Jesse R. McLean
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View article: International Survey: Ventricular Assist Device Program Staffing Structure and the Role of VAD Coordinator
International Survey: Ventricular Assist Device Program Staffing Structure and the Role of VAD Coordinator Open
View article: Pandemic Responsiveness in an Acute Care Setting: A Community Hospital’s Utilization of Operational Resources During COVID-19
Pandemic Responsiveness in an Acute Care Setting: A Community Hospital’s Utilization of Operational Resources During COVID-19 Open
A community hospital's operational preparedness for COVID-19 was supported by inter-operability, leveraging internal and external expertise and partnerships, creative problem solving, and developing novel tools to support occupational heal…
View article: Glucocerebrosidase gene therapy prevents α-synucleinopathy of midbrain dopamine neurons
Glucocerebrosidase gene therapy prevents α-synucleinopathy of midbrain dopamine neurons Open
Diminished lysosomal function can lead to abnormal cellular accumulation of specific proteins, including α-synuclein, contributing to disease pathogenesis of vulnerable neurons in Parkinson's disease (PD) and related α-synucleinopathies. G…
View article: Isoform‐specific antibodies reveal distinct subcellular localizations of <scp>C</scp>9orf72 in amyotrophic lateral sclerosis
Isoform‐specific antibodies reveal distinct subcellular localizations of <span>C</span>9orf72 in amyotrophic lateral sclerosis Open
Objective A noncoding hexanucleotide repeat expansion in C9orf72 is the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). It has been reported that the repeat expansion causes a downregu…
View article: Sustained Systemic Glucocerebrosidase Inhibition Induces Brain α-Synuclein Aggregation, Microglia and Complement C1q Activation in Mice
Sustained Systemic Glucocerebrosidase Inhibition Induces Brain α-Synuclein Aggregation, Microglia and Complement C1q Activation in Mice Open
These data reveal a link between reduced glucocerebrosidase and the development of α-synucleinopathy and pathophysiological abnormalities in mice, and support the development of GCase therapeutics to reduce α-synucleinopathy in PD and rela…
View article: Jump from Pre-mutation to Pathologic Expansion in C9orf72
Jump from Pre-mutation to Pathologic Expansion in C9orf72 Open
View article: A Nurr1 Agonist Causes Neuroprotection in a Parkinson’s Disease Lesion Model Primed with the Toll-Like Receptor 3 dsRNA Inflammatory Stimulant Poly(I:C)
A Nurr1 Agonist Causes Neuroprotection in a Parkinson’s Disease Lesion Model Primed with the Toll-Like Receptor 3 dsRNA Inflammatory Stimulant Poly(I:C) Open
Dopaminergic neurons in the substantia nigra pars compacta (SNpc) are characterized by the expression of genes required for dopamine synthesis, handling and reuptake and the expression of these genes is largely controlled by nuclear recept…