Jesse Dunnack
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View article: Alternative pre-mRNA Splicing and Gene Expression Patterns in Midbrain Lineage Cells Carrying Familial Parkinson’s Disease Mutations
Alternative pre-mRNA Splicing and Gene Expression Patterns in Midbrain Lineage Cells Carrying Familial Parkinson’s Disease Mutations Open
Summary Parkinson’s disease (PD) arises from genetic and environmental factors. Human genetics has identified mutations in ∼20 inherited familial genes linked to monogenic forms of PD. To investigate the effects of individual familial PD m…
View article: iSCORE-PD: an isogenic stem cell collection to research Parkinson’s Disease
iSCORE-PD: an isogenic stem cell collection to research Parkinson’s Disease Open
Parkinson’s disease (PD) is a neurodegenerative disorder caused by complex genetic and environmental factors. Genome-edited human pluripotent stem cells (hPSCs) offer a unique experimental platform to advance our understanding of PD etiolo…
View article: EPEN-05. MUTATIONAL ANALYSIS OF THE C11ORF95 DOMAIN AND SINGLE-CELL RNA-SEQ PROFILE OF A MOUSE MODEL OF SUPRATENTORIAL EPENDYMOMA
EPEN-05. MUTATIONAL ANALYSIS OF THE C11ORF95 DOMAIN AND SINGLE-CELL RNA-SEQ PROFILE OF A MOUSE MODEL OF SUPRATENTORIAL EPENDYMOMA Open
We used a recently developed mouse model to better understand the cellular and molecular determinants of tumors driven by the oncogenic fusion protein C11orf95-RELA. Our approach makes use of in utero electroporation and a binary transposa…
View article: TMOD-32. MUTATIONAL ANALYSIS OF THE C11orf95 DOMAIN AND SINGLE CELL RNASEQ PROFILE OF A MOUSE MODEL OF SUPRATENTORIAL EPENDYMOMA
TMOD-32. MUTATIONAL ANALYSIS OF THE C11orf95 DOMAIN AND SINGLE CELL RNASEQ PROFILE OF A MOUSE MODEL OF SUPRATENTORIAL EPENDYMOMA Open
We used a recently developed mouse model to better understand the cellular and molecular determinants of tumors driven by the oncogenic fusion protein C11orf95-RELA. Our approach makes use of in utero electroporation and a binary transposa…
View article: PDTM-29. STRUCTURE FUNCTION AND CELL TYPE DETERMINANTS OF C11orf95-RELA DRIVEN TUMORS IN MICE
PDTM-29. STRUCTURE FUNCTION AND CELL TYPE DETERMINANTS OF C11orf95-RELA DRIVEN TUMORS IN MICE Open
We used a new mouse model to better understand the cellular and molecular determinants of tumors driven by the C11orf95-RELA fusion. Our approach makes use of in utero electroporation and a binary transposase system to introduce human C11o…
View article: Notch Inhibitors and the BET Inhibitor JQ-1 Decrease the Growth of Primary Tumor Cells Derived from a Novel Mouse Model of C11orf95-RELA Induced Brain Tumor
Notch Inhibitors and the BET Inhibitor JQ-1 Decrease the Growth of Primary Tumor Cells Derived from a Novel Mouse Model of C11orf95-RELA Induced Brain Tumor Open
Brain tumors are the most common childhood solid malignancy, and because of remarkable advances in treating many cancers outside of the brain, they have become the leading cause of cancer mortality in children. Ependymomas are a class of b…