Explanipedia

A Dapl1 <sup>+</sup> subpopulation of naïve CD8 T cells is enriched for memory-lineage precursors Open

Adam C. Lynch, Kaito A. Hioki, Xueting Liang, Iris Thesmar, Julia Cernjul , et al. · 2025

Memory CD8 T cells provide long-lasting immunity, but their developmental origins remain incompletely defined. Growing evidence suggests that functional heterogeneity exists within the naïve T cell pool, shaping lineage potential before an…

Engineered Zwitterionic Diblock Copolymer‐siRNA Polyplexes Provide Highly Effective Treatment of Triple‐Negative Breast Cancer in a 4T1 Murine Model Open

Taewon Jeon, Ritabrita Goswami, Harini Nagaraj, Yağız Anıl Çiçek, Victor Lehot , et al. · 2024

Self‐assembly of small interfering RNA (siRNA) with a block copolymer featuring guanidinium and zwitterion functionalized blocks generates core‐shell‐like nanovectors that provide cytosolic access to siRNA and efficiently evade phagocytic …

Loss of KANSL3 leads to defective inner cell mass and early embryonic lethality Open

Ashmita Chander, Jesse Mager · 2024

e–Lysine acetylation is a prominent histone mark found at transcriptionally active loci. Among many lysine acetyl transferases, nonspecific lethal complex (NSL) members are known to mediate the modification of histone H4. In addition to hi…

Tata-Binding Associated Factors are Essential for Distinct Roles During Early Mammalian Development Open

Xinjian He, Shelby Phillips, Kaito A. Hioki, PRABIN KUMAR MAJHI, Courtney C. Babbitt , et al. · 2024

Roles of the Rlim–Rex1 axis during X chromosome inactivation in mice Open

Feng Wang, Ashmita Chander, Yeonsoo Yoon, Janelle Welton, Mary C. Wallingford , et al. · 2023

In female mice, the gene dosage from X chromosomes is adjusted by a process called X chromosome inactivation (XCI) that occurs in two steps. An imprinted form of XCI (iXCI) that silences the paternally inherited X chromosome (Xp) is initia…

Exosome complex components 1 and 2 are vital for early mammalian development Open

Sanjana Srinivasan, Xinjian He, Sarah Mirza, Jesse Mager · 2023

Let-7 enhances murine anti-tumor CD8 T cell responses by promoting memory and antagonizing terminal differentiation Open

Alexandria Wells, Kaito A. Hioki, Constance C Angelou, Adam C. Lynch, Xueting Liang , et al. · 2023

hnRNPL expression dynamics in the embryo and placenta Open

Vineetha Mathew, Ariel Mei, Hamida Giwa, Agnes Cheong, Ashmita Chander , et al. · 2023

Engineered Polymer–siRNA Polyplexes Provide Effective Treatment of Lung Inflammation Open

Taewon Jeon, David C. Luther, Ritabrita Goswami, Charlotte Bell, Harini Nagaraj , et al. · 2023

Uncontrolled inflammation is responsible for acute and chronic diseases in the lung. Regulating expression of pro-inflammatory genes in pulmonary tissue using small interfering RNA (siRNA) is a promising approach to combatting respiratory …

Exosome Complex Components 1 and 2 are Vital for Early Mammalian Development Open

Sanjana Srinivasan, Jesse Mager, Xinjian He, Sarah Mirza · 2023

Antimicrobial polymer-siRNA polyplexes as a dual-mode platform for the treatment of wound biofilm infections Open

Taewon Jeon, Jessa Marie Makabenta, Jungmi Park, Ahmed Nabawy, Yağız Anıl Çiçek , et al. · 2023

Dual therapeutics use cationic polymers to kill bacteria and deliver siRNA to macrophages to decrease inflammation and enhance wound healing.

Early embryonic lethality of mice lacking POLD2 Open

Xiaoqing Wu, Yong Liu, Wenying Wang, Kate Crimmings, Andrea Williams , et al. · 2022

As a highly conserved DNA polymerase (Pol), Pol δ plays crucial roles in chromosomal DNA synthesis and various DNA repair pathways. However, the function of POLD2, the second small subunit of DNA Pol δ (p50 subunit), has not been character…

Cell autonomous requirement of imprinted XCI in extra-embryonic polar trophoblast cells Open

Feng Wang, Ashmita Chander, Yeonsoo Yoon, Mary C. Wallingford, Carmen Espejo-Serrano , et al. · 2022

Summary In female mice the gene dosage from X chromosomes is adjusted by a process called X chromosome inactivation (XCI) that occurs in two steps. An imprinted form of XCI (iXCI) silencing the paternally inherited X chromosome (Xp) is ini…

Mendelian gene identification through mouse embryo viability screening Open

Pilar Cacheiro, Carl Henrik Westerberg, Jesse Mager, Mary E. Dickinson, Lauryl M. J. Nutter , et al. · 2022

Background The diagnostic rate of Mendelian disorders in sequencing studies continues to increase, along with the pace of novel disease gene discovery. However, variant interpretation in novel genes not currently associated with disease is…

Deciphering the role of retinoic acid in hepatic patterning and induction in the mouse Open

Taylor M. Guertin, Amrita Palaria, Jesse Mager, Linda J. Sandell, Paul A. Trainor , et al. · 2022

Borcs6 is required for endo‐lysosomal degradation during early development Open

Charlotte J. Bell, Neha Gupta, Kimberly D. Tremblay, Jesse Mager · 2022

Early development and differentiation require precise control of cellular functions. Lysosomal degradation is a critical component of normal cellular homeostasis, allowing for degradation of signaling molecules, proteins, and other macromo…

Mendelian gene identification through mouse embryo viability screening Open

Pilar Cacheiro, Carl Henrik Westerberg, Jesse Mager, Mary E. Dickinson, Lauryl M. J. Nutter , et al. · 2022

The diagnostic rate of Mendelian disorders in sequencing studies continues to increase, along with the pace of novel disease gene discovery. However, variant interpretation in novel genes not currently associated with disease is particular…

Dynamic morphogenetic events characterize the mouse visceral endoderm Open

Jaime A. Rivera‐Pérez, Jesse Mager, Terry Magnuson · 2021

Several lines of evidence suggest that the extraembryonic endoderm of vertebrate embryos plays an important role in the development of rostral neural structures. In mice, neural inductive signals are thought to reside in an area of viscera…

Paternal preconception phthalate exposure alters sperm methylome and embryonic programming Open

Oladele Oluwayiose, Chelsea Marcho, Haotian Wu, Emily Houle, Stephen A. Krawetz , et al. · 2021

Preconception environmental conditions have been demonstrated to shape sperm epigenetics and subsequently offspring health and development. Our previous findings in humans showed that urinary anti-androgenic phthalate metabolites in males …

Author response: Deficient spermiogenesis in mice lacking Rlim Open

Feng Wang, Marıá Gracia Gervasi, Ana Bošković, Fengyun Sun, Vera D. Rinaldi , et al. · 2021

Nanotherapeutics using all-natural materials. Effective treatment of wound biofilm infections using crosslinked nanoemulsions Open

Cheng-Hsuan Li, Ryan F. Landis, Jessa Marie Makabenta, Ahmed Nabawy, Tiphaine Tronchet , et al. · 2021

All-natural cross-linked nanoemulsions provide effective treatment of wound biofilm infections.

ZC3H4—a novel Cys-Cys-Cys-His-type zinc finger protein—is essential for early embryogenesis in mice† Open

Jianmin Su, Xiaosu Miao, Danielle Archambault, Jesse Mager, Wei Cui · 2020

Zinc finger domains of the Cys-Cys-Cys-His (CCCH) class are evolutionarily conserved proteins that bind nucleic acids and are involved in various biological processes. Nearly 60 CCCH-type zinc finger proteins have been identified in humans…

Loss of POLR1D results in embryonic lethality prior to blastocyst formation in mice Open

Xiaosu Miao, Tieqi Sun, Morgane Golan, Jesse Mager, Wei Cui · 2020

In eukaryotic cells, RNA polymerase (Pol) I and Pol III are dedicated to the synthesis of ribosomal RNA precursors and a variety of small RNAs, respectively. Although RNA Pol I and Pol III complexes are crucial for the regulation of cell g…

Expression analysis of mammalian mitochondrial ribosomal protein genes Open

Agnes Cheong, Ranjana Lingutla, Jesse Mager · 2020

Deficient spermiogenesis in mice lacking<i>Rlim</i> Open

Feng Wang, Marıá Gracia Gervasi, Ana Bošković, Fengyun Sun, Vera D. Rinaldi , et al. · 2020

Summary The X-linked gene Rlim plays major roles in female mouse development and reproduction, where it is crucial for the maintenance of imprinted X chromosome inactivation in extraembryonic tissues of embryos. However, while females carr…

Protein phosphatase 1 regulatory subunit 35 is required for ciliogenesis, notochord morphogenesis, and cell-cycle progression during murine development Open

Danielle Archambault, Agnes Cheong, Elizabeth Iverson, Kimberly D. Tremblay, Jesse Mager · 2020

The people behind the papers – Agnes Cheong and Jesse Mager Open

Agnes Cheong, Jesse Mager, Jesse At · 2020

Nuclear-encoded mitochondrial ribosomal proteins (MRPs) are crucial for mitochondrial function and hence cellular energy production. A new paper in Development investigates the function of MRPs in early mouse development, thanks to a batte…

Loss of RBBP4 results in defective inner cell mass, severe apoptosis, hyperacetylated histones and preimplantation lethality in mice† Open

Xiaosu Miao, Tieqi Sun, Holly L Barletta, Jesse Mager, Wei Cui · 2020

Retinoblastoma-binding protein 4 (RBBP4) (also known as chromatin-remodeling factor RBAP48) is an evolutionarily conserved protein that has been involved in various biological processes. Although a variety of functions have been attributed…

Nuclear encoded mitochondrial ribosomal proteins are required to initiate gastrulation Open

Agnes Cheong, Danielle Archambault, Rinat Degani, Elizabeth Iverson, Kimberly D. Tremblay , et al. · 2020

Mitochondria are essential for energy production and while they have their own genome, many nuclear-encoded mitochondrial ribosomal proteins (MRPs) are required for proper function of the organelle. Although mutations in MRPs have been ass…

Transient Sperm Starvation Improves the Outcome of Assisted Reproductive Technologies Open

Felipe Navarrete, Luis Águila, David Martín‐Hidalgo, Darya A. Tourzani, Guillermina M. Luque , et al. · 2019

To become fertile, mammalian sperm must undergo a series of biochemical and physiological changes known as capacitation. These changes involve crosstalk between metabolic and signaling pathways and can be recapitulated in vitro. In …

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