Jessica E. Frith
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A Visible Light‐Responsive Hydrogel to Study the Effect of Dynamic Tissue Stiffness on Cellular Mechanosensing Open
Dynamic changes in elasticity during tissue development, remodeling, and aging influence cell behavior through mechanotransduction, yet most studies rely on hydrogels with fixed mechanical properties. Although photoresponsive azobenzene‐ba…
View article: Transcriptome‐Optimized Hydrogel Design of a Stem Cell Niche for Enhanced Tendon Regeneration
Transcriptome‐Optimized Hydrogel Design of a Stem Cell Niche for Enhanced Tendon Regeneration Open
Bioactive hydrogels have emerged as promising artificial niches for enhancing stem cell‐mediated tendon repair. However, a substantial knowledge gap remains regarding the optimal combination of niche features for targeted cellular response…
View article: Creation of Grooved Tissue Engineering Scaffolds from Architectured Multilayer Polymer Composites by a Tuneable One‐Step Degradation Process
Creation of Grooved Tissue Engineering Scaffolds from Architectured Multilayer Polymer Composites by a Tuneable One‐Step Degradation Process Open
The surface properties of biomaterials interact directly with biological systems, influencing cellular responses, tissue integration, and biocompatibility. Surface topography plays a critical role in cardiac tissue engineering by affecting…
Delivery of miRNAs Using Porous Silicon Nanoparticles Incorporated into 3D Hydrogels Enhances MSC Osteogenesis by Modulation of Fatty Acid Signaling and Silicon Degradation Open
Strategies incorporating mesenchymal stromal cells (MSC), hydrogels and osteoinductive signals offer promise for bone repair. Osteoinductive signals such as growth factors face challenges in clinical translation due to their high cost, low…
Global signatures of the human mesenchymal stromal cell secretome: A comparative proteomic analysis of iPSC and tissue-derived MSC secretomes before and after inflammatory licensing Open
Multipotent mesenchymal stromal cells (MSCs) are one of the most heavily studied cell therapies worldwide, with much of their therapeutic potential underpinned by their complex secretory profiles. Like MSCs themselves, their secretome vari…
View article: Substrate mechanical properties bias MSC paracrine activity and therapeutic potential
Substrate mechanical properties bias MSC paracrine activity and therapeutic potential Open
Mesenchymal stromal cells (MSCs) have significant therapeutic potential due to their ability to differentiate into musculoskeletal lineages suitable for tissue-engineering, as well as the immunomodulatory and pro-regenerative effects of th…
View article: Fabrication of Architectured Biomaterials by Multilayer Co‐Extrusion and Additive Manufacturing
Fabrication of Architectured Biomaterials by Multilayer Co‐Extrusion and Additive Manufacturing Open
Tissue engineering benefits from advances in 3D printing and multi‐material assembly to attain certain functional benefits over existing man‐made materials. Multilayered tissue engineering constructs might unlock a unique combination of pr…
View article: Effect of 2D and 3D Culture Microenvironments on Mesenchymal Stem Cell-Derived Extracellular Vesicles Potencies
Effect of 2D and 3D Culture Microenvironments on Mesenchymal Stem Cell-Derived Extracellular Vesicles Potencies Open
Therapeutic benefits of mesenchymal stem cells (MSCs) are now widely believed to come from their paracrine signalling, i.e. secreted factors such as cytokines, chemokines, and extracellular vesicles (EVs). Cell-free therapy using EVs is an…
Review: Nanomaterials for Reactive Oxygen Species Detection and Monitoring in Biological Environments Open
Reactive oxygen species (ROS) and dissolved oxygen play key roles across many biological processes, and fluorescent stains and dyes are the primary tools used to quantify these species in vitro. However, spatio-temporal monitoring of ROS a…
View article: Next Generation Cell Culture Tools Featuring Micro‐ and Nanotopographies for Biological Screening
Next Generation Cell Culture Tools Featuring Micro‐ and Nanotopographies for Biological Screening Open
Cells can perceive complex mechanical cues across both the micro‐ and nanoscale which can influence their development. While causative effects between surface topography and cellular function can be demonstrated, the variability in materia…
View article: Precision Surface Microtopography Regulates Cell Fate via Changes to Actomyosin Contractility and Nuclear Architecture
Precision Surface Microtopography Regulates Cell Fate via Changes to Actomyosin Contractility and Nuclear Architecture Open
Cells are able to perceive complex mechanical cues from their microenvironment, which in turn influences their development. Although the understanding of these intricate mechanotransductive signals is evolving, the precise roles of substra…
View article: Osteogenic Potential of Additively Manufactured TiTa Alloys
Osteogenic Potential of Additively Manufactured TiTa Alloys Open
The only alloy currently utilized for additive manufacture of bone implants, Ti–6Al–4V, has a high elastic modulus and bioinert surface, potentially inducing stress shielding and hindering osseointegration. Low-modulus materials with bioac…
View article: Editorial: Stem Cells as Targeted Drug Delivery Vehicles
Editorial: Stem Cells as Targeted Drug Delivery Vehicles Open
EDITORIAL article Front. Pharmacol., 21 December 2020Sec. Translational Pharmacology https://doi.org/10.3389/fphar.2020.614730
Microencapsulation improves chondrogenesis<i>in vitro</i>and cartilaginous matrix stability<i>in vivo</i>compared to bulk encapsulation Open
The encapsulation of cells into microgels is attractive for applications in tissue regeneration.
View article: Cell Adhesion, Morphology, and Metabolism Variation via Acoustic Exposure within Microfluidic Cell Handling Systems
Cell Adhesion, Morphology, and Metabolism Variation via Acoustic Exposure within Microfluidic Cell Handling Systems Open
Acoustic fields are capable of manipulating biological samples contained within the enclosed and highly controlled environment of a microfluidic chip in a versatile manner. The use of acoustic streaming to alter fluid flows and radiation f…
Understanding the effects of PBF process parameter interplay on Ti-6Al-4V surface properties Open
Ti-6Al-4V is commonly used in orthopaedic implants, and fabrication techniques such as Powder Bed Fusion (PBF) are becoming increasingly popular for the net-shape production of such implants, as PBF allows for complex customisation and min…
View article: <i>In situ</i> miRNA delivery from a hydrogel promotes osteogenesis of encapsulated mesenchymal stromal cells
<i>In situ</i> miRNA delivery from a hydrogel promotes osteogenesis of encapsulated mesenchymal stromal cells Open
A bstract Hydrogels have many properties that emulate biological tissues and are therefore attractive candidates for use in tissue engineering. In particular the encapsulation and subsequent differentiation of mesenchymal stem/stromal cell…
Multiplicity of Mesenchymal Stromal Cells: Finding the Right Route to Therapy Open
Over the last decade, the acceleration in the clinical use of mesenchymal stromal cells (MSCs) has been nothing short of spectacular. Perhaps most surprising is how little we know about the "MSC product." Although MSCs are being delivered …
Bioorthogonal hydrogels by thiol–halide click crosslinking with fast gelation time and tunable stability in aqueous media Open
Thiol‐halide click reaction is utilized in polymer crosslinking to form hydrogels with tailored rate of disintegration suitable. The crosslinking process is bioorthogonal, which allows for encapsulation of living cells for three‐dimensiona…
View article: To Protect and to Preserve: Novel Preservation Strategies for Extracellular Vesicles
To Protect and to Preserve: Novel Preservation Strategies for Extracellular Vesicles Open
Extracellular vesicles (EVs)-based therapeutics are based on the premise that EVs shed by stem cells exert similar therapeutic effects and these have been proposed as an alternative to cell therapies. EV-mediated delivery is an effective a…
Additive Manufacturing of Titanium Alloys for Orthopedic Applications: A Materials Science Viewpoint Open
Titanium‐based orthopedic implants are increasingly being fabricated using additive manufacturing (AM) processes such as selective laser melting (SLM), direct laser deposition (DLD), and electron beam melting (EBM). These techniques have t…
Mechanical Properties and In Vitro Behavior of Additively Manufactured and Functionally Graded Ti6Al4V Porous Scaffolds Open
Functionally graded lattice structures produced by additive manufacturing are promising for bone tissue engineering. Spatial variations in their porosity are reported to vary the stiffness and make it comparable to cortical or trabecular b…
View article: Polyethylene glycol–gelatin hydrogels with tuneable stiffness prepared by horseradish peroxidase-activated tetrazine–norbornene ligation
Polyethylene glycol–gelatin hydrogels with tuneable stiffness prepared by horseradish peroxidase-activated tetrazine–norbornene ligation Open
Mild oxidation of dihydrogen tetrazine by horseradish peroxidase was utilised in bioorthogonal crosslinking, via tetrazine–norbornene ligation, of polyethylene glycol–gelatin hydrogels.
View article: Polyethylene glycol–gelatin hydrogels with tuneable stiffness prepared by horseradish peroxidase-activated tetrazine–norbornene ligation
Polyethylene glycol–gelatin hydrogels with tuneable stiffness prepared by horseradish peroxidase-activated tetrazine–norbornene ligation Open
Tetrazine–norbornene ligation has previously been applied in bioorthognal polymer crosslinking to form hydrogels suitable for 3D cell culture. However, the tetrazine group is prone to reduction by the free thiol in a biological environment…
Microfluidic Encapsulation of Human Mesenchymal Stem Cells for Articular Cartilage Tissue Regeneration Open
Stem cell injections for the treatment of articular cartilage damage are a promising approach to achieve tissue regeneration. However, this method is encumbered by high cell apoptosis rates, low retention in the cartilage lesion, and ineff…