Jesse Pellman
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View article: Expanding the druggable zinc-finger proteome defines properties of drug-induced degradation
Expanding the druggable zinc-finger proteome defines properties of drug-induced degradation Open
Glutarimide analogs, such as thalidomide, redirect the E3 ubiquitin ligase CRL4CRBN to induce degradation of certain zinc finger (ZF) proteins. Although the core structural motif recognized by CRBN has been characterized, it does not fully…
View article: Human E3 ubiquitin ligases: accelerators and brakes for SARS-CoV-2 infection
Human E3 ubiquitin ligases: accelerators and brakes for SARS-CoV-2 infection Open
E3 ubiquitin ligases regulate the composition of the proteome. These enzymes mono- or poly-ubiquitinate their substrates, directly altering protein function or targeting proteins for degradation by the proteasome. In this review, we discus…