Jessica R. Webb
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View article: Challenges and considerations for whole-genome-based antimicrobial resistance plasmid investigations
Challenges and considerations for whole-genome-based antimicrobial resistance plasmid investigations Open
Plasmids are self-replicating, extrachromosomal genetic elements that serve as vehicles for antimicrobial resistance (AMR) genes. In bacteria, plasmids frequently carry critical AMR genes such as extended spectrum beta-lactamases ( bla CTX…
View article: Genomic and epidemiological characteristics of <i>Shigella boydii</i> in Australia, 1991–2022
Genomic and epidemiological characteristics of <i>Shigella boydii</i> in Australia, 1991–2022 Open
Shigellosis is a leading cause of diarrheal mortality worldwide. Shigella boydii is one of four Shigella species that contributes to this burden, however studies on S. boydii are limited. Here we combined epidemiologic…
View article: Genomics to understand the global landscape of linezolid resistance in Enterococcus faecium and Enterococcus faecalis
Genomics to understand the global landscape of linezolid resistance in Enterococcus faecium and Enterococcus faecalis Open
Linezolid is an oxazolidinone antibiotic and is a last-line agent for treating infections caused by vancomycin-resistant Enterococcus (VRE). Limited work has been done to study the genomic epidemiology and population structure of linezolid…
View article: <i>Burkholderia pseudomallei</i> Sequence Type 46 Transmission from Asia to Australia
<i>Burkholderia pseudomallei</i> Sequence Type 46 Transmission from Asia to Australia Open
Melioidosis is caused by the environmental pathogen Burkholderia pseudomallei. Among 1,331 patients with melioidosis during 1989-2023 in the Darwin Prospective Melioidosis Study in Australia, we identified 6 locally acquired cases caused b…
View article: Parameters for one health genomic surveillance of Escherichia coli from Australia
Parameters for one health genomic surveillance of Escherichia coli from Australia Open
Genomics is a cornerstone of modern pathogen epidemiology yet demonstrating transmission in a One Health context is challenging, as strains circulate and evolve within and between diverse hosts and environments. To identify phylogenetic li…
View article: Implementing a national programme of pathogen genomics for public health: the Australian Pathogen Genomics Program (AusPathoGen)
Implementing a national programme of pathogen genomics for public health: the Australian Pathogen Genomics Program (AusPathoGen) Open
Delivering large-scale routine pathogen genomics surveillance for public health is of considerable interest, although translational research models that promote national-level implementation are not well defined. We describe the developmen…
View article: Epidemiology and genetic diversity of Burkholderia pseudomallei from Riau Province, Indonesia
Epidemiology and genetic diversity of Burkholderia pseudomallei from Riau Province, Indonesia Open
Melioidosis is a bacterial infection caused by Burkholderia pseudomallei , that is common in tropical and subtropical countries including Southeast Asia and Northern Australia. The magnitude of undiagnosed and untreated melioidosis across …
View article: Seed mix design and floral resources drive multitrophic interactions in prairie restoration
Seed mix design and floral resources drive multitrophic interactions in prairie restoration Open
Ecological restoration often targets plant community recovery, but restoration success may depend on the recovery of a complex web of biotic interactions to maintain biodiversity and promote ecosystem services. Specifically, management tha…
View article: Bringing TB Genomics to the Clinic: A Comprehensive Pipeline to Predict Antimicrobial Susceptibility from Genomic Data, Validated and Accredited to ISO Standards
Bringing TB Genomics to the Clinic: A Comprehensive Pipeline to Predict Antimicrobial Susceptibility from Genomic Data, Validated and Accredited to ISO Standards Open
View article: Bringing TB genomics to the clinic: A comprehensive pipeline to predict antimicrobial susceptibility from genomic data, validated and accredited to ISO standards
Bringing TB genomics to the clinic: A comprehensive pipeline to predict antimicrobial susceptibility from genomic data, validated and accredited to ISO standards Open
Background Whole genome sequencing (WGS) is increasingly contributing to the clinical management of tuberculosis. Whilst the availability of bioinformatic tools for analysis and clinical reporting of Mycobacterium tuberculosis sequence dat…
View article: Conversations on Cannabis and Mental Health: Recommendations for Health and Social Care Providers from Indigenous 2SLGTBQQIA+ People in Canada
Conversations on Cannabis and Mental Health: Recommendations for Health and Social Care Providers from Indigenous 2SLGTBQQIA+ People in Canada Open
With the recent legalization of cannabis in Canada, there is an urgent need for information about its effects on Indigenous populations due to the impact of cannabis on the mental health of Indigenous Peoples in Canada being largely unknow…
View article: Melioidosis in Timor-Leste: First Case Description and Phylogenetic Analysis
Melioidosis in Timor-Leste: First Case Description and Phylogenetic Analysis Open
Burkholderia pseudomallei, the causative agent of melioidosis, has not yet been reported in Timor-Leste, a sovereign state northwest of Australia. In the context of improved access to diagnostic resources and expanding clinical networks in…
View article: Exploring Cefiderocol Resistance Mechanisms in Burkholderia pseudomallei
Exploring Cefiderocol Resistance Mechanisms in Burkholderia pseudomallei Open
Cefiderocol is a siderophore cephalosporin designed mainly for treatment of infections caused by β-lactam and multidrug-resistant Gram-negative bacteria. Burkholderia pseudomallei clinical isolates are usually highly cefiderocol susceptibl…
View article: A conserved active site PenA β-lactamase Ambler motif specific for Burkholderia pseudomallei/B. mallei is likely responsible for intrinsic amoxicillin-clavulanic acid sensitivity and facilitates a simple diagnostic PCR assay for melioidosis
A conserved active site PenA β-lactamase Ambler motif specific for Burkholderia pseudomallei/B. mallei is likely responsible for intrinsic amoxicillin-clavulanic acid sensitivity and facilitates a simple diagnostic PCR assay for melioidosis Open
Burkholderia pseudomallei is a soil- and water-dwelling Gram-negative bacterium that causes melioidosis in humans and animals. Amoxicillin-clavulanic acid (AMC) susceptibility has been hailed as an integral part of the screening algorithm …
View article: 2356 Melioidosis of the central nervous system; impact of the bimABm allele on patient presentation and outcome
2356 Melioidosis of the central nervous system; impact of the bimABm allele on patient presentation and outcome Open
Objectives The autotransporter protein Burkholderia intracellular motility A (BimA) facilitates the entry of Burkholderia pseudomallei into the central nervous system (CNS) in mouse models of melioidosis. Its role in the pathogenesis of hu…
View article: Melioidosis in the remote Katherine region of northern Australia
Melioidosis in the remote Katherine region of northern Australia Open
Melioidosis is endemic in the remote Katherine region of northern Australia. In a population with high rates of chronic disease, social inequities, and extreme remoteness, the impact of melioidosis is exacerbated by severe weather events a…
View article: Modified horseshoe crab peptides target and kill bacteria inside host cells
Modified horseshoe crab peptides target and kill bacteria inside host cells Open
View article: Unsupervised Machine Learning Approaches Reveal Distinct Phenotypes of Perceived Bladder Pain: A Pilot Study
Unsupervised Machine Learning Approaches Reveal Distinct Phenotypes of Perceived Bladder Pain: A Pilot Study Open
Interstitial cystitis/bladder pain syndrome (IC/BPS) is defined as an unpleasant sensation perceived to be related to the bladder with associated urinary symptoms. Due to difficulties discriminating pelvic visceral sensation, IC/BPS likely…
View article: Robust and prototypical immune responses toward influenza vaccines in the high-risk group of Indigenous Australians
Robust and prototypical immune responses toward influenza vaccines in the high-risk group of Indigenous Australians Open
Significance Indigenous populations worldwide are highly susceptible to influenza virus infections. Vaccination with inactivated virus is highly recommended to protect Indigenous populations, including Indigenous Australians. There is no s…
View article: Modified defence peptides from horseshoe crab target and kill bacteria inside host cells
Modified defence peptides from horseshoe crab target and kill bacteria inside host cells Open
Bacteria that occupy an intracellular niche can evade extracellular host immune responses and antimicrobial molecules. In addition to classic intracellular pathogens, other bacteria including uropathogenic Escherichia coli (UPEC) can adopt…
View article: Conservation of Resistance-Nodulation-Cell Division Efflux Pump-Mediated Antibiotic Resistance in Burkholderia cepacia Complex and Burkholderia pseudomallei Complex Species
Conservation of Resistance-Nodulation-Cell Division Efflux Pump-Mediated Antibiotic Resistance in Burkholderia cepacia Complex and Burkholderia pseudomallei Complex Species Open
Burkholderia cepacia complex (Bcc) and Burkholderia pseudomallei complex (Bpc) species include pathogens that are typically multidrug resistant. Dominant intrinsic and acquired multidrug resistance mechanisms are efflux mediated by pumps o…
View article: Robust and Prototypical Immune Responses Towards Influenza Vaccines in the High-Risk Group of Indigenous Australians
Robust and Prototypical Immune Responses Towards Influenza Vaccines in the High-Risk Group of Indigenous Australians Open
View article: The Darwin Prospective Melioidosis Study: a 30-year prospective, observational investigation
The Darwin Prospective Melioidosis Study: a 30-year prospective, observational investigation Open
View article: Enhanced melioidosis surveillance in patients attending four tertiary hospitals in Yangon, Myanmar
Enhanced melioidosis surveillance in patients attending four tertiary hospitals in Yangon, Myanmar Open
To investigate the current epidemiology of melioidosis in Yangon, Myanmar, between June 2017 and May 2019 we conducted enhanced surveillance for melioidosis in four tertiary hospitals in Yangon, where the disease was first discovered in 19…
View article: Emergence of <i>Burkholderia pseudomallei</i> Sequence Type 562, Northern Australia
Emergence of <i>Burkholderia pseudomallei</i> Sequence Type 562, Northern Australia Open
Since 2005, the range of Burkholderia pseudomallei sequence type 562 (ST562) has expanded in northern Australia. During 2005-2019, ST562 caused melioidosis in 61 humans and 3 animals. Cases initially occurred in suburbs surrounding a creek…
View article: Burkholderia ubonensis High-Level Tetracycline Resistance Is Due to Efflux Pump Synergy Involving a Novel TetA(64) Resistance Determinant
Burkholderia ubonensis High-Level Tetracycline Resistance Is Due to Efflux Pump Synergy Involving a Novel TetA(64) Resistance Determinant Open
Burkholderia ubonensis , a nonpathogenic soil bacterium belonging to the Burkholderia cepacia complex (Bcc), is highly resistant to some clinically significant antibiotics. The concern is that B. ubonensis may serve as a resistance reservo…
View article: Taking the next-gen step: Comprehensive antimicrobial resistance detection from Burkholderia pseudomallei
Taking the next-gen step: Comprehensive antimicrobial resistance detection from Burkholderia pseudomallei Open
National Health and Medical Research Council (BJC, EPP, DSS); Australian Government (DEM, ES); Advance Queensland (EPP, DSS).
View article: Using Land Runoff To Survey the Distribution and Genetic Diversity of Burkholderia pseudomallei Strains in Vientiane, Laos
Using Land Runoff To Survey the Distribution and Genetic Diversity of Burkholderia pseudomallei Strains in Vientiane, Laos Open
The environmental bacterium B. pseudomallei is the etiological agent of melioidosis, a tropical disease with one model estimating a global annual incidence of 165,000 cases and 89,000 deaths. In the Lao People’s Democratic Republic (Laos),…
View article: A Persisting Nontropical Focus of Burkholderia pseudomallei with Limited Genome Evolution over Five Decades
A Persisting Nontropical Focus of Burkholderia pseudomallei with Limited Genome Evolution over Five Decades Open
Burkholderia pseudomallei is predominantly a tropical pathogen uncommonly found in the environment of temperate climatic regions. It is unclear if introduction into temperate regions is sporadic and temporary or if B. pseudomallei can pers…
View article: Myanmar Burkholderia pseudomallei strains are genetically diverse and originate from Asia with phylogenetic evidence of reintroductions from neighbouring countries
Myanmar Burkholderia pseudomallei strains are genetically diverse and originate from Asia with phylogenetic evidence of reintroductions from neighbouring countries Open