Jesuthas Ajendra
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View article: Escalation of Germinal Center Responses in Chronic <i>Litomosoides sigmodontis</i> Filarial Infection
Escalation of Germinal Center Responses in Chronic <i>Litomosoides sigmodontis</i> Filarial Infection Open
T follicular helper (T FH ) cells are the primary CD4 + T helper cell subset providing help to B cells for efficient antibody responses in vaccination, allergy, autoimmunity, and infectious diseases. Despite their critical involvement in i…
View article: Major basic protein and eosinophil peroxidase support microfilariae motility inhibition by eosinophil ETosis
Major basic protein and eosinophil peroxidase support microfilariae motility inhibition by eosinophil ETosis Open
Eosinophils are a hallmark of filarial infections. They are primary effector cells and can attack filariae by releasing extracellular traps that contain toxic cationic proteins, such as eosinophil peroxidase and major basic protein. Previo…
View article: Repeated sensitization of mice with microfilariae of Litomosoides sigmodontis induces pulmonary eosinophilia in an IL-33-dependent manner
Repeated sensitization of mice with microfilariae of Litomosoides sigmodontis induces pulmonary eosinophilia in an IL-33-dependent manner Open
Background Eosinophilia is a hallmark of helminth infections and eosinophils are essential in the protective immune responses against helminths. Nevertheless, the distinct role of eosinophils during parasitic filarial infection, allergy an…
View article: Eosinophils are an endogenous source of IL-4 during filarial infections and contribute to the development of an optimal T helper 2 response
Eosinophils are an endogenous source of IL-4 during filarial infections and contribute to the development of an optimal T helper 2 response Open
Interleukin-4 (IL-4) is a central regulator of type 2 immunity, crucial for the defense against multicellular parasites like helminths. This study focuses on its roles and cellular sources during Litomosoides sigmodontis infection, a model…
View article: Eosinophils are an endogenous source of IL-4 during filarial infections and contribute to the development of an optimal T helper 2 response
Eosinophils are an endogenous source of IL-4 during filarial infections and contribute to the development of an optimal T helper 2 response Open
Interleukin-4 (IL-4) is a central regulator of type 2 immunity, crucial for the defense against multicellular parasites like helminths. This study focuses on its roles and cellular sources during Litomosoides sigmodontis infection, a model…
View article: The IL-17A-neutrophil axis promotes epithelial cell IL-33 production during nematode lung migration
The IL-17A-neutrophil axis promotes epithelial cell IL-33 production during nematode lung migration Open
View article: Potential of Nucleic Acid Receptor Ligands to Improve Vaccination Efficacy against the Filarial Nematode Litomosoides sigmodontis
Potential of Nucleic Acid Receptor Ligands to Improve Vaccination Efficacy against the Filarial Nematode Litomosoides sigmodontis Open
More than two-hundred-million people are infected with filariae worldwide. However, there is no vaccine available that confers long-lasting protection against filarial infections. Previous studies indicated that vaccination with irradiated…
View article: T helper 2 cells control monocyte to tissue-resident macrophage differentiation during nematode infection of the pleural cavity
T helper 2 cells control monocyte to tissue-resident macrophage differentiation during nematode infection of the pleural cavity Open
View article: IL-17A promotes epithelial cell IL-33 production during nematode lung migration
IL-17A promotes epithelial cell IL-33 production during nematode lung migration Open
The early migratory phase of pulmonary helminth infections is characterized by tissue injury leading to the release of the alarmin IL-33 and subsequent induction of type 2 immune responses. We recently described a role for IL-17A, through …
View article: Nucleic acid receptor ligands improve vaccination efficacy against the filarial nematode<i>Litomosoides sigmodontis</i>
Nucleic acid receptor ligands improve vaccination efficacy against the filarial nematode<i>Litomosoides sigmodontis</i> Open
Infections with helminths affect more than one billion people worldwide. Despite an urgent need there is no vaccine available that would confer long lasting protection against helminth infections. Previous studies indicated that a vaccinat…
View article: Biology of the Human Filariases
Biology of the Human Filariases Open
Filarial nematodes are parasitic worms transmitted by blood-feeding insects. Mainly found in tropical and subtropical areas of the developing world, diseases such as lymphatic filariasis and onchocerciasis represent major public health iss…
View article: Genotype and Th2 cells control monocyte to tissue resident macrophage differentiation during nematode infection of the pleural cavity
Genotype and Th2 cells control monocyte to tissue resident macrophage differentiation during nematode infection of the pleural cavity Open
The recent revolution in tissue-resident macrophage biology has resulted largely from murine studies performed in the C57BL/6 strain. Here, we provide a comprehensive analysis of immune cells in the pleural cavity using both C57BL/6 and BA…
View article: IL-13 deficiency exacerbates lung damage and impairs epithelial-derived type 2 molecules during nematode infection
IL-13 deficiency exacerbates lung damage and impairs epithelial-derived type 2 molecules during nematode infection Open
IL-13 is implicated in effective repair after acute lung injury and the pathogenesis of chronic diseases such as allergic asthma. Both these processes involve matrix remodelling, but understanding the specific contribution of IL-13 has bee…
View article: Genotype and Th2 Cells Control Monocyte to Tissue Resident Macrophage Differentiation During Nematode Infection of the Pleural Cavity
Genotype and Th2 Cells Control Monocyte to Tissue Resident Macrophage Differentiation During Nematode Infection of the Pleural Cavity Open
View article: IL-17A both initiates, via IFNγ suppression, and limits the pulmonary type-2 immune response to nematode infection
IL-17A both initiates, via IFNγ suppression, and limits the pulmonary type-2 immune response to nematode infection Open
Nippostrongylus brasiliensis is a well-defined model of type-2 immunity but the early lung-migrating phase is dominated by innate IL-17A production. In this study, we confirm previous observations that Il17a-KO mice infected with N. brasil…
View article: TGFβ depletion does neither modulate acute E. coli-induced inflammatory immune responses nor impair the protective effect by chronic filarial infection
TGFβ depletion does neither modulate acute E. coli-induced inflammatory immune responses nor impair the protective effect by chronic filarial infection Open
TGFβ is an anti-inflammatory molecule that suppresses pro-inflammatory immune responses. Previously, we demonstrated that chronic filarial infection has a beneficial impact on Escherichia coli-induced sepsis. In the present study, we inves…
View article: IL-17A both initiates (via IFNγ suppression) and limits the pulmonary type-2 immune response to nematode infection
IL-17A both initiates (via IFNγ suppression) and limits the pulmonary type-2 immune response to nematode infection Open
Nippostrongylus brasiliensis is a well-defined model of type-2 immunity but the early lung-migrating phase is dominated by innate IL-17A production and neutrophilia. Using N. brasiliensis infection we confirm previous observations that Il1…
View article: Inflammasome-Independent Role for NLRP3 in Controlling Innate Antihelminth Immunity and Tissue Repair in the Lung
Inflammasome-Independent Role for NLRP3 in Controlling Innate Antihelminth Immunity and Tissue Repair in the Lung Open
Alternatively activated macrophages are essential effector cells during type 2 immunity and tissue repair following helminth infections. We previously showed that Ym1, an alternative activation marker, can drive innate IL-1R–dependent neut…
View article: Susceptibility to L. sigmodontis infection is highest in animals lacking IL-4R/IL-5 compared to single knockouts of IL-4R, IL-5 or eosinophils
Susceptibility to L. sigmodontis infection is highest in animals lacking IL-4R/IL-5 compared to single knockouts of IL-4R, IL-5 or eosinophils Open
View article: Inflammasome-independent role for NLRP3 in controlling innate anti-helminth immunity and tissue repair in the lung
Inflammasome-independent role for NLRP3 in controlling innate anti-helminth immunity and tissue repair in the lung Open
Alternatively activated macrophages are essential effector cells during type 2 immunity and tissue repair following helminth infections. We previously showed that Ym1, an alternative activation marker, can drive innate IL-1R-dependent neut…
View article: NOD2 dependent neutrophil recruitment is required for early protective immune responses against infectious Litomosoides sigmodontis L3 larvae
NOD2 dependent neutrophil recruitment is required for early protective immune responses against infectious Litomosoides sigmodontis L3 larvae Open
View article: Supplementary Material for: Filarial Infection or Antigen Administration Improves Glucose Tolerance in Diet-Induced Obese Mice
Supplementary Material for: Filarial Infection or Antigen Administration Improves Glucose Tolerance in Diet-Induced Obese Mice Open
Helminths induce type 2 immune responses and establish an anti-inflammatory milieu in their hosts. This immunomodulation was previously shown to improve diet-induced insulin resistance which is linked to chronic inflammation. In the curren…
View article: Filarial Infection or Antigen Administration Improves Glucose Tolerance in Diet-Induced Obese Mice
Filarial Infection or Antigen Administration Improves Glucose Tolerance in Diet-Induced Obese Mice Open
Helminths induce type 2 immune responses and establish an anti-inflammatory milieu in their hosts. This immunomodulation was previously shown to improve diet-induced insulin resistance which is linked to chronic inflammation. In the curren…
View article: Supplementary Material for: Filarial Infection or Antigen Administration Improves Glucose Tolerance in Diet-Induced Obese Mice
Supplementary Material for: Filarial Infection or Antigen Administration Improves Glucose Tolerance in Diet-Induced Obese Mice Open
Helminths induce type 2 immune responses and establish an anti-inflammatory milieu in their hosts. This immunomodulation was previously shown to improve diet-induced insulin resistance which is linked to chronic inflammation. In the curren…
View article: Transfer of primed macrophages improves <i>E. coli</i>-induced sepsis.
Transfer of primed macrophages improves <i>E. coli</i>-induced sepsis. Open
Macrophages derived from Thioglycollate-treated BALB/c or TLR2-/- mice were pre-treated in vitro with LsAg, Wolbachia or medium for 24 hours and subsequently transferred into naïve recipient wild type mice (n = 6/g…
View article: Development of patent Litomosoides sigmodontis infections in semi-susceptible C57BL/6 mice in the absence of adaptive immune responses
Development of patent Litomosoides sigmodontis infections in semi-susceptible C57BL/6 mice in the absence of adaptive immune responses Open
View article: Chronic Filarial Infection Provides Protection against Bacterial Sepsis by Functionally Reprogramming Macrophages
Chronic Filarial Infection Provides Protection against Bacterial Sepsis by Functionally Reprogramming Macrophages Open
Helminths immunomodulate their hosts and induce a regulatory, anti-inflammatory milieu that prevents allergies and autoimmune diseases. Helminth immunomodulation may benefit sepsis outcome by preventing exacerbated inflammation and severe …