Explanipedia

Brain injury and neurodevelopmental outcomes in children undergoing surgery for congenital heart disease Open

Justus G. Reitz, David Zurakowski, Viktoria Kuhn, Johnathan Murnick, Mary T. Donofrio , et al. · 2023

One right can make a left: sentence processing in the right hemisphere after perinatal stroke Open

K. Martin, Anna Seydell‐Greenwald, Peter E. Turkeltaub, Catherine E. Chambers, Margot L. Giannetti , et al. · 2023

When brain regions that are critical for a cognitive function in adulthood are irreversibly damaged at birth, what patterns of plasticity support the successful development of that function in an alternative location? Here we investigate t…

Early Clinical Variables Associated With Refractory Convulsive Status Epilepticus in Children Open

Katrina Peariso, Ravindra Arya, Tracy A. Glauser, Nicholas S. Abend, Cristina Barcia Aguilar , et al. · 2023

This study provides Class II evidence that patient and clinical factors may predict RSE in children with convulsive seizures.

Survey of Pediatric ICU EEG Monitoring–Reassessment After a Decade Open

France W. Fung, Jessica L. Carpenter, Kevin Chapman, William B. Gallentine, Christopher C. Giza , et al. · 2023

Purpose: In 2011, the authors conducted a survey regarding continuous EEG (CEEG) utilization in critically ill children. In the interim decade, the literature has expanded, and guidelines and consensus statements have addressed CEEG utiliz…

Language and developmental plasticity after perinatal stroke Open

Elissa L. Newport, Anna Seydell‐Greenwald, Barbara Landau, Peter E. Turkeltaub, Catherine E. Chambers , et al. · 2022

The mature human brain is lateralized for language, with the left hemisphere (LH) primarily responsible for sentence processing and the right hemisphere (RH) primarily responsible for processing suprasegmental aspects of language such as v…

A Virtual Community of Practice: An International Educational Series in Pediatric Neurocritical Care Open

Jennifer Erklauer, Ajay X. Thomas, Sue J. Hong, Brian Appavu, Jessica L. Carpenter , et al. · 2022

Pediatric neurocritical care (PNCC) is a rapidly growing field. Challenges posed by the COVID-19 pandemic on trainee exposure to educational opportunities involving direct patient care led to the creative solutions for virtual education su…

Comparative Effectiveness of Diversion of Cerebrospinal Fluid for Children With Severe Traumatic Brain Injury Open

Michael J. Bell, Bedda L. Rosario, Patrick M. Kochanek, P. David Adelson, Kevin Morris , et al. · 2022

In this comparative effectiveness study, CSF diversion was not associated with improved outcome at 6 months after TBI, but a decrease in ICP was observed. Given the higher quality of evidence generated by this study, current evidence-based…

Continuing Care For Critically Ill Children Beyond Hospital Discharge: Current State of Follow-up Open

Cydni N. Williams, Trevor A. Hall, Conall Francoeur, Jonathan E. Kurz, Lindsey Rasmussen , et al. · 2022

OBJECTIVES Survivors of the PICU face long-term morbidities across health domains. In this study, we detail active PICU follow-up programs (PFUPs) and identify perceptions and barriers about development and maintenance of PFUPs. METHODS A …

Comparison of Intracranial Pressure Measurements Before and After Hypertonic Saline or Mannitol Treatment in Children With Severe Traumatic Brain Injury Open

Patrick M. Kochanek, P. David Adelson, Bedda L. Rosario, James S. Hutchison, Nikki Miller Ferguson , et al. · 2022

In this comparative effectiveness research study, bolus HTS was associated with lower ICP and higher CPP, whereas mannitol was associated only with higher CPP. After adjustment for confounders, both therapies showed no association with ICP…

SeizureSeeker: A Novel Approach to Epileptic Seizure Detection Using Machine Learning Open

Hamza Lateef, Gabriel Ralston, Tony Bright, Aravindh Soundarajan, Jessica L. Carpenter · 2022

Background: Epilepsy is a neurologic disease characterized by seizures which occur due to sudden and synchronized bursts of excessive electrical energy in the brain.An electroencephalogram, or EEG, can detect seizures in real time but requ…

SeizureSeeker: A Novel Approach to Epileptic Seizure Detection Using Machine Learning Open

Hamza Lateef, Gabriel Ralston, Tony Bright, Aravindh Soundarajan, Jessica L. Carpenter · 2022

Background: Epilepsy is a neurologic disease characterized by seizures which occur due to sudden and synchronized bursts of excessive electrical energy in the brain.An electroencephalogram, or EEG, can detect seizures in real time but requ…

Low Rates of Cerebral Infarction after Hematopoietic Stem Cell Transplantation in Patients with Sickle Cell Disease at High Risk for Stroke Open

Jessica L. Carpenter, Robert Sheppard Nickel, Jennifer Webb, Zarir Khademian, Barbara Speller‐Brown , et al. · 2021

Hematopoietic stem cell transplantation (HSCT) can be curative for sickle cell disease (SCD). SCD patients with cerebrovascular disease are often referred for HSCT. The objective of this study was to describe neurologic outcomes after HSCT…

Benzodiazepine administration patterns before escalation to second‐line medications in pediatric refractory convulsive status epilepticus Open

Theodore Sheehan, Marta Amengual‐Gual, Alejandra Vasquez, Nicholas S. Abend, Anne E. Anderson , et al. · 2021

Objective This study was undertaken to evaluate benzodiazepine (BZD) administration patterns before transitioning to non‐BZD antiseizure medication (ASM) in pediatric patients with refractory convulsive status epilepticus (rSE). Methods Th…

Factors associated with long‐term outcomes in pediatric refractory status epilepticus Open

Marina Gaínza‐Lein, Cristina Barcia Aguilar, Juan Piantino, Kevin Chapman, Iván Sánchez Fernández , et al. · 2021

Objective This study was undertaken to describe long‐term clinical and developmental outcomes in pediatric refractory status epilepticus (RSE) and identify factors associated with new neurological deficits after RSE. Methods We performed r…

Clinical presentation of new onset refractory status epilepticus in children (the pSERG cohort) Open

Claudine Sculier, Cristina Barcia Aguilar, Nicolas Gaspard, Marina Gaínza‐Lein, Iván Sánchez Fernández , et al. · 2021

Objective We aimed to characterize the clinical profile and outcomes of new onset refractory status epilepticus (NORSE) in children, and investigated the relationship between fever onset and status epilepticus (SE). Methods Patients with r…

Multiplexed Signal Ion Emission Reactive Release Amplification (SIERRA) Assay for the Culture-Free Detection of Gram-Negative and Gram-Positive Bacteria and Antimicrobial Resistance Genes Open

Michael J. Pugia, Tiyash Bose, Marco Tjioe, Dylan Frabutt, Zane Baird , et al. · 2021

The global prevalence of antibiotic-resistant bacteria has increased the risk of dangerous infections, requiring rapid diagnosis and treatment. The standard method for diagnosis of bacterial infections remains dependent on slow culture-bas…

Artificial Intelligence to Assist in Exclusion of Coronary Atherosclerosis During CCTA Evaluation of Chest Pain in the Emergency Department: Preparing an Application for Real-world Use Open

Richard White, Barbaros S. Erdal, Mutlu Demirer, Vikash Gupta, Matthew Bigelow , et al. · 2021

Supplementary Material for: Advanced Machine Learning Tools to Monitor Biomarkers of Dysphagia: A Wearable Sensor Proof-of-Concept Study Open

O’Brien M.K., Botonis O.K., E. Larkin, Jessica L. Carpenter, Bonnie Martin‐Harris , et al. · 2021

Introduction: Difficulty swallowing (dysphagia) occurs frequently in patients with neurological disorders and can lead to aspiration, choking, and malnutrition. Dysphagia is typically diagnosed using costly, invasive imaging …

Acute flaccid myelitis: cause, diagnosis, and management Open

Olwen C. Murphy, Kevin Messacar, Lina Benson, Riley Bove, Jessica L. Carpenter , et al. · 2020

Imaging Predictors of Neurologic Outcome After Pediatric Arterial Ischemic Stroke Open

Bin Jiang, Nancy K. Hills, Rob Forsyth, Lori C. Jordan, Mahmoud Slim , et al. · 2020

Background and Purpose: To assess whether initial imaging characteristics independently predict 1-year neurological outcomes in childhood arterial ischemic stroke patients. Methods: We used prospectively collected demographic and clinical …

Anakinra usage in febrile infection related epilepsy syndrome: an international cohort Open

Yi‐Chen Lai, Eyal Muscal, Elizabeth Wells, Nikita Shukla, Krista Eschbach , et al. · 2020

Febrile‐infection related epilepsy syndrome (FIRES) is a devastating neurological condition characterized by a febrile illness preceding new onset refractory status epilepticus (NORSE). Increasing evidence suggests innate immune dysfunctio…

Proposal to optimize evaluation and treatment of Febrile infection‐related epilepsy syndrome (FIRES): A Report from FIRES workshop Open

Sookyong Koh, Elaine Wirrell, Annamaria Vezzani, Rima Nabbout, Eyal Muscal , et al. · 2020

Febrile infection‐related epilepsy syndrome (FIRES) is a rare catastrophic epileptic encephalopathy that presents suddenly in otherwise normal children and young adults causing significant neurological disability, chronic epilepsy, and hig…

170. Acute Flaccid Myelitis: Patient Characteristics and Prospective Follow-up Study at Children’s National Hospital, 2013–2019 Open

Alexandra B. Yonts, Nada Harik, Alyssa Doslea, Jonathan Murnick, Jessica L. Carpenter , et al. · 2020

Background Acute Flaccid Myelitis (AFM), diagnosed almost exclusively in children, is characterized by sudden onset flaccid weakness in one or more extremities with distinct gray matter spinal cord lesions on magnetic resonance imaging (MR…

Mechanical Thrombectomy for Acute Ischemic Stroke Open

Lisa R. Sun, Dana Harrar, Gerald Drocton, Carlos Castillo, Ryan J. Felling , et al. · 2020

The use of mechanical thrombectomy for the treatment of acute childhood arterial ischemic stroke with large vessel occlusion is increasing, with mounting evidence for its feasibility and safety. Despite this emerging evidence, clear guidel…

First-line medication dosing in pediatric refractory status epilepticus Open

Alejandra Vasquez, Marina Gaínza‐Lein, Nicholas S. Abend, Marta Amengual‐Gual, Anne E. Anderson , et al. · 2020

This study provides Class III evidence that patients with RSE who present with male sex, older age, no prior diagnosis of epilepsy, and delayed BZD treatment are more likely to receive low total BZD doses. This study provides Class III evi…

Artificial Intelligence to Assist in Exclusion of Coronary\n Atherosclerosis during CCTA Evaluation of Chest-Pain in the Emergency\n Department: Preparing an Application for Real-World Use Open

Richard D. White, Barbaros S. Erdal, Mutlu Demirer, Vikas Gupta, Matthew Bigelow , et al. · 2020

Coronary Computed Tomography Angiography (CCTA) evaluation of chest-pain\npatients in an Emergency Department (ED) is considered appropriate. While a\nnegative CCTA interpretation supports direct patient discharge from an ED,\nlabor-intens…

Association of guideline publication and delays to treatment in pediatric status epilepticus Open

Iván Sánchez Fernández, Nicholas S. Abend, Marta Amengual‐Gual, Anne E. Anderson, Ravindra Arya , et al. · 2020

Publication of evidence on delays in time to treatment was not associated with improvements in time to treatment of rSE, although it was associated with an increase in the proportion of patients who received at least 1 BZD before hospital …

Spectrum of cerebral arteriopathies in children with arterial ischemic stroke Open

Mubeen F. Rafay, Kevin A. Shapiro, Ann-Marie Surmava, Gabrielle deVeber, Adam Kirton , et al. · 2020

Specific clinical profiles are associated with cerebral arteriopathies in children with AIS. These observations may be helpful indicators in guiding early diagnosis and defining subgroups who may benefit most from future therapeutic trials.

The Role of Clinical Guidelines in a Managed Long Term Services & Supports Framework Open

Jessica L. Carpenter, Jill Morrow-Gorton · 2019

Best Practices in Care Coordination & Transitions of Care Communications Open

Jessica L. Carpenter · 2019

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