Jesús G. Galaz-Montoya
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View article: MicroVQA: A Multimodal Reasoning Benchmark for Microscopy-Based Scientific Research
MicroVQA: A Multimodal Reasoning Benchmark for Microscopy-Based Scientific Research Open
Scientific research demands sophisticated reasoning over multimodal data, a challenge especially prevalent in biology. Despite recent advances in multimodal large language models (MLLMs) for AI-assisted research, existing multimodal reason…
View article: CryoViT: Efficient Segmentation of Cryogenic Electron Tomograms with Vision Foundation Models
CryoViT: Efficient Segmentation of Cryogenic Electron Tomograms with Vision Foundation Models Open
Cryogenic electron tomography (cryoET) directly visualizes subcellular structures in 3D at the nanometer scale. Quantitative analyses of cryoET data can reveal structural biomarkers of diseases, provide novel mechanistic insights, and info…
View article: The advent of preventive high-resolution structural histopathology by artificial-intelligence-powered cryogenic electron tomography
The advent of preventive high-resolution structural histopathology by artificial-intelligence-powered cryogenic electron tomography Open
Advances in cryogenic electron microscopy (cryoEM) single particle analysis have revolutionized structural biology by facilitating the in vitro determination of atomic- and near-atomic-resolution structures for fully hydrated macromolecula…
View article: Missing Wedge Completion via Unsupervised Learning with Coordinate Networks
Missing Wedge Completion via Unsupervised Learning with Coordinate Networks Open
Cryogenic electron tomography (cryoET) is a powerful tool in structural biology, enabling detailed 3D imaging of biological specimens at a resolution of nanometers. Despite its potential, cryoET faces challenges such as the missing wedge p…
View article: Missing Wedge Completion via Unsupervised Learning with Coordinate Networks
Missing Wedge Completion via Unsupervised Learning with Coordinate Networks Open
Cryogenic electron tomography (cryoET) is a powerful tool in structural biology, enabling detailed 3D imaging of biological specimens at a resolution of nanometers. Despite its potential, cryoET faces challenges such as the missing wedge p…
View article: The advent of preventive high-resolution structural histopathology by artificial-intelligence-powered cryogenic electron tomography
The advent of preventive high-resolution structural histopathology by artificial-intelligence-powered cryogenic electron tomography Open
Advances in cryogenic electron microscopy (cryoEM) single particle analysis have revolutionized structural biology by facilitating the in vitro determination of atomic- and near-atomic-resolution structures for fully hydrated macromolecula…
View article: Previously uncharacterized rectangular bacterial structures in the dolphin mouth
Previously uncharacterized rectangular bacterial structures in the dolphin mouth Open
View article: CryoET reveals organelle phenotypes in huntington disease patient iPSC-derived and mouse primary neurons
CryoET reveals organelle phenotypes in huntington disease patient iPSC-derived and mouse primary neurons Open
View article: Efficient manual annotation of cryogenic electron tomograms using IMOD
Efficient manual annotation of cryogenic electron tomograms using IMOD Open
View article: CryoET Reveals Organelle Phenotypes in Huntington Disease Patient iPSC-Derived and Mouse Primary Neurons
CryoET Reveals Organelle Phenotypes in Huntington Disease Patient iPSC-Derived and Mouse Primary Neurons Open
Huntington’s Disease (HD) is caused by an expanded CAG repeat in the huntingtin gene, yielding a Huntingtin protein with an expanded polyglutamine tract. Patient-derived induced pluripotent stem cells (iPSCs) can help understand disease; h…
View article: CryoET Reveals Organelle Phenotypes in Huntington Disease Patient iPSC-Derived and Mouse Primary Neurons
CryoET Reveals Organelle Phenotypes in Huntington Disease Patient iPSC-Derived and Mouse Primary Neurons Open
Huntington’s Disease (HD) is caused by an expanded CAG repeat in the huntingtin gene, yielding a Huntingtin protein with an expanded polyglutamine tract. Patient-derived induced pluripotent stem cells (iPSCs) can help understand disease; h…
View article: Cryo-electron tomography provides topological insights into mutant huntingtin exon 1 and polyQ aggregates
Cryo-electron tomography provides topological insights into mutant huntingtin exon 1 and polyQ aggregates Open
Huntington disease (HD) is a neurodegenerative trinucleotide repeat disorder caused by an expanded poly-glutamine (polyQ) tract in the mutant huntingtin (mHTT) protein. The formation and topology of filamentous mHTT inclusions in the brain…
View article: Topological Insights into Mutant Huntingtin Exon 1 and PolyQ Aggregates by Cryo-Electron Tomography
Topological Insights into Mutant Huntingtin Exon 1 and PolyQ Aggregates by Cryo-Electron Tomography Open
Huntington disease (HD) is a neurodegenerative trinucleotide repeat disorder caused by an expanded poly-glutamine (polyQ) tract in the mutant huntingtin (mHTT) protein. The formation and topology of filamentous mHTT inclusions in the brain…
View article: Topological Insights into Mutant Huntingtin Exon 1 and PolyQ Aggregates by Cryo-Electron Tomography
Topological Insights into Mutant Huntingtin Exon 1 and PolyQ Aggregates by Cryo-Electron Tomography Open
Huntington disease (HD) is a neurodegenerative trinucleotide repeat disorder caused by an expanded poly-glutamine (polyQ) tract in the mutant huntingtin (mHTT) protein. The formation and topology of filamentous mHTT inclusions in the brain…
View article: Multi-scale 3D Cryo-Correlative Microscopy for Vitrified Cells
Multi-scale 3D Cryo-Correlative Microscopy for Vitrified Cells Open
View article: Multi-Scale 3D Cryo-Correlative Microscopy for Vitrified Cells
Multi-Scale 3D Cryo-Correlative Microscopy for Vitrified Cells Open
SUMMARY Three-dimensional (3D) visualization of vitrified cells can uncover structures of subcellular complexes without chemical fixation or staining. Here, we present a pipeline integrating three imaging modalities to visualize the same s…
View article: Neutralizing Antibodies Inhibit Chikungunya Virus Budding at the Plasma Membrane
Neutralizing Antibodies Inhibit Chikungunya Virus Budding at the Plasma Membrane Open
View article: CryoEM Maps and Associated Data Submitted to the 2015/2016 EMDataBank Map Challenge
CryoEM Maps and Associated Data Submitted to the 2015/2016 EMDataBank Map Challenge Open
<p>Files and metadata associated with the EMDataBank/Unified Data Resource for 3DEM 2015/2016 Map Challenge hosted at challenges.emdatabank.org are deposited.</p>\n\n<p>All members of the Scientific Community--at all leve…
View article: CryoEM Maps and Associated Data Submitted to the 2015/2016 EMDataBank Map Challenge
CryoEM Maps and Associated Data Submitted to the 2015/2016 EMDataBank Map Challenge Open
Files and metadata associated with the EMDataBank/Unified Data Resource for 3DEM 2015/2016 Map Challenge hosted at challenges.emdatabank.org are deposited. All members of the Scientific Community--at all levels of experience--were invited …
View article: CryoEM Maps and Associated Data Submitted to the 2015/2016 EMDataBank Map Challenge
CryoEM Maps and Associated Data Submitted to the 2015/2016 EMDataBank Map Challenge Open
<p>Files and metadata associated with the EMDataBank/Unified Data Resource for 3DEM 2015/2016 Map Challenge hosted at challenges.emdatabank.org are deposited.</p>\n\n<p>All members of the Scientific Community--at all leve…
View article: The advent of structural biology in situ by single particle cryo-electron tomography
The advent of structural biology in situ by single particle cryo-electron tomography Open
Single particle tomography (SPT), also known as subtomogram averaging, is a powerful technique uniquely poised to address questions in structural biology that are not amenable to more traditional approaches like X-ray crystallography, nucl…
View article: Visualizing Adsorption of Cyanophage P-SSP7 onto Marine Prochlorococcus
Visualizing Adsorption of Cyanophage P-SSP7 onto Marine Prochlorococcus Open
View article: Visualizing Adsorption of Cyanophage P-SSP7 onto Marine Prochlorococcus
Visualizing Adsorption of Cyanophage P-SSP7 onto Marine Prochlorococcus Open
Marine cyanobacteria perform roughly a quarter of global carbon fixation, and cyanophages that infect them liberate some of this carbon during infection and cell lysis. Studies of the cyanobacterium Prochlorococcus MED4 and its associated …
View article: Chaperonin TRiC/CCT Recognizes Fusion Oncoprotein AML1-ETO through Subunit-Specific Interactions
Chaperonin TRiC/CCT Recognizes Fusion Oncoprotein AML1-ETO through Subunit-Specific Interactions Open
View article: Alignment algorithms and per-particle CTF correction for single particle cryo-electron tomography
Alignment algorithms and per-particle CTF correction for single particle cryo-electron tomography Open
View article: Computational Tools to Improve Visualization by Cryo-Electron Tomography
Computational Tools to Improve Visualization by Cryo-Electron Tomography Open
View article: Chaperonin TRiC/CCT Modulates the Folding and Activity of Leukemogenic Fusion Oncoprotein AML1-ETO
Chaperonin TRiC/CCT Modulates the Folding and Activity of Leukemogenic Fusion Oncoprotein AML1-ETO Open
AML1-ETO is the most common fusion oncoprotein causing acute myeloid leukemia (AML), a disease with a 5-year survival rate of only 24%. AML1-ETO functions as a rogue transcription factor, altering the expression of genes critical for myelo…
View article: Dimeric Organization of Blood Coagulation Factor VIII bound to Lipid Nanotubes
Dimeric Organization of Blood Coagulation Factor VIII bound to Lipid Nanotubes Open
View article: Structural Mechanisms of Mutant Huntingtin Aggregation Suppression by the Synthetic Chaperonin-like CCT5 Complex Explained by Cryoelectron Tomography
Structural Mechanisms of Mutant Huntingtin Aggregation Suppression by the Synthetic Chaperonin-like CCT5 Complex Explained by Cryoelectron Tomography Open
Huntington disease, a neurodegenerative disorder characterized by functional deficits and loss of striatal neurons, is linked to an expanded and unstable CAG trinucleotide repeat in the huntingtin gene (HTT). This DNA sequence translates t…
View article: Single particle tomography in EMAN2
Single particle tomography in EMAN2 Open