Jessica R. Crawshaw
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View article: Modeling the Ocular Pharmacokinetics and Pharmacodynamics of Ranibizumab for Improved Understanding and Data Collection Strategies in Ocular Diseases
Modeling the Ocular Pharmacokinetics and Pharmacodynamics of Ranibizumab for Improved Understanding and Data Collection Strategies in Ocular Diseases Open
This study extends our understanding of the ocular pharmacokinetics and pharmacodynamics of ranibizumab and provides theoretical insights for enhanced data collection schemes to be considered for clinical trials and in the development of n…
View article: A Model of the Mechanisms Underpinning Unconventional Aqueous Humor Outflow
A Model of the Mechanisms Underpinning Unconventional Aqueous Humor Outflow Open
We have developed a theoretical model of the unconventional aqueous outflow pathway that successfully captures its physiological features and elucidates the actions of prostaglandin F2α analogues and other drugs.
View article: A First-Passage Model of Intravitreal Drug Delivery and Residence Time—Influence of Ocular Geometry, Individual Variability, and Injection Location
A First-Passage Model of Intravitreal Drug Delivery and Residence Time—Influence of Ocular Geometry, Individual Variability, and Injection Location Open
The modeling results suggest that experimental variability in ocular half-life is partially attributed to anatomical differences and injection site location. Simulations further suggest a potential role of the posterior pathway permeabilit…
View article: A first passage model of intravitreal drug delivery and residence time, in relation to ocular geometry, individual variability, and injection location
A first passage model of intravitreal drug delivery and residence time, in relation to ocular geometry, individual variability, and injection location Open
Purpose: Standard of care for various retinal diseases involves recurrent intravitreal injections. This motivates mathematical modelling efforts to identify influential factors for drug residence time, aiming to minimise administration fre…
View article: Mathematical models of developmental vascular remodelling: A review
Mathematical models of developmental vascular remodelling: A review Open
Over the past 40 years, there has been a strong focus on the development of mathematical models of angiogenesis, while developmental remodelling has received little such attention from the mathematical community. Sprouting angiogenesis can…
View article: Traffic Patterns of the Migrating Endothelium: How Force Transmission Regulates Vascular Malformation and Functional Shunting During Angiogenic Remodelling
Traffic Patterns of the Migrating Endothelium: How Force Transmission Regulates Vascular Malformation and Functional Shunting During Angiogenic Remodelling Open
Angiogenesis occurs in distinct phases: initial spouting is followed by remodelling in which endothelial cells (ECs) composing blood vessels rearrange by migrating against the direction of flow. Abnormal remodelling can result in vascular …
View article: A simple history-dependent remeshing technique to increase finite element model stability in elastic surface deformations
A simple history-dependent remeshing technique to increase finite element model stability in elastic surface deformations Open
View article: A modular framework for multiscale, multicellular, spatiotemporal modeling of acute primary viral infection and immune response in epithelial tissues and its application to drug therapy timing and effectiveness
A modular framework for multiscale, multicellular, spatiotemporal modeling of acute primary viral infection and immune response in epithelial tissues and its application to drug therapy timing and effectiveness Open
Simulations of tissue-specific effects of primary acute viral infections like COVID-19 are essential for understanding disease outcomes and optimizing therapies. Such simulations need to support continuous updating in response to rapid adv…
View article: A simple history dependent remeshing technique to increase finite\n element model stability in elastic surface deformations
A simple history dependent remeshing technique to increase finite\n element model stability in elastic surface deformations Open
In this paper, we present and validate a simple adaptive surface remeshing\ntechnique to transfer history dependent variables from an old distorting mesh\nto a new mesh during finite element simulations of elastic surface deformation.\nThi…
View article: A modular framework for multiscale, multicellular, spatiotemporal modeling of acute primary viral infection and immune response in epithelial tissues and its application to drug therapy timing and effectiveness
A modular framework for multiscale, multicellular, spatiotemporal modeling of acute primary viral infection and immune response in epithelial tissues and its application to drug therapy timing and effectiveness Open
Simulations of tissue-specific effects of primary acute viral infections like COVID-19 are essential for understanding disease outcomes and optimizing therapies. Such simulations need to support continuous updating in response to rapid adv…
View article: Laryngeal closure impedes non-invasive ventilation at birth
Laryngeal closure impedes non-invasive ventilation at birth Open
Background Non-invasive ventilation is sometimes unable to provide the respiratory needs of very premature infants in the delivery room. While airway obstruction is thought to be the main problem, the site of obstruction is unknown. We inv…
View article: Effect of betamethasone, surfactant, and positive end-expiratory pressures on lung aeration at birth in preterm rabbits
Effect of betamethasone, surfactant, and positive end-expiratory pressures on lung aeration at birth in preterm rabbits Open
Antenatal glucocorticoids, exogenous surfactant, and positive end-expiratory pressure (PEEP) ventilation are commonly provided to preterm infants to enhance respiratory function after birth. It is unclear how these treatments interact to i…