Jessie K. Edwards
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View article: Examining the effect of universal testing and treatment strategies for HIV prevention in Zambia and South Africa: generalizing the results of the HPTN 071 (PopART) trial
Examining the effect of universal testing and treatment strategies for HIV prevention in Zambia and South Africa: generalizing the results of the HPTN 071 (PopART) trial Open
INTRODUCTION: HIV Prevention Trials Network (HPTN) 071 (PopART) was a cluster-randomized trial to evaluate universal testing and treatment (UTT) strategies for HIV prevention. HPTN071 compared three arms: (A) combination prevention with UT…
View article: Examining the effect of universal testing and treatment strategies for HIV prevention in Zambia and South Africa: generalizing the results of the HPTN 071 (PopART) trial
Examining the effect of universal testing and treatment strategies for HIV prevention in Zambia and South Africa: generalizing the results of the HPTN 071 (PopART) trial Open
Introduction HIV Prevention Trials Network (HPTN) 071 (PopART) was a cluster‐randomized trial to evaluate universal testing and treatment (UTT) strategies for HIV prevention. HPTN071 compared three arms: (A) combination prevention with UTT…
View article: False-positive malaria rapid diagnostic tests are prevalent among children under 5 years of age in Uganda
False-positive malaria rapid diagnostic tests are prevalent among children under 5 years of age in Uganda Open
Background Malaria rapid diagnostic tests (mRDTs) are a cornerstone of malaria testing and treatment efforts globally. However, positive mRDT results can occur after treatment due to antigen persistence, even in the absence of malaria para…
View article: Evaluating the role of self-collected home swab data in enhancing influenza vaccine effectiveness estimates in general practice
Evaluating the role of self-collected home swab data in enhancing influenza vaccine effectiveness estimates in general practice Open
This study evaluated the feasibility of utilising general practitioner (GP)-initiated, laboratory-confirmed self-collected home swab data (iSwab) for estimating influenza vaccine effectiveness (VE), compared to traditional health practitio…
View article: Postpartum Intrauterine Device Removal and Access to Removal in the 18 Months Following an Intervention in Tanzania, Sri Lanka, and Nepal
Postpartum Intrauterine Device Removal and Access to Removal in the 18 Months Following an Intervention in Tanzania, Sri Lanka, and Nepal Open
Family planning programs in the Global South promote long‐acting reversible contraception (LARC), but research suggests that women face barriers to LARC discontinuation, inhibiting their reproductive autonomy. Scholars have called for impr…
View article: Confidence Regions for Multiple Outcomes, Effect Modifiers, and Other Multiple Comparisons
Confidence Regions for Multiple Outcomes, Effect Modifiers, and Other Multiple Comparisons Open
In epidemiology, some have argued that multiple comparison corrections are not necessary as there is rarely interest in the universal null hypothesis. From a parameter estimation perspective, epidemiologists may still be interested in mult…
View article: Assessing the association between a postpartum intrauterine device intervention and perceived pressure to adopt contraception in Sri Lanka
Assessing the association between a postpartum intrauterine device intervention and perceived pressure to adopt contraception in Sri Lanka Open
Evaluating family planning programs solely on contraceptive use overlooks critical aspects of reproductive autonomy. We find that a postpartum IUD intervention in Sri Lanka was associated with increased contraceptive use but also increased…
View article: Volatile Hydrocarbon Exposures and Incident Coronary Heart Disease Events: Up to Ten Years of Follow-up among Deepwater Horizon Oil Spill Workers
Volatile Hydrocarbon Exposures and Incident Coronary Heart Disease Events: Up to Ten Years of Follow-up among Deepwater Horizon Oil Spill Workers Open
BACKGROUND: During the 2010 Deepwater Horizon (DWH) disaster, response and cleanup workers were potentially exposed to toxic volatile components of crude oil. However, to our knowledge, no study has examined exposure to i…
View article: The association between depressive symptoms and antibody response following SARS-CoV-2 vaccination among central North Carolina residents
The association between depressive symptoms and antibody response following SARS-CoV-2 vaccination among central North Carolina residents Open
A large body of research suggests that stress can affect how the immune system responds to vaccines. The impact of mental health disorders on humoral antibody response following immunization is not well understood, particularly for the COV…
View article: Leveraging infant visit PrEP screening INtegration & tasK shifting to improve post-partum HIV prevention in Malawi (LINK): a cluster-randomized trial evaluation of a postpartum HIV prevention package among breastfeeding women in Malawi
Leveraging infant visit PrEP screening INtegration & tasK shifting to improve post-partum HIV prevention in Malawi (LINK): a cluster-randomized trial evaluation of a postpartum HIV prevention package among breastfeeding women in Malawi Open
View article: Leveraging infant visit PrEP screening INtegration & tasK shifting to improve post-partum HIV prevention in Malawi (LINK): a cluster-randomized trial evaluation of a postpartum HIV prevention package among breastfeeding women in Malawi
Leveraging infant visit PrEP screening INtegration & tasK shifting to improve post-partum HIV prevention in Malawi (LINK): a cluster-randomized trial evaluation of a postpartum HIV prevention package among breastfeeding women in Malawi Open
Clinicaltrials.gov NCT06506188 (registered: 2024/07/17).
View article: Comparative effectiveness of initiating nifedipine versus labetalol in early gestation for chronic hypertension in pregnancy
Comparative effectiveness of initiating nifedipine versus labetalol in early gestation for chronic hypertension in pregnancy Open
Background: Limited data exist on the comparative effectiveness and safety of first-line medications to treat chronic hypertension in pregnancy. We compared nifedipine versus labetalol initiation before 23 weeks gestation for risk of pregn…
View article: Study design and procedures for a hybrid effectiveness-implementation incomplete stepped-wedge cluster-randomized trial to evaluate a differentiated point-of-care HIV diagnosis and management model for the prevention of vertical transmission of HIV in Malawi: The PAC-Man trial protocol
Study design and procedures for a hybrid effectiveness-implementation incomplete stepped-wedge cluster-randomized trial to evaluate a differentiated point-of-care HIV diagnosis and management model for the prevention of vertical transmission of HIV in Malawi: The PAC-Man trial protocol Open
View article: Study design and procedures for a hybrid effectiveness-implementation incomplete stepped-wedge cluster-randomized trial to evaluate a differentiated point-of-care HIV diagnosis and management model for the prevention of vertical transmission of HIV in Malawi: The PAC-Man trial protocol
Study design and procedures for a hybrid effectiveness-implementation incomplete stepped-wedge cluster-randomized trial to evaluate a differentiated point-of-care HIV diagnosis and management model for the prevention of vertical transmission of HIV in Malawi: The PAC-Man trial protocol Open
This study is registered at ClinicalTrials.gov, NCT06493357.
View article: Life course socioeconomic disadvantage and persistent infection burden: Links to cellular immunosenescence in U.S. young adults
Life course socioeconomic disadvantage and persistent infection burden: Links to cellular immunosenescence in U.S. young adults Open
Persistent SES disadvantage was consistently associated with higher infection burden and more aged immune cell profiles before midlife. Understanding this link is key for addressing health disparities.
View article: Correction to: Modeling Cash Plus Other Psychosocial and Structural Interventions to Prevent HIV Among Adolescent Girls and Young Women in South Africa (HPTN 068)
Correction to: Modeling Cash Plus Other Psychosocial and Structural Interventions to Prevent HIV Among Adolescent Girls and Young Women in South Africa (HPTN 068) Open
View article: Semiparametric g-computation for survival outcomes with time-fixed exposures: An illustration
Semiparametric g-computation for survival outcomes with time-fixed exposures: An illustration Open
View article: Children with hepatitis B virus infections, Democratic Republic of the Congo
Children with hepatitis B virus infections, Democratic Republic of the Congo Open
Our investigation highlights the importance of subnational prevalence estimates in large countries such as the Democratic Republic of the Congo, and we have identified regions that may benefit from improved childhood vaccination delivery s…
View article: Assessing Exposure to Plastic Related Chemicals in Second-Trimester Pregnancy: A Suspect Screening Approach
Assessing Exposure to Plastic Related Chemicals in Second-Trimester Pregnancy: A Suspect Screening Approach Open
Given the dramatic increase in plastic production with a concurrent increase in exposure to plastic-related chemicals, we developed a suspect screening approach to assess prenatal exposure to plastic-related chemicals. Using liquid chromat…
View article: Effectiveness of peer-led health behaviour interventions on adolescent’s mental health and wellbeing: a systematic review and meta-analysis
Effectiveness of peer-led health behaviour interventions on adolescent’s mental health and wellbeing: a systematic review and meta-analysis Open
Mental health disorders affect 15% of youth aged 10-19 years globally, typically emerging before age 15. While school-based peer-led programs show promise in improving physical health behaviours by leveraging existing social networks, redu…
View article: 178 Assessing variability in nutrient composition and hydration properties of US soybean meal sources through dimensionality reduction
178 Assessing variability in nutrient composition and hydration properties of US soybean meal sources through dimensionality reduction Open
In the US, 85% of soybean meal (SBM) is used in swine and poultry diets. The recent increase supply from new processing plants highlights the importance of characterizing SBM quality and variability to optimize nutrition. This study determ…
View article: 223 Dimensionality reduction-based analysis identifies key drivers of nutrient and physicochemical variability in U.S. soybean hull sources
223 Dimensionality reduction-based analysis identifies key drivers of nutrient and physicochemical variability in U.S. soybean hull sources Open
Soybean hulls (SH) are a fibrous by-product obtained from soybean processing. In the U.S., where fiber sources for swine are limited, SH offers a valuable source of soluble fiber. However, SH nutrient and physicochemical variability are po…
View article: Emotional and functional well-being in long-term breast cancer survivorship
Emotional and functional well-being in long-term breast cancer survivorship Open
View article: Bias in studies of prenatal exposures using real-world data due to pregnancy identification method
Bias in studies of prenatal exposures using real-world data due to pregnancy identification method Open
Background: Researchers typically identify pregnancies in healthcare data based on observed outcomes (e.g., delivery). This outcome-based approach misses pregnancies that received prenatal care but whose outcomes were not recorded (e.g., a…
View article: Assessing Exposure to Plastic Related Chemicals in Second-Trimester Pregnancy: A Suspect Screening Approach
Assessing Exposure to Plastic Related Chemicals in Second-Trimester Pregnancy: A Suspect Screening Approach Open
Given the dramatic increase in plastic production with a concurrent increase in exposure to plastic-related chemicals, we developed a suspect screening approach to assess prenatal exposure to plastic-related chemicals. Using liquid chromat…
View article: Double robust variance estimation with parametric working models
Double robust variance estimation with parametric working models Open
Doubly robust estimators have gained popularity in the field of causal inference due to their ability to provide consistent point estimates when either an outcome or an exposure model is correctly specified. However, for nonrandomized expo…
View article: Seasonal variation and interspecies dynamics among<i>Plasmodium falciparum</i>and<i>ovale</i>species in Bagamoyo, Tanzania
Seasonal variation and interspecies dynamics among<i>Plasmodium falciparum</i>and<i>ovale</i>species in Bagamoyo, Tanzania Open
Background Malaria control in sub-Saharan Africa is typically focused on Plasmodium falciparum ( Pf ), but non-falciparum species like P. ovale curtisi ( Poc ) and P. ovale wallikeri ( Pow ) appear to be rising in prevalence, especially in…
View article: Performance of a Claims-Based Frailty Proxy Using Varying Frailty Ascertainment Lookback Windows
Performance of a Claims-Based Frailty Proxy Using Varying Frailty Ascertainment Lookback Windows Open
BACKGROUND: Frailty is an aging-related syndrome of reduced physiological reserve to maintain homeostasis. The Faurot frailty index has been validated as a Medicare claims-based proxy for predicting frailty using billing information from a…
View article: Effectiveness of dolutegravir-based vs boosted darunavir-based first-line 3-drug regimens in people with HIV with advanced disease: A trial emulation
Effectiveness of dolutegravir-based vs boosted darunavir-based first-line 3-drug regimens in people with HIV with advanced disease: A trial emulation Open
View article: Accounting for Missing Data in Public Health Research Using a Synthesis of Statistical and Mathematical Models
Accounting for Missing Data in Public Health Research Using a Synthesis of Statistical and Mathematical Models Open
Introduction: Accounting for missing data by imputing or weighting conditional on covariates relies on the variable with missingness being observed at least some of the time for all unique covariate values. This requirement is referred to …