Jessica L. Abel
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View article: Efficacy of Linaclotide in Reducing Abdominal Symptoms of Bloating, Discomfort, and Pain: A Phase 3B Trial Using a Novel Abdominal Scoring System
Efficacy of Linaclotide in Reducing Abdominal Symptoms of Bloating, Discomfort, and Pain: A Phase 3B Trial Using a Novel Abdominal Scoring System Open
INTRODUCTION: Linaclotide improves abdominal pain and constipation in patients with constipation-predominant irritable bowel syndrome (IBS-C). Patients report additional bothersome abdominal symptoms of bloating and discomfort. The intenti…
View article: Improved work productivity and health-related quality of life in patients with irritable bowel syndrome with diarrhea receiving eluxadoline following inadequate response to loperamide
Improved work productivity and health-related quality of life in patients with irritable bowel syndrome with diarrhea receiving eluxadoline following inadequate response to loperamide Open
BACKGROUND: Irritable bowel syndrome with diarrhea (IBS-D) is a chronic disorder of gut-brain interaction that negatively affects work productivity and health-related quality of life (HRQOL). IBS-D therapeutic options are limited an…
View article: Lessons learned: Chronic idiopathic constipation patient experiences with over-the-counter medications
Lessons learned: Chronic idiopathic constipation patient experiences with over-the-counter medications Open
Introduction Chronic idiopathic constipation (CIC) is a prevalent functional gastrointestinal disorder diagnosed based on patient-reported symptoms and the absence of structural gastrointestinal abnormalities. Individuals with CIC typicall…
View article: Comprehensive assessment of patients with irritable bowel syndrome with constipation and chronic idiopathic constipation using deterministically linked administrative claims and patient-reported data: the Chronic Constipation and IBS-C Treatment and Outcomes Real-World Research Platform (CONTOR)
Comprehensive assessment of patients with irritable bowel syndrome with constipation and chronic idiopathic constipation using deterministically linked administrative claims and patient-reported data: the Chronic Constipation and IBS-C Treatment and Outcomes Real-World Research Platform (CONTOR) Open
By combining administrative claims and patient-reported data over time, CONTOR afforded a deeper understanding of the IBS-C/CIC patient experience than could be achieved with 1 data source alone; for example, participants self-reported bur…
View article: Psychometric Analysis of the Abdominal Score From the Diary for Irritable Bowel Syndrome Symptoms–Constipation Using Phase IIb Clinical Trial Data
Psychometric Analysis of the Abdominal Score From the Diary for Irritable Bowel Syndrome Symptoms–Constipation Using Phase IIb Clinical Trial Data Open
Overall, this study provides evidence that the DIBSS-C abdominal score is valid, reliable, responsive to change, and interpretable for assessing treatment benefit in patients with IBS-C.
View article: The Impact of Stool Consistency on Bowel Movement Satisfaction in Patients With IBS-C or CIC Treated With Linaclotide or Other Medications
The Impact of Stool Consistency on Bowel Movement Satisfaction in Patients With IBS-C or CIC Treated With Linaclotide or Other Medications Open
Goals: This study aimed to characterize the impact of stool consistency on patient-reported bowel movement (BM) satisfaction in patients with irritable bowel syndrome with constipation (IBS-C) or chronic idiopathic constipation, with a foc…
View article: Su1587 – New Patient Reported Outcome Measure: Diary for Irritable Bowel Syndrome Symptoms—Constipation, Guidelines for Interpretation of Change in Abdominal Symptoms Using Phase 2B Clinical Trial Data
Su1587 – New Patient Reported Outcome Measure: Diary for Irritable Bowel Syndrome Symptoms—Constipation, Guidelines for Interpretation of Change in Abdominal Symptoms Using Phase 2B Clinical Trial Data Open
View article: The impact of treatment with eluxadoline on health-related quality of life among adult patients with irritable bowel syndrome with diarrhea
The impact of treatment with eluxadoline on health-related quality of life among adult patients with irritable bowel syndrome with diarrhea Open
Compared to placebo, twice-daily eluxadoline treatment significantly improved HRQOL among patients with IBS-D in two phase III trials.
View article: A32 IMPACT OF DISEASE SEVERITY ON HEALTH-RELATED QUALITY OF LIFE AMONG PATIENTS WITH IRRITABLE BOWEL SYNDROME WITH DIARRHEA
A32 IMPACT OF DISEASE SEVERITY ON HEALTH-RELATED QUALITY OF LIFE AMONG PATIENTS WITH IRRITABLE BOWEL SYNDROME WITH DIARRHEA Open
BACKGROUND: Irritable bowel syndrome with diarrhea (IBS-D) is a chronic gastrointestinal disorder shown to significantly impact patients’ health-related quality of life (HRQoL). The relationship between IBS-D disease severity and HRQoL imp…