Explanipedia

Enabling dual hazard assessment for single-chain polychlorinated n-alkane mixtures at environmentally relevant levels: a proof of concept Open

Louise van Mourik, Jessica Legradi, Quinn Groenewoud, Caroline Pérez, Peter Cenijn , et al. · 2025

Physiology-informed toxicokinetic model for the zebrafish embryo test developed for bisphenols Open

Ioana Chelcea, Carolina Vogs, Timo Hamers, Jacco Koekkoek, Jessica Legradi , et al. · 2023

A comprehensive untargeted metabolomics study in zebrafish embryos exposed to perfluorohexane sulfonate (PFHxS) Open

Mengmeng Xu, Jessica Legradi, P.E.G. Leonards · 2023

A Comprehensive Untargeted Metabolomics Study of Perfluorohexane Sulfonate (Pfhxs) in Developing Zebrafish Embryos Open

Mengmeng Xu, Jessica Legradi, P.E.G. Leonards · 2023

Metabolite alterations in zebrafish embryos exposed to hydroxylated polybrominated diphenyl ethers Open

Johan Gustafsson, Jessica Legradi, M.H. Lamoree, Lillemor Asplund, P.E.G. Leonards · 2022

P04-07 Physiologically based toxicokinetic modelling of bisphenols in zebrafish (Danio rerio) accounting for variation in metabolic rates, brain distribution and liver accumulation Open

Ioana Chelcea, Stefan Örn, Timo Hamers, Jacco Koekkoek, Jessica Legradi , et al. · 2022

Physiologically Based Toxicokinetic Modeling of Bisphenols in Zebrafish (<i>Danio rerio</i>) Accounting for Variations in Metabolic Rates, Brain Distribution, and Liver Accumulation Open

Ioana Chelcea, Stefan Örn, Timo Hamers, Jacco Koekkoek, Jessica Legradi , et al. · 2022

Bisphenol A (BPA) is an industrial chemical, which has raised human health and environmental concerns due to its endocrine-disrupting properties. BPA analogues are less well-studied despite their wide use in consumer products. These analog…

Implementation of Zebrafish Ontologies for Toxicology Screening Open

Anne Thessen, Skylar W. Marvel, John C. Achenbach, Stephan Fischer, Melissa Haendel , et al. · 2022

Toxicological evaluation of chemicals using early-life stage zebrafish ( Danio rerio ) involves the observation and recording of altered phenotypes. Substantial variability has been observed among researchers in phenotypes reported from si…

Getting more out of the zebrafish light dark transition test Open

Ann-Cathrin Haigis, Richard Ottermanns, Andreas Schiwy, Henner Hollert, Jessica Legradi · 2022

Using comprehensive lipid profiling to study effects of PFHxS during different stages of early zebrafish development Open

Mengmeng Xu, Jessica Legradi, P.E.G. Leonards · 2021

Assessment of oil refinery wastewater and effluent integrating bioassays, mechanistic modelling and bioavailability evaluation Open

Graham Whale, Markus Hjort, Carolina Di Paolo, Aaron D. Redman, Jaap F. Postma , et al. · 2021

Cross platform solutions to improve the zebrafish polar metabolome coverage using LC-QTOF MS: Optimization of separation mechanisms, solvent additives, and resuspension solvents Open

Mengmeng Xu, Jessica Legradi, P.E.G. Leonards · 2021

Untargeted metabolomics has been widely used for studies with zebrafish embryos. Until now, the number of analytical approaches to determine metabolites in zebrafish is limited, and there is a lack of consensus on the best platforms for co…

Developmental Neurotoxicity of Environmentally Relevant Pharmaceuticals and Mixtures Thereof in a Zebrafish Embryo Behavioural Test Open

Alessandro Atzei, Ingrid Jense, Edwin Zwart, Jessica Legradi, Bastiaan J. Venhuis , et al. · 2021

Humans are exposed daily to complex mixtures of chemical substances via food intake, inhalation, and dermal contact. Developmental neurotoxicity is an understudied area and entails one of the most complex areas in toxicology. Animal studie…

diatomsRcool/zebrafish_phenotype_survey: v1.0.0 Zebrafish Phenotype Survey Open

Anne Thessen, John C. Achenbach, Stephan Fischer, Kimberly Hayward, Jonathan T. Hamm , et al. · 2021

No description provided.

diatomsRcool/zebrafish_phenotype_survey: v1.0.0 Zebrafish Phenotype Survey Open

Anne Thessen, John C. Achenbach, Stephan Fischer, Kimberly Hayward, Jonathan T. Hamm , et al. · 2021

No description provided.

Evaluation of the effects of acetylcholinesterase inhibitors in the zebrafish touch-evoked response: quantitative vs. qualitative assessment Open

Laura María Díaz Guzmán, Gisela Besa, Daniela Linares, L Gonzalez, Caterina Pont , et al. · 2020

Evaluation of LC-MS and LC×LC-MS in analysis of zebrafish embryo samples for comprehensive lipid profiling Open

Mengmeng Xu, Jessica Legradi, P.E.G. Leonards · 2020

An ecotoxicological view on neurotoxicity assessment Open

Jessica Legradi, Carolina Di Paolo, Michiel H.S. Kraak, Harm G. van der Geest, Emma Schymanski , et al. · 2018

The numbers of potential neurotoxicants in the environment are raising and pose a great risk for humans and the environment. Currently neurotoxicity assessment is mostly performed to predict and prevent harm to human populations. Despite a…

Time-Integrative Passive sampling combined with TOxicity Profiling (TIPTOP): an effect-based strategy for cost-effective chemical water quality assessment Open

Timo Hamers, Jessica Legradi, Nick Zwart, Foppe Smedes, Jasperien de Weert , et al. · 2018

Combining ex-ante LCA and EHS screening to assist green design: A case study of cellulose nanocrystal foam Open

Lianghui Tan, Steven Mandley, Willie J.G.M. Peijnenburg, Susanne L. Waaijers, Daniel Giesen , et al. · 2018

Mode of Action Assignment of Chemicals Using Toxicogenomics: A Case Study with Oxidative Uncouplers Open

Alessa Hawliczek-Ignarski, Peter Cenijn, Juliette Legler, Helmut Segner, Jessica Legradi · 2017

A criterion frequently used to group chemicals in risk assessment is “mode of toxic action” (MoA). Routinely, structure-based approaches are used for the MoA categorization of chemicals, but they can produce conflicting results or fail to …

Effects of Hydroxylated Polybrominated Diphenyl Ethers in Developing Zebrafish Are Indicative of Disruption of Oxidative Phosphorylation Open

Jessica Legradi, M. van Pomeren, Anna-Karin Dahlberg, Juliette Legler · 2017

Hydroxylated polybrominated diphenyl ethers (OH-PBDEs) have been detected in humans and wildlife. Using in vitro models, we recently showed that OH-PBDEs disrupt oxidative phosphorylation (OXPHOS), an essential process in energy metabolism…

Determination of monoamine neurotransmitters in zebrafish (Danio rerio) by gas chromatography coupled to mass spectrometry with a two-step derivatization Open

Álvaro Aragón, Jessica Legradi, Ana Ballesteros‐Gómez, Juliette Legler, Martin van Velzen , et al. · 2017

Lmx1b is required for the glutamatergic fates of a subset of spinal cord neurons Open

William C. Hilinski, Jonathan R. Bostrom, Samantha J. England, José L. Juárez‐Morales, Sarah de Jager , et al. · 2016

Alterations in locomotor activity of feeding zebrafish larvae as a consequence of exposure to different environmental factors Open

Renate Kopp, Juliette Legler, Jessica Legradi · 2016

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