Jesse Gitaka
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View article: Demystifying cervical cancer care pathways in private facilities in Kenya
Demystifying cervical cancer care pathways in private facilities in Kenya Open
Background Despite advances in HPV vaccination and screening technologies, the uptake of these preventive measures remains low in Kenya, particularly within private healthcare settings. This study evaluates the integration of routine HPV t…
View article: Long-lasting insecticidal net ownership and malaria infection by socio-economic status: a cross-sectional household study in an area along Lake Victoria, Kenya
Long-lasting insecticidal net ownership and malaria infection by socio-economic status: a cross-sectional household study in an area along Lake Victoria, Kenya Open
Background This study focused on the importance of long-lasting insecticide treated nets (LLINs) in malaria control in a study area where socio-economic disparities are widening. The objective was to assess the effectiveness of LLIN owners…
View article: The second-round evaluation of financial incentives on malaria prevalence in the Lake Victoria Basin, Kenya: updated study protocol for a cluster-randomized controlled trial
The second-round evaluation of financial incentives on malaria prevalence in the Lake Victoria Basin, Kenya: updated study protocol for a cluster-randomized controlled trial Open
View article: Evaluating the Impacts of Piperonyl Butoxide-Treated Ceiling Nets on Malaria Risk Among High-Risk Populations with Limited Access to Conventional LLINs in Homa Bay Country, Kenya: Study Protocol for a Household Randomized Control Trial
Evaluating the Impacts of Piperonyl Butoxide-Treated Ceiling Nets on Malaria Risk Among High-Risk Populations with Limited Access to Conventional LLINs in Homa Bay Country, Kenya: Study Protocol for a Household Randomized Control Trial Open
Introduction: Progress in reducing the global malaria burden has stalled since 2015, with increases in malaria incidence and mortality reported in many African countries after 2020. In 2021, the WHO issued a conditional recommendation for …
View article: Global-scale population genetic analysis of Plasmodium falciparum identifies country- and region-specific patterns of malaria parasite adaptation
Global-scale population genetic analysis of Plasmodium falciparum identifies country- and region-specific patterns of malaria parasite adaptation Open
To investigate the global evolution and adaptation of Plasmodium falciparum, we analysed 17,565 isolates collected over three decades from 39 countries. This large-scale genomic study integrates identity-by-descent (IBD) networks, populati…
View article: The impact of Schistosoma haematobium hybridization on molecular diagnosis of schistosomiasis: A review with emphasis on female genital schistosomiasis
The impact of Schistosoma haematobium hybridization on molecular diagnosis of schistosomiasis: A review with emphasis on female genital schistosomiasis Open
Female genital schistosomiasis (FGS) is a gynecological manifestation of urinary schistosomiasis in female genitals. FGS is a neglected tropical disease; not only are most patients unaware of the condition, but healthcare workers and polic…
View article: Exploring the P. falciparum antigens associated with reduced risk of malaria in pregnancy
Exploring the P. falciparum antigens associated with reduced risk of malaria in pregnancy Open
Plasmodium falciparum infection in pregnancy leads to substantial maternal and infant morbidity and mortality. Such an infection may result in placental malaria (PM) due to P. falciparum -infected red blood cells adhering to the placenta v…
View article: Plasma protein biomarkers of Plasmodium falciparum infection in pregnant women: a high-throughput proteomics study
Plasma protein biomarkers of Plasmodium falciparum infection in pregnant women: a high-throughput proteomics study Open
Introduction Pregnant women in sub-Saharan Africa face heightened susceptibility to Plasmodium falciparum malaria, with placental sequestration driving adverse outcomes. The infection may lead to pregnancy-associated malaria (PAM) because …
View article: Economic Evaluation of Implementing SD Biosensor Antigen Detecting SARS-COV-2 Rapid Diagnostic Tests in Kenya
Economic Evaluation of Implementing SD Biosensor Antigen Detecting SARS-COV-2 Rapid Diagnostic Tests in Kenya Open
The COVID-19 pandemic has created a need to rapidly scale-up testing services. In Kenya, services for SARS-CoV-2 nucleic acid amplifying test (NAAT) have often been unavailable or delayed, precluding the clinical utility of the results. Th…
View article: Mortality and Predictors of Mortality Among COVID-19 Patients in Kiambu County, Kenya
Mortality and Predictors of Mortality Among COVID-19 Patients in Kiambu County, Kenya Open
SARS-CoV-2 continues to circulate with new variants of uncertain transmissibility and virulence arising over time and resulting in varying morbidity and mortality between and within countries. This study aimed to identify the predictors of…
View article: Development of monoclonal antibodies against SARS-CoV-2 nucleocapsid protein for COVID-19 antigen detection
Development of monoclonal antibodies against SARS-CoV-2 nucleocapsid protein for COVID-19 antigen detection Open
View article: Prevalence of Long COVID in<i>Mycobacterium tuberculosis-</i>exposed Groups in Peru and Kenya
Prevalence of Long COVID in<i>Mycobacterium tuberculosis-</i>exposed Groups in Peru and Kenya Open
Background Long COVID (LC), also referred to as post-COVID condition, refers to new or worsening symptoms lasting more than three months after SARS-CoV-2 infection. The prevalence of LC, and the impact of co-infection with prevalent pathog…
View article: Previously Undiagnosed Disease “X” in the Democratic Republic of the Congo: Malaria's Potential Role in the Outbreak
Previously Undiagnosed Disease “X” in the Democratic Republic of the Congo: Malaria's Potential Role in the Outbreak Open
View article: Development of Monoclonal Antibodies Against SARS-CoV-2 Nucleocapsid Protein for COVID-19 Antigen Detection
Development of Monoclonal Antibodies Against SARS-CoV-2 Nucleocapsid Protein for COVID-19 Antigen Detection Open
Background The coronavirus disease 2019 (COVID-19) pandemic underscored the global need for reliable diagnostic tools with quick turnaround time for effective patient management and mitigation of virus spread. This study aimed to express s…
View article: Impact of home-based follow-up care on hypertension control among patients attending Thika Level Five Hospital, Kiambu County, Kenya: A randomized control study
Impact of home-based follow-up care on hypertension control among patients attending Thika Level Five Hospital, Kiambu County, Kenya: A randomized control study Open
Background Hypertension contributes to a large burden of cardiovascular diseases, with a higher prevalence in low- and middle-income countries. Hypertension management is mainly hospital-based, but it faces low retention rates in facilitie…
View article: Malaria Chemotherapeutics What Next for Africa
Malaria Chemotherapeutics What Next for Africa Open
Malaria remains a significant health challenge in sub‐Saharan Africa, accounting for 90% of the global burden of disease. Recent studies have reported an increase in the number of malaria cases and a decrease in deaths. However, these gain…
View article: Where is the hard-to-reach population? Spatial analysis from a cross-sectional study on the access to bed net and malaria vaccine in the Lake Victoria Region, Kenya
Where is the hard-to-reach population? Spatial analysis from a cross-sectional study on the access to bed net and malaria vaccine in the Lake Victoria Region, Kenya Open
Background Long-lasting insecticidal nets (LLIN) and vaccines are effective malaria control tools. However, inadequate uptake has been reported in countries where both interventions are available. To maximize the impact these tools provide…
View article: Placental malaria infection is associated with downregulation of STAT-6 and ANG-1 in decidual macrophages
Placental malaria infection is associated with downregulation of STAT-6 and ANG-1 in decidual macrophages Open
Introduction Macrophages play a crucial immunological role in maintaining pregnancy. Placental malaria infection may cause dysfunction in decidual macrophages which then culminates in the associated pregnancy complications. Here, we determ…
View article: Highly sensitive molecular assay based on Identical Multi-Repeat Sequence (IMRS) algorithm for the detection of Trichomonas vaginalis infection
Highly sensitive molecular assay based on Identical Multi-Repeat Sequence (IMRS) algorithm for the detection of Trichomonas vaginalis infection Open
Introduction Annually, approximately 174 million people globally are affected by Trichomonas vaginalis ( T . vaginalis ) infection. Half of these infections occur in resource-limited regions. Untreated T . vaginalis infections are associat…
View article: Targeting Plasmodium falciparum chondroitin sulfate a ligand: A highly conserved malaria antigen with potential for pregnancy-associated malaria vaccine development
Targeting Plasmodium falciparum chondroitin sulfate a ligand: A highly conserved malaria antigen with potential for pregnancy-associated malaria vaccine development Open
Background Pregnant women in malaria-endemic regions exhibit heightened susceptibility to Plasmodium falciparum infection due to accumulation of infected red blood cells (iRBCs) in the placenta. This is aided by the variant antigen 2 chond…
View article: Evaluation of the protective efficacy of OlysetPlus ceiling nets for reduction of malaria incidence in children in Homa Bay County, Kenya: a cluster-randomised controlled study protocol
Evaluation of the protective efficacy of OlysetPlus ceiling nets for reduction of malaria incidence in children in Homa Bay County, Kenya: a cluster-randomised controlled study protocol Open
Introduction Malaria is still a major health problem in sub-Saharan Africa, where 98% of global malaria mortality occurs. In addition, the spread of Plasmodium falciparum with partial artemisinin resistance in East Africa and beyond is a g…
View article: A biobank resource for placental malaria and placental health research
A biobank resource for placental malaria and placental health research Open
Background Malaria during pregnancy is a serious threat to maternal and child health in malaria-endemic regions. Malaria during pregnancy often leads to placental malaria, which has severely detrimental effects on fetal outcomes, including…
View article: Plasmodium falciparum with pfhrp2 and pfhrp3 gene deletions in asymptomatic malaria infections in the Lake Victoria region, Kenya
Plasmodium falciparum with pfhrp2 and pfhrp3 gene deletions in asymptomatic malaria infections in the Lake Victoria region, Kenya Open
View article: Unraveling the ‘community effects’ of interventions against malaria endemicity: a systematic scoping review
Unraveling the ‘community effects’ of interventions against malaria endemicity: a systematic scoping review Open
Objectives There is an urgent need to maximise the effectiveness of existing malaria interventions and optimise the deployment of novel countermeasures. When assessing the effects of interventions against malaria, it is imperative to consi…
View article: Who are the hard-to-reach population? Spatial analysis from a cross-sectional study on the access to bed net and malaria vaccine in the Lake Victoria Region, Kenya
Who are the hard-to-reach population? Spatial analysis from a cross-sectional study on the access to bed net and malaria vaccine in the Lake Victoria Region, Kenya Open
Background Long-lasting insecticidal nets (LLIN) and vaccines are effective malaria control tools. However, inadequate uptake has been reported in countries where both interventions are available. To maximize the impact these tools provide…
View article: Presence of Plasmodium falciparum strains with artemisinin-resistant K13 mutation C469Y in Busia County, Western Kenya
Presence of Plasmodium falciparum strains with artemisinin-resistant K13 mutation C469Y in Busia County, Western Kenya Open
View article: The pregnancy-associated secretome in malaria pathogenesis and immunity during gestation
The pregnancy-associated secretome in malaria pathogenesis and immunity during gestation Open
In pregnancy, fetal health, growth and development are dependent on normal placental development. However, the mechanisms that support maternal immune tolerance for the fetus, fetal nourishment, and pregnancy maintenance to term are not fu…
View article: Effectiveness of long-lasting insecticide treated net use by socioeconomic status: a cross-sectional household study in area along Lake Victoria, Kenya
Effectiveness of long-lasting insecticide treated net use by socioeconomic status: a cross-sectional household study in area along Lake Victoria, Kenya Open
Background This study focused on the importance of integrated vector mosquito management (IVM) in malaria control, particularly the pivotal role of long-lasting insecticide treated nets (LLINs). The objective was to assess the effectivenes…
View article: Gendered farmer perceptions towards soil nutrition and willingness to pay for a cafetière-style filter system for in-situ soil testing: Evidence from Central Kenya
Gendered farmer perceptions towards soil nutrition and willingness to pay for a cafetière-style filter system for in-situ soil testing: Evidence from Central Kenya Open
Soil nutrition is a key pillar in agricultural productivity. However, point-of-need testing for soil nutrition is not readily available in resource-limited settings such as Kenya. We set out to study the perceived need for soil testing amo…
View article: The Second-Round Evaluation of Financial Incentives on Malaria Prevalence in the Lake Victoria Basin, Kenya: Updated Study Protocol for a Cluster-Randomized Controlled Trial
The Second-Round Evaluation of Financial Incentives on Malaria Prevalence in the Lake Victoria Basin, Kenya: Updated Study Protocol for a Cluster-Randomized Controlled Trial Open
Background : Despite significant progress in global malaria reduction since 2000, driven primarily by supply-side interventions including improvements in bed nets and medication availability, recent years have seen a stagnation in this dec…