Jesse D. Vargas
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View article: Data from Comparative Oncology Assessment of a Novel Inhibitor of Valosin-Containing Protein in Tumor-Bearing Dogs
Data from Comparative Oncology Assessment of a Novel Inhibitor of Valosin-Containing Protein in Tumor-Bearing Dogs Open
Pet dogs with naturally occurring cancers play an important role in studies of cancer biology and drug development. We assessed tolerability, efficacy, and pharmacokinetic/pharmacodynamic relationships with a first-in-class small molecule …
View article: Supplementary Data from Comparative Oncology Assessment of a Novel Inhibitor of Valosin-Containing Protein in Tumor-Bearing Dogs
Supplementary Data from Comparative Oncology Assessment of a Novel Inhibitor of Valosin-Containing Protein in Tumor-Bearing Dogs Open
Supplementary Data from Comparative Oncology Assessment of a Novel Inhibitor of Valosin-Containing Protein in Tumor-Bearing Dogs
View article: Supplementary Data from Comparative Oncology Assessment of a Novel Inhibitor of Valosin-Containing Protein in Tumor-Bearing Dogs
Supplementary Data from Comparative Oncology Assessment of a Novel Inhibitor of Valosin-Containing Protein in Tumor-Bearing Dogs Open
Supplementary Data from Comparative Oncology Assessment of a Novel Inhibitor of Valosin-Containing Protein in Tumor-Bearing Dogs
View article: Data from Comparative Oncology Assessment of a Novel Inhibitor of Valosin-Containing Protein in Tumor-Bearing Dogs
Data from Comparative Oncology Assessment of a Novel Inhibitor of Valosin-Containing Protein in Tumor-Bearing Dogs Open
Pet dogs with naturally occurring cancers play an important role in studies of cancer biology and drug development. We assessed tolerability, efficacy, and pharmacokinetic/pharmacodynamic relationships with a first-in-class small molecule …
View article: Comparative Oncology Assessment of a Novel Inhibitor of Valosin-Containing Protein in Tumor-Bearing Dogs
Comparative Oncology Assessment of a Novel Inhibitor of Valosin-Containing Protein in Tumor-Bearing Dogs Open
Pet dogs with naturally occurring cancers play an important role in studies of cancer biology and drug development. We assessed tolerability, efficacy, and pharmacokinetic/pharmacodynamic relationships with a first-in-class small molecule …
View article: VCP/p97 inhibitor CB-5083 modulates muscle pathology in a mouse model of VCP inclusion body myopathy
VCP/p97 inhibitor CB-5083 modulates muscle pathology in a mouse model of VCP inclusion body myopathy Open
Background Pathogenic gain of function variants in Valosin-containing protein ( VCP ) cause a unique disease characterized by inclusion body myopathy with early-onset Paget disease of bone and frontotemporal dementia (also known as Multisy…
View article: Targeting AML dependency on VCP-mediated DNA repair through a selective second-generation small molecule inhibitor
Targeting AML dependency on VCP-mediated DNA repair through a selective second-generation small molecule inhibitor Open
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View article: Targeting acute myeloid leukemia dependency on VCP-mediated DNA repair through a selective second-generation small-molecule inhibitor
Targeting acute myeloid leukemia dependency on VCP-mediated DNA repair through a selective second-generation small-molecule inhibitor Open
Acute myeloid leukemia cells are dependent on the DNA repair function of valosin-containing protein, opening up an avenue for disease treatment.
View article: Sweet Blood Surveillance: An ethnographic approach to diabetes management through the Diabetes Care Network
Sweet Blood Surveillance: An ethnographic approach to diabetes management through the Diabetes Care Network Open
Is the management of Type 1 Diabetes best left to the medical sciences, or do the social sciences have a stake as well? In ‘Sweet Blood Surveillance,’ I push back against the perceived domination of scientific objectivity to make space for…
View article: Functional importance of stripping in NFκB signaling revealed by a stripping-impaired IκBα mutant
Functional importance of stripping in NFκB signaling revealed by a stripping-impaired IκBα mutant Open
Significance Stress-response transcription factors turn on hundreds of genes, and their activity must be turned off completely and quickly. The inhibitor protein IκBα turns off NFκB by forming a transient ternary complex with the NFκB–DNA …
View article: Signaling via the <scp>NFκB</scp> system
Signaling via the <span>NFκB</span> system Open
The nuclear factor kappa B ( NFκB ) family of transcription factors is a key regulator of immune development, immune responses, inflammation, and cancer. The NFκB signaling system (defined by the interactions between NFκB dimers, IκB regul…
View article: Anatomy of a negative feedback loop: the case of I <i>κ</i> B <i>α</i>
Anatomy of a negative feedback loop: the case of I <i>κ</i> B <i>α</i> Open
The magnitude, duration and oscillation of cellular signalling pathway responses are often limited by negative feedback loops, defined as an ‘activator-induced inhibitor’ regulatory motif. Within the NF κ B signalling pathway, a key negati…
View article: A multi‐scale approach reveals that NF‐κB <scp>cR</scp> el enforces a B‐cell decision to divide
A multi‐scale approach reveals that NF‐κB <span>cR</span> el enforces a B‐cell decision to divide Open
Understanding the functions of multi-cellular organs in terms of the molecular networks within each cell is an important step in the quest to predict phenotype from genotype. B-lymphocyte population dynamics, which are predictive of immune…