyve kinase and TMPRSS2 protease Open

Alex J.B. Kreutzberger, Anwesha Sanyal, Ravi Ojha, Jesse D. Pyle, Olli Vapalahti , et al. · 2021

Repurposing FDA-approved inhibitors able to prevent infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) could provide a rapid path to establish new therapeutic options to mitigate the effects of coronavirus disease 20…

Panicum Mosaic Virus and Its Satellites Acquire RNA Modifications Associated with Host-Mediated Antiviral Degradation Open

Jesse D. Pyle, Kranthi K. Mandadi, Karen‐Beth G. Scholthof · 2019

The genomes of positive-sense RNA viruses have an intrinsic capacity to serve directly as mRNAs upon viral entry into a host cell. These RNAs often lack a 5′ cap structure and 3′ polyadenylation sequence, requiring unconventional strategie…

RNA ligands activate the Machupo virus polymerase and guide promoter usage Open

Jesse D. Pyle, Sean P. J. Whelan · 2019

Significance Atomic structures of the polymerase–endonuclease complex of the orthomyxovirus influenza and the orthobunyavirus La Crosse—two distinct segmented negative-sense (SNS) RNA viruses—demonstrate that binding of the genomic 5′ RNA …

Amalga-like virus infecting Antonospora locustae , a microsporidian pathogen of grasshoppers, plus related viruses associated with other arthropods Open

Jesse D. Pyle, Patrick J. Keeling, Max L. Nibert · 2017

A +1 ribosomal frameshifting motif prevalent among plant amalgaviruses Open

Max L. Nibert, Jesse D. Pyle, Andrew E. Firth · 2016

Molecular Pathogenesis of Viral and Subviral Agents in Model and Crop Grasses Open

Jesse D. Pyle · 2015

Viral diseases cause significant agricultural yield losses globally. Because grasses constitute most of our food, forage, and bioenergy sources, the resulting economic losses caused by grass-infecting viruses are particularly devastating. …

Characterization of SCL33 splicing patterns during diverse virus infections in Brachypodium distachyon Open

Kranthi K. Mandadi, Jesse D. Pyle, Karen‐Beth G. Scholthof · 2015

In eukaryotes alternative splicing (AS) influences transcriptome and proteome diversity. The mechanism and the genetic components mediating AS during plant-virus interactions are not known. Using RNA sequencing approaches, we recently anal…

Multi-Year Pathogen Survey of Biofuel Switchgrass Breeding Plots Reveals High Prevalence of Infections by Panicum mosaic virus and Its Satellite Virus Open

Catherine Louise Stewart, Jesse D. Pyle, Charlene C. Jochum, Kenneth P. Vogel, Gary Y. Yuen , et al. · 2015

Switchgrass (Panicum virgatum) cultivars are currently under development as lignocellulosic feedstock. Here we present a survey of three established switchgrass experimental nurseries in Nebraska in which we identified Panicum mosaic virus…

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