Explanipedia

Abnormal Magnetic Resonance Imaging in the Medial Prefrontal Cortex Following Prenatal Alcohol Exposure and Placental Insufficiency in a Preclinical Model Open

Riddhi Patel, Americo Rivera, Jessie R. Maxwell · 2025

Introduction: The combination of Prenatal Alcohol Exposure (PAE) and Placental Insufficiency (PI) places infants at an increased risk for preterm birth and may worsen brain injury and neurobehavioral outcomes. In this preclinical study, th…

The protocol for a pilot feasibility trial of Improving Neurodevelopmental ouTcomes After prenatal Cannabinoid in uTero exposure (INTACT) study for a multi-center trial Open

Jessie R. Maxwell, Leigh‐Anne Cioffredi, Maria M. Talavera‐Barber, M. Henry, Sandra Sundquist Beauman , et al. · 2025

Background Legalization of recreational cannabis use is expanding across the United States, and prenatal cannabis has steadily increased. Evidence suggests that many pregnant individuals use cannabis to relieve symptoms like nausea. Resear…

Abnormal neurobehavior profiles observed in the newborn period following low‐to‐moderate prenatal alcohol exposure Open

Jessie R. Maxwell, Melissa Roberts, Jean Lowe, Xingya Ma, Jillian F. Kotulski , et al. · 2025

Background Prenatal alcohol exposure (PAE) has lifelong consequences on affected individuals, with a range of physical, neurodevelopmental, learning, and behavioral adverse outcomes. There is no method to identify children at risk of these…

Prenatal Alcohol Exposure and Transient Systemic Hypoxia–Ischemia Result in Subtle Alterations in Dendritic Complexity in Medial Frontal Cortical Neurons in Juvenile and Young Adult Rat Offspring in a Pilot Study Open

Zarena M. Dominguez, Suzy Davies, Nathaniel G. Pavlik, Jessie Newville, B Dunn , et al. · 2024

Prenatal alcohol exposure (PAE) is associated with long-term neurodevelopmental deficits resulting in impaired executive functioning and motor control. Intriguingly, PAE has been linked with an increased risk of transient systemic hypoxia–…

Cerebral oxygenation in preterm infants at high altitude: a prospective pilot cohort study Open

Leah Enright, Jessica Gross, D. Novak, Jessie R. Maxwell · 2024

Introduction: Near-infrared spectroscopy (NIRS) is a non-invasive technique for measuring regional oxygen saturation. Because preterm infants are susceptible to brain injury secondary to immaturity of the central nervous system (CNS) and c…

Infant Feeding and Weight Trajectories in the Eat, Sleep, Console Trial Open

Stephanie L. Merhar, Zhuopei Hu, Lori A. Devlin, Songthip Ounpraseuth, Alan E. Simon , et al. · 2024

Importance Infants with neonatal opioid withdrawal syndrome (NOWS) cared for with the Eat, Sleep, Console (ESC) care approach receive less pharmacologic treatment and have shorter hospital stays compared to usual care with the Finnegan Neo…

Infant and early childhood physical health assessments in the HEALthy Brain and Child Development (HBCD) Study Open

Leigh‐Anne Cioffredi, Bailey Garner, Jessie R. Maxwell, Stephanie L. Merhar, Myriam Peralta‐Carcelen , et al. · 2024

The HEALthy Brain and Child Development (HBCD) Study, a multi-site prospective longitudinal cohort study, will examine human brain, cognitive, behavioral, social and emotional development beginning prenatally and planned through early chil…

Moderate Prenatal Alcohol Exposure Increases Toll-like Receptor Activity in Umbilical Cord Blood at Birth: A Pilot Study Open

Jessie R. Maxwell, Shahani Noor, Nathaniel Pavlik, Dominique E. Rodriguez, Lidia Enriquez Marquez , et al. · 2024

The prevalence of prenatal alcohol exposure (PAE) is increasing, with evidence suggesting that PAE is linked to an increased risk of infections. PAE is hypothesized to affect the innate immune system, which identifies pathogens through pat…

Influence of Eat, Sleep, and Console on Infants Pharmacologically Treated for Opioid Withdrawal Open

Lori A. Devlin, Zhuopei Hu, Stephanie L. Merhar, Songthip Ounpraseuth, Alan E. Simon , et al. · 2024

Importance The function-based eat, sleep, console (ESC) care approach substantially reduces the proportion of infants who receive pharmacologic treatment for neonatal opioid withdrawal syndrome (NOWS). This reduction has led to concerns fo…

The impact of recreational cannabinoid legalization on utilization in a pregnant population Open

Jacob M. Torres, Colton Miller, Michael Apostol, Jessica Gross, Jessie R. Maxwell · 2024

Background Marijuana potency and utilization both continue to increase across the United States. While the overall prevalence of cannabinoid utilization during pregnancy has been surveyed in various studies, the direct impact of changing g…

Prenatal cannabinoid exposure: why expecting individuals should take a pregnancy pause from using cannabinoid products Open

Alexis Lin, Gelonia Dent, Suzy Davies, Zarena M. Dominguez, Leigh‐Anne Cioffredi , et al. · 2023

Cannabinoid use in all populations is increasing as legalization across the United States continues. Concerningly, there is a lack of caution provided by medical providers to pregnant individuals as to the impact the use of cannabinoids co…

Pilot study shows skin-to-skin care with parents improves heart rate variability in preterm infants in the neonatal intensive care unit Open

Erin Swieter, Jessica Gross, Julia M. Stephen, Kristi L. Watterberg, Jessie R. Maxwell · 2023

Background Skin-to-skin care in the newborn intensive care unit typically lasts for short periods of time and enhances breastfeeding, attachment, and parental self-esteem. Heart rate variability (HRV) increases with gestational age and is …

Impact of low-level prenatal alcohol exposure and maternal stress on autonomic regulation Open

Jessie R. Maxwell, Jared DiDomenico, Melissa Roberts, Lidia Enriquez Marquez, Rajani Rai , et al. · 2023

Medication for Opioid Use Disorder During Pregnancy — Maternal and Infant Network to Understand Outcomes Associated with Use of Medication for Opioid Use Disorder During Pregnancy (MAT-LINK), 2014–2021 Open

Kathryn Miele, Shin Y. Kim, R.G. Jones, Juneka H. Rembert, Elisha M. Wachman , et al. · 2023

MAT-LINK is a timely and flexible surveillance system with data on approximately 5,500 pregnancies. Ongoing data collection and analyses of these data will provide information to support clinical and public health guidance to improve healt…

Eat, Sleep, Console Approach or Usual Care for Neonatal Opioid Withdrawal Open

Leslie Young, Songthip Ounpraseuth, Stephanie L. Merhar, Zhuopei Hu, Alan E. Simon , et al. · 2023

As compared with usual care, use of the Eat, Sleep, Console care approach significantly decreased the number of days until infants with neonatal opioid withdrawal syndrome were medically ready for discharge, without increasing specified ad…

The Impact of Coronavirus Disease 2019 on Maternal and Fetal Wellbeing in New Mexico Open

Tiffany Emery, Kati Baillie, Orrin Myers, Hellen Ko, Jessie R. Maxwell · 2022

Coronavirus disease 2019 (COVID-19) has been shown to affect the vasculature, including placental changes. Insults to the placenta, especially in the first and second trimester, can affect placental functionality with a resultant impact on…

Prenatal diagnosis of cloacal anomaly: A case of unexpected anatomical abnormalities after birth Open

Erin Swieter, Jason McKee, Jessica M. Ming, Jessie R. Maxwell · 2022

Post-discharge healthcare utilization in infants with neonatal opioid withdrawal syndrome Open

Shikhar Shrestha, Melissa Roberts, Jessie R. Maxwell, Lawrence Leeman, Ludmila N. Bakhireva · 2021

Moderate Prenatal Alcohol Exposure Increases Toll-Like Receptors Activity Detectable in Umbilical Cord Blood at Birth Open

Jessie R. Maxwell, Shahani Noor, Nathaniel Pavlik, Dominique E. Rodriguez, Lidia Enriquez Marquez , et al. · 2021

One in nine pregnant women report drinking during pregnancy. Prenatal alcohol exposure (PAE) increases the risk of infection in the newborn by altering development with resultant changes in immune function including cytokine expression. To…

Perinatal Opioid Exposure Primes the Peripheral Immune System Toward Hyperreactivity Open

Jessie Newville, Jessie R. Maxwell, Yuma Kitase, Shenandoah Robinson, Lauren L. Jantzie · 2020

The increased incidence of opioid use during pregnancy warrants investigation to reveal the impact of opioid exposure on the developing fetus. Exposure during critical periods of development could have enduring consequences for affected in…

Neonatal Hypoxic-Ischemic Encephalopathy Yields Permanent Deficits in Learning Acquisition: A Preclinical Touchscreen Assessment Open

Jessie R. Maxwell, Amber Zimmerman, Nathaniel G Pavlik, Jessie Newville, Katherine Carlin , et al. · 2020

Neonatal hypoxic-ischemic encephalopathy (HIE) remains a common problem world-wide for infants born at term. The impact of HIE on long-term outcomes, especially into adulthood, is not well-described. To facilitate identification of biobeha…

Amyand's hernia with perforated appendicitis complicated by post-operative bowel Necrosis in an extremely preterm infant Open

Sonal Patel, Jason McKee, Jessie R. Maxwell · 2020

Amyand's hernia is an exceedingly rare condition in which the appendix is found in an inguinal hernia. The appendix can be normal, inflamed, infected, or perforated. Here, we present a case of perforated appendicitis in an Amyand's hernia …

The Impact of Maternal Infection on the Neonate Open

Hellen Ko, Walter Dehority, Jessie R. Maxwell · 2020

Maternal infection is a common occurrence during pregnancy, with a substantial impact on the infant. Some infections result in impaired development in utero and even death of the fetus. Other infections may be insidious in the mother but r…

Increased Incidence of Asthma in Children with Prenatal Opioid Exposure Open

Isabella Cervantes, Shikhar Shrestha, Sharon L. Ruyak, Jessie R. Maxwell · 2020

Prenatal opioid exposure (POE) has increased dramatically in the last 10 years, with nearly 100 babies born daily in the United States with Neonatal Opioid Withdrawal Syndrome (NOWS). The impact on long-term outcomes continues to be invest…

Prenatal Alcohol Exposure and Chorioamnionitis Results in Microstructural Brain Injury in a Preclinical Investigation. Open

Jessie R. Maxwell, Tracylyn R. Yellowhair, Suzy Davies, Danny Rogers, Krystle Lynn McCarson , et al. · 2020

The combination of moderate PAE+CHORIO results in an increased mortality, concomitant with diffuse microstructural brain injury noted in young adolescent offspring at PD28. Future studies should examine the extent to which PAE exacerbates …

Prenatal Alcohol Exposure and Placental Insufficiency Results in Reduced Neuronal Complexity in the Rat Prefrontal Cortex Open

Nathaniel Pavlik, Jessie Newville, Clement P. Jose, Suzy Davies, Jennifer L. Wagner , et al. · 2020

Prenatal Alcohol Exposure (PAE) can produce long-term neurodevelopmental deficits and impaired executive function. Alcohol exposure during gestation is associated with impaired fetal development caused by placental insufficiency. The impac…

Why Alcohol Can Hurt Babies Before They Are Born Open

Nathaniel G. Pavlik, Jessie Newville, Jessie R. Maxwell · 2019

Some chemicals can be really harmful to the body. This is especially true for babies before they are born, because many important parts of their bodies are still forming. Alcohol is a chemical found in some adult drinks that is harmful for…

Prenatal opioid exposure: The next neonatal neuroinflammatory disease Open

Lauren L. Jantzie, Jessie R. Maxwell, Jessie Newville, Tracylyn R. Yellowhair, Yuma Kitase , et al. · 2019

CXCR2 Blockade Mitigates Neural Cell Injury Following Preclinical Chorioamnionitis Open

Tracylyn R. Yellowhair, Jessie Newville, Shahani Noor, Jessie R. Maxwell, Erin D. Milligan , et al. · 2019

Minimizing central nervous system (CNS) injury from preterm birth depends upon identification of the critical pathways that underlie essential neurodevelopmental and CNS pathophysiology. While chorioamnionitis (CHORIO), is a leading cause …

Postnatal diagnosis of de novo complex der(8) in a boy with prenatal diagnosis of recombinant chromosome 8 syndrome Open

Marina S. Oren, Jenny E. Camacho, Hongyan Xie, Jean Lowe, Tom Cushing , et al. · 2019

Key Clinical Message Recombinant chromosome 8 syndrome is caused by duplication of 8q and deletion of 8p. A fetus with anomalies was misdiagnosed with this syndrome based on an amniocyte karyotype. Postnatal chromosomal microarray and othe…

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