Explanipedia

Visualizing PIEZO1 localization and activity in hiPSC-derived single cells and organoids with HaloTag technology Open

Gabriella A. Bertaccini, Ignasi Casanellas, Elizabeth L. Evans, Jamison L. Nourse, George D. Dickinson , et al. · 2025

PIEZO1 regulates leader cell formation and cellular coordination during collective keratinocyte migration Open

Jinghao Chen, Jesse R. Holt, Elizabeth L. Evans, John Lowengrub, Medha M. Pathak · 2024

The collective migration of keratinocytes during wound healing requires both the generation and transmission of mechanical forces for individual cellular locomotion and the coordination of movement across cells. Leader cells along the woun…

Visualizing PIEZO1 Localization and Activity in hiPSC-Derived Single Cells and Organoids with HaloTag Technology Open

Gabriella A. Bertaccini, Ignasi Casanellas, Elizabeth L. Evans, Jamison L. Nourse, George D. Dickinson , et al. · 2023

PIEZO1 is critical to numerous physiological processes, transducing diverse mechanical stimuli into electrical and chemical signals. Recent studies underscore the importance of visualizing endogenous PIEZO1 activity and localization to und…

PIEZO1 regulates leader cell formation and cellular coordination during collective keratinocyte migration Open

Jinghao Chen, Jesse R. Holt, Elizabeth L. Evans, John Lowengrub, Medha M. Pathak · 2022

The collective migration of keratinocytes during wound healing requires both the generation and transmission of mechanical forces for individual cellular locomotion and the coordination of movement across cells. Leader cells along the woun…

Correction: Spatiotemporal dynamics of PIEZO1 localization controls keratinocyte migration during wound healing Open

Jesse R. Holt, Wei-Zheng Zeng, Elizabeth L. Evans, Seung‐Hyun Woo, Shang Ma , et al. · 2022

Spatiotemporal dynamics of PIEZO1 localization controls keratinocyte migration during wound healing Open

Jesse R. Holt, Wei-Zheng Zeng, Elizabeth L. Evans, Seung‐Hyun Woo, Shang Ma , et al. · 2021

Keratinocytes, the predominant cell type of the epidermis, migrate to reinstate the epithelial barrier during wound healing. Mechanical cues are known to regulate keratinocyte re-epithelialization and wound healing; however, the underlying…

Author response: Spatiotemporal dynamics of PIEZO1 localization controls keratinocyte migration during wound healing Open

Jesse R. Holt, Wei-Zheng Zeng, Elizabeth L. Evans, Seung‐Hyun Woo, Shang Ma , et al. · 2021

Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Keratinocytes, the predominan…

Piezo1 channels restrain regulatory T cells but are dispensable for effector CD4 <sup>+</sup> T cell responses Open

Amit Jairaman, Shivashankar Othy, Joseph L. Dynes, Andriy V. Yeromin, Angel Zavala , et al. · 2021

Mechanosensitive Piezo1 channels restrict regulatory T cell expansion and limit disease remission in EAE.

Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing Open

Hamza Atcha, Amit Jairaman, Jesse R. Holt, Vijaykumar S. Meli, Raji R. Nagalla , et al. · 2021

Myosin-II mediated traction forces evoke localized Piezo1-dependent Ca2+ flickers Open

Kyle L. Ellefsen, Jesse R. Holt, Alice C. Chang, Jamison L. Nourse, Janahan Arulmoli , et al. · 2019

Myosin-II Mediated Traction Forces Evoke Localized Piezo1 Ca2+ Flickers Open

Kyle L. Ellefsen, Alice C. Chang, Jamison L. Nourse, Jesse R. Holt, Janahan Arulmoli , et al. · 2019

When rats rescue robots Open

Laleh K. Quinn, Luisa P. Schuster, Marcelo Aguilar‐Rivera, Joshua Arnold, David Ball , et al. · 2018

Robots are increasingly being used to monitor and even participate in social interactions with animals in their own environments. Robotic animals enable social behaviors to be observed in natural environments, or specifically elicited unde…

Myosin-II mediated traction forces evoke localized Piezo1 Ca<sup>2+</sup> flickers Open

Kyle L. Ellefsen, Jesse R. Holt, Alice C. Chang, Jamison L. Nourse, Janahan Arulmoli , et al. · 2018

Piezo channels transduce mechanical stimuli into electrical and chemical signals, and in doing so, powerfully influence development, tissue homeostasis, and regeneration. While much is known about how Piezo1 responds to external forces, it…

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