Jessika Bertacchini
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View article: On the Interplay Between Roughness and Elastic Modulus at the Nanoscale: A Methodology Study with Bone as Model Material
On the Interplay Between Roughness and Elastic Modulus at the Nanoscale: A Methodology Study with Bone as Model Material Open
Atomic force microscopy (AFM)-based nanoindentation enables investigation of the mechanical response of biological materials at a subcellular scale. However, quantitative estimates of mechanical parameters such as the elastic modulus (E) r…
View article: Surface Charge Overrides Protein Corona Formation in Determining the Cytotoxicity, Cellular Uptake, and Biodistribution of Silver Nanoparticles
Surface Charge Overrides Protein Corona Formation in Determining the Cytotoxicity, Cellular Uptake, and Biodistribution of Silver Nanoparticles Open
Silver nanoparticles (AgNPs) hold great promise in biomedical applications due to their unique properties and potential for specific tissue targeting. However, the clinical translation of nanoparticle-based therapeutics remains challenging…
View article: Differential Cytotoxicity of Surface-Functionalized Silver Nanoparticles in Colorectal Cancer and Ex-Vivo Healthy Colonocyte Models
Differential Cytotoxicity of Surface-Functionalized Silver Nanoparticles in Colorectal Cancer and Ex-Vivo Healthy Colonocyte Models Open
Background/Objectives: Engineered nanomaterials, particularly silver nanoparticles (AgNPs), have emerged as promising tools in oncology due to their ability to enhance tumor targeting and minimize off-target effects. This study investigate…
View article: ANKRD2 Knockdown as a Therapeutic Strategy in Osteosarcoma: Effects on Proliferation and Drug Response in U2OS and HOS Cells
ANKRD2 Knockdown as a Therapeutic Strategy in Osteosarcoma: Effects on Proliferation and Drug Response in U2OS and HOS Cells Open
Ankrd2, a mechanoresponsive protein primarily studied in muscle physiology, is emerging as a player in cancer progression. This study investigates the functional role of Ankrd2 in osteosarcoma cells, revealing its critical involvement in c…
View article: Surface charge overrides protein corona formation in determining the cytotoxicity, cellular uptake, and biodistribution of silver nanoparticles
Surface charge overrides protein corona formation in determining the cytotoxicity, cellular uptake, and biodistribution of silver nanoparticles Open
Silver nanoparticles (AgNPs) hold great promise in biomedical applications due to their unique properties and potential for specific tissue targeting. However, the clinical translation of nanoparticle-based therapeutics remains challenging…
View article: Evaluating Laser‐Based Microfabrication in Microfluidics: An Experimental and Computational Trial
Evaluating Laser‐Based Microfabrication in Microfluidics: An Experimental and Computational Trial Open
The aim of this research is to validate a new prototyping method for microfluidic devices which could compete with the widely used polydimethylsiloxane soft lithography. This alternative methodology uses laser‐etched glass and pre‐cured si…
View article: Myoblast-Derived Galectin 3 Impairs the Early Phases of Osteogenesis Affecting Notch and Akt Activity
Myoblast-Derived Galectin 3 Impairs the Early Phases of Osteogenesis Affecting Notch and Akt Activity Open
Galectin-3 (Gal-3) is a pleiotropic lectin produced by most cell types, which regulates multiple cellular processes in various tissues. In bone, depending on its cellular localization, Gal-3 has a dual and opposite role. If, on the one han…
View article: Zirconia Hybrid Dental Implants Influence the Biological Properties of Neural Crest-Derived Mesenchymal Stromal Cells
Zirconia Hybrid Dental Implants Influence the Biological Properties of Neural Crest-Derived Mesenchymal Stromal Cells Open
Dental implants are regularly employed in tooth replacement, the good clinical outcome of which is strictly correlated to the choice of an appropriate implant biomaterial. Titanium-based implants are considered the gold standard for rehabi…
View article: Ultrasound Stimulation of Piezoelectric Nanocomposite Hydrogels Boosts Chondrogenic Differentiation <i>in Vitro</i>, in Both a Normal and Inflammatory Milieu
Ultrasound Stimulation of Piezoelectric Nanocomposite Hydrogels Boosts Chondrogenic Differentiation <i>in Vitro</i>, in Both a Normal and Inflammatory Milieu Open
The use of piezoelectric nanomaterials combined with ultrasound stimulation is emerging as a promising approach for wirelessly triggering the regeneration of different tissue types. However, it has never been explored for boosting chondrog…
View article: Fluid dynamic parameters of naturally derived hydroxyapatite scaffolds for in vitro studies of bone cells
Fluid dynamic parameters of naturally derived hydroxyapatite scaffolds for in vitro studies of bone cells Open
Hydroxyapatite scaffolds obtained from the biomorphic transformation of wood are characterized from a fluid dynamic point of view. Such material of recent introduction offers great advantages for the in vitro study of bone cells, mostly in…
View article: Human dental pulp stem cells (hDPSCs) promote the lipofibroblast transition in the early stage of a fibro-inflammatory process
Human dental pulp stem cells (hDPSCs) promote the lipofibroblast transition in the early stage of a fibro-inflammatory process Open
Introduction: In autoimmune diseases, particularly in systemic sclerosis and chronic periaortitis, a strict correlation between chronic inflammation and fibrosis exists. Since the currently used drugs prove mostly effective in suppressing …
View article: Flow-dependent shear stress affects the biological properties of pericyte-like cells isolated from human dental pulp
Flow-dependent shear stress affects the biological properties of pericyte-like cells isolated from human dental pulp Open
View article: Experimental measurements and CFD modelling of hydroxyapatite scaffolds in perfusion bioreactors for bone regeneration
Experimental measurements and CFD modelling of hydroxyapatite scaffolds in perfusion bioreactors for bone regeneration Open
In the field of bone tissue engineering, particular interest is devoted to the development of 3D cultures to study bone cell proliferation under conditions similar to in vivo ones, e.g. by artificially producing mechanical stresses promoti…
View article: An Alternative Solution for Microfluidic Chip Fabrication
An Alternative Solution for Microfluidic Chip Fabrication Open
This paper focuses on microfluidic devices, widely used in bioengineering. Their fabrication for research is almost entirely made of PDMS (a silicone), using photolithography and replica molding technologies, which involve many processing …
View article: Ultrasound stimulation of piezoelectric nanocomposite hydrogels boosts cartilage regeneration
Ultrasound stimulation of piezoelectric nanocomposite hydrogels boosts cartilage regeneration Open
Osteoarthritis implies a progressive degeneration of the whole joint. Cartilage is particularly affected, with inflammation playing a pivotal role1. In recent years, cartilage regeneration has been pursued through several bioengineering st…
View article: Characterization of Dental Pulp Stem Cells Response to Bone Substitutes Biomaterials in Dentistry
Characterization of Dental Pulp Stem Cells Response to Bone Substitutes Biomaterials in Dentistry Open
Bone substitute biomaterials (BSBs) represent a promising alternative to bone autografts, due to their biocompatibility, osteoconduction, slow resorption rates, and the ability to define and maintain volume for bone gain in dentistry. Many…
View article: Liquid flow in scaffold derived from natural source: experimental observations and biological outcome
Liquid flow in scaffold derived from natural source: experimental observations and biological outcome Open
This study investigates the biological effects on a 3D scaffold based on hydroxyapatite cultured with MC3T3 osteoblasts in response to flow-induced shear stress (FSS). The scaffold adopted here (B-HA) derives from the biomorphic transforma…
View article: The Combination of AHCC and ETAS Decreases Migration of Colorectal Cancer Cells, and Reduces the Expression of LGR5 and Notch1 Genes in Cancer Stem Cells: A Novel Potential Approach for Integrative Medicine
The Combination of AHCC and ETAS Decreases Migration of Colorectal Cancer Cells, and Reduces the Expression of LGR5 and Notch1 Genes in Cancer Stem Cells: A Novel Potential Approach for Integrative Medicine Open
The AHCC standardized extract of cultured Lentinula edodes mycelia, and the standardized extract of Asparagus officinalis stem, trademarked as ETAS, are well known supplements with immunomodulatory and anticancer potential. Several reports…
View article: Role of PD-L1 in licensing immunoregulatory function of dental pulp mesenchymal stem cells
Role of PD-L1 in licensing immunoregulatory function of dental pulp mesenchymal stem cells Open
View article: Mechanisms Involved in the Promoting Activity of Fibroblasts in HTLV-1-Mediated Lymphomagenesis: Insights into the Plasticity of Lymphomatous Cells
Mechanisms Involved in the Promoting Activity of Fibroblasts in HTLV-1-Mediated Lymphomagenesis: Insights into the Plasticity of Lymphomatous Cells Open
Among the mechanisms leading to progression to Adult T-cell Leukaemia/Lymphoma in Human T-cell Leukaemia Virus type 1 (HTLV-1)-infected subjects, the contribution of stromal components remains poorly understood. To dissect the role of fibr…
View article: Autoimmunity Profiles as Prognostic Indicators in Patients with Colorectal Cancer versus Those with Cancer at Other Sites: A Prospective Study
Autoimmunity Profiles as Prognostic Indicators in Patients with Colorectal Cancer versus Those with Cancer at Other Sites: A Prospective Study Open
Colorectal cancer represents a paradigmatic model of inflammatory carcinogenesis accompanied by the production of several kinds of tumor-associated autoantibodies (TAABs). The specific aim of this study is to define the clinical impact of …
View article: Surface properties modulate protein corona formation and determine cellular uptake and cytotoxicity of silver nanoparticles
Surface properties modulate protein corona formation and determine cellular uptake and cytotoxicity of silver nanoparticles Open
The lack of the basic understanding of how NPs interact with the biological environment has severely limited their delivery efficiency to target tissue and clinical translation. Here, we show the effective regulation of the surface propert…
View article: Surface properties modulate protein corona formation and determine cellular uptake and cytotoxicity of silver nanoparticles
Surface properties modulate protein corona formation and determine cellular uptake and cytotoxicity of silver nanoparticles Open
The lack of the basic understanding of how NPs interact with the biological environment has severely limited their delivery efficiency to target tissue and clinical translation. Here, we show the effective regulation of the surface propert…
View article: Evaluation of Antimicrobial Effect of Air-Polishing Treatments and Their Influence on Human Dental Pulp Stem Cells Seeded on Titanium Disks
Evaluation of Antimicrobial Effect of Air-Polishing Treatments and Their Influence on Human Dental Pulp Stem Cells Seeded on Titanium Disks Open
Dental implants are one of the most frequently used treatment options for tooth replacement, and titanium is the metal of choice due to its demonstrated superiority in resisting corrosion, lack of allergic reactions and mechanical strength…
View article: Identification of Sclerostin as a Putative New Myokine Involved in the Muscle-to-Bone Crosstalk
Identification of Sclerostin as a Putative New Myokine Involved in the Muscle-to-Bone Crosstalk Open
Bone and muscle have been recognized as endocrine organs since they produce and secrete “hormone-like factors” that can mutually influence each other and other tissues, giving rise to a “bone–muscle crosstalk”. In our study, we made use of…
View article: Surface properties modulate protein corona formation and determine cellular uptake and cytotoxicity of silver nanoparticles
Surface properties modulate protein corona formation and determine cellular uptake and cytotoxicity of silver nanoparticles Open
The role of the surface properties of nanoparticles in serum protein adsorption, cellular uptake and cytotoxicity is reported. The surface properties of nanoparticles regulate their ability to adsorb proteins and determine their biological…
View article: WISP-2 expression induced by Teriparatide treatment affects in vitro osteoblast differentiation and improves in vivo osteogenesis
WISP-2 expression induced by Teriparatide treatment affects in vitro osteoblast differentiation and improves in vivo osteogenesis Open
View article: GnRH Antagonists Produce Differential Modulation of the Signaling Pathways Mediated by GnRH Receptors
GnRH Antagonists Produce Differential Modulation of the Signaling Pathways Mediated by GnRH Receptors Open
Commercial gonadotropin-releasing hormone (GnRH) antagonists differ by 1–2 amino acids and are used to inhibit gonadotropin production during assisted reproduction technologies (ART). In this study, potencies of three GnRH antagonists, Cet…
View article: Interaction among Calcium Diet Content, PTH (1-34) Treatment and Balance of Bone Homeostasis in Rat Model: The Trabecular Bone as Keystone
Interaction among Calcium Diet Content, PTH (1-34) Treatment and Balance of Bone Homeostasis in Rat Model: The Trabecular Bone as Keystone Open
The present study is the second step (concerning normal diet restoration) of the our previous study (concerning the calcium-free diet) to determine whether normal diet restoration, with/without concomitant PTH (1-34) administration, can in…
View article: Interplay among calcium diet content, PTH(1-34) treatment and balance of bone homeostases in rat model: the trabecular bone as keystone
Interplay among calcium diet content, PTH(1-34) treatment and balance of bone homeostases in rat model: the trabecular bone as keystone Open
The present study is the second step (concerning the normal-diet restoration) of the our previous one (concerning the calcium-free diet) to determine whether the normal-diet restoration, with/without concomitant PTH(1-34) administration, c…