Jessica Pingel
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View article: Stored Intestinal Biopsies in Inflammatory Bowel Disease Research: A Danish Nationwide Population-Based Register Study
Stored Intestinal Biopsies in Inflammatory Bowel Disease Research: A Danish Nationwide Population-Based Register Study Open
Background. Inflammatory bowel disease (IBD), encompassing Crohn’s disease (CD) and ulcerative colitis (UC), is a complex inflammatory condition affecting the intestinal tract. Currently, immune-modulating treatments are inadequate for 30–…
View article: Microfibrillar-associated protein 4 as a predictive biomarker of treatment response in patients with chronic inflammatory diseases initiating biologics: secondary analyses based on the prospective BELIEVE cohort study
Microfibrillar-associated protein 4 as a predictive biomarker of treatment response in patients with chronic inflammatory diseases initiating biologics: secondary analyses based on the prospective BELIEVE cohort study Open
View article: Determinants of Frame Running Capacity in Athletes With Cerebral Palsy to Improve Training Routines and Classification Strategies
Determinants of Frame Running Capacity in Athletes With Cerebral Palsy to Improve Training Routines and Classification Strategies Open
Objectives The aim of the study were to (1) investigate what physical and physiological parameters are most important for Frame Running capacity, a parasport for individuals with ambulatory difficulties, and (2) determine whether Frame Run…
View article: Extracellular vesicle characteristics and microRNA content in cerebral palsy and typically developed individuals at rest and in response to aerobic exercise
Extracellular vesicle characteristics and microRNA content in cerebral palsy and typically developed individuals at rest and in response to aerobic exercise Open
In this study, the properties of circulating extracellular vesicles (EVs) were examined in cerebral palsy (CP) and typically developed (TD) individuals at rest and after aerobic exercise, focusing on the size, concentration, and microRNA c…
View article: The Health Effects of 14 Weeks of Physical Activity in a Real-Life Setting for Adults with Intellectual Disabilities
The Health Effects of 14 Weeks of Physical Activity in a Real-Life Setting for Adults with Intellectual Disabilities Open
Background. The life expectancy of individuals with intellectual disabilities (ID) is reduced compared to the general population, and one of the main contributors to earlier death is inactivity. Aim. To investigate how 14 weeks of physical…
View article: 3D synchrotron imaging of muscle tissues at different atrophic stages in stroke and spinal cord injury: a proof-of-concept study
3D synchrotron imaging of muscle tissues at different atrophic stages in stroke and spinal cord injury: a proof-of-concept study Open
Synchrotron X-ray computed tomography (SXCT) allows 3D imaging of tissue with a very large field of view and an excellent micron resolution and enables the investigation of muscle fiber atrophy in 3D. The study aimed to explore the 3D micr…
View article: The health effects of 14 weeks of physical activity in a real-life setting for adults with intellectual disabilities
The health effects of 14 weeks of physical activity in a real-life setting for adults with intellectual disabilities Open
Background Individuals with intellectual disabilities (ID) have a reduced physical health compared to the general population, and one of the main contributors is inactivity. Aim To investigate how 14 weeks of physical activity (PA) in a re…
View article: Singing Therapy Improving Peak Flow, Speech and Eating Abilities in Adults with Cerebral Palsy
Singing Therapy Improving Peak Flow, Speech and Eating Abilities in Adults with Cerebral Palsy Open
Introduction: Individuals with cerebral palsy (CP) often suffer from speech impairments and dysphagia due to impaired motor control of the tongue and lips. Aim: To investigate the effect of singing on peak flow, speech- and swallowing abil…
View article: Reduced mitochondrial DNA and OXPHOS protein content in skeletal muscle of children with cerebral palsy
Reduced mitochondrial DNA and OXPHOS protein content in skeletal muscle of children with cerebral palsy Open
Aim To provide a detailed gene and protein expression analysis related to mitochondrial biogenesis and assess mitochondrial content in skeletal muscle of children with cerebral palsy (CP). Method Biceps brachii muscle samples were collecte…
View article: Intramuscular BoNT/A injections cause an inflammatory response in the muscle tissue of rats
Intramuscular BoNT/A injections cause an inflammatory response in the muscle tissue of rats Open
Objectives The purpose of the present study was to investigate whether intramuscular BoNT/A injections cause an systemic inflammatory response and a local inflammatory response in the muscle tissue. Methods Thirty-two male Sprague Dawley r…
View article: Cerebral Palsy and Stroke—Early and Late Brain Lesion Present Differences in Systemic Biomarkers and Gene Expression Related to Muscle Contractures
Cerebral Palsy and Stroke—Early and Late Brain Lesion Present Differences in Systemic Biomarkers and Gene Expression Related to Muscle Contractures Open
Background: CNS lesions that are acquired early in life e.g. cerebral palsy (CP) disturb muscle development and growth, while CNS injuries acquired later in life e.g. stroke, affect fully matured muscles and cause paresis and atrophy. Thes…
View article: Epigenetic Marks at the Ribosomal DNA Promoter in Skeletal Muscle Are Negatively Associated With Degree of Impairment in Cerebral Palsy
Epigenetic Marks at the Ribosomal DNA Promoter in Skeletal Muscle Are Negatively Associated With Degree of Impairment in Cerebral Palsy Open
Introduction: Cerebral palsy (CP) is the most common motor impairment in children. Skeletal muscles in individuals with CP are typically weak, thin, and stiff. Whether epigenetic changes at the ribosomal DNA (rDNA) promoter are invo…
View article: Contracture Development in Whales
Contracture Development in Whales Open
It is well known that whales in captivity suffer from dorsal fin bending. However, the mechanisms behind this change are poorly understood. Humans can suffer from similar symptoms either after a period of immobilization or after suffering …
View article: A non-Invasive Assessment of Ground Reaction Forces in the Human Leg in Response to Walking, Jogging, Running and Jumping
A non-Invasive Assessment of Ground Reaction Forces in the Human Leg in Response to Walking, Jogging, Running and Jumping Open
Running is one of the most popular forms of exercise. Even though regular exercise is beneficial to human health, running is also often associated with an increased risk of injury. Lack of shock absorption in running shoes has often been s…
View article: Impact of Menstrual Function on Hormonal Response to Repeated Bouts of Intense Exercise
Impact of Menstrual Function on Hormonal Response to Repeated Bouts of Intense Exercise Open
No major differences in the hormonal or BDNF responses between the two exercise bouts as a result of menstrual function could be detected.
View article: The Beneficial Effect of Acute Exercise on Motor Memory Consolidation is Modulated by Dopaminergic Gene Profile
The Beneficial Effect of Acute Exercise on Motor Memory Consolidation is Modulated by Dopaminergic Gene Profile Open
When aerobic exercise is performed following skilled motor practice, it can enhance motor memory consolidation. Previous studies have suggested that dopamine may play a role in motor memory consolidation, but whether it is involved in the …
View article: Suboptimal Nutrition and Low Physical Activity Are Observed Together with Reduced Plasma Brain-Derived Neurotrophic Factor (BDNF) Concentration in Children with Severe Cerebral Palsy (CP)
Suboptimal Nutrition and Low Physical Activity Are Observed Together with Reduced Plasma Brain-Derived Neurotrophic Factor (BDNF) Concentration in Children with Severe Cerebral Palsy (CP) Open
Brain-derived neurotrophic factor (BDNF) is a mediator of exercise and nutrition-induced neural plasticity. In children with cerebral palsy (CP), neuromuscular deficits and mobility impairment have a negative impact on their physical activ…
View article: Systemic inflammatory markers in individuals with cerebral palsy
Systemic inflammatory markers in individuals with cerebral palsy Open
Individuals with cerebral palsy (CP) develop skeletal muscle contractures that impair muscle function. In turn, contractures affect the ability to ambulate and often promote a sedentary lifestyle. The aim of the present study was to invest…
View article: Tendinosis-like changes in denervated rat Achilles tendon
Tendinosis-like changes in denervated rat Achilles tendon Open
View article: Microvascularization is not a limiting factor for exercise in adults with cerebral palsy
Microvascularization is not a limiting factor for exercise in adults with cerebral palsy Open
Muscle contractures are a common complication in patients with central nervous system (CNS) lesions which limit range of movement and cause joint deformities. Furthermore, it has previously been shown that muscles with contractures have a …
View article: Injection of high dose botulinum-toxin A leads to impaired skeletal muscle function and damage of the fibrilar and non-fibrilar structures
Injection of high dose botulinum-toxin A leads to impaired skeletal muscle function and damage of the fibrilar and non-fibrilar structures Open
View article: Muscle disuse caused by botulinum toxin injection leads to increased central gain of the stretch reflex in the rat
Muscle disuse caused by botulinum toxin injection leads to increased central gain of the stretch reflex in the rat Open
Botulinum toxin (Btx) is used in children with cerebral palsy and in other neurological patients to diminish spasticity and reduce the risk of development of contractures. We investigated changes in the central gain of the stretch reflex c…
View article: New perspectives on the development of muscle contractures following central motor lesions
New perspectives on the development of muscle contractures following central motor lesions Open
Muscle contractures are common in patients with central motor lesions, but the mechanisms responsible for the development of contractures are still unclear. Increased or decreased neural activation, protracted placement of a joint with the…
View article: Botulinum toxin injection causes hyper-reflexia and increased muscle stiffness of the triceps surae muscle in the rat
Botulinum toxin injection causes hyper-reflexia and increased muscle stiffness of the triceps surae muscle in the rat Open
Botulinum toxin is used with the intention of diminishing spasticity and reducing the risk of development of contractures. Here, we investigated changes in muscle stiffness caused by reflex activity or elastic muscle properties following b…
View article: Inflammatory and Metabolic Alterations of Kager's Fat Pad in Chronic Achilles Tendinopathy
Inflammatory and Metabolic Alterations of Kager's Fat Pad in Chronic Achilles Tendinopathy Open
BackgroundAchilles tendinopathy is a painful inflammatory condition characterized by swelling, stiffness and reduced function of the Achilles tendon. Kager’s fat pad is an adipose tissue located in the area anterior to the Achilles tendon.…