Jesse Mindel
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View article: OSA symptom subtypes and hypoxic burden independently predict distinct cardiovascular outcomes
OSA symptom subtypes and hypoxic burden independently predict distinct cardiovascular outcomes Open
Study objectives Studies on obstructive sleep apnoea (OSA) have identified clinically relevant symptom-based subtypes and novel OSA-specific nocturnal hypoxic measures. Both traits are individually associated with cardiovascular outcomes, …
View article: 0437 Obstructive Sleep Apnea Symptom Subtypes and Hypoxic Burden Independently Predict Distinct Cardiovascular Outcomes
0437 Obstructive Sleep Apnea Symptom Subtypes and Hypoxic Burden Independently Predict Distinct Cardiovascular Outcomes Open
Introduction Studies on heterogeneity of obstructive sleep apnea (OSA) have identified clinically relevant symptom-based subtypes and novel OSA-specific nocturnal hypoxemia measures. Evidence suggests that moderate-severe OSA patients with…
View article: A phase 1 open‐label trial evaluating focused ultrasound unilateral anterior thalamotomy for focal onset epilepsy
A phase 1 open‐label trial evaluating focused ultrasound unilateral anterior thalamotomy for focal onset epilepsy Open
Objective Focused ultrasound ablation (FUSA) is an emerging treatment for neurological and psychiatric diseases. We describe the initial experience from a pilot, open‐label, single‐center clinical trial of unilateral anterior nucleus of th…
View article: 0038 Sleeping with Low Levels of Artificial Light at Night Increases Systemic Inflammation in Humans
0038 Sleeping with Low Levels of Artificial Light at Night Increases Systemic Inflammation in Humans Open
Artificial light at night (ALAN) has become a ubiquitous part of our society. Animal studies have shown that ALAN exposure promotes a depressive-like mood and increases peripheral inflammation likely due to circadian disruption. We hypothe…
View article: 0459 Diagnostic Performance of Symptomless Obstructive Sleep Apnea Prediction Tools in Clinical and Community-based Samples
0459 Diagnostic Performance of Symptomless Obstructive Sleep Apnea Prediction Tools in Clinical and Community-based Samples Open
Most prediction tools for obstructive sleep apnea (OSA) include patient reported symptoms. However, symptoms may not be available in electronic medical records for widespread identification of OSA. Thus, we developed OSA predictions withou…
View article: Opportunities for utilizing polysomnography signals to characterize obstructive sleep apnea subtypes and severity
Opportunities for utilizing polysomnography signals to characterize obstructive sleep apnea subtypes and severity Open
Together with current technological advance, it is only a matter of time before advanced automatic signal processing and analysis is widely applied to precision medicine of OSA in the clinical setting.
View article: Recognizable clinical subtypes of obstructive sleep apnea across international sleep centers: a cluster analysis
Recognizable clinical subtypes of obstructive sleep apnea across international sleep centers: a cluster analysis Open
Results confirm and extend previously identified clinical clusters in OSA. These clusters provide an opportunity for a more personalized approach to the management of OSA.
View article: 0460 DEFINING OSA EXTREME PHENOTYPES ACROSS THE WORLD: A SLEEP APNEA GLOBAL INTERDISCIPLINARY CONSORTIUM EFFORT
0460 DEFINING OSA EXTREME PHENOTYPES ACROSS THE WORLD: A SLEEP APNEA GLOBAL INTERDISCIPLINARY CONSORTIUM EFFORT Open
Obstructive sleep apnea (OSA) is a common disorder with complex pathophysiology and heterogeneous clinical presentation, making it challenging to identify underlying biological factors. This study aims to characterize extreme phenotypes of…