Junjie Peng
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View article: Andrographolide suppresses triple-negative breast cancer proliferation through the p53/CDK1 axis: a multiscale analysis combining network pharmacology and machine learning
Andrographolide suppresses triple-negative breast cancer proliferation through the p53/CDK1 axis: a multiscale analysis combining network pharmacology and machine learning Open
Triple-negative breast cancer (TNBC), a highly aggressive molecular subtype characterized by a lack of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) expression, remains a major clin…
View article: A Machine Learning–Based Scoring System to Identify High Immunoactivity Microsatellite Stability Tumors by Quantifying Similarity to Microsatellite Instability-High Tumors in Colorectal Cancers: Development and Quantitative Study
A Machine Learning–Based Scoring System to Identify High Immunoactivity Microsatellite Stability Tumors by Quantifying Similarity to Microsatellite Instability-High Tumors in Colorectal Cancers: Development and Quantitative Study Open
Background Microsatellite stability (MSS) colorectal cancers (CRCs) have a limited response to immune checkpoint inhibitors (ICIs) compared to microsatellite instability-high (MSI-H) CRCs. Nevertheless, previous studies have shown that som…
View article: Prevalence and influencing factors of cognitive frailty in Chinese maintenance hemodialysis patients: a systematic review and meta-analysis
Prevalence and influencing factors of cognitive frailty in Chinese maintenance hemodialysis patients: a systematic review and meta-analysis Open
CRD42023493122CRD42023475424.
View article: Segmental resection of myxoid chondrosarcoma: a case report
Segmental resection of myxoid chondrosarcoma: a case report Open
We report a rare case of extradural spinal chondrosarcoma in a 48-year-old female. The patient was asymptomatic until a traumatic injury led to lumbar pain, revealing a tumor with atypical imaging characteristics in adjacent vertebral segm…
View article: Effectiveness of virtual reality technology in rehabilitation after anterior cruciate ligament reconstruction: A systematic review and meta-analysis
Effectiveness of virtual reality technology in rehabilitation after anterior cruciate ligament reconstruction: A systematic review and meta-analysis Open
Background Anterior cruciate ligament reconstruction (ACLR) can be fully recovered with effective rehabilitation, which also lowers the risk of developing osteoarthritis in the knee. Virtual reality technology (VRT) has been used for rehab…
View article: Chain mediating role of moral values identification and positive psychological capital in the relationship between meaning in life and crisis vulnerability
Chain mediating role of moral values identification and positive psychological capital in the relationship between meaning in life and crisis vulnerability Open
To explore the relationship between meaning in life and vulnerability to crisis among undergraduate nursing students and the chain mediating effect between moral values identification and positive psychological capital (PsyCap). A total of…
View article: Morphological characteristics and phylogenetic analyses revealed two new species from China and a new record from Jilin Province of Agaricales
Morphological characteristics and phylogenetic analyses revealed two new species from China and a new record from Jilin Province of Agaricales Open
In this study, we have found two new species— Stropharia subrugosoannulata and Stropharia microaeruginosa . Phylogenetic analyses, based on the internal transcribed spacer regions (ITS) and the nuclear ribosomal RNA gene (nrLSU), suggest t…
View article: A predictive assay for chemotherapeutic efficacy of stage IV colorectal cancer using serum metabolic features profiling
A predictive assay for chemotherapeutic efficacy of stage IV colorectal cancer using serum metabolic features profiling Open
Background Currently, there is no unbiased colorectal cancer (CRC) prognostic and predictive model based on serum molecular biomarkers to evaluate potential treatment outcomes and risk of CRC relapse for stage IV CRC patients. In addition,…
View article: Personalized circulating tumor DNA monitoring improves recurrence surveillance and management after curative resection of colorectal liver metastases: a prospective cohort study
Personalized circulating tumor DNA monitoring improves recurrence surveillance and management after curative resection of colorectal liver metastases: a prospective cohort study Open
Background: Approximately 60% of patients with colorectal liver metastases (CRLM) experience relapse within 2 years after radical resection, previous studies have proven that repeat local treatment (LT) could prolong survival, however, it …
View article: The development and implementation of pathological parameters and molecular testing impact prognosis of colorectal adenocarcinoma
The development and implementation of pathological parameters and molecular testing impact prognosis of colorectal adenocarcinoma Open
Over the past few decades, updates in elements in pathological reports, as well as the development of standardized tests for MMR/MSI status and RAS/BRAF gene mutations have significantly improved patient outcomes.
View article: The risk prediction models of neonatal necrotizing enterocolitis in China: a systematic review
The risk prediction models of neonatal necrotizing enterocolitis in China: a systematic review Open
Objective Systematically evaluate the risk prediction model for neonatal necrotizing enterocolitis (NEC) in China, providing reference for clinical work and future research. Methods We searched Chinese and English databases were systematic…
View article: Global metabolomics revealed deviations from the metabolic aging clock in colorectal cancer patients
Global metabolomics revealed deviations from the metabolic aging clock in colorectal cancer patients Open
Background: Markers of aging hold promise in the context of colorectal cancer (CRC) care. Utilizing high-resolution metabolomic profiling, we can unveil distinctive age-related patterns that have the potential to predict early CRC developm…
View article: Revealing the microstructure evolution, deformation behavior and tensile properties of AZ31/AM60 dissimilar Mg alloy joints under different welding technologies
Revealing the microstructure evolution, deformation behavior and tensile properties of AZ31/AM60 dissimilar Mg alloy joints under different welding technologies Open
In this work, friction stir welding (FSW) and tungsten inert gas welding (TIG) were applied to prepare two kinds of dissimilar AZ31/AM60 Mg joints. The relationship between mechanical properties, deformation behavior, and microstructure ch…
View article: The prevalence and influencing factors of cognitive frailty in patients with maintenance hemodialysis in China: a meta-analysis
The prevalence and influencing factors of cognitive frailty in patients with maintenance hemodialysis in China: a meta-analysis Open
Objective :To investigate the prevalence and influencing factors. Methods : CNKI, VIP, Wanfang Data Knowledge Service platform(Wanfang), China Biomedical Literature Database (CBM), PubMed, Embase, Cochrane Library, Web of Science were sear…
View article: Prevalence and related factors of cognitive frailty in diabetic patients in China: a systematic review and meta-analysis
Prevalence and related factors of cognitive frailty in diabetic patients in China: a systematic review and meta-analysis Open
Objective Cognitive frailty ( CF ) is characterized by physical frailty and potentially reversible cognitive impairment without Alzheimer’s disease and other dementias. Clarifying the prevalence and related factors of cognitive frailty can…
View article: The Chain Mediating Effect of Socialist Core Values and Positive Psychological Capital on Relationship Between Meaning in Life and Crisis Vulnerability
The Chain Mediating Effect of Socialist Core Values and Positive Psychological Capital on Relationship Between Meaning in Life and Crisis Vulnerability Open
Objective : To explore the relationship between the sense of meaning in life and crisis vulnerability of undergraduate nursing student and the chain mediating effect of socialist core value identification and positive psychological capital…
View article: Association between chronic obstructive pulmonary disease and periodontal disease: a systematic review and meta-analysis
Association between chronic obstructive pulmonary disease and periodontal disease: a systematic review and meta-analysis Open
Objectives Studies have suggested contradictory results on the relationship between chronic obstructive pulmonary disease (COPD) and periodontal disease (PD). The aim of this study was to determine whether PD increased the risk of COPD and…
View article: Patient-derived organoids as a platform for drug screening in metastatic colorectal cancer
Patient-derived organoids as a platform for drug screening in metastatic colorectal cancer Open
Introduction: Most advanced colorectal cancers are aggressive, and there is a lack of effective methods for selecting appropriate anticancer regimens. Patient-derived organoids (PDOs) have emerged as preclinical platforms for modeling clin…
View article: Newly developed 3D in vitro models to study tumor–immune interaction
Newly developed 3D in vitro models to study tumor–immune interaction Open
Immunotherapy as a rapidly developing therapeutic approach has revolutionized cancer treatment and revitalized the field of tumor immunology research. 3D in vitro models are emerging as powerful tools considering their feature to maintain …