Jesus J. Benito-Lopez
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View article: A Comprehensive Review of Long Non-Coding RNAs in the Cancer–Immunity Cycle: Mechanisms and Therapeutic Implications
A Comprehensive Review of Long Non-Coding RNAs in the Cancer–Immunity Cycle: Mechanisms and Therapeutic Implications Open
Long non-coding RNAs (lncRNAs) have emerged as pivotal regulators of the dynamic interplay between cancer progression and immune responses. This review explored their influence on key processes of the cancer–immunity cycle, such as immune …
View article: SOCS1 Inhibits IL-6-Induced CD155 Overexpression in Lung Adenocarcinoma
SOCS1 Inhibits IL-6-Induced CD155 Overexpression in Lung Adenocarcinoma Open
CD155, also known as the poliovirus receptor (PVR), is a crucial molecule in the development and progression of cancer, as its overexpression favors immune evasion and resistance to immunotherapy. However, little is known about the mechani…
View article: Transcriptomic Analysis Reveals Early Alterations Associated with Intrinsic Resistance to Targeted Therapy in Lung Adenocarcinoma Cell Lines
Transcriptomic Analysis Reveals Early Alterations Associated with Intrinsic Resistance to Targeted Therapy in Lung Adenocarcinoma Cell Lines Open
Lung adenocarcinoma is the most prevalent form of lung cancer, and drug resistance poses a significant obstacle in its treatment. This study aimed to investigate the overexpression of long non-coding RNAs (lncRNAs) as a mechanism that prom…
View article: Transcriptomic Analysis Reveals Early Alterations Associated with Intrinsic Resistance to Target Therapy in Lung Adenocarcinoma Cell Lines
Transcriptomic Analysis Reveals Early Alterations Associated with Intrinsic Resistance to Target Therapy in Lung Adenocarcinoma Cell Lines Open
Lung adenocarcinoma is the most prevalent form of lung cancer, and drug resistance is a significant obstacle in its treatment. This study aimed to investigate the overexpression of long non-coding RNAs (lncRNAs) as a mechanism that promote…
View article: Transcriptional signature of early cisplatin drug-tolerant persister cells in lung adenocarcinoma
Transcriptional signature of early cisplatin drug-tolerant persister cells in lung adenocarcinoma Open
Resistance to cisplatin is the main cause of treatment failure in lung adenocarcinoma. Drug-tolerant-persister (DTP) cells are responsible for intrinsic resistance, since they survive the initial cycles of treatment, representing a reservo…
View article: Partners in crime: The feedback loop between metabolic reprogramming and immune checkpoints in the tumor microenvironment
Partners in crime: The feedback loop between metabolic reprogramming and immune checkpoints in the tumor microenvironment Open
The tumor microenvironment (TME) is a complex and constantly changing cellular system composed of heterogeneous populations of tumor cells and non-transformed stromal cells, such as stem cells, fibroblasts, endothelial cells, pericytes, ad…
View article: The systemic-level repercussions of cancer-associated inflammation mediators produced in the tumor microenvironment
The systemic-level repercussions of cancer-associated inflammation mediators produced in the tumor microenvironment Open
The tumor microenvironment is a dynamic, complex, and redundant network of interactions between tumor, immune, and stromal cells. In this intricate environment, cells communicate through membrane–membrane, ligand–receptor, exosome, soluble…