Jesse Jaso
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View article: Genomic Landscape of Mixed Phenotype Acute Leukemia Associated With Immunophenotypic Lineage Predominance: Impact on Diagnosis and Treatment
Genomic Landscape of Mixed Phenotype Acute Leukemia Associated With Immunophenotypic Lineage Predominance: Impact on Diagnosis and Treatment Open
Objectives Mixed phenotype acute leukemia ( MPAL ) often poses challenges in diagnosis and clinical management. This is the first study to assess the lineage/immunophenotype‐genotype association and the significance of AML ‐myelodysplasia‐…
View article: Clinicopathologic and Molecular Characterization of <i>NUP98</i>‐Rearranged Acute Leukemias
Clinicopathologic and Molecular Characterization of <i>NUP98</i>‐Rearranged Acute Leukemias Open
Introduction NUP98 rearrangements are rare in acute leukemias and portend a poor prognosis. Methods This study explored clinicopathologic and molecular features of five patients with NUP98 rearranged ( NUP98‐ r) acute leukemias, including …
View article: Non-secretory Multiple Myeloma Associated with Diffuse Osteosclerotic Bone Lesions: A Case Report and Review of Cases since 1997
Non-secretory Multiple Myeloma Associated with Diffuse Osteosclerotic Bone Lesions: A Case Report and Review of Cases since 1997 Open
Background: Multiple myeloma is the second most common hematologic malignancy typically involving monoclonal immunoglobulin secretion by malignant plasma cells and lytic bone lesions. Sclerotic lesions appear in 3% of cases, and only 1-3% …
View article: Sars-Cov-2 Infection Associated with Aplastic Anemia and Pure Red Cell Aplasia
Sars-Cov-2 Infection Associated with Aplastic Anemia and Pure Red Cell Aplasia Open
Introduction: Aplastic anemia (AA) is a life-threatening disorder characterized by pancytopenia and a hypocellular bone marrow. Pure red cell aplasia (PRCA) is a similar disorder with primary reduction in the red blood cell population and …
View article: Colony-stimulating factor 3 receptor gene (CSF3R) T618I mutated chronic myelomonocytic leukemia: A proliferative subtype with a distinct mutational profile
Colony-stimulating factor 3 receptor gene (CSF3R) T618I mutated chronic myelomonocytic leukemia: A proliferative subtype with a distinct mutational profile Open
Introduction/Objective Chronic myelomonocytic leukemia (CMML) is a myeloid neoplasm characterized by sustained monocytosis, ranging from cytopenia with a dysplastic subtype to leukocytosis with a proliferative subtype, with a typical mutat…
View article: Lymphomatoid granulomatosis of the central nervous system (CNS‐LYG) posing a management challenge
Lymphomatoid granulomatosis of the central nervous system (CNS‐LYG) posing a management challenge Open
Isolated central nervous system lymphomatoid granulomatosis (CNS‐LYG) can mimic aggressive glioblastomas. We describe a complex presentation of CNS‐LYG coexisting with immune thrombocytopenia successfully managed with rituximab and ultra‐l…
View article: A Wandering Missionary’s Burden: Persistent Fever and Progressive Somnolence in a Returning Traveler
A Wandering Missionary’s Burden: Persistent Fever and Progressive Somnolence in a Returning Traveler Open
Human African trypanosomiasis incidence has declined, but diagnosis remains difficult, especially in nonendemic areas. Our patient presented with fever, progressive lethargy, and weight loss for 5 months and had previously traveled to Ghan…
View article: Lymphomatoid granulomatosis of the central nervous system (CNS-LYG), immune thrombocytopenia, disseminated zoster and venous thrombosis: “Hickam’s dictum posing a management challenge”
Lymphomatoid granulomatosis of the central nervous system (CNS-LYG), immune thrombocytopenia, disseminated zoster and venous thrombosis: “Hickam’s dictum posing a management challenge” Open
We describe a case of isolated primary CNS lymphomatoid granulomatosis and a discordant low-grade B-cell lymphoma involving the bone marrow causing chronic immune thrombocytopenia. Clinical course was complicated with disseminated zoster a…
View article: Lenalidomide-Associated Secondary B-Lymphoblastic Leukemia/Lymphoma—A Unique Entity
Lenalidomide-Associated Secondary B-Lymphoblastic Leukemia/Lymphoma—A Unique Entity Open
Objectives Autologous stem cell transplant with lenalidomide maintenance therapy has greatly improved the relapse-free and overall survival rates of patients with multiple myeloma but also has been associated with an increased risk of seco…
View article: Flow Cytometric Features in Double/Triple Hit Lymphomas: Dim CD45 Expression of Limited Diagnostic Utility
Flow Cytometric Features in Double/Triple Hit Lymphomas: Dim CD45 Expression of Limited Diagnostic Utility Open
Thank you for your interest in our recently published article of “bright CD38 expression by flow cytometric analysis is a biomarker for double/triple hit lymphomas (DH/THL) with a moderate sensitivity and high specificity” 1. The case desc…
View article: Bright CD38 Expression by Flow Cytometric Analysis Is a Biomarker for Double/Triple Hit Lymphomas with a Moderate Sensitivity and High Specificity
Bright CD38 Expression by Flow Cytometric Analysis Is a Biomarker for Double/Triple Hit Lymphomas with a Moderate Sensitivity and High Specificity Open
Background High‐grade B‐cell lymphomas (HGBCL) with MYC and BCL2 or/and BCL6 rearrangements (R), so‐called double/triple‐hit lymphomas (DH/THL), are uncommon, clinically aggressive lymphomas that require a prompt diagnosis. We aim to ident…
View article: Impact of Cross-Sex Hormone Therapy on Laboratory Values: A Study of Transgender Men
Impact of Cross-Sex Hormone Therapy on Laboratory Values: A Study of Transgender Men Open
Transgender patients are increasingly presenting to clinical settings for care, but basic components of primary care have not been established for these patients. Endocrine society clinical guidelines are somewhat limited as they are based…