Jesús Planagumà
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View article: Autoimmune neuropsychiatric disorders manifesting with psychosis
Autoimmune neuropsychiatric disorders manifesting with psychosis Open
The increasing recognition of a new category of encephalitides that occur in association with antibodies against neuronal surface proteins has prompted the use of terms like "autoimmune psychosis" and "autoimmune psychiatric disorders." Ho…
View article: Assessing Commercial Tissue-Based Assays for Autoimmune Neurologic Disorders (II)
Assessing Commercial Tissue-Based Assays for Autoimmune Neurologic Disorders (II) Open
The diagnostic performance of EUROIMMUN IIF-TBA in detecting NSAbs in autoimmune encephalitis is suboptimal. NMDAR antibodies, among the most common NSAbs, can be missed in 50% of cases. This commercial TBA should not be used alone as a sc…
View article: Assessing Commercial Tissue-Based Assays for Autoimmune Neurologic Disorders (I)
Assessing Commercial Tissue-Based Assays for Autoimmune Neurologic Disorders (I) Open
The performance of commercial IIF-TBAs for IC-Abs detection is suboptimal, exhibiting high false-negative rates of 25%-35%. Therefore, commercial TBAs should not be used alone for IC-Abs screening, but alongside more sensitive techniques, …
View article: Neuro-immunobiology and treatment assessment in a mouse model of anti-NMDAR encephalitis
Neuro-immunobiology and treatment assessment in a mouse model of anti-NMDAR encephalitis Open
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a disorder mediated by autoantibodies against the GluN1 subunit of NMDAR. It occurs with severe neuropsychiatric symptoms that often improve with immunotherapy. Clinical studies an…
View article: Neuro-immunobiology and treatment assessment in a mouse model of anti-NMDAR encephalitis
Neuro-immunobiology and treatment assessment in a mouse model of anti-NMDAR encephalitis Open
Anti-N-methyl- D -aspartate receptor (NMDAR) encephalitis is a disorder mediated by autoantibodies against the GluN1 subunit of NMDAR. It occurs with severe neuropsychiatric symptoms that often improve with immunotherapy. Clinical studies …
View article: Supplementary Figure 1 from ERM/ETV5 Up-regulation Plays a Role during Myometrial Infiltration through Matrix Metalloproteinase-2 Activation in Endometrial Cancer
Supplementary Figure 1 from ERM/ETV5 Up-regulation Plays a Role during Myometrial Infiltration through Matrix Metalloproteinase-2 Activation in Endometrial Cancer Open
Supplementary Figure 1 from ERM/ETV5 Up-regulation Plays a Role during Myometrial Infiltration through Matrix Metalloproteinase-2 Activation in Endometrial Cancer
View article: Supplementary Figure 2 from ERM/ETV5 Up-regulation Plays a Role during Myometrial Infiltration through Matrix Metalloproteinase-2 Activation in Endometrial Cancer
Supplementary Figure 2 from ERM/ETV5 Up-regulation Plays a Role during Myometrial Infiltration through Matrix Metalloproteinase-2 Activation in Endometrial Cancer Open
Supplementary Figure 2 from ERM/ETV5 Up-regulation Plays a Role during Myometrial Infiltration through Matrix Metalloproteinase-2 Activation in Endometrial Cancer
View article: Supplementary Figure Legends 1-3 from ERM/ETV5 Up-regulation Plays a Role during Myometrial Infiltration through Matrix Metalloproteinase-2 Activation in Endometrial Cancer
Supplementary Figure Legends 1-3 from ERM/ETV5 Up-regulation Plays a Role during Myometrial Infiltration through Matrix Metalloproteinase-2 Activation in Endometrial Cancer Open
Supplementary Figure Legends 1-3 from ERM/ETV5 Up-regulation Plays a Role during Myometrial Infiltration through Matrix Metalloproteinase-2 Activation in Endometrial Cancer
View article: Supplementary Figure Legends 1-3 from ERM/ETV5 Up-regulation Plays a Role during Myometrial Infiltration through Matrix Metalloproteinase-2 Activation in Endometrial Cancer
Supplementary Figure Legends 1-3 from ERM/ETV5 Up-regulation Plays a Role during Myometrial Infiltration through Matrix Metalloproteinase-2 Activation in Endometrial Cancer Open
Supplementary Figure Legends 1-3 from ERM/ETV5 Up-regulation Plays a Role during Myometrial Infiltration through Matrix Metalloproteinase-2 Activation in Endometrial Cancer
View article: Supplementary Figure 3 from ERM/ETV5 Up-regulation Plays a Role during Myometrial Infiltration through Matrix Metalloproteinase-2 Activation in Endometrial Cancer
Supplementary Figure 3 from ERM/ETV5 Up-regulation Plays a Role during Myometrial Infiltration through Matrix Metalloproteinase-2 Activation in Endometrial Cancer Open
Supplementary Figure 3 from ERM/ETV5 Up-regulation Plays a Role during Myometrial Infiltration through Matrix Metalloproteinase-2 Activation in Endometrial Cancer
View article: Data from ERM/ETV5 Up-regulation Plays a Role during Myometrial Infiltration through Matrix Metalloproteinase-2 Activation in Endometrial Cancer
Data from ERM/ETV5 Up-regulation Plays a Role during Myometrial Infiltration through Matrix Metalloproteinase-2 Activation in Endometrial Cancer Open
We have described recently the Ets family transcription factor, ERM/ETV5, specifically up-regulated in endometrioid endometrial carcinoma (EEC) and associated with myometrial infiltration. Ets family members have been correlated to tumor p…
View article: Supplementary Figure 1 from ERM/ETV5 Up-regulation Plays a Role during Myometrial Infiltration through Matrix Metalloproteinase-2 Activation in Endometrial Cancer
Supplementary Figure 1 from ERM/ETV5 Up-regulation Plays a Role during Myometrial Infiltration through Matrix Metalloproteinase-2 Activation in Endometrial Cancer Open
Supplementary Figure 1 from ERM/ETV5 Up-regulation Plays a Role during Myometrial Infiltration through Matrix Metalloproteinase-2 Activation in Endometrial Cancer
View article: Supplementary Figure 3 from ERM/ETV5 Up-regulation Plays a Role during Myometrial Infiltration through Matrix Metalloproteinase-2 Activation in Endometrial Cancer
Supplementary Figure 3 from ERM/ETV5 Up-regulation Plays a Role during Myometrial Infiltration through Matrix Metalloproteinase-2 Activation in Endometrial Cancer Open
Supplementary Figure 3 from ERM/ETV5 Up-regulation Plays a Role during Myometrial Infiltration through Matrix Metalloproteinase-2 Activation in Endometrial Cancer
View article: Supplementary Figure 2 from ERM/ETV5 Up-regulation Plays a Role during Myometrial Infiltration through Matrix Metalloproteinase-2 Activation in Endometrial Cancer
Supplementary Figure 2 from ERM/ETV5 Up-regulation Plays a Role during Myometrial Infiltration through Matrix Metalloproteinase-2 Activation in Endometrial Cancer Open
Supplementary Figure 2 from ERM/ETV5 Up-regulation Plays a Role during Myometrial Infiltration through Matrix Metalloproteinase-2 Activation in Endometrial Cancer
View article: Data from ERM/ETV5 Up-regulation Plays a Role during Myometrial Infiltration through Matrix Metalloproteinase-2 Activation in Endometrial Cancer
Data from ERM/ETV5 Up-regulation Plays a Role during Myometrial Infiltration through Matrix Metalloproteinase-2 Activation in Endometrial Cancer Open
We have described recently the Ets family transcription factor, ERM/ETV5, specifically up-regulated in endometrioid endometrial carcinoma (EEC) and associated with myometrial infiltration. Ets family members have been correlated to tumor p…
View article: The diagnosis of anti-LGI1 encephalitis varies with the type of immunodetection assay and sample examined
The diagnosis of anti-LGI1 encephalitis varies with the type of immunodetection assay and sample examined Open
Detection of Leucine-rich glioma inactivated 1 (LGI1) antibodies in patients with suspected autoimmune encephalitis is important for diagnostic confirmation and prompt implementation of immunomodulatory treatment. However, the clinical lab…
View article: Active Immunization Against NMDA NR1 Subunit as a Model of Autoimmune Encephalitis
Active Immunization Against NMDA NR1 Subunit as a Model of Autoimmune Encephalitis Open
Objective To identify and develop the optimal active immunization induction method for NMDAR encephalitis in rodents. Background Encephalitis is a devastating neurologic disorder with high morbidity and mortality. Many cases are autoimmune…
View article: Hippocampal Neuronal Cultures to Detect and Study New Pathogenic Antibodies Involved in Autoimmune Encephalitis
Hippocampal Neuronal Cultures to Detect and Study New Pathogenic Antibodies Involved in Autoimmune Encephalitis Open
Over the last 15 years, a new category of antibody-mediated diseases of the central nervous system (CNS) has been characterized and is now defined as "autoimmune encephalitis" (AE). There are currently 17 known AE syndromes, and all are as…
View article: Human Metabotropic Glutamate Receptor 5 Antibodies Alter Receptor Levels and Behavior in Mice
Human Metabotropic Glutamate Receptor 5 Antibodies Alter Receptor Levels and Behavior in Mice Open
Ophelia syndrome or encephalitis with antibodies against the metabotropic glutamate receptor 5 (mGluR5) manifests with behavioral changes, memory deficits, and anxiety. To study the antibody pathogenicity, mice received continuous cerebrov…
View article: Human CASPR2 Antibodies Reversibly Alter Memory and the CASPR2 Protein Complex
Human CASPR2 Antibodies Reversibly Alter Memory and the CASPR2 Protein Complex Open
Objective The encephalitis associated with antibodies against contactin‐associated proteinlike 2 (CASPR2) is presumably antibody‐mediated, but the antibody effects and whether they cause behavioral alterations are not well known. Here, we …
View article: Allosteric Modulation of NMDARs Reverses Patients' Autoantibody Effects in Mice
Allosteric Modulation of NMDARs Reverses Patients' Autoantibody Effects in Mice Open
An oxysterol biology-based PAM of NMDARs is able to reverse the synaptic and memory deficits caused by CSF from patients with anti-NMDAR encephalitis. These findings suggest a novel adjuvant treatment approach that deserves future clinical…
View article: Blocking Placental Class G Immunoglobulin Transfer Prevents NMDA Receptor Antibody Effects in Newborn Mice
Blocking Placental Class G Immunoglobulin Transfer Prevents NMDA Receptor Antibody Effects in Newborn Mice Open
FcRn blockade prevents placental transfer of IgG from patients with anti-NMDAR encephalitis and abrogates the synaptic and neurodevelopmental alterations caused by patients' antibodies. This model has potential therapeutic implications for…
View article: Thymoma and Autoimmune Encephalitis
Thymoma and Autoimmune Encephalitis Open
Objective: To report the clinical, neuroimaging, and antibody associations in patients with autoimmune encephalitis (AE) and thymoma. Methods: A retrospective cohort study of 43 patients was conducted. Antibody determination and immunoprec…
View article: Thymoma and Autoimmune Encephalitis
Thymoma and Autoimmune Encephalitis Open
AE in patients with thymoma include several clinical-radiologic syndromes that vary according to the associated antibodies. Anti-GABAAR encephalitis was the most frequent AE and occurred more frequently in Japanese patients.
View article: Encephalitis with Autoantibodies against the Glutamate Kainate Receptors <scp>GluK2</scp>
Encephalitis with Autoantibodies against the Glutamate Kainate Receptors <span>GluK2</span> Open
Objective The objective of this study was to report the identification of antibodies against the glutamate kainate receptor subunit 2 (GluK2‐abs) in patients with autoimmune encephalitis, and describe the clinical‐immunological features an…
View article: Placental transfer of NMDAR antibodies causes reversible alterations in mice
Placental transfer of NMDAR antibodies causes reversible alterations in mice Open
In this model, placental transfer of patients' NMDAR antibodies caused severe but reversible synaptic and neurodevelopmental alterations. Reversible antibody effects may contribute to the infrequent and limited number of complications desc…
View article: Seizure-related 6 homolog like 2 autoimmunity
Seizure-related 6 homolog like 2 autoimmunity Open
SEZ6L2-abs associate with a subacute cerebellar syndrome with frequent extrapyramidal symptoms. The potential pathogenic effect of the antibodies is not mediated by internalization of the antigen.
View article: Allosteric modulation of NMDA receptors prevents the antibody effects of patients with anti-NMDAR encephalitis
Allosteric modulation of NMDA receptors prevents the antibody effects of patients with anti-NMDAR encephalitis Open
Anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis is an immune-mediated disease characterized by a complex neuropsychiatric syndrome in association with an antibody-mediated decrease of NMDAR. About 85% of patients respond to immunot…