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View article: Defective Olfactomedin-2 connects adipocyte dysfunction to obesity
Defective Olfactomedin-2 connects adipocyte dysfunction to obesity Open
View article: Exploring differential miRNA expression profiles in muscular and visceral adipose tissue of patients with severe obesity
Exploring differential miRNA expression profiles in muscular and visceral adipose tissue of patients with severe obesity Open
This is the first study unveiling distinct miRNA expression profiles in paired samples of visceral adipose tissue and skeletal muscle in humans. The identification of obesity-specific miRNAs in these tissues opens up promising avenues for …
View article: A novel long non-coding RNA connects obesity to impaired adipocyte function
A novel long non-coding RNA connects obesity to impaired adipocyte function Open
View article: Gut microbiota signatures of vulnerability to food addiction in mice and humans
Gut microbiota signatures of vulnerability to food addiction in mice and humans Open
Objective Food addiction is a multifactorial disorder characterised by a loss of control over food intake that may promote obesity and alter gut microbiota composition. We have investigated the potential involvement of the gut microbiota i…
View article: Lack of the Histone Deacetylase SIRT1 Leads to Protection against Endoplasmic Reticulum Stress through the Upregulation of Heat Shock Proteins
Lack of the Histone Deacetylase SIRT1 Leads to Protection against Endoplasmic Reticulum Stress through the Upregulation of Heat Shock Proteins Open
Histone deacetylase SIRT1 represses gene expression through the deacetylation of histones and transcription factors and is involved in the protective cell response to stress and aging. However, upon endoplasmic reticulum (ER) stress, SIRT1…
View article: Potential therapeutic implications of histidine catabolism by the gut microbiota in NAFLD patients with morbid obesity
Potential therapeutic implications of histidine catabolism by the gut microbiota in NAFLD patients with morbid obesity Open
View article: Inflammatory response to bacterial lipopolysaccharide drives iron accumulation in human adipocytes
Inflammatory response to bacterial lipopolysaccharide drives iron accumulation in human adipocytes Open
The association among increased inflammation, disrupted iron homeostasis, and adipose tissue dysfunction in obesity has been widely recognized. However, the specific impact of inflammation on iron homeostasis during human adipogenesis and …
View article: Impaired Plakophilin-2 in obesity breaks cell cycle dynamics to breed adipocyte senescence
Impaired Plakophilin-2 in obesity breaks cell cycle dynamics to breed adipocyte senescence Open
View article: Adipose tissue coregulates cognitive function
Adipose tissue coregulates cognitive function Open
Obesity is associated with cognitive decline. Recent observations in mice propose an adipose tissue (AT)–brain axis. We identified 188 genes from RNA sequencing of AT in three cohorts that were associated with performance in different cogn…
View article: Downregulated adipose tissue expression of browning genes with increased environmental temperatures
Downregulated adipose tissue expression of browning genes with increased environmental temperatures Open
<p>The main study has investigated how the outside temperature might impact on adipose tissue physiology and metabolic traits, in which different regions of the same country were compared. <br>\n<br>\nTable 1 sh…
View article: Impaired Plakophilin-2 in obesity breaks cell cycle dynamics to breed adipocyte senescence
Impaired Plakophilin-2 in obesity breaks cell cycle dynamics to breed adipocyte senescence Open
Raw data multiomics for NCOMMS-22-35714A
View article: Liver lipopolysaccharide binding protein prevents hepatic inflammation in physiological and pathological non-obesogenic conditions
Liver lipopolysaccharide binding protein prevents hepatic inflammation in physiological and pathological non-obesogenic conditions Open
Lipopolysaccharide binding protein (LBP) knockout mice models are protected against the deleterious effects of major acute inflammation but its possible physiological role has been less well studied. We aimed to evaluate the impact of live…
View article: The relevance of EGFR, ErbB receptors and neuregulins in human adipocytes and adipose tissue in obesity
The relevance of EGFR, ErbB receptors and neuregulins in human adipocytes and adipose tissue in obesity Open
View article: DPP9 as a Potential Novel Mediator in Gastrointestinal Virus Infection
DPP9 as a Potential Novel Mediator in Gastrointestinal Virus Infection Open
Dipeptidyl peptidase 9 (DPP9) is a member of the dipeptidyl peptidase IV family. Inhibition of DPP9 has recently been shown to activate the nucleotide-binding domain leucine-rich repeat 1 (NLRP1) inflammasome. NLRP1 is known to bind nuclei…
View article: Adipose tissue cysteine dioxygenase type 1 is associated with an anti-inflammatory profile, impacting on systemic metabolic traits
Adipose tissue cysteine dioxygenase type 1 is associated with an anti-inflammatory profile, impacting on systemic metabolic traits Open
This work was partially supported by research grants PI16/01173, PI19/01712, PI20/01090 and PI21/01361 from the Instituto de Salud Carlos III from Spain, Fondo Europeo de Desarrollo Regional (FEDER) funds, and VII Spanish Diabetes Associat…
View article: Serum neuregulin 4 is negatively correlated with insulin sensitivity in humans and impairs mitochondrial respiration in HepG2 cells
Serum neuregulin 4 is negatively correlated with insulin sensitivity in humans and impairs mitochondrial respiration in HepG2 cells Open
Neuregulin 4 (NRG4) has been described to improve metabolic disturbances linked to obesity status in rodent models. The findings in humans are controversial. We aimed to investigate circulating NRG4 in association with insulin action in hu…
View article: Downregulation of hepatic lipopolysaccharide binding protein improves lipogenesis-induced liver lipid accumulation
Downregulation of hepatic lipopolysaccharide binding protein improves lipogenesis-induced liver lipid accumulation Open
Circulating lipopolysaccharide-binding protein (LBP) is increased in individuals with liver steatosis. We aimed to evaluate the possible impact of liver LBP downregulation using lipid nanoparticle-containing chemically modified LBP small i…
View article: A compound directed against S6K1 hampers fat mass expansion and mitigates diet-induced hepatosteatosis
A compound directed against S6K1 hampers fat mass expansion and mitigates diet-induced hepatosteatosis Open
The ribosomal protein S6 kinase 1 (S6K1) is a relevant effector downstream of the mammalian target of rapamycin complex 1 (mTORC1), best known for its role in the control of lipid homeostasis. Consistent with this, mice lacking the S6k1 ge…
View article: Lysozyme Gene Expression in 3T3-L1 Cells Sustains Expression of Adipogenic Genes and Adipocyte Differentiation
Lysozyme Gene Expression in 3T3-L1 Cells Sustains Expression of Adipogenic Genes and Adipocyte Differentiation Open
Substantial levels of lysozyme in adipose tissue in association to obesity have been recently demonstrated in mice and humans. In addition, experiments in mice suggest that lysozyme might impact on adipose tissue adipogenesis. To further i…
View article: The Combined Partial Knockdown of CBS and MPST Genes Induces Inflammation, Impairs Adipocyte Function-Related Gene Expression and Disrupts Protein Persulfidation in Human Adipocytes
The Combined Partial Knockdown of CBS and MPST Genes Induces Inflammation, Impairs Adipocyte Function-Related Gene Expression and Disrupts Protein Persulfidation in Human Adipocytes Open
Recent studies in mice and humans demonstrated the relevance of H2S synthesising enzymes, such as CTH, CBS, and MPST, in the physiology of adipose tissue and the differentiation of preadipocyte into adipocytes. Here, our objective was to i…
View article: Downregulation of peripheral lipopolysaccharide binding protein impacts on perigonadal adipose tissue only in female mice
Downregulation of peripheral lipopolysaccharide binding protein impacts on perigonadal adipose tissue only in female mice Open
View article: Specific adipose tissue Lbp gene knockdown prevents diet-induced body weight gain, impacting fat accretion-related gene and protein expression
Specific adipose tissue Lbp gene knockdown prevents diet-induced body weight gain, impacting fat accretion-related gene and protein expression Open
View article: A compound directed against S6K1 hampers fat mass expansion and mitigates diet-induced hepatosteatosis
A compound directed against S6K1 hampers fat mass expansion and mitigates diet-induced hepatosteatosis Open
We present here liver lipidomic data from eight-week old male C57BL/6N wild-type mice receving normal chow diet (NCD), high-fat diet (HFD) or a combination of high-fat diet treated with the S6K1 inhibitor LY2584702 tosylate (HFD+LY) during…
View article: A microRNA Cluster Controls Fat Cell Differentiation and Adipose Tissue Expansion By Regulating SNCG
A microRNA Cluster Controls Fat Cell Differentiation and Adipose Tissue Expansion By Regulating SNCG Open
The H19X‐encoded miR‐424(322)/503 cluster regulates multiple cellular functions. Here, it is reported for the first time that it is also a critical linchpin of fat mass expansion. Deletion of this miRNA cluster in mice results in obesity, …
View article: Iron status influences non-alcoholic fatty liver disease in obesity through the gut microbiome
Iron status influences non-alcoholic fatty liver disease in obesity through the gut microbiome Open
View article: Additional file 2 of Iron status influences non-alcoholic fatty liver disease in obesity through the gut microbiome
Additional file 2 of Iron status influences non-alcoholic fatty liver disease in obesity through the gut microbiome Open
Additional file 1:. Baseline characteristics of the independent cohort.
View article: Additional file 3 of Iron status influences non-alcoholic fatty liver disease in obesity through the gut microbiome
Additional file 3 of Iron status influences non-alcoholic fatty liver disease in obesity through the gut microbiome Open
Additional file 2:. Gut microbiome bacterial species associated with the serum ferritin. Results of differential bacterial abundance associated with ferritin as calculated from shotgun metagenomic sequencing in an independent cohort of obe…
View article: Additional file 5 of Iron status influences non-alcoholic fatty liver disease in obesity through the gut microbiome
Additional file 5 of Iron status influences non-alcoholic fatty liver disease in obesity through the gut microbiome Open
Additional file 4:. Metagenome functions based on EggNOG annotation associated with the serum ferritin. Results of metagenome EggNOG functions associated with ferritin as calculated from shotgun metagenomic sequencing in an independent coh…
View article: A microRNA cluster controls fat cell differentiation and adipose tissue expansion by regulating SNCG
A microRNA cluster controls fat cell differentiation and adipose tissue expansion by regulating SNCG Open
We present here lipidomic data from subcutaneous adipose tissue from 20 miR-KO mice and Wt controls under normal chow (1:1, male/females) (5 animals/experimental condition). Prior to lipid extraction, fat samples were spiked with internal …
View article: Additional file 4 of Iron status influences non-alcoholic fatty liver disease in obesity through the gut microbiome
Additional file 4 of Iron status influences non-alcoholic fatty liver disease in obesity through the gut microbiome Open
Additional file 3:. Metagenome functions based on KEGG annotation associated with the serum ferritin. Results of metagenome KEGG functions associated with ferritin as calculated from shotgun metagenomic sequencing in an independent cohort …